Thyroid 130 [Discontinued] by Priority One Nutritional Supplements

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Hypothyroidism. Although there has been interest in using oral thyroid extract for hypothyroidism, there is insufficient reliable information about the clinical effects of thyroid extract for this purpose.
• Infertility. It is unclear if oral thyroid extract is beneficial in females with infertility. Details: A small clinical study in female patients with infertility caused by luteal-phase deficiency shows that taking a specific thyroid extract (Thyranon) 25 mg daily to start, and then doubling the dose every 2 weeks to a maximum 100 mg daily, for three menstrual cycles increases pregnancy rate when compared with placebo. Of the patients receiving thyroid extract, 8 out of 17 became pregnant by the fourth month, while only 1 out of 7 patients in the placebo group became pregnant (28618).
• Thyroid cancer. Although there has been interest in using oral thyroid extract after treatment for thyroid cancer, there is insufficient reliable information about the clinical effects of thyroid extract for this purpose. More evidence is needed to rate thyroid extract for these uses.

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POSSIBLY UNSAFE ...when taken orally. Thyroid extract contains triiodothyronine (T3) and thyroxine (T4) (29981). However, the potency of these hormones varies, making dose titration difficult (29982,29983,29984,109614). Using thyroid extract increases the risk of hyperthyroidism and associated cardiac and neurological complications (28621,29987,97621).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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LEVOTHYROXINE (Synthroid, others) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, thyroid extract might increase the effects and adverse effects of levothyroxine.  Details Thyroid extract contains triiodothyronine (T3) and thyroxine (T4) (29981,97621). Taking thyroid extract increases blood levels of T3 and T4, in some cases to abnormally high levels (28621,29987,97621).

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General ...Orally, thyroid extract may be unsafe due to hormone potency inconsistencies.
Most Common Adverse Effects:
Orally: Elevated levels of triiodothyronine (T3) and/or thyroxine (T4).
Serious Adverse Effects (Rare):
Orally: Thyroid storm or thyrotoxic crisis.

Dermatologic ...In one case report, a teenage female taking thyroid extract developed multiple nevi on the skin (28622). In another case report, a 30-year-old female with allergic rhinitis and multinodular goiter developed allergic urticaria after treatment with desiccated thyroid extract (28619).

Endocrine ...Clinical research shows that many patients treated with thyroid extract experience abnormally high levels of triiodothyronine (T3) and/or thyroxine (T4) (28621,29987,97621). In some patients, these elevated hormone levels result in thyrotoxic crisis or thyroid storm, with symptoms including nausea, vomiting, myalgia, fever, tachycardia, hypertension, agitation, and altered mental state (28621,29987,97621). In one case, a healthy 62-year-old female took a thyroid extract that was accidentally compounded to provide T3 and T4 at levels of 720,000 and 30,000 micrograms, respectively, daily. The patient required plasmapheresis for two days to reduce levels of T3 and T4 and reduce the symptoms of thyroid storm (97621).

Immunologic ...A 30-year-old female with allergic rhinitis and multinodular goiter developed allergic urticaria after treatment with desiccated thyroid extract (28619).

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