Each 5 mL vial contains: Medicinal Ingredients (strength 2X, 25 SPU/mL [tree, grass], strength 2X, 25 SAU/mL [dust mite]): Tree: Alnus Rugosa , Alder (source: pollen) • Betula Lenta , Black Birch (source: pollen) • Grass: hydrolyzed collagen%type II , Timothy (source: pollen) • Dactylis Glomerata , Orchard Grass (source: pollen) • Poa Pretensis , June Grass (source: pollen) • Agrostis Alba , Red Top (source: pollen) • Anthoxanthum odoratum , Sweet Vernal (source: pollen) • Dust Mite: Dermatophagoides Pteryonyssinus , House Dust Mite (source: whole organism) • Dermatophagoides Farinae , House Dust Mite (source: whole organism). Non-Medicinal Ingredients: Glycerin 50%, Phenol 0.4%, Water For Injection qsp 5 mL.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product Pollenguard Tree, Grass and Dust Mite Mix. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Below is general information about the safety of the known ingredients contained in the product Pollenguard Tree, Grass and Dust Mite Mix. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used sublingually and appropriately. An FDA-approved prescription combination product (Oralair, Stallergenes SA) containing sweet vernal grass, orchard grass, perennial rye grass, Timothy grass, and Kentucky blue grass pollen extracts has been used safely for the treatment of grass-pollen induced allergic rhinitis and conjunctivitis (97264,97265).
LIKELY UNSAFE ...when used orally in large quantities. Dried sweet vernal grass contains the constituent dicoumarol, which has anticoagulant properties (6,18). There is insufficient reliable information available about the safety of sweet vernal grass when used topically.
PREGNANCY AND LACTATION: POSSIBLY SAFE
when used sublingually as prescribed.
An FDA-approved prescription combination product (Oralair) containing sweet vernal grass, orchard grass, perennial rye grass, Timothy grass, and Kentucky blue grass pollen extracts has been used sublingually with apparent safety during pregnancy (97265).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when dried sweet vernal grass is used orally (6,18); avoid using.
POSSIBLY SAFE ...when a specific prescription extract (GRASTEK, Alk Abello A/S) is used sublingually and appropriately. This product has been safely used in clinical trials for up to 34 weeks (15480,15483,15485,97287). ...when administered subcutaneously by a healthcare provider in doses of less than 1.5 mcg pollen extract. Timothy grass pollen allergen extract has been safely administered in clinical trials for up to 2 years (15479,15489,97281,97282,97285).
POSSIBLY UNSAFE ...when used subcutaneously at doses of 1. 5 mcg pollen extract or greater. Severe reactions, including anaphylaxis and angioedema, have occurred in patients receiving these doses (97282,97286). There is insufficient reliable information available about the safety of non-prescription timothy grass products when used orally.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
CHILDREN: POSSIBLY SAFE
when a specific prescription extract (GRASTEK, Alk Abello A/S) is used sublingually and appropriately.
This product has been safely used in clinical trials for up to 34 weeks in children 5 years of age and older (97284,97287). ...when administered subcutaneously by a healthcare provider. Timothy grass has been safely administered in children ages 3-16 years for up to 3 years (15482,15484).
Below is general information about the interactions of the known ingredients contained in the product Pollenguard Tree, Grass and Dust Mite Mix. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Hay prepared from dried sweet vernal grass contains an anticoagulant, dicoumarol, which has been associated with fatal hemorrhages in animals (6). Theoretically, taking dried sweet vernal grass might cause additive effects and side effects with drugs having anticoagulant or antiplatelet properties (19).
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Below is general information about the adverse effects of the known ingredients contained in the product Pollenguard Tree, Grass and Dust Mite Mix. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Sublingually, an FDA-approved prescription combination product (Oralair) of sweet vernal grass, orchard grass, perennial rye grass, Timothy grass, and Kentucky blue grass pollen allergen extracts can cause mouth edema and pruritus, throat edema, dyspepsia, and cough. There are also rare reports of severe hypersensitivity reactions (97264). Orally, use of large doses of sweet vernal grass can cause headaches, dizziness, and liver dysfunction (18).
Hepatic ...Orally, large doses of sweet vernal grass taken for prolonged periods have been associated with liver injury. Abnormal liver function tests return to normal when sweet vernal grass is discontinued (18).
Immunologic ...Sublingually, an FDA-approved combination product (Oralair) containing sweet vernal grass, orchard grass, perennial rye grass, Timothy grass, and Kentucky blue grass pollen extracts can cause pruritus, oral edema, throat irritation, and urticaria. It can also cause severe, life threatening allergic reactions including laryngopharyngeal swelling, angioedema, and anaphylaxis in highly sensitized individuals (97264,97265).
Neurologic/CNS ...Orally, use of large doses of sweet vernal grass can cause headaches and dizziness (18).
General
...Timothy grass pollen is a common airborne allergen, causing allergic rhinitis in sensitive individuals.
It is highly cross reactive with a variety of other grasses (97287).
Sublingually, timothy grass pollen allergen extract can cause local reactions at the site of application, including pruritus, oral blisters, nasopharyngitis, rhinitis, and throat irritation, which occur more frequently at the onset of treatment and with higher doses (15480,15483,15485,15486,97287). In a dose escalation study, doses up to 100 mcg per day were tolerated without exacerbation of asthma or serious adverse effects (15485).
Subcutaneously, timothy grass pollen allergen extract can cause local reactions at the injection site (15481,15482,15489,97282), as well as systemic reactions which occur more frequently at higher doses and include urticaria, angioedema, and anaphylaxis (97282).
Dermatologic ...When taken sublingually, timothy grass pollen allergen extract can cause local reactions at the site of application. These reactions include oral, nasal, and ear pruritus, oral blisters, nasopharyngitis, rhinitis, and throat irritation. Such reactions are generally early-occurring and self-resolving (15480,15483,15485,15486,97287). Subcutaneous administration of timothy grass pollen allergen extract can cause local reactions at the injection site (15481,15482,15489,97282). Reactions to timothy grass pollen allergen extract, regardless of the route of administration, tend to occur more frequently at increased doses.
Immunologic ...Timothy grass pollen is a common airborne allergen, causing allergic rhinitis upon exposure by sensitive individuals. Timothy grass is cross-reactive with a variety of other grasses, including cocksfoot, Kentucky bluegrass, perennial rye, sweet vernal, redtop, and meadow fescue. It is also partially cross-reactive with Johnson grass (97287). Subcutaneous administration of timothy grass pollen allergen extract has been associated with systemic reactions, including anaphylaxis, angioedema, allergic pruritus, cough, and rhinorrhea (97282,97286). Severe reactions, including anaphylaxis and angioedema, have only been reported with higher doses of 1.5-3 mcg of pure timothy grass pollen allergen 5 (97282,97286).