Ingredients | Amount Per Serving |
---|---|
(from Sophora japonica)
(Rutin (Form: from Sophora japonica PlantPart: leaf Genus: Sophora Species: japonica) )
|
500 mg |
(and [100 mg] 20% active Flavonols, supplying [120 mg] 24% active Flavonones, from Citrus limon, and Flavones)
(Bioflavonoids (Form: from Citrus limon PlantPart: exocarp Genus: Citrus Species: limon, supplying [120 mg] 24% active Flavonones, and [100 mg] 20% active Flavonols, and Flavones) )
|
500 mg |
Microcrystalline Cellulose, Stearic Acid (Alt. Name: C18:0), Magnesium Stearate, Pharmaceutical Glaze, Silica
Below is general information about the effectiveness of the known ingredients contained in the product Biorutin 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Biorutin 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used in amounts commonly found in foods. Lemon has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when inhaled in amounts used for aromatherapy, short-term. Lemon essential oil has been used with apparent safety as aromatherapy for up to 2 weeks in clinical research (93475,98128,98129). There is insufficient reliable information available about the safety of lemon when used topically, or when used orally or intranasally in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available.
Avoid using in amounts greater than those typically found in foods.
LIKELY SAFE ...when used orally in amounts found in foods, such as fruits and vegetables.
POSSIBLY SAFE ...when used orally in medicinal amounts, short-term. Rutin has been used with apparent safety at doses of up to 600 mg daily for up to 12 weeks (6252,24560,91104,96766,105298). ...when applied topically as a cream (92236,99258,99260).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods.
There is insufficient reliable information available about the use of supplemental rutin; avoid amounts greater than those found in foods.
Below is general information about the interactions of the known ingredients contained in the product Biorutin 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
Details
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage (110781).
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Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Details
Animal research suggests that rutin has hypoglycemic effects (105299).
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Below is general information about the adverse effects of the known ingredients contained in the product Biorutin 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, lemon is well tolerated in amounts commonly found in foods.
A thorough evaluation of safety outcomes has not been conducted on the use of larger amounts.
Most Common Adverse Effects:
Orally: Epigastralgia and heartburn with the regular consumption of fresh lemon juice.
Dermatologic ...Topically, the application of lemon oil might cause photosensitivity, due to furocoumarin derivative content. This occurs most often in fair-skinned people (11019).
Gastrointestinal ...Orally, fresh lemon juice, taken as 60 mL twice daily, has been reported to cause gastrointestinal disturbances in 37% of patients in one clinical trial, compared with 8% of patients in the placebo group. Specifically, of the patients consuming lemon juice, 21% experienced heartburn and 8% experienced epigastralgia, compared to 1% and 3%, respectively, in the placebo group (107489).
General ...Orally, rutin is generally well tolerated.
Dermatologic ...Orally, rutin may cause flushing and rashes in some people (313).
Gastrointestinal ...Orally, rutin may cause gastrointestinal disturbance in some people (313).
Neurologic/CNS ...Orally, rutin may cause headache in some people (313).