Clinical data on psilocybin is growing rapidly, providing a more comprehensive picture of its potential benefits and filling in gaps about safety. Here’s the latest.
Several new clinical trials and meta-analyses have recently been published. Overall, most clinical research now shows that taking pure psilocybin, usually as a single 25 mg dose together with supportive or integrative psychotherapy, might improve depression and increase the chances of remission. The benefits are typically seen immediately post treatment and for up to 12 months thereafter. But it’s not clear how psilocybin compares to antidepressants or psychotherapy when used alone.
As for safety concerns, single doses of psilocybin 0.2-0.6 mg/kg have been used without serious adverse effects. Short-term headache, increased blood pressure, and increased heart rate are some of the most common side effects. But it’s important to note that these studies were conducted in controlled environments under medical supervision. It’s unclear whether taking psilocybin without proper monitoring is safe.
Tell patients that while the body of evidence is growing, psilocybin is still being investigated and remains a Schedule I controlled substance, even though the risk for abuse seems low. Lastly, remind patients to be cautious about “micro dosing,” which has grown in popularity over the past few years. Micro dosing products are increasingly available – the FDA recently issued a recall for a micro dosing chocolate product that’s caused almost 30 hospitalizations and possibly one death. Tell patients to steer clear.
Check out our recently updated monograph to learn more.
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