| Ingredients | Amount Per Serving |
|---|---|
|
(Cinnamomum burmanii )
(bark)
|
300 mg |
HPMC Vegetable Capsule, Maltodextrin, Vegetable Magnesium Stearate
Below is general information about the effectiveness of the known ingredients contained in the product Cinnamon 300 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Cinnamon 300 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts typically found in food. Padang cassia has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when Padang cassia is used orally and appropriately as a medicine, short-term (93117,93118,93147,92848,92849,108268). A specific Padang cassia extract (Cinnulin PF, Integrity Nutraceuticals International) has been used with apparent safety at doses up to 1500 mg daily for 6 months (93117,93118,93147). Padang cassia powder has been used with apparent safety at doses of up to 2000 mg daily for 8 weeks (108268).
POSSIBLY UNSAFE ...when used orally in high doses, long-term. Padang cassia bark contains higher levels of coumarin than other cinnamon species (93121,93122,93123). Coumarin can cause hepatotoxicity in animal models (15299,21920). In humans, very high doses of coumarin, about 50-7000 mg daily, can result in hepatotoxicity that resolves when coumarin use is discontinued (15302). In most cases, ingestion of Padang cassia will not provide a high enough amount of coumarin to cause significant toxicity; however, in especially sensitive people, such as those with liver disease, prolonged ingestion of large amounts of Padang cassia might exacerbate the condition.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of Padang cassia when used in medicinal amounts during pregnancy and breast-feeding; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Cinnamon 300 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Some clinical research shows that Padang cassia can reduce blood glucose levels in healthy patients (93127) and in patients with diabetes or impaired glucose tolerance (prediabetes) (93118, 93147,92848,92849). Theoretically, Padang cassia might have additive effects in patients treated with antidiabetes drugs. Dose adjustments to diabetes medications may be necessary.
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In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity (93126). Theoretically, taking Padang cassia with CYP3A4 substrates might increase the effects and side effects of these substrates.
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There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people. Padang cassia contains coumarin (93121,93122,93123). Coumarin has caused hepatotoxicity in animal models (15299,21920). In otherwise healthy humans, very high doses of coumarin, from 50-7000 mg daily, can result in hepatotoxicity that resolves when coumarin use is discontinued (15302). Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
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Below is general information about the adverse effects of the known ingredients contained in the product Cinnamon 300 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, Padang cassia appears to be well tolerated.
No adverse effects have been reported in clinical trials when Padang cassia is used alone (93117,93147). When Padang cassia extract is used with banaba leaf extract in a specific combination product (Inlacin, Dexa Medica), adverse effects reported in clinical trials have included dizziness, headache, tremor, palpitations, weakness, diaphoresis, and stomach upset. However, it is unclear if these adverse effects were caused by Padang cassia extract, banaba leaf extract, or the combination (92848,92849).
Padang cassia contains coumarin. There is some concern that ingesting large amounts of Padang cassia and its coumarin constituent might cause hepatotoxicity in some people, especially those with pre-existing liver disease (93121,93122,93123).
Cardiovascular ...Orally, a specific product containing extracts of Padang cassia and banaba leaf (Inlacin, Dexa Medica) has been reported to cause palpitations. However, it is unclear if this adverse effect was caused by Padang cassia extract, banaba leaf extract, or the combination (92848).
Gastrointestinal ...Orally, a specific product containing extracts of Padang cassia and banaba leaf (Inlacin, Dexa Medica) has been reported to cause stomach upset. However, it is unclear if this adverse effect was caused by Padang cassia extract, banaba leaf extract, or the combination (92849).
Hepatic ...Padang cassia contains coumarin. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people due to its coumarin content (93121,93122,93123). In otherwise healthy humans, very high doses of coumarin, from 50-7000 mg daily, can result in hepatotoxicity that resolves when coumarin use is discontinued (15302). In clinical trials, taking Padang cassia powder 2 grams daily for 8 weeks or the extract (Cinnulin PF) 500 mg daily for 12 weeks did not significantly increase aspartate transaminase (AST) or alanine transaminase (ALT) levels when compared with placebo (93147,108268). In most cases, ingestion of Padang cassia won't provide a high enough amount of coumarin to cause significant toxicity; however, in especially sensitive people, such as those with liver disease, there is concern that prolonged ingestion of large amounts of Padang cassia might exacerbate liver dysfunction.
Neurologic/CNS ...Orally, a specific product containing extracts of Padang cassia and banaba leaf (Inlacin, Dexa Medica) has been reported to cause dizziness, headache, tremor, and weakness. However, it is unclear if these adverse effects were caused by Padang cassia extract, banaba leaf extract, or the combination (92848,92849).
Other ...Orally, a specific product containing extracts of Padang cassia and banaba leaf (Inlacin, Dexa Medica) has been reported to cause diaphoresis. However, it is unclear if this adverse effect was caused by Padang cassia extract, banaba leaf extract, or the combination (92849).
