Two softgets contain: Astaxanthin 5 mg • Beta-Carotene • Lutein . Other Ingredients: Algal Meal extract (haematococcus pluvialis), Rice Bean oil, Gelatin, Vegetable Glycerin Water.
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Below is general information about the effectiveness of the known ingredients contained in the product Bio Rejuvenate. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Bio Rejuvenate. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used in amounts found in foods. Astaxanthin has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when taken orally and appropriately. Astaxanthin 4-18 mg daily has been used with apparent safety for up to 12 weeks. Doses of 40 mg daily have been used with apparent safety for up to 4 weeks (19165,19167,19197,32621,96884,105100).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using in amounts greater than those typically found in foods.
LIKELY SAFE ...when used orally and appropriately. Beta-carotene supplements are appropriate for certain specific conditions; however, beta-carotene supplementation is not recommended for the general population (4844,6393). There is no tolerable upper intake level (UL) set for beta-carotene. However, doses as low as 20 mg/day have been associated with increased risk of lung and prostate cancer in people who smoke (1371,3359,3937,3959,6393,11786). There is also concern that taking high doses of antioxidants such as beta-carotene might do more harm than good. In several analyses of clinical studies involving smokers and healthy non-smokers, taking beta-carotene supplements alone or in combination with other antioxidants is associated with an increased risk of mortality from all causes (15305,34514,90775).
POSSIBLY UNSAFE ...when used orally in high doses or in people who smoke or have a history of asbestos exposure. Supplemental beta-carotene 20 mg daily for 5-8 years seems to increase the risk of lung cancer, prostate cancer, intracerebral hemorrhage, and cardiovascular and total mortality in people who smoke cigarettes or have a history of high-level exposure to asbestos (1371,3359,3937,3959,6393,11786,34591). There is also concern that taking high doses of antioxidants such as beta-carotene might do more harm than good in the general population. In several analyses of clinical studies involving smokers and healthy non-smokers, taking beta-carotene supplements alone or in combination with other antioxidants is associated with an increased risk of mortality from all causes (15305,34514,90775). Beta-carotene from foods does not seem to have this effect.
CHILDREN: LIKELY SAFE
when used orally and appropriately (4844).
High doses (greater than 60 mg per day) have been used with apparent safety for specific conditions such as erythropoietic protoporphyria (11793).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally and appropriately (4844,6393).
There is insufficient reliable information available about the safety of large doses of beta-carotene in pregnancy and lactation.
LIKELY SAFE ...when used orally and appropriately. Consuming up to 20 mg of lutein daily from both dietary and supplemental sources appears to be safe (3219,3220,60167). Lutein supplements have been safely used in clinical trials at doses of up to 20 mg daily for up to 10 years (11798,60133,60177,94703,94701,100986,104570,107107,108615,109763).
CHILDREN: LIKELY SAFE
when used orally and appropriately.
A specific product containing lutein (LUTEINofta, SOOFT Italia SpA) has been used with apparent safety in infants at a dose of 0.14 mg daily for 36 weeks (91163).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally and appropriately in amounts found in foods.
The high end of dietary lutein intake ranges from 6.9-11.7 mg/day (3219,3220).
Below is general information about the interactions of the known ingredients contained in the product Bio Rejuvenate. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
 Details
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes (32613). This effect has not been reported in humans.
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Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Details
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes (32613). This effect has not been reported in humans.
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Beta-carotene might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
Details
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (beta-carotene, vitamin C, vitamin E, and selenium) along with niacin and simvastatin attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease (7388,11537). It is not known whether this adverse effect is due to a single antioxidant such as beta-carotene, or to the combination. It also is not known whether it will occur in other patient populations.
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Below is general information about the adverse effects of the known ingredients contained in the product Bio Rejuvenate. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, astaxanthin seems to be well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, diarrhea, red fecal color.
Gastrointestinal ...Orally, astaxanthin 6 mg daily has caused two cases of increased bowel movements and two cases of red fecal color (91736). A higher dose of astaxanthin (AstaCarox, AstaReal AB) 40 mg daily has caused severe stomach/abdominal pain in two patients (19165).
Ocular/Otic ...Canthaxanthin, another carotenoid substance that is chemically related to astaxanthin, has caused crystals in the retina and loss of visual acuity in one patient (8455). This effect has not been observed with astaxanthin, but patients who have visual changes while taking astaxanthin should stop taking it immediately.
General
...Orally, beta-carotene is well-tolerated when used in appropriate amounts.
Most Common Adverse Effects:
Orally: Belching, orange skin (temporary).
Serious Adverse Effects (Rare):
Orally: Increased cardiovascular mortality and cancer risk in smokers and other specific patient populations.
Cardiovascular ...Orally, beta-carotene 20 to 30 mg daily seems to increase cardiovascular mortality by 12% to 26% in people who smoke (2642,3949,108641). Smokers and people with a history of asbestos exposure should not use beta-carotene supplements. In males who smoke and have had a prior myocardial infarction (MI), the risk of fatal coronary heart disease increases by as much as 43% with beta-carotene 20 mg daily (3937). These adverse effects do not seem to occur in people who eat foods high in beta-carotene content (1440,2657).
Dermatologic ...High oral doses of beta-carotene in foods or supplements can cause yellow or orange skin pigmentation called carotenoderma (11786,34572,34594,91382,108641). In clinical trials, the incidence of carotenoderma has been reported to be up to 15.8% (34626).
Gastrointestinal ...Orally, beta-carotene may cause belching (34572,34594).
Ocular/Otic ...In a case report, treatment with a high dose of beta-carotene and canthaxanthin for more than 6 years resulted in the development of glistening bright yellow crystalline deposits around the maculae. This resulted in a slight decrease in visual acuity and adaptation to the dark (34641).
Oncologic ...Smokers and people with a history of asbestos exposure should not use beta-carotene supplements. Beta-carotene in doses of 20 mg per day for 5-8 years has been associated with an increased risk of lung and prostate cancer and increased total mortality in people who smoke cigarettes (21 or more daily), and in people with a history of high-level asbestos exposure (3959,6393,11303,11786,104467,108641). These adverse effects do not seem to occur in people who eat foods high in beta-carotene content (1440,2657). There is also concern that beta-carotene might increase the risk of adverse outcomes in non-smokers. In one large-scale population study, males who took a multivitamin more than 7 times per week and who also took a separate beta-carotene supplement had a significantly increased risk of developing advanced prostate cancer (15607).
Pulmonary/Respiratory ...Clinical research shows that taking beta-carotene 20 mg daily, alone or along with vitamin E 50 mg daily, increases the risk of common colds by 21% to 25% in individuals participating in heavy exercise at leisure. However, it does not appear to affect the risk of common cold in individuals who participate in heavy activity at work (34508).
Other ...Analysis of studies in smokers and non-smokers suggests that taking beta-carotene supplements alone or in combination with other antioxidants increases the risk of mortality from all causes (15305).
General ...Orally, dietary and supplemental lutein is generally well tolerated. Doses up to 20 mg daily have not resulted in adverse effects.
