Calcium D-Glucarate 500 mg [Discontinued] by Amy Myers MD

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Breast cancer. Although there has been interest in using oral calcium D-glucarate for preventing breast cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose.
• Colorectal cancer. Although there has been interest in using oral calcium D-glucarate for preventing colorectal cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose.
• Prostate cancer. Although there has been interest in using oral calcium D-glucarate for preventing prostate cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose. More evidence is needed to rate calcium D-glucarate for these uses.

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There is insufficient reliable information available about the safety of calcium D-glucarate.

PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of calcium D-glucarate during pregnancy and lactation; avoid using.

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ALCOHOL (Ethanol) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = B Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.  Details There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol (779).

GLUCURONIDATED DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = B Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.  Details The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs (772,3952,107377).

KANAMYCIN Interaction Rating = Minor Be watchful with this combination. Severity = Insignificant •  Occurrence = Possible •  Level of Evidence = D Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.  Details Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects (777).

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General ...No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted.

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