Ingredients | Amount Per Serving |
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250 mg |
Gelatin Note: capsule, Microcrystalline Cellulose
Below is general information about the effectiveness of the known ingredients contained in the product Phenibut 250 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Phenibut 250 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY UNSAFE ...when used orally. Short-term use of phenibut has been associated with delirium, diminished consciousness, reduced respirations, sedation, and death (96748,96750,96752,96753,104510,106837). Phenibut is also addictive. Regular use of phenibut for 3 days or more has been associated with the development of tolerance and withdrawal symptoms including aggression, anxiety, agitation, hallucinations, psychosis, insomnia, tachycardia, and seizures (96749,96751,96753,96755,96756,96757,101107,101108,101109,101111)(104510,104511,106839,112293,112294).
PREGNANCY:
Insufficient reliable information available; avoid using.
A case of phenibut withdrawal in the neonate is reported after use of high doses (i.e. 5-12 grams daily) for an unknown duration during pregnancy (110476).
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Phenibut 250 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
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Theoretically, phenibut might increase the risk for additive adverse effects, including sedation, when taken with pregabalin.
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Phenibut is structurally related to pregabalin, and both chemicals act at GABA receptors in the brain. In a case report, a patient who had experienced tolerance to the effects of pregabalin for treatment of chronic neuropathic pain experienced a reduction in tolerance when phenibut was taken concurrently (104511).
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Below is general information about the adverse effects of the known ingredients contained in the product Phenibut 250 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, phenibut is generally regarded as unsafe.
Any benefits of therapy may not outweigh the risk of toxicity.
Most Common Adverse Effects:
Orally: Balance impairment, dizziness, drowsiness, lethargy, and nausea. Withdrawal symptoms, including agitation, anxiety, decreased appetite, depression, hallucinations, hypertension, insomnia, nausea, seizures, and tachycardia, can occur after 3 or more consecutive days of use.
Serious Adverse Effects (Rare):
Orally: Agitation, delirium, hallucinations, respiratory depression, sedation, coma, and death when used at high doses.
Cardiovascular ...Orally, phenibut has been associated with withdrawal symptoms, including tachycardia, palpitations, and hypertension (101108,101111,104511,106839,112293,112294).
Gastrointestinal ...Orally, phenibut has been associated with nausea and vomiting (96753,101110). Regular phenibut use followed by abrupt discontinuation is associated with withdrawal symptoms, including decreased appetite and nausea (96754).
Musculoskeletal ...Orally, phenibut has been associated with withdrawal symptoms, including one case report of rhabdomyolysis and acute kidney injury in a previously healthy 24-year-old male who was also using anabolic steroids (96756). In other case reports, phenibut withdrawal was associated with muscle aches and clonus (96751,101108,101111,112293).
Neurologic/CNS ...Orally, phenibut use has been associated with a hangover effect, dizziness, balance impairment, and electric shock symptoms in the limbs (96753). Use of higher doses, ranging from 3 grams daily for 4 days to 25 grams in a single dose, has been associated with altered mental status, diminished consciousness, and sedation (96748,96750,96752). In one case report, a 25-year-old male experienced acute toxicity involving significant sedation and diminished consciousness that lasted for several hours after taking phenibut 1.5 grams twice daily for 4 days (96750). A 20-year-old female was found in a state of confusion and decreased consciousness that lasted for 24 hours after ingestion of phenibut 25 grams in one day. A 38-year-old male experienced agitated delirium requiring intubation and sedation after consumption of alcohol, marijuana, and phenibut the prior evening (96748). In another case, a 59-year-old female experienced withdrawal symptoms, including two tonic-clonic seizures, after discontinuing phenibut (96753). After several years of regular phenibut use, a 29-year-old male began taking approximately 50 grams daily over 4 daily doses due to having developed tolerance. He was hospitalized with confusion, disorientation, agitation, delusions, progressive delirium, echolalia, perseverating, insomnia, horizontal nystagmus, diaphoresis, orofacial dyskinesias, encephalopathy and mydriasis (112293).
Psychiatric
...Orally, phenibut has been associated with aggression, agitation, altered mental status, anxiety, sedation, hallucinations, insomnia, and coma in case reports and case series (96748,96750,96753,101108,101109,101110,101111,110474,110475,112293)(112294).
Phenibut is often used concurrently with other addictive substances, including alcohol (101107,101108,101109).
Observational research and case reports have found that the use of phenibut can lead to the rapid development of tolerance within 3 days, and that use for 3 or more consecutive days is associated with withdrawal symptoms including anxiety, depression, cognitive changes, insomnia, agitation, visual hallucinations, paranoid delusions, nausea, and seizures (96749,96751,96753,96754,96755,96757,101107,101108,101111,104511)(106839,110474,110475,112293).
Pulmonary/Respiratory ...Orally, phenibut use at high doses, ranging from 3 grams daily for 4 days to 25 grams in a single dose, has been associated with respiratory depression (96748,96750,96752).