St. John's wort is commonly taken with drugs that might cause dangerous interactions, according to a new study.
Extracts of Hypericum perforatum L. (St. John's wort) have been recommended traditionally for a wide range of medical conditions. The most common modern-day use of St. John's wort is for depression. Studies have shown St. John's wort may be equally effective as tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitor (SSRI) antidepressants for mild to moderate depression. St. John's wort may cause serious interactions with prescription drugs, herbs, or supplements. Therefore, people using any medications should consult their healthcare providers, including a pharmacist, prior to starting therapy.
In a recent study, researchers analyzed data from the National Ambulatory Medical Care Survey, including patients who were prescribed to take St. John’s wort between 1993 and 2010. The authors reviewed which medications were also prescribed with St. John’s wort.
The researchers found that 28% of the people taking St. John’s wort also took a drug with the potential to cause a serious interaction. Some of these drugs included selective serotonin reuptake inhibitor (SSRI), benzodiazepines, warfarin, birth control pills, statins, verapamil, and digoxin.
The authors concluded that physicians should be aware of the potentially dangerous interactions associated with St. John’s wort and warn their patients before use.
For more information about St. John’s wort, please visit Natural Standard’s Foods, Herbs & Supplements Database.
The information in this brief report is intended for informational purposes only, and is meant to help users better understand health concerns. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions. Copyright © 2024 NatMed. Commercial distribution or reproduction prohibited. NatMed is the leading provider of high-quality, evidence-based, clinically-relevant information on natural medicine, dietary supplements, herbs, vitamins, minerals, functional foods, diets, complementary practices, CAM modalities, exercises and medical conditions. Monograph sections include interactions with herbs, drugs, foods and labs, contraindications, depletions, dosing, toxicology, adverse effects, pregnancy and lactation data, synonyms, safety and effectiveness.
