The American Academy of Neurology (AAN) released new guidelines for restless legs syndrome (RLS). Some evidence shows that iron deficiency is associated with RLS. The AAN now recommends iron 325 mg along with vitamin C 100 mg twice daily for RLS patients with low blood ferritin levels (<75 mcg/L). Iron can also be given intravenously as two doses of ferric carboxymaltose 500 mg, 5 days apart. This has been shown to improve RLS symptoms regardless of serum ferritin levels.
For more information about the use of iron in RLS, see our iron monograph.
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