Rue .
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Below is general information about the effectiveness of the known ingredients contained in the product Rue Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Rue Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Rue and rue oil have Generally Recognized as Safe (GRAS) status for use in foods at concentrations that do not exceed 2 parts per million (ppm) (12,4912).
POSSIBLY SAFE ...when products containing dried rue leaves are used medicinally in appropriate doses (6,12,18,515). However, therapeutic doses can cause drowsiness, dizziness, and gastrointestinal irritation and cramps (12).
LIKELY UNSAFE ...when fresh rue and rue oil are used orally, or when large doses of the dried herb are used orally (2,12,18). Overdose is associated with severe abdominal pain, vomiting, liver damage, kidney damage, vertigo, respiratory distress, and delirium, and can be fatal (12,18). ...when fresh rue is applied topically. Rue can cause contact dermatitis and severe photodermatitis (2,6,11,19,104119,107948).
PREGNANCY: LIKELY UNSAFE
when used orally.
Rue has uterine stimulant and abortifacient effects (12,19); avoid using. Deaths have been reported in women who used rue as an abortifacient (2).
LACTATION:
There is insufficient reliable information available about the use of rue when breast-feeding; avoid use.
Below is general information about the interactions of the known ingredients contained in the product Rue Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Details
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Below is general information about the adverse effects of the known ingredients contained in the product Rue Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, rue is well tolerated when taken in the amounts found in foods.
The dried herb seems to be generally well tolerated when taken in medicinal doses; however, a thorough evaluation of safety outcomes has not been conducted. Fresh rue is generally considered unsafe.
Most Common Adverse Effects:
Orally: Cramps, drowsiness, depression, dizziness, gastrointestinal irritation, and sleep disturbances with medicinal use of the dried herb.
Topically: Contact dermatitis and phototoxic skin reactions with the fresh plant.
Cardiovascular ...Orally, large doses of rue have been associated with bradycardia (2).
Dermatologic ...Topically, rue can cause contact dermatitis (2). Exposure to the fresh rue plant followed by sun exposure within 48 hours can lead to severe phototoxic reactions (2,6). Multiple case reports describe patients who developed pruritus, erythema, and severe blistering on the back of the hands and wrists, equivalent to a partial thickness burn, after contact with the fresh plant leaves and exposure to sunlight (104119,107948). One patient was successfully treated with cetirizine and oral and topical corticosteroids (107948).
Gastrointestinal ...Orally, rue can cause gastrointestinal irritation and cramps at therapeutic doses (2,12). When taken in large doses, it causes severe abdominal pain and vomiting (2,12,18).
Genitourinary ...Orally, rue can cause uterine stimulation and abortion (2).
Hepatic ...Orally, high doses of rue can cause liver damage (2,12,18).
Neurologic/CNS ...Orally, therapeutic doses of rue can cause tremor, dizziness, drowsiness, sleep disorders, and depression. High doses can cause vertigo, seizures, and delirium (2,12,18).
Pulmonary/Respiratory ...Orally, high doses of rue can cause respiratory distress (2,12,18).
Renal ...Orally, high doses of rue can cause kidney damage (2,12,18).