| Ingredients | Amount Per Serving |
|---|---|
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Calories
|
9 Calorie(s) |
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Calories from Fat
|
9 Calorie(s) |
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Total Fat
|
0.9 Gram(s) |
| 40 mg | |
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Total Cannabinoids
|
1200 mg |
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Active Ingredients
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(aerial parts)
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|
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(seed)
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Phytocannabinoid-Rich Hemp extract PlantPart: aerial parts, Grape seed Oil PlantPart: seed
Below is general information about the effectiveness of the known ingredients contained in the product Delta 8 THC 1200 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
(Read more about DELTA-8-TETRAHYDROCANNABINOL (DELTA-8-THC))
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Delta 8 THC 1200 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the safety of delta-8-THC.
CHILDREN: POSSIBLY UNSAFE
when used orally.
Delta-8-THC-containing gummies and other products resembling candy or cookies have been mistakenly consumed by children, resulting in hospital admission (106107,106108,107322,113033). Deep sedation with low blood pressure and a slowed heart rate have occurred (106108,107322).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
(Read more about DELTA-8-TETRAHYDROCANNABINOL (DELTA-8-THC))
LIKELY SAFE ...when used orally in amounts commonly found in foods. Grapes and grape skin extracts have Generally Recognized As Safe (GRAS) status for use in foods in the US (4912).
POSSIBLY SAFE ...when the whole fruit of the grape, or extracts of the fruit, seed, or leaf, are used orally and appropriately in medicinal amounts. Grape seed extracts have been used with apparent safety in doses up to 200 mg daily for up to 11 months (9182,53016) and in doses up to 2000 mg daily for up to 3 months (53149,53190). Specific grape fruit extracts (Stilvid, Actafarma; Cognigrape, Bionap srl) have been used with apparent safety in doses up to 250-350 mg daily for 3-12 months or 700 mg daily for 6 months (53254,53256,96198). A specific grape leaf extract (AS 195, Antistax, Boehringer Ingelheim) has been used with apparent safety in doses up to 720 mg daily for up to 3 months (2538,52985,53005,53206). A preparation of dehydrated whole grapes, equivalent to 250 grams of fresh grapes daily, has also been used with apparent safety for up to 30 days (18228). A specific grape seed extract (Enovita; Indena SpA) 150 mg twice daily, standardized to provide at least 95% oligomeric proanthocyanins, has been used with apparent safety for up to 16 weeks (108091) ...when used topically and appropriately. Creams and ointments containing grape seed extract 2% or 5% have been used topically with apparent safety for up to 3 weeks (91539,100955). There is insufficient reliable information available about the safety of other grape plant parts when used topically.
CHILDREN: LIKELY SAFE
when used orally in amounts commonly found in foods.
Grapes and grape skin extracts have Generally Recognized As Safe (GRAS) status for use in foods in the US (4912). However, whole grapes should be eaten with caution in children aged 5 years and under. Whole grapes can be a choking hazard for young children (96193). To reduce the risk of choking, whole grapes should be cut in half or quartered before being given to children. There is insufficient reliable information available about the safety of grape when used in medicinal amounts in children.
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods.
There is insufficient reliable information available about the safety of medicinal amounts during pregnancy and breast-feeding; avoid using in amounts greater than what is commonly found in foods.
LIKELY SAFE ...when hemp seed, hemp protein, and hemp seed oil are used orally in food amounts. Hulled hemp seed, hemp seed protein powder, and hemp seed oil are generally recognized as safe (GRAS) in the US (100531).
POSSIBLY SAFE ...when hemp seed oil is used orally and appropriately as medicine, short-term. Hemp seed oil in doses of 2-6.3 grams daily has been safely used for 3-6 months (88183,16791,101145). Hemp seed oil in doses of 30 mL (27.6 grams) daily has been used safely for 2 months (101125). There is insufficient reliable evidence available about the safety of hemp oil, flowers, or leaves.
CHILDREN:
There is insufficient reliable information available about the safety of hemp in children.
Adverse effects have been noted in case reports, but details related to specific hemp products are limited (101153,110287).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Delta 8 THC 1200 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
 Details
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Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
Details
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water (53177). Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.
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Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
Details
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2 (2539).
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It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Details
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes (11094,53011,53089). However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism (11094). The effects of continued grape juice consumption are unclear.
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Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Details
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes (53011). However, this interaction has not been reported in humans.
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Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Details
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes (52949). However, this interaction has not been reported in humans.
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It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Details
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Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Details
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination (53011).
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Grape juice might decrease phenacetin absorption.
Details
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2) (2539).
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Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Details
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Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Details
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Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
Details
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals (101136). Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans (101144).
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Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Details
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol (101132). The mechanism of action for this effect is unclear.
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Below is general information about the adverse effects of the known ingredients contained in the product Delta 8 THC 1200 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...There is limited information available about the safety of delta-8-THC.
A thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
Orally: Anxiety, cough, difficulty thinking and speaking, dream-like state, euphoria, feeling "high", paranoia, and vision and time distortion.
Serious Adverse Effects (Rare):
Orally: Brugada EKG pattern, cannabinoid hyperemesis syndrome (CHS).
Cardiovascular ...An otherwise healthy 31-year-old male experienced sudden onset substernal, non-exertional chest pain within 20 minutes of taking a gummy containing delta-8-THC. Brugada type I pattern was noted on EKG, with notable progression from a baseline EKG 2 months prior that showed Brugada type III pattern. EKG returned to baseline by 16 hours post-ingestion and the Brugada pattern ultimately resolved by one-month follow up (107323). Three cases report tachycardia in pediatric patients after unintentional ingestion of delta-8-THC that resolved with supportive care (113033,113042).
Gastrointestinal ...A 38-year-old female developed cannabinoid hyperemesis syndrome (CHS) after taking gummies containing delta-8-THC most nights of the week for approximately one month. Symptoms resolved almost immediately after treatment with topical capsaicin cream and intravenous haloperidol 5 mg (106104). A case in a 6-year-old female reports nausea and vomiting after ingestion of delta-8-THC gummies that resolved over 2 days with supportive care (113042).
Neurologic/CNS ...Delta-8-THC has been reported to cause psychoactive effects and a feeling of being "high". It is estimated to be 50% to 75% as psychoactive as delta-9-THC, the primary psychoactive constituent of cannabis. Effects include euphoria, vision and time distortion, difficulty thinking and speaking, and a dream-like feeling (106100,106107,106108). A large case series reports neurologic disorders (e.g., dizziness, somnolence, altered consciousness) as some of the most frequently noted adverse effects with delta-8-THC after assessing a public forum of 98,700 subscribers (113017). Of 183 adverse events related to delta-8-THC reported to the US Food and Drug Administration, 16 report occurrence of seizure (113026). A 2-year-old child presented with sedation and acute encephalopathy requiring intubation following accidental ingestion of gummies containing an estimated delta-8-THC dose of 15 mg/kg. Resolution occurred after approximately 1.5 days of supportive care (107322). Six cases in pediatric patients, ranging from 18 months old to 16 years old, report 5 ingestions and 1 inhalation of delta-8-THC resulting in neurologic presentations (e.g., lethargy, somnolence, agitation, dizziness, unresponsiveness, or possible seizure) requiring supportive care. Resolution occurred over 2 days in most cases (113033,113042).
Psychiatric ...A large case series reports psychiatric disorders as some of the most frequently noted adverse effects with delta-8-THC after assessing a public forum of 98,700 subscribers. Furthermore, anxiety and paranoia were 2 of the most cited adverse effect terms, about 16% and 9%, respectively (113017). Additionally, 3 cases report psychosis in adults after ingesting or inhaling delta-8-THC. All 3 patients required admission to a psychiatric hospital and antipsychotic medications prior to discharge. However, 2 of the patients had underlying psychiatric histories (113047).
Pulmonary/Respiratory ...A large case series reports pulmonary disorders g., cough, dry throat, dyspnea, painful respiration) as some of the most frequently noted adverse effects with delta-8-THC after assessing a public forum of 98,700 subscribers (113017). Of 183 adverse events related to delta-8-THC reported to the US Food and Drug Administration, 33 report dyspnea, 17 report respiratory disorder, and 15 report cough (113026). Additionally, 2 cases in pediatric patients report slowed respiratory breathing with varying initial presentations of somnolence and agitation after ingesting delta-8-THC in the form of candy at doses of 16 mg/kg and 38 mg/kg. Resolution occurred in both cases with supportive care and intensive care admission for approximately 2 days (113033).
Other ...Based on statistics from the American Association of Poison Control Centers, hospitalization occurred in 18% of 661 reported exposures to delta-8-THC in the first 7 months of 2021 (106108). In the 8-month period ending in July 2021, 14 of 22 cases reported to the US FDA presented to the hospital for adverse effects related to delta-8-THC-containing products (106107). In addition, the CDC's National Syndromic Surveillance Program (NSSP) has found an increase in visits to emergency departments due to complaints related to delta-8-THC (106108). Symptoms of delta-8-THC intoxication include vomiting, lethargy, hallucinations, lack of muscle coordination, increased and decreased heart rate, low blood pressure, difficulty breathing, and coma (106107,106108,107322).
(Read more about DELTA-8-TETRAHYDROCANNABINOL (DELTA-8-THC))
General
...Orally, the whole fruit, as well as the seed, fruit, and leaf extracts, seem to be well tolerated.
Topically, grape seed extracts seem to be well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, diarrhea, dry mouth, dyspepsia, headache, joint pain, and nausea.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis to grape skin has been reported.
Dermatologic ...Orally, mild hair thinning has been reported in a patient taking a specific grape leaf extract AS195 KG) (2538). Urticaria (hives) has also been reported with this same extract (53206). Cases of contact dermatitis have been reported in grape workers, including those working in California vineyards (53270,53272,53275).
Gastrointestinal ...Orally, abdominal pain and nausea have been reported with use of grape seed extract, but these effects typically occur at rates similar to placebo (9182,13162). In a case report of a 57-year-old man, intermittent nausea, vomiting, and diarrhea occurred over a 10-day period and improved once grape seed extract was stopped (96764). Gastrointestinal adverse effects have also been reported with use of a different grape seed extract (Entelon, Hanlim Pharm). However, the specific types of gastrointestinal effects were not described (100954). A specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG) has reportedly caused flatulence, mild constipation, gastrointestinal discomfort, diarrhea, dyspepsia, dry mouth, and retching (2538,52985,53206). Diarrhea, gastrointestinal distress, indigestion, and aversion to taste have been reported with use of Concord grape juice (52972,53166,53175,53181,53199). Loose stools have been reported in a clinical trial of grape pomace (99270). Bowel obstruction caused by intact grapes and grape seeds has been described in case reports (53241,53284,53278). Excessive consumption of grapes, dried grapes, raisins, or sultanas might cause diarrhea due to laxative effects (4201).
Hematologic ...Orally, one case of leg hematoma following a minor trauma was reported in a person using grape leaf extract (2538). Also, one case of bruising was reported in a person drinking Concord grape juice daily for 2 weeks (52972).
Immunologic ...Orally, there is one report of an anaphylactic reaction to oral grape skin extract, which included urticaria and angioedema (4073).
Musculoskeletal ...Orally, musculoskeletal disorders, including back pain, have been reported with use of a specific grape leaf extract AS195 KG) (2538,53206). Joint pain and lumbago have been reported with use of grape seed extract, but these effects occur at rates similar to placebo (91541).
Neurologic/CNS ...Orally, headache has been reported with use of grape seed extract, but this effect occurs at rates similar to placebo (9182,91541). A specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG) has reportedly caused dizziness, tiredness, headache, and sleep problems (2538,53206). As a class, nervous system adverse effects have been reported with use of a specific grape seed extract (Entelon, Hanlim Pharm). However, the specific types of adverse neurologic effects were not described (100954).
Ocular/Otic ...Orally, ocular adverse effects have been reported with use of a specific grape seed extract (Entelon, Hanlim Pharm). However, the specific types of ocular adverse effects were not described (100954).
Pulmonary/Respiratory ...Orally, nasopharyngitis and oropharyngeal pain have been reported with use of a specific grape leaf extract AS195 KG) (53206). Sore throat, cough, allergic rhinitis, and nasopharyngitis have been reported with use of grape seed extract, but these effects occur at rates similar to placebo (9182,91541). One case report describes a 16-year-old female who developed increased levels of immunoglobulin E (IgE) following skin-prick exposure to grape vine pollen, as well as positive test responses following bronchial and conjunctival provocation (53301). Reduced forced vital capacity has been described in California grape workers (53080,53081). Occupational eosinophilic lung was diagnosed in a grape grower with a history of asthma. Respiratory exposure to sulfites in grape was implicated as the cause of the adverse reaction (53285).
Other
...Orally, grape products can cause adverse effects due to contamination with pesticides or mycotoxins.
Some evidence has shown that pesticides used in vineyards may remain on grape surfaces post-harvesting. For example, the fungicide folpet sprayed on grapevines has been shown to remain on the grape surface. Although there was minimal penetration of the epicuticular wax, it showed high resistance to washing (52935). Carbaryl has been identified in over 58% of juice samples collected in Canada. This pesticide reportedly occurred more frequently in grape than in other juices. However, estimates of short-term intake were below proposed acute reference doses (53003).
Ochratoxin A is a mycotoxin that is suspected to be nephrotoxic, teratogenic, hepatotoxic and carcinogenic and has been identified in grape juice, frozen grape pulps, and red and white wine sold in Rio de Janeiro, Brazil. However, the highest levels identified in grape products were lower than the established virtually safe dose of 5 ng/kg of body weight daily (53010,53004). Ochratoxin A has also been identified in red, but not white, grape juice marketed in Switzerland, Canada, and the U.S. (53292,53020).
General
...Orally, hemp products are generally well tolerated in food amounts.
In larger amounts, hemp seed oil seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Rare cases of anaphylaxis have been reported. Long QT syndrome, torsades de pointes, and syncope have also been reported rarely.
Cardiovascular ...Acquired long QT syndrome, torsades de pointes, and syncope have been reported in a 56-year-old woman following the intake of supplements containing hemp oil. The hemp supplements provided cannabidiol (CBD), and possibly cannabigerol (CBG). Although the exact dose is unknown, up to six times the recommended dose had been used for approximately 6 weeks, in combination with a supplement containing berberine. While hospitalized, intravenous magnesium and saline were used to stabilize heart rhythm. It is unknown whether this adverse effect was related to the hemp oil, berberine, or their interaction (110104).
Hepatic ...Orally, there is a case report of elevated liver enzymes and hepatitis in a two-year-old boy given hemp extract 2. 5 mL, providing 125 mg phytocannabinoid, five to eight times daily for infantile spasms and refractory seizures. The total dose of phytocannabinoids was approximately 60-100 mg/kg daily (110287).
Immunologic
...Orally, there are case reports of allergy to hemp seed, although this is uncommon (101140,101154).
A 44-year-old male developed hives during a meal of hemp seed-crusted seafoods. Later, he developed facial swelling, shortness of breath, and problems speaking. Evaluation revealed allergy to a specific protein in hemp seed. He did not react to smoked cannabis (101140). In other cases, anaphylaxis, facial swelling, and worsening asthma have been reported in association with a first exposure to hemp seed, although some had smoked cannabis previously (101154).
Topically, a case of patch-test confirmed allergic contact dermatitis to hemp seed oil has been reported in a 22-year-old woman. The initial rash started at the application point on her back and spread to her arms, hands, and neck (110288).
Airborne exposure to hemp pollen is a relatively common cause of allergic respiratory symptoms in some locations (101155).
Neurologic/CNS ...Orally, cases of acute cannabinoid toxicity with neurological symptoms in children and adults have been associated with intake of hemp seed oil. There is a case report of decreased alertness, stupor, bloodshot eyes, and fixed gaze in a 2-year-old male probably related to the intake of one teaspoon hemp seed oil (CANAH) containing 0.06% delta-9-tetrahydrocannabinol (THC) twice daily for 3 weeks. After stopping the oil, irritability was reported over the next few days (101153).
