Leaf of God [Discontinued] by Hawaii Pharm

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Anxiety. Although there is interest in using oral Calea zacatechichi for anxiety, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this purpose.
• Asthma. Although there is interest in using oral Calea zacatechichi for asthma, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Cognitive function. Although there is interest in using oral Calea zacatechichi for cognitive function, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this purpose.
• Diabetes. Although there is interest in using oral Calea zacatechichi for diabetes, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Dysmenorrhea. Although there is interest in using oral Calea zacatechichi for dysmenorrhea, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Headache. Although there is interest in using oral Calea zacatechichi for headache, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Insomnia. Although there is interest in using oral Calea zacatechichi for insomnia, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Irritable bowel syndrome (IBS). Although there is interest in using oral Calea zacatechichi for IBS, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Malaria. Although there is interest in using oral Calea zacatechichi for malaria, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Rheumatoid arthritis (RA). Although there is interest in using oral Calea zacatechichi for RA, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.
• Stress. Although there is interest in using oral Calea zacatechichi for stress, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this purpose.
• Urticaria. Although there is interest in using topical Calea zacatechichi for urticaria, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this purpose. More evidence is needed to rate Calea zacatechichi for these uses.

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POSSIBLY UNSAFE ...when used orally or by inhalation. The safety of Calea zacatechichi has not been evaluated in clinical trials; however, it is illegal to use in certain jurisdictions due to hallucinogenic and hypnotic effects (23604).

PREGNANCY AND LACTATION:
Insufficient reliable evidence; avoid using.

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ANTIDIABETES DRUGS Interaction Rating = Minor Be watchful with this combination. Severity = Mild •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.  Details Animal research shows that Calea zacatechichi lowers blood glucose levels (23603). Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

CNS DEPRESSANTS Interaction Rating = Minor Be watchful with this combination. Severity = Mild •  Occurrence = Possible •  Level of Evidence = D Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.  Details Calea zacatechichi can cause CNS depression in animals and humans (23602).

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General ...There is currently a limited amount of information on the adverse effects of Calea zacatechichi. Observations in healthy volunteers indicate that it is bitter tasting and may cause vomiting and somnolence.

Gastrointestinal ...Observations in healthy volunteers indicate that Calea zacatechichi is bitter tasting and can cause nausea, vomiting, and retching (23602).

Neurologic/CNS ...In healthy volunteers, a methanol extract of Calea zacatechichi produces somnolence with short periods of light sleep and decreases in deep slow-wave sleep and rapid eye movement (REM) sleep (23602).

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