Ingredients | Amount Per Serving |
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MesoFX Formula454 Proprietary Formulation
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1365 mg |
Ajuga turkestanica extract
(Ajuga reptans)
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(Rhaponticum carthamoides )
(root)
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(Eurycoma longifolia )
(100:1)
(Tongkat Ali Genus: Eurycoma Species: longifolia Note: 100:1 )
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(Aspidosperma quebracho-blanco )
(0.3%)
(Quebracho blanco Genus: Aspidosperma Species: quebracho-blanco Note: 0.3% )
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6,7 Dihydroxybergamottin
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5-Methoxy-Isoflavone
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Gelatin Note: capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide (Alt. Name: SiO2), Titanium, FD&C Blue #1
Below is general information about the effectiveness of the known ingredients contained in the product MesoFX. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of quebracho blanco.
Below is general information about the safety of the known ingredients contained in the product MesoFX. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts. Eurycoma longifolia has been safely used in doses of 400 mg daily for up to 3 months and in doses of 200 mg daily for up to 9 months (17924,18138,93490,97312).
POSSIBLY UNSAFE ...when used orally in excessive amounts, long-term. There are some concerns about the safety of Eurycoma longifolia due to contamination with mercury and lead or adulteration with sildenafil (17925,17926,17927,18137,49087,93494). Some research shows that 36% and 17% of Eurycoma longifolia preparations from Malaysia contain high levels of mercury and lead, respectively (17925,17926,17927,49087). While safety issues related to these contaminants have not been reported in humans, taking high doses of Eurycoma longifolia long-term might cause symptoms of heavy metal poisoning or sildenafil-related adverse effects.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Animal research suggests that there are no negative effects of Eurycoma longifolia on the offspring (93493). However, research in humans is lacking.
LIKELY SAFE ...when used orally and appropriately. Ipriflavone seems to be safe when used for up to 3 years (427,428,430,431,432,433,1196,2169,2170,2171,2172) (2173,2174,2175,4749,10228,104208). However, there is concern that ipriflavone can cause subclinical lymphocytopenia in some patients when taken for greater than 6 months (1196,104208).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
There is insufficient reliable information available about the safety of maral root.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used in amounts commonly found in foods. Quebracho blanco bark has Generally Recognized As Safe (GRAS) status for use in foods in the US (4912). There is insufficient reliable information available about the safety of using quebracho blanco bark in medicinal amounts.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of using medicinal amounts of quebracho blanco during pregnancy and breast-feeding; avoid using.
Below is general information about the interactions of the known ingredients contained in the product MesoFX. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Details
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes (93489). This effect has not been reported in humans.
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Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
Details
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes (93489). This effect has not been reported in humans.
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Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
Details
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes (93489). This effect has not been reported in humans.
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Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
Details
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism (17923). It is not known if separating administration will prevent this interaction.
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Theoretically, Eurycoma longifolia may further increase levels of testosterone.
Details
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo (108451). It is unclear whether this increase would occur in individuals with normal testosterone levels.
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Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2) (2178). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.
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Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9) (2178). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.
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Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia (1196); avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
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Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone (2178,6604). Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme (2178,6604).
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In vitro research shows that maral root tincture can reduce platelet aggregation (27412). Theoretically, maral root might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
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Below is general information about the adverse effects of the known ingredients contained in the product MesoFX. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, Eurycoma longifolia seems to be well tolerated.
Most Common Adverse Effects:
Orally: None reported.
Endocrine ...Some research in both humans and animals suggests that Eurycoma longifolia might increase testosterone levels (17924). If testosterone levels are increased beyond the normal range, there is risk of testosterone-related side effects which could include acne, insulin resistance, hepatotoxicity, and others.
General ...Orally, ipriflavone is generally well-tolerated. However, some patients taking ipriflavone can experience epigastric pain, diarrhea, and dizziness (432,104208). There is some concern that ipriflavone can cause lymphocytopenia when used for at least 6 months (1196,104208).
Gastrointestinal ...Orally, ipriflavone can cause epigastric pain and diarrhea in some people (432,104208).
Hematologic ...Orally, ipriflavone was associated with subclinical lymphocytopenia in about 13% of patients in one study. A decrease in lymphocyte counts to less than 500/mcL seems to be most likely to occur after at least 6 months of treatment, although some patients develop lymphocytopenia after a longer duration of use (1196). Lymphocyte counts seem to normalize in most patients within 12 months after discontinuing ipriflavone (1196,104208).
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
General ...Orally, quebracho blanco seems to be well tolerated. However, a thorough evaluation of safety outcomes has not been conducted. Some people who take quebracho blanco bark may experience salivation, headache, outbreaks of sweating, vertigo, stupor, and drowsiness. In large doses, it can cause nausea and vomiting (18).
Dermatologic ...Orally, quebracho blanco bark may cause sweating (18).
Gastrointestinal ...Orally, quebracho blanco bark may cause salivation. In large doses, it can cause nausea and vomiting (18).
Neurologic/CNS ...Orally, quebracho blanco bark may cause headache, vertigo, stupor, and drowsiness (18).