A new clinical trial shows that taking melatonin 3 mg at bedtime for 12 weeks is as effective for migraine prevention as amitriptyline 25 mg once daily in people with 2-8 migraine attacks monthly. Melatonin reduced headache days by 2.7 compared to 2.2 days for those receiving amitriptyline. Melatonin also cut migraine frequency in half for more patients than those taking amitriptyline and resulted in fewer side effects.
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