Abuta

There is insufficient reliable information available about the safety of abuta.

PREGNANCY AND LACTATION: Insufficient reliable information available; avoid using.

Adult

Oral:

Research is limited; typical dosing is unavailable.

Topical:

Research is limited; typical dosing is unavailable.

Standardization & Formulation

There is insufficient reliable information available about the standardization of abuta.

There is insufficient reliable information available about the presentation or treatment of overdose with abuta.

There is insufficient reliable information available about the pharmacokinetics of abuta.

General

The applicable parts of abuta are the bark, root, seed, and above ground parts (101065, 101066). Several potentially active constituents of abuta have been isolated. Constituents of abuta root include terpenoids, flavonoids, and the alkaloids hayatinin, hayatin, cissamine, cissampareine, pareirubrines A and B, pelosine, bebeerine, tetrandrine, and others (15188, 15189, 15191, 30196, 101065, 101066, 101067). The chalcone-flavone dimer cissampeloflavone has also been isolated from the above ground parts of abuta (15189).

Analgesic effects

Abuta is traditionally used for pain. In animal models, abuta extract reduced pain and inflammation (101066).

Anti-cancer effects

Abuta is traditionally used for cancer. In animal models, abuta extract protected against the development of cancer. The possible mechanism of action might be related to the antioxidant effects of some of its flavonoid and/or alkaloid constituents (101065).

Anti-diarrheal effects

Abuta is traditionally used for diarrhea. In an animal model, abuta extract was shown to reduce intestinal fluid accumulation and the number of fecal droppings (101065).

Anti-fertility effects

Abuta is traditionally used in birth control. In animal research, abuta prolonged the length of the estrous cycle by altering gonadotropin release and estradiol secretion (101065).

Anti-ulcer effects

Abuta is traditionally used for ulcers. In animal models, abuta, and the constituent quercetin, had anti-ulcer effects, protecting against the development of ulcers (101065).

Anti-urolithic effects

Abuta is traditionally used for its anti-urolithic effects. In an animal model, abuta extract increased urinary output and reduced levels of calcium and uric acid in the urine, preventing kidney damage (101067).

Anti-venom effects

Abuta is used traditionally as a treatment for snake bites. In an animal model, abuta extract neutralized the hemorrhagic and proteolytic actions of snake venom (101065).

Antiprotozoal effects

Abuta is traditionally used for malaria. Abuta extract has shown anti-plasmodial effects in animal models and in vitro (101065). The constituent cissampeloflavone has antiprotozoal activity in vitro (15189).

Cardiovascular effects

Abuta is traditionally used for heart problems. Abuta extract has been shown to have cardioprotective effects in an animal model (101065).

CNS/Neurological effects

Animal research in mice shows that taking abuta leaf extract 400 mg/kg once daily for 14 days improves signs of anxiety and depression when compared with control (109516).

Muscle relaxant effects

Abuta is thought to have muscle relaxant effects and has been used for uterine contractions and death by asphyxiation. The constituent hayatinin and hayatin alkaloids are chemically related to curare and have neuromuscular blocking and muscle relaxant effects similar to tubocurarine (15190, 101065). Animal research in mice also shows that taking abuta leaf extract 400 mg/g once daily for 14 days increases muscle relaxation when compared with control (109516).