Various isoflavones have been studied for therapeutic effects in women with menopause.
Isoflavones were first discovered due to their ability to disrupt the action of estrogen in animals. As a result, they are classified as a type of phytoestrogen, which, as the name suggests, is a naturally occurring plant ("phyto") chemical with estrogen-like properties. In the diet, isoflavones may be found in soybeans; soy-based foods, including soy milk, flour, nuts, tempeh, and tofu; and legumes, such as peas, peanuts, chick peas, and navy beans.
Sequol, a daidzein (a soy isoflavone) metabolite, may improve certain menopausal symptoms. According to several well-designed clinical trials, sequol decreased the number and severity of daily hot flashes. Furthermore, sequol decreased joint and muscle pain, neck and muscle stiffness, mood as well as crow's feet wrinkles in multiple studies.
Daidzein, prior to absorption, has also been studied in menopausal women, but with mixed results. Some studies showed a decrease in hot flash frequency, improved sexuality and reduced hot flash severity, as well as improved bone health, quality of life and cholesterol. However, other studies found that daidzein lacked effects on bone and heart health, vaginal and menopausal symptoms, and brain function.
Finally, genistein has been studied with conflicting results. Some studies reported beneficial results for heart health, hot flashes, skeletal health and even blood sugar. Conversely, many other trials found inconclusive or temporary results when measuring these same parameters.
Overall, researchers continue to reiterate the need for further exploration, larger trials, safety and efficacy studies and more studies in differing populations.
For more information about isoflavones and their effect on menopause, please visit Natural Standard's Foods, Herbs & Supplements Database.
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