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Below is general information about the effectiveness of the known ingredients contained in the product Periwinkle (Vinpocetine) Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of Madagascar periwinkle.
There is insufficient reliable information available about the effectiveness of periwinkle.
Below is general information about the safety of the known ingredients contained in the product Periwinkle (Vinpocetine) Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY UNSAFE ...when the plant or root are used orally. Madagascar periwinkle contains toxic vinca alkaloids, which can cause death (6). There is insufficient reliable information available about the safety of Madagascar periwinkle when used topically.
PREGNANCY: LIKELY UNSAFE
when used orally.
Madagascar periwinkle has abortifacient and teratogenic properties (19).
LACTATION: LIKELY UNSAFE
when used orally (6); avoid using.
Below is general information about the interactions of the known ingredients contained in the product Periwinkle (Vinpocetine) Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats (104764). Theoretically, using Madagascar periwinkle in combination with antidiabetes drugs might increase the risk of hypoglycemia; monitor blood glucose closely.
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Madagascar periwinkle is thought to have diuretic properties (6). Theoretically, due to these potential diuretic effects, Madagascar periwinkle might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
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Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle (12,19).
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Below is general information about the adverse effects of the known ingredients contained in the product Periwinkle (Vinpocetine) Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, Madagascar periwinkle is generally regarded as unsafe for use.
Any benefits of therapy may not outweigh the risk of toxicity. Madagascar periwinkle can cause hallucinations, seizures, gastrointestinal upset, hepatotoxicity, and alopecia (17). The vinca alkaloid constituents of Madagascar periwinkle have been reported to cause nausea, vomiting, alopecia, dizziness, nystagmus, vertigo, hearing impairment, leukopenia, thrombocytopenia, bleeding, hyperuricemia, neurotoxicity, and possibly death (6,15).
Exposure to the airborne pollen of Madagascar periwinkle can cause respiratory allergic reactions in sensitive individuals (100665).
Dermatologic ...Orally, Madagascar periwinkle can cause alopecia (17).
Gastrointestinal ...Orally, Madagascar periwinkle can cause gastrointestinal upset (17). The vinca alkaloid constituents of Madagascar periwinkle have been reported to cause nausea and vomiting (6,15).
Hematologic ...Orally, the vinca alkaloid constituents of Madagascar periwinkle have been reported to cause leukopenia, thrombocytopenia, bleeding, and hyperuricemia (6,15).
Hepatic ...Orally, Madagascar periwinkle can cause hepatotoxicity (17).
Immunologic ...Exposure to the airborne pollen of Madagascar periwinkle can cause allergic respiratory reactions. In one population of adults with respiratory allergies, 29.8% tested positive to Madagascar periwinkle pollen during skin prick testing (100665).
Neurologic/CNS ...Orally, Madagascar periwinkle can cause hallucinations and seizures (17). The vinca alkaloid constituents of Madagascar periwinkle have been reported to cause dizziness, vertigo, and neurotoxicity (6,15).
Ocular/Otic ...Orally, the vinca alkaloid constituents of Madagascar periwinkle have been reported to cause nystagmus and hearing impairment (6,15).
General ...Periwinkle is generally regarded as unsafe for use. Orally, periwinkle can cause cytotoxic, neurologic, liver, and kidney damage due to its vinca alkaloid constituents (17). Periwinkle has also been reported to cause gastrointestinal complaints, skin flushing, and hypotension (18).
Cardiovascular ...Orally, large amounts of periwinkle can cause a severe drop in blood pressure (18).
Dermatologic ...Orally, periwinkle can cause skin flushing (18).
Gastrointestinal ...Orally, periwinkle can cause gastrointestinal complaints (18).
Hepatic ...Orally, periwinkle can cause liver damage due to its vinca alkaloid constituents (17).
Neurologic/CNS ...Orally, periwinkle can cause neurologic damage due to its vinca alkaloid constituents (17).
Renal ...Orally, periwinkle can cause kidney damage due to its vinca alkaloid constituents (17).