Pure Rooibos Warm Balance by Ecoteas

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Allergic rhinitis (hay fever). Although there has been interest in using oral rooibos for allergic rhinitis, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Age-related cognitive decline. Although there has been interest in using oral rooibos for age-related cognitive decline, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Anxiety. Although there has been interest in using oral rooibos for anxiety, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Cardiovascular disease (CVD). Although there has been interest in using oral rooibos for CVD, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Cancer. Although there has been interest in using oral rooibos for cancer, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Diabetes. Although there has been interest in using oral rooibos for diabetes, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Dyspepsia. Although there has been interest in using oral rooibos for dyspepsia, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• HIV/AIDS. Although there has been interest in using oral rooibos for HIV/AIDS, there is insufficient reliable information about the clinical effects of rooibos for this purpose.
• Obesity. Although there has been interest in using oral rooibos for obesity, there is insufficient reliable information about the clinical effects of rooibos for this purpose. More evidence is needed to rate rooibos for these uses.

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LIKELY SAFE ...when used orally in food amounts (6,4120). There is insufficient reliable information available about the safety of rooibos when used orally in medicinal amounts.

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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ACE INHIBITORS (ACEIs) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with ACEIs may increase the therapeutic and adverse effects of ACEIs.  Details Clinical research in healthy adults shows that taking a single dose of rooibos tea, 400 mL orally, inhibits angiotensin-converting enzyme activity (101253).

ATORVASTATIN (Lipitor) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with atorvastatin may increase the therapeutic and adverse effects of atorvastatin.  Details Animal research shows that consuming green rooibos extract with atorvastatin daily for 3 weeks increases the maximum plasma concentration of atorvastatin by 6-fold and reduces the clearance of atorvastatin (104211).

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.  Details In vitro research shows that the methanol extract of rooibos leaves and stems inhibits CYP1A2 enzyme activity (101251).

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with CYP2C19 substrates may increase the effects of CYP2C19 substrates.  Details In vitro research shows that the methanol extract of rooibos leaves and stems strongly inhibits CYP2C19 enzyme activity (101251).

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with CYP2C9 substrates may increase the effects of CYP2C9 substrates.  Details In vitro research shows that the methanol extract of rooibos leaves and stems inhibits CYP2C9 enzyme activity (101251).

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.  Details In vitro research shows that the methanol extract of rooibos leaves and stems inhibits CYP2D6 enzyme activity (101251).

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.  Details In vitro research shows that the methanol extract of rooibos leaves and stems strongly inhibits CYP3A4 enzyme activity (101251).

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General ...There is currently a limited amount of information on the adverse effects of roobios. A thorough evaluation of safety outcomes has not been conducted.
Serious Adverse Effects (Rare):
Orally: Hepatotoxicity.

Hepatic ...Orally, large and long-term doses of rooibos tea might cause hepatotoxicity in some susceptible patients. In a case-report, a 37-year-old man drinking 10 cups of rooibos tea daily for over a year presented with hepatic dysfunction and thrombocytopenia (101254).

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