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June 2014

Resveratrol Benefits Questioned

Contrary to previous findings, a recent study suggests that resveratrol might not reduce the risk of heart disease, cancer or death from any cause.

Resveratrol is a natural compound that is found in more than 70 plant species, including nuts, grapes, pine trees, and certain vines, as well as in red wine. It is thought to play a role in preventing heart disease. Much research has focused on the potential health benefits of resveratrol due to the "French paradox," the finding that death rates from heart disease are lower in France, where red wine consumption is common.

In a new study, researchers analyzed data on 783 older men and women from the Invecchiare in Chianti (InCHIANTI) Study to assess the effects of resveratrol levels on the risk of death from any cause. Levels of resveratrol in the urine were measured, and markers for inflammation, cancer, and heart disease were also assessed.

Throughout the 9 year follow-up period, 268 of the participants died. The researchers found that from highest to lowest levels of resveratrol, the proportion of people who died from any cause was 34.4%, 31.6%, 33.5%, and 37.4%, respectively. Resveratrol levels were also not associated with inflammation or the risk of heart disease or cancer.

The authors concluded that resveratrol concentration in the urine is not associated with the risk of death from any cause, including heart disease and cancer. Further research is warranted.

For more information about resveratrol, please visit Natural Standard’s Foods, Herbs & Supplements Database.


  1. Natural Standard: The Authority on Integrative Medicine.
  2. Semba RD, Ferrucci L, Bartali B, et al. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Intern Med. 2014 May 12.

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