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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Allergic rhinitis (hay fever). It is unclear if oral fulvic acid is beneficial in patients with allergic rhinitis. Details: Preliminary clinical research in people with allergic rhinitis shows that taking fulvic acid solution 3.8%, 40 mL orally twice daily for 7 days, reduces the size of cutaneous wheals from pollen prick tests by about 1.5 mm when compared with baseline (90589). The validity of this finding is limited by the lack of a comparator group.
• Alzheimer disease. Although there has been interest in using oral fulvic acid for Alzheimer disease, there is insufficient reliable information about the clinical effects of fulvic acid for this purpose.
• Atopic dermatitis (eczema). It is unclear if topical fulvic acid is beneficial in patients with atopic dermatitis. Details: Preliminary clinical research in adults with eczema shows that applying fulvic acid 5% in an emollient base twice daily to affected areas for 4 weeks modestly improves eczema symptom scores when compared with placebo (90588).
• Cancer. Although there has been interest in using oral fulvic acid for cancer, there is insufficient reliable information about the clinical effects of fulvic acid for this purpose.
• Fatigue. Although there has been interest in using oral fulvic acid for fatigue, there is insufficient reliable information about the clinical effects of fulvic acid for this purpose.
• Lead toxicity. Although there has been interest in using oral fulvic acid for lead toxicity, there is insufficient reliable information about the clinical effects of fulvic acid for this purpose.
• Respiratory tract infections. Although there has been interest in using oral fulvic acid for respiratory tract infections, there is insufficient reliable information about the clinical effects of fulvic acid for this purpose. More evidence is needed to rate fulvic acid for these uses.

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There is insufficient reliable information available about the effectiveness of humic acid.

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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Common cold. Preliminary clinical research shows that taking a specific larch arabinogalactan extract (ResistAid, Lonza Ltd.) 4.5 grams daily for 12 weeks does not significantly decrease the number, intensity, or symptoms of common colds when compared with placebo in patients who frequently suffer from colds. However, larch arabinogalactan appears to increase the percentage of patients who experience no cold episodes. About 42% of patients receiving larch arabinogalactan extract had no cold episodes, compared to only 28% of patients receiving placebo (93104).
• Hyperlipidemia. Preliminary clinical research shows that taking larch arabinogalactan 8.4 grams daily for 6 months, or 15-30 grams daily for 6 weeks, does not significantly lower total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoprotein B (apo B), apolipoprotein A-1, body weight, blood pressure, or glucose levels in healthy people (15617,15620). It is not known if larch arabinogalactan lowers lipid levels in patients with hyperlipidemia. More evidence is needed to rate larch arabinogalactan for these uses.

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There is insufficient reliable information available about the safety of humic acid.

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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LIKELY SAFE ...when used orally in amounts found in foods. Larch arabinogalactan has Generally Recognized As Safe (GRAS) status in the US (3529).

POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts, short-term. Larch arabinogalactan has been safely used at doses of 1.5-8.4 grams daily for up to 6 months (15617,15618,17370,93102,93104,104281). Higher doses of 15-30 grams daily have been used with apparent safety for up to 6 weeks (15620). There is insufficient reliable information available about the safety of larch arabinogalactan when used long-term.

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

(Read more about LARCH ARABINOGALACTAN)

ANTICOAGULANT/ANTIPLATELET DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.  Details In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation (27726).

IMMUNOSUPPRESSANTS Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.  Details Animal research shows that fulvic acid stimulates immune function (27727).

THYROID HORMONE Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.  Details Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio (27727).

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General ...Orally, fulvic acid appears to be well tolerated. Topically, adverse effects seem to be rare; however, a thorough safety evaluation has not been conducted.
Most Common Adverse Effects:
Orally: Diarrhea, headache, sore throat.
Serious Adverse Effects (Rare):
Orally: Kashin-Beck bone disease.

Gastrointestinal ...In one clinical trial, fulvic acid 3. 8% 40 mL taken orally twice daily resulted in diarrhea and sore throat in some patients (90589).

Musculoskeletal ...Although there is no evidence from well-conducted studies, there is concern that pollution of water with high concentrations of fulvic acids may contribute to the development of Kashin-Beck bone disease, particularly in areas in which selenium intake is insufficient (27722,27725,29971).

Neurologic/CNS ...In one clinical trial, fulvic acid 3. 8% 40 mL taken orally twice daily resulted in headache in some patients (90589).

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General ...None reported; however, a thorough evaluation of safety outcomes has not been conducted.

(Read more about HUMIC ACID)

General ...Orally, larch arabinogalactan is generally well tolerated (3530,17370,93102). Some people can experience bloating and flatulence (3530).

Gastrointestinal ...Orally, larch arabinogalactan can cause bloating and flatulence (3530).

(Read more about LARCH ARABINOGALACTAN)