Ingredients | Amount Per Serving |
---|---|
(Sassafras )
(Sassafras albidum Root Bark Extract, Dry)
(Extraction rate: about 1/3-4 (up to 333 mg of dry raw material per 1 ml of extract).)
|
983 mg |
Alcohol, Water, Glycerin
Below is general information about the effectiveness of the known ingredients contained in the product Sassafras. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of sassafras.
Below is general information about the safety of the known ingredients contained in the product Sassafras. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used in amounts commonly found in foods. Safrole-free sassafras has Generally Recognized As Safe status (GRAS) for use in foods in the US (4912).
POSSIBLY UNSAFE ...when safrole-free sassafras is used in medicinal amounts. Some studies link safrole-free sassafras extracts to tumors (515).
LIKELY UNSAFE ...when used orally as a medicinal agent; avoid using (3,4). Sassafras root bark and oil contain safrole and related compounds that are carcinogenic and hepatotoxic in animals (4,12,17). Consumption of 5 mL sassafras oil can be fatal in adults (4). ...when used topically; avoid external use due to toxic safrole content (4).
CHILDREN: LIKELY UNSAFE
when used orally.
A few drops of sassafras oil can be fatal in children (4).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally (12); avoid using.
Sassafras oil has abortifacient effects (4).
Below is general information about the interactions of the known ingredients contained in the product Sassafras. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects (19).
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In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole (101899). So far, this interaction has not been reported in humans. Also, it is not known if CYP1A2 inducers increase the toxicity of sassafras. Inducers of CYP1A2 include omeprazole (Prilosec).
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Below is general information about the adverse effects of the known ingredients contained in the product Sassafras. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Sassafras is generally regarded as unsafe for use in medicinal amounts.
Any benefits of therapy may not outweigh the risks of toxicity. Orally, sassafras can cause diaphoresis and hot flashes (11). Consumption of large amounts of sassafras oil can cause hallucinations lasting for several days (4). In adults, 5 mL sassafras oil can cause shakes, vomiting, dilated pupils, hypertension, tachycardia, stupor, collapse, abortion, paralysis, liver cancer, and death (4,6). The safrole constituent of sassafras oil and tea is carcinogenic (73138,73134). Increased incidence of esophageal cancer has been noted in areas with habitual sassafras consumption (73137).
Topically, sassafras can cause contact dermatitis (6).
Cardiovascular ...Orally, consuming 5 mL sassafras oil can cause hypertension and tachycardia (4,6).
Gastrointestinal ...Orally, consuming 5 mL sassafras oil can cause vomiting (4,6).
Immunologic ...Topically, sassafras can cause contact dermatitis (6).
Neurologic/CNS ...Orally, sassafras can cause diaphoresis and hot flashes (11,73136). Consumption of large amounts of sassafras oil can cause hallucinations lasting for several days (4). In adults, 5 mL sassafras oil can cause shakes, dilated pupils, stupor, collapse, and paralysis (4,6).
Oncologic ...Orally, consuming sassafras oil can cause liver cancer (4,6). The safrole constituent of sassafras oil and tea is carcinogenic (73134,73138). Increased incidence of esophageal cancer has been noted in areas with habitual sassafras consumption (73137).
Other
...Orally, consuming 5 mL sassafras oil can cause death in adults (4,6).
One study estimates that safrole at doses as low as 0.66 mg/kg could be toxic. One cup of tea made with 2.5 grams of sassafras is estimated to contain 200 mg of safrole, or approximately 3 mg/kg for the average adult. This is 4.5 times the estimated toxic dose (4). A few drops of sassafras oil may be fatal in children (4).