Below is general information about the effectiveness of the known ingredients contained in the product Hordenine 5 g. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of hordenine.
Below is general information about the interactions of the known ingredients contained in the product Hordenine 5 g. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro (91878). Theoretically, hordenine might increase the levels of CYP2D6 substrates.
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Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
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Hordenine is structurally similar to tyramine (29888) In vitro research shows that hordenine is a selective substrate for monoamine oxidase-B in the liver (27943). Theoretically, concomitant use of hordenine with MAOIs might increase blood pressure, potentially leading to a hypertensive crisis.
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Some MAOIs include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).
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Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties (29888). Theoretically, taking hordenine with drugs with stimulant properties might increase the risk of hypertension and other adverse cardiovascular effects.
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Some of these drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.
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Below is general information about the adverse effects of the known ingredients contained in the product Hordenine 5 g. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...No clinical studies have evaluated the safety of hordenine in humans. However, hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange (29888). Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension.
Cardiovascular ...Hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange (29888). Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension. However, this has not been assessed or reported in humans.