Each 3.1 mL (50 drops) serving contains: Sinupret Proprietary Blend 880 mg: Cowslip flower (primula veris), Common Sorrel herb (rumex acetosa), European Elderflower (sambucus nigra), European Vervain herb (verbena officinalis), Gentian root (gentiana lutea). Other Ingredients: Water, Ethanol. Contains 19% Alcohol by volume.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
This product has been discontinued by the manufacturer.
This product has been studied in clinical research. Based on this research, this product's Effectiveness Rating is:
POSSIBLY EFFECTIVEBelow is general information about the effectiveness of the known ingredients contained in the product Sinupret Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Sinupret Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally. Cowslip has been used with apparent safety in combination with other herbs (SinuComp, Sinupret, Sinupret +, Bronchipret) (374,379,13557).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in food amounts. Elderflower has generally recognized as safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when used orally and appropriately, short-term. Dried elderflower 3.9 grams daily has been used with apparent safety for 8 days (94939). A specific combination product containing elderflower, gentian root, sorrel, verbena, and cowslip flower (SinuComp, Phytopharmica) has been used with apparent safety for up to 14 days (374,64515,95907).
POSSIBLY UNSAFE ...when excessive amounts of elderflower are consumed. The elder tree contains a cyanide-producing chemical in the leaves, stems, and unripe fruit, which can cause symptoms of nausea, vomiting, and diarrhea. Elderflower may also contain this toxin. Ingestion of large quantities may cause serious toxicity (17020,17021). Cooking eliminates the toxin. There is insufficient reliable information available about the safety of elderflower when used topically.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when the root preparations are used in amounts commonly found in foods. Gentian root is categorized by the FDA as a safe food additive flavoring in the US (4912).
POSSIBLY SAFE ...when gentian root is used orally in a specific combination that contains gentian root, elderflower, verbena, cowslip flower, and sorrel (SinuComp, Sinupret) (374,379,95907). There is insufficient reliable information available about the safety of the topical use of gentian.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of gentian in medicinal amounts during pregnancy and lactation; avoid using.
POSSIBLY SAFE ...when used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts.
POSSIBLY UNSAFE ...when used orally in large amounts. The oxalate content may cause serious adverse effects, including damage to the kidneys, liver, and gastrointestinal tract (71314,75138,94019).
PREGNANCY AND LACTATION: POSSIBLY SAFE
when used orally in amounts commonly found in foods.
There is insufficient reliable information available about the safety of sorrel used in medicinal amounts during pregnancy and lactation; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Verbena has Generally Recognized As Safe status (GRAS) for use in foods in the US (4912). There is insufficient reliable information available about the safety of verbena when used orally or topically in medicinal amounts.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of verbena in medicinal amounts during pregnancy and lactation; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Sinupret Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, elderflower might lower blood glucose levels (13427) and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
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Theoretically, concurrent use might increase risk of hypotension with drugs that lower blood pressure (13439,13441). These include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
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Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
 Details
In vitro, sorrel has been shown to inhibit platelet aggregation (103607). However, this effect has not been reported in humans.
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Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
Details
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC) (103606).
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Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
Details
In vitro research shows that sorrel inhibits OATP1A2 (103606). Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.
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In vitro research suggests that beta-myrcene, a terpene constituents of verbena, can significantly inhibit cytochrome P450 2B1 (CYP2B1) enzyme activity (82024). Theoretically, verbena might increase levels of drugs metabolized by this enzyme. However, this interaction has not been reported in humans.
Details
Some substrates of CYP2B1 include cyclophosphamide, ifosfamide, barbiturates, bromobenzene, and others.
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Below is general information about the adverse effects of the known ingredients contained in the product Sinupret Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally, cowslip in combination with other herbs is generally well tolerated (95907). Studies show it can cause gastrointestinal adverse effects and allergic skin reactions (374,379,13557).
Dermatologic ...Orally, cowslip in combination with other herbs can cause allergic skin reactions (374,379,13557).
Gastrointestinal ...Orally, cowslip in combination with other herbs can cause gastrointestinal adverse effects (374,379,13557).
General
...Elderflower is well tolerated in the amounts used in foods and beverages (4912).
No adverse effects have been reported when elderflower alone is used medicinally. However, a thorough evaluation of safety outcomes has not been conducted.
Elder tree leaves, stems, bark, seeds, and unripe fruit contain cyanogenic glycosides, which release cyanide when consumed (17020,17021). Elderflower may also contain this toxin, and ingesting large amounts might result in gastrointestinal and neurologic toxicity. However, instances of toxicity from elderflower ingestion have not been described.
Gastrointestinal ...Diarrhea and colic have been reported after drinking a tea made from elderflower, anise fruit, fennel fruit, and senna flowers (49494). It is not clear if these effects were due to elderflower or the other ingredients.
Immunologic ...The pollen of the elder tree can cause an allergic reaction with rhinitis and dyspnea in some people who are allergic to grass pollen. These people might experience a similar allergic reaction to elderflower (11095).
General ...Orally, gentian root, in combination with other herbs, seems to be generally well tolerated (95907). Side effects reported in clinical studies include gastrointestinal discomfort and allergic skin reactions (374,379). There is insufficient reliable information available about the adverse effects of gentian when taken as a medicine alone.
Gastrointestinal ...Orally, gentian root, in combination with other herbs, has been reported to cause gastrointestinal adverse effects (374,379). Gastrointestinal intolerance occurred in patients with cancer-associated anorexia who took gentian tincture 1 mL three times daily, in conjunction with turmeric 1 gram and ginger 1 gram twice daily, for 14 days. Six of 17 patients discontinued the regimen due to nausea, 3 due to vomiting, 2 due to diarrhea, and 2 due to bloating. It is unclear if this gastrointestinal intolerance was caused by gentian, the other herbs, or the patients' predisposing conditions (96263).
Immunologic ...Orally, gentian root, in combination with other herbs, has been reported to cause allergic skin reactions (374,379). It is unclear if these reactions were caused by gentian, the other herbs, or the combination.
General
...Orally, sorrel seems to be generally well tolerated, based on limited data, mainly from studies with combination products.
Serious Adverse Effects (Rare):
Orally: Gastrointestinal irritation, kidney damage, liver necrosis.
Dermatologic ...Orally, sorrel, when used in combination with other herbs, has been reported to cause allergic skin reactions (374,379).
Gastrointestinal ...Orally, sorrel, when used in combination with other herbs, has been reported to cause gastrointestinal side effects including nausea and an unpleasant aftertaste (374,379,37419).
Hepatic ...Extensive liver necrosis with hepatic failure has been reported with the ingestion of large amounts of sorrel; this was likely due to its oxalate content (75138).
Pulmonary/Respiratory ...Environmental exposure to sorrel pollen may trigger allergic rhinitis or bronchial asthma in hypersensitive individuals, and allergic cross-sensitivity may occur in up to 19% of people who are allergic to weed pollen (75141).
Renal ...Sorrel contains oxalates; irolithiasis and nephrosis may be caused by the systemic absorption of oxalates and may result in kidney damage (71314). A case of acute tubulointerstitial nephritis (TIN) has been reported in a 12-year-old who consumed an unknown amount of wild sorrel. The patient presented with polyuria, hypophosphatemia, proteinuria, glucosuria, and hyperoxaluria. Recovery occurred after oral rehydration and electrolyte replacement. The TIN was likely due to formation of calcium oxalate crystals in the kidneys (94019).
General
...Orally, verbena is well tolerated when used orally in amounts commonly found in foods (4912).
When used in medicinal amounts and in combination with other herbs, adverse effects have included gastrointestinal adverse effects and allergic skin reactions (374,379).
Topically, verbena can cause contact dermatitis (13431).
Gastrointestinal ...Orally, verbena in combination with other herbs can cause gastrointestinal adverse effects (374,379).
Immunologic ...Orally, verbena in combination with other herbs can cause allergic skin reactions (374,379). Topically, verbena can cause contact dermatitis (13431).
