Ingredients | Amount Per Capsule |
---|---|
Proprietary Blend
(Carmelite Water Blend)
|
450 mg |
(Angelica )
(root)
|
|
(seed)
|
|
(Melissa )
(Leaf)
|
|
(peel)
|
|
Gelatin, Water
Below is general information about the effectiveness of the known ingredients contained in the product Carmelite Water Blend 450 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Carmelite Water Blend 450 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Angelica archangelica has Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of Angelica archangelica when used orally or topically for medicinal purposes.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Coriander and coriander oil have Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when used orally and appropriately for medicinal purposes (12). ...when used topically and appropriately. Coriander oil 6% ointment has been used with apparent safety twice daily for up to 28 days (97874).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid amounts in excess of those found in foods.
LIKELY SAFE ...when used in amounts commonly found in foods. Lemon has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when inhaled in amounts used for aromatherapy, short-term. Lemon essential oil has been used with apparent safety as aromatherapy for up to 2 weeks in clinical research (93475,98128,98129). There is insufficient reliable information available about the safety of lemon when used topically, or when used orally or intranasally in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available.
Avoid using in amounts greater than those typically found in foods.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Lemon balm has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when used orally and appropriately, short-term. Lemon balm extract has been used with apparent safety at a dose of 500 mg daily for 6 months or at a dose of 3000 mg daily for 2 months (9993,9994,104435,104435,110136). ...when used topically and appropriately, short-term. Lemon balm 1% dried leaf extract has been used up to 4 times daily with apparent safety for a few days (790,9995).
CHILDREN: POSSIBLY SAFE
when used orally and appropriate, short-term.
A single dose of lemon balm extract 3-6 mg/kg has been safely used in children aged 6-7 years (19525). A specific combination product providing lemon balm leaf extract 80 mg and valerian root extract 160 mg (Euvegal forte, Dr. Willmar Schwabe Pharmaceuticals) 1-2 tablets once or twice daily has been safely used in children under 12 years of age for 30 days (14416). In infants up to 4 weeks old, multi-ingredient products (ColiMil, ColiMil Plus) containing lemon balm 64-97 mg daily have been used with apparent safety for up to 7 days (16735,96278).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally and appropriately in amounts commonly found in foods. Nutmeg is commonly used as a spice. Nutmeg and nutmeg oil have Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of nutmeg when used orally in larger doses, up to 120 mg daily. These doses have not been adequately evaluated in clinical research. However, doses at or above 120 mg daily have been associated with serious adverse effects (19292).
POSSIBLY UNSAFE ...when used orally in doses of 120 mg or greater. Chronic use of nutmeg in these doses has been associated with psychotic episodes and hallucinations (19292,19296,19487). Acute intoxication from nutmeg has been described in several case reports in which subjects ingested a single dose of 5-80 grams (2563,19297,19300,19491,111750). Symptoms of toxicity ranged from nausea, dry mouth, and dizziness to palpitations, agitation, and hallucinations (2563,3494,19293,19294,19295,19297,19298,19299,19489,19490)(19491,103373,111750). Two deaths involving nutmeg intoxication have also been reported (19300,112016) . Symptoms generally start 0.5-8 hours after ingestion and last up to 24-48 hours (19298,19488,19491,103372,103373). There is insufficient reliable information available about the safety of nutmeg when used topically.
PREGNANCY: LIKELY SAFE
when used orally and appropriately in amounts commonly found in foods.
PREGNANCY: POSSIBLY UNSAFE
when used orally in medicinal amounts.
Nutmeg might have abortifacient activity, and its safrole content might be mutagenic (12).
LACTATION: LIKELY SAFE
when used orally and appropriately in amounts commonly found in foods.
There is insufficient reliable information available about the safety of nutmeg when used in larger, medicinal amounts during lactation; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Carmelite Water Blend 450 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Details
|
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Details
Evidence from animal research suggests that coriander fruit can lower blood pressure (46221).
|
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Details
Evidence from animal research suggests that coriander fruit extract has sedative effects (46184).
|
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Details
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects (46228).
|
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
Details
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage (110781).
|
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Details
|
Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
Details
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity (19727,19728). In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion (19726).
|
Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.
Details
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels (25549).
|
Theoretically, concomitant use of nutmeg with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Details
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels (25549).
|
Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.
Details
Animal studies suggest that nutmeg extracts and several volatile oils in nutmeg, such as methyleugenol, isoeugenol, safrole, myristicin, trimyristin, 1,8-cineole, and geranyl acetate, have sedative effects (2563,25544,25545,25547,25548). One animal study shows that petroleum ether extracts of nutmeg can potentiate the effects of pentobarbital or phenobarbital (25547). However, evidence from other animal research suggests that the nutmeg constituent myristicin can actually reduce sleeping time in rats pretreated with phenobarbital (3492,3493).
|
Theoretically, nutmeg might decrease the levels and clinical effects of drugs metabolized by CYP1A1.
Details
Animal research suggests that intraperitoneal injections of myristicin, a constituent of nutmeg, can induce CYP1A1 (3493).
|
Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.
Details
Animal research suggests that intraperitoneal injections of myristicin, a constituent of nutmeg, can induce CYP1A2 (3493).
|
Theoretically, nutmeg might decrease levels of drugs metabolized by CYP2B1.
Details
Animal research suggests that intraperitoneal injections of myristicin, a constituent of nutmeg, can induce CYP2B1 (3493).
|
Theoretically, nutmeg might increase or decrease the effects and adverse effects of phenobarbital.
Details
|
Below is general information about the adverse effects of the known ingredients contained in the product Carmelite Water Blend 450 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, Angelica archangelica is generally well tolerated in food amounts.
There is limited information available about the adverse effects of Angelica archangelica when used as medicine.
Most Common Adverse Effects:
Orally: Constipation, photosensitivity.
Dermatologic ...Orally or topically, Angelica archangelica might cause photosensitivity reactions (13406). Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis" (18).
Gastrointestinal ...Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica) (92461).
General
...Orally and topically, coriander seems to be well tolerated.
Most Common Adverse Effects:
Topically: Contact dermatitis in sensitive individuals.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis in sensitive individuals.
Dermatologic ...Topically, coriander can cause pruritus and a burning sensation (97874).
Immunologic ...A case of anaphylactic reaction characterized by generalized urticaria, conjunctivitis, oropharyngeal angioedema, and bronchospasms has been reported in a 25-year-old spice worker who consumed food containing coriander fruit. The digestive spice allergy was attributed to sensitization to coriander caused by occupational exposure to coriander fruit, powder, and dust (46192). Also, cases of rhinitis and symptoms of asthma have been reported for patients exposed to dust from coriander spice, particularly people working with spices in the food industry (46226,46245). Like other members of the Apiaceae/Umbelliferae (carrot family), coriander can cause contact dermatitis (19). A case of occupational protein contact dermatitis has been reported for an individual exposed to coriander fruit (46168).
General
...Orally, lemon is well tolerated in amounts commonly found in foods.
A thorough evaluation of safety outcomes has not been conducted on the use of larger amounts.
Most Common Adverse Effects:
Orally: Epigastralgia and heartburn with the regular consumption of fresh lemon juice.
Dermatologic ...Topically, the application of lemon oil might cause photosensitivity, due to furocoumarin derivative content. This occurs most often in fair-skinned people (11019).
Gastrointestinal ...Orally, fresh lemon juice, taken as 60 mL twice daily, has been reported to cause gastrointestinal disturbances in 37% of patients in one clinical trial, compared with 8% of patients in the placebo group. Specifically, of the patients consuming lemon juice, 21% experienced heartburn and 8% experienced epigastralgia, compared to 1% and 3%, respectively, in the placebo group (107489).
General
...Orally, lemon balm seems to be well tolerated in food amounts and larger, medicinal amounts.
Topically, lemon balm seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Wheezing has been rarely reported.
Cardiovascular ...Orally, a case of transient complete atrioventricular block and QT prolongation is reported in a 25-year-old female following the post-workout use of a specific product (Muscle Eze Advanced) containing lemon balm and several other ingredients. Symptoms of fatigue and lightheadedness started 1 week into use of the product. Product discontinuation led to restoration of normal sinus rhythm within 24 hours and normalization of the electrocardiogram within 2 weeks (112556). It is unclear whether this occurrence is due to lemon balm, other ingredients, or the combination.
Dermatologic ...Topically, lemon balm 1% cream applied 5 times daily to cold sores has been associated with two cases of irritation and one case of cold sore exacerbation. However, these effects do not appear to occur more often with lemon balm than with placebo (790).
Gastrointestinal ...Orally, lemon balm might increase appetite in some patients (91732,104433). Nausea, vomiting, and abdominal pain have been reported rarely and do not seem to occur more often than in patients taking placebo (9993).
Neurologic/CNS ...Orally, lemon balm has been reported to cause dizziness and sedation; however, it does not seem to occur more often with lemon balm than placebo (9993,104433). Additionally, other clinical research shows that using lemon balm in conjunction with alcohol does not affect reaction time or influence cognitive performance (19427,19723).
Pulmonary/Respiratory ...Orally, lemon balm has been associated with rare cases of wheezing (9993).
General
...Orally, nutmeg is generally well tolerated when used as a spice in foods.
Acute or chronic use of nutmeg at high doses is unsafe.
Most Common Adverse Effects:
Topically: Allergic contact dermatitis in sensitive individuals.
Serious Adverse Effects (Rare):
Orally: Accidental or intentional overdose with nutmeg has been associated with several serious adverse cardiovascular, gastrointestinal, neurological, and psychiatric events. Death due to overdose has also been reported.
Cardiovascular ...Orally, in cases of nutmeg overdose, tachycardia, palpitations, weak pulse, hypotension, and nonspecific electrocardiographic changes have been reported (3494,19293,19295,19299,19300,19488,19489,25943,103372,103373)(111750).
Dermatologic ...Topically, allergic contact dermatitis to nutmeg has been reported (25945,25946).
Gastrointestinal ...Orally, nausea was reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis (2563). Vomiting was reported in a case of a 19-year-old female using high doses of nutmeg with a history of lysergic acid diethylamide (LSD) and cannabis use (19294). Burning epigastric pain, gastroenteritis, diarrhea, nausea, and increased thirst have been reported in other cases of intentional or unintentional nutmeg overdose (19293,19299,19300,19489,19490,103372,103373). Vomiting has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder (103372).
Hematologic ...Orally, hyponatremia and leukocytosis with neutrophilia associated with nutmeg overdose have been rarely reported (103372).
Hepatic ...Orally, elevated liver enzymes associated with nutmeg overdose have been reported rarely (103372).
Immunologic ...Topically, allergic contact dermatitis to nutmeg has been reported (25945,25946).
Musculoskeletal ...Orally, muscle weakness, numbness, and ataxia were reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis (2563). An ataxic gait has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder (103372).
Neurologic/CNS ...Orally, headache, dizziness, and drowsiness were reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis (2563). Adverse effects associated with high intake of nutmeg have included confusion, dizziness, drowsiness, hallucinations, headache, incoherent speech, hot and cold sensations, sensations of limb loss, convulsions, and coma (19294,19299,19300,19487,19489,19490,103372,103373,111750). Sweating and hypothermia have also been reported following intake of high doses of nutmeg (19293,19294). Lethargy has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder (103372).
Ocular/Otic ...Orally, a case of double, triple, and blurred vision has been reported for a 13-year-old female who consumed nutmeg capsules while smoking cannabis (2563). Pupil dilation and pupil constriction has been reported from exposure to nutmeg (25948). Involuntary eye movement has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder (103372).
Psychiatric ...Orally, visual, auditory, and tactile hallucinations, depression, suicidal ideation, insomnia, restlessness, and bizarre behavior have been reported following nutmeg intoxication in various reports (12,2563,19300,19492,103372,103373). Other adverse effects associated with high intake of nutmeg have included disorientation, stupor, euphoria, anxiety, and agitation (19300,19489,103373,103374). Chronic psychosis has been associated with rare cases of prolonged abuse of nutmeg (103372). However, some researchers suggest that nutmeg does not have significant psychological or behavioral effects, even when taken at high doses (25939,25947). Restlessness and anxiety have been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder (103372).
Other ...Orally, fatal poisoning associated with nutmeg is rare (19300,103372,103373).