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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Epilepsy. Although there has been interest in using oral caprylic acid for epilepsy, there is insufficient reliable information about the clinical effects of caprylic acid for this purpose.
• Essential tremor. Small clinical studies suggest that oral caprylic acid may slightly improve symptoms of central and peripheral essential tremor, as well as essential voice tremor. Details: Two very small crossover studies in patients with essential tremor show that taking caprylic acid 4 mg/kg as a single dose may slightly reduce the power of both central and peripheral essential tremor. However, the impact of caprylic acid on tremor power was not consistently demonstrated across all time points after administration (97663,100175). One study only found a significant improvement over placebo at 300 minutes after administration, with no statistically significant benefit of caprylic acid at any other time point prior to 300 minutes (97663). These studies may have been underpowered to detect differences between caprylic acid and placebo. One very small clinical trial in patients with essential tremor of the voice shows that taking caprylic acid 16 mg/kg daily for 20 days improves tremor amplitude and frequency by 31% and 23%, respectively, compared with 4% in those taking placebo. However, there were no benefits on audio-perceptual ratings or voice handicap (100176). A secondary analysis of results from this study suggests that patients with more severe acoustic tremors respond better to caprylic acid treatment than those with weaker acoustic tremors (106519). More evidence is needed to rate caprylic acid for these uses.

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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Bronchitis. Although there is interest in using oral lauric acid for bronchitis, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• Common cold. Although there is interest in using oral lauric acid for the common cold, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• Genital herpes. Although there is interest in using oral lauric acid for genital herpes, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• HIV/AIDS. Although there is interest in using oral lauric acid for HIV/AIDS, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• Influenza. Although there is interest in using oral lauric acid for influenza, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• Intestinal parasite infection. Although there is interest in using oral lauric acid for intestinal parasite infection, there is insufficient reliable information about the clinical effects of lauric acid for this condition.
• Vaginal candidiasis. Although there is interest in using oral lauric acid for vaginal candidiasis, there is insufficient reliable information about the clinical effects of lauric acid for this condition. More evidence is needed to rate lauric acid for these uses.

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LIKELY SAFE ...when used orally in amounts commonly found in foods. Caprylic acid has Generally Recognized as Safe (GRAS) status in the US (19507).

POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts, short-term. Caprylic acid has been safely used in clinical research at a daily dose of 16 mg/kg for 20 days (97662,100176).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using in amounts greater than those found in foods.

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LIKELY SAFE ...when used orally in amounts commonly found in foods. Lauric acid has generally recognized as safe (GRAS) status in the US (7705). There is insufficient reliable information available about the safety of lauric acid when used in medicinal amounts.

PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods (7706). There is insufficient reliable information available about the safety of lauric acid when used in medicinal amounts during pregnancy or lactation. Dietary lauric acid is excreted into breast milk (14086).

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ANTIHYPERTENSIVE DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.  Details Animal research suggests that caprylic acid might have positive inotropic effects, resulting in reduced arterial pressure and vascular resistance and increased cardiac output (25805).

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.  Details In vitro research suggests that caprylic acid might displace NSAIDs from binding sites on albumin (25804,25806). This effect has not been reported in humans.

WARFARIN (Coumadin) Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, caprylic acid might increase plasma concentrations of warfarin.  Details In vitro research suggests that high doses of caprylic acid might displace warfarin from albumin binding sites (25807). This effect has not been reported in humans.

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General ...Orally, caprylic acid seems to be well tolerated, short-term.
Most Common Adverse Effects:
Orally: Mild abdominal discomfort and change in taste perception.
Topically: Skin irritation.

Dermatologic ...Topically, caprylic acid is irritating to the skin of some people (20277,25076). Orally, a single dose of caprylic acid was associated with the development of a rash under the dressing of an inserted catheter in one patient in a clinical study (97662).

Gastrointestinal ...Orally, caprylic acid may cause mild abdominal discomfort and a change in taste perception (97662).

Neurologic/CNS ...Orally, caprylic acid has rarely been reported to cause mild dizziness, headache, and fatigue (97662).

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General ...Lauric acid is usually well tolerated when used in food amounts. Information on its use in medicinal amounts is limited.

Cardiovascular ...Lauric acid is a saturated fatty acid. If present in the diet in large amounts, it increases total and low-density lipoprotein (LDL) cholesterol levels, but also increases high-density lipoprotein (HDL) cholesterol levels (14082). Therefore, lauric acid might not increase heart disease risk as much as trans-fatty acids. Lauric acid does not seem to affect triglyceride or lipoprotein(a) levels (14083,14084,14085,14087).

Gastrointestinal ...Orally, nausea appears to be fairly common when lauric acid is infused into the duodenum at a rate of 0. 4 kcal/minute or faster (106421). The rate of nausea with oral administration is unknown.

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