Ingredients | Amount Per Serving |
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(5,7-Dihydroxyflavone)
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500 mg |
Cellulose, Silicon Dioxide (Alt. Name: SiO2), Magnesium Stearate Note: vegetable source, Capsule (Form: consists of Gelatin)
Below is general information about the effectiveness of the known ingredients contained in the product Chrysin 500 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Chrysin 500 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the safety of chrysin.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Chrysin 500 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
In vitro evidence suggests that chrysin might inhibit platelet aggregation (7502,42914,42920,42952,93640). Theoretically, taking chrysin with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
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Theoretically, chrysin may have an additive effect on other aromatase inhibitors such as aminoglutethimide (Cytadren), anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara) (7507,7508).
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In vitro evidence suggests that chrysin might have antiestrogenic activity (42905,42960,42962). Theoretically, use of chrysin with estrogen-containing contraceptive drugs might reduce the efficacy of these drugs.
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There is some preliminary evidence that chrysin inhibits CYP1A2 isozymes (7503, 8172, 42936, 42956). Theoretically, chrysin might decrease the metabolism of CYP1A2 substrates and increase serum concentrations. However, chrysin was not found to inhibit CYP1A2-dependent caffeine metabolism in animal research (93643). Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely (7502,7504,7505,8168,42931,42938,93643). Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
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In vitro research shows that chrysin and its sulfate conjugate inhibit diclofenac metabolism (106436). It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9 (106436). This effect has not been reported in humans.
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In vitro evidence suggests that chrysin might have antiestrogenic activity (42905,42960,42962). Theoretically, chrysin might interfere with the effects of hormone therapy.
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There is some preliminary evidence that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1) (7504,7513,8170). Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, such as acetaminophen (Tylenol), estrogens (Estrace, Premarin, others) and oral contraceptives, entacapone (Comtan), irinotecan (Camptosar), and others.
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In vitro research shows that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19 (106436). This effect has not been reported in humans.
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In vitro research shows that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4 (106436). This effect has not been reported in humans.
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Below is general information about the adverse effects of the known ingredients contained in the product Chrysin 500 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.