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Sanchez-Ramos, L., Briones, D. K., Kaunitz, A. M., Delvalle, G. O., Gaudier, F. L., and Walker, C. D. Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients. Obstet.Gynecol. 1994;84(3):349-353. View abstract.

Thomas, M. G., Thomson, J. P., and Williamson, R. C. Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis. Br.J Surg. 1993;80(4):499-501. View abstract.

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Terano, T., Fujishiro, S., Ban, T., Yamamoto, K., Tanaka, T., Noguchi, Y., Tamura, Y., Yazawa, K., and Hirayama, T. Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids 1999;34 Suppl:S345-S346. View abstract.

Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W., and Wolf, P. A. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol. 2006;63(11):1545-1550. View abstract.

Jacques, P. F., Selhub, J., Bostom, A. G., Wilson, P. W., and Rosenberg, I. H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N.Engl.J Med 5-13-1999;340(19):1449-1454. View abstract.

Tee, E. S., Kandiah, M., Awin, N., Chong, S. M., Satgunasingam, N., Kamarudin, L., Milani, S., Dugdale, A. E., and Viteri, F. E. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. Am.J.Clin.Nutr. 1999;69(6):1249-1256. View abstract.

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Berry, R. J., Li, Z., Erickson, J. D., Li, S., Moore, C. A., Wang, H., Mulinare, J., Zhao, P., Wong, L. Y., Gindler, J., Hong, S. X., and Correa, A. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N.Engl.J.Med. 11-11-1999;341(20):1485-1490. View abstract.

Torrioli, M. G., Vernacotola, S., Mariotti, P., Bianchi, E., Calvani, M., De Gaetano, A., Chiurazzi, P., and Neri, G. Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome. Am.J Med Genet. 12-3-1999;87(4):366-368. View abstract.

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Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India. Indian J Med Res 2000;112:206-211. View abstract.

Christiansen, C., Rodbro, P., and Nielsen, C. T. Iatrogenic osteomalacia in epileptic children. A controlled therapeutic trial. Acta Paediatr.Scand 1975;64(2):219-224. View abstract.

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Sellers, T. A., Kushi, L. H., Cerhan, J. R., Vierkant, R. A., Gapstur, S. M., Vachon, C. M., Olson, J. E., Therneau, T. M., and Folsom, A. R. Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 2001;12(4):420-428. View abstract.

Doshi, S. N., McDowell, I. F., Moat, S. J., Lang, D., Newcombe, R. G., Kredan, M. B., Lewis, M. J., and Goodfellow, J. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide? Arterioscler.Thromb.Vasc.Biol. 2001;21(7):1196-1202. View abstract.

van Ede, A. E., Laan, R. F., Rood, M. J., Huizinga, T. W., van de Laar, M. A., van Denderen, C. J., Westgeest, T. A., Romme, T. C., de Rooij, D. J., Jacobs, M. J., de Boo, T. M., van der Wilt, G. J., Severens, J. L., Hartman, M., Krabbe, P. F., Dijkmans, B. A., Breedveld, F. C., and van de Putte, L. B. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2001;44(7):1515-1524. View abstract.

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van Dijk, R. A., Rauwerda, J. A., Steyn, M., Twisk, J. W., and Stehouwer, C. D. Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler.Thromb.Vasc.Biol. 2001;21(12):2072-2079. View abstract.

Doshi, S. N., McDowell, I. F., Moat, S. J., Payne, N., Durrant, H. J., Lewis, M. J., and Goodfellow, J. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 1-1-2002;105(1):22-26. View abstract.

Jorissen, B. L., Brouns, F., van Boxtel, M. P., Ponds, R. W., Verhey, F. R., Jolles, J., and Riedel, W. J. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci 2001;4(2):121-134. View abstract.

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Giardiello, F. M., Yang, V. W., Hylind, L. M., Krush, A. J., Petersen, G. M., Trimbath, J. D., Piantadosi, S., Garrett, E., Geiman, D. E., Hubbard, W., Offerhaus, G. J., and Hamilton, S. R. Primary chemoprevention of familial adenomatous polyposis with sulindac. N.Engl.J Med 4-4-2002;346(14):1054-1059. View abstract.

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Maxwell, C. J., Hogan, D. B., and Ebly, E. M. Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. Dement.Geriatr Cogn Disord 2002;13(4):225-234. View abstract.

Mayer, O., Filipovsky, J., Hromadka, M., Svobodova, V., Racek, J., Mayer, O., Jr., Stehlik, P., Trefil, L., and Zarybnicka, M. Treatment of hyperhomocysteinemia with folic acid: effects on homocysteine levels, coagulation status, and oxidative stress markers. J Cardiovasc.Pharmacol. 2002;39(6):851-857. View abstract.

Bryan, J., Calvaresi, E., and Hughes, D. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 2002;132(6):1345-1356. View abstract.

Williams, L. J., Mai, C. T., Edmonds, L. D., Shaw, G. M., Kirby, R. S., Hobbs, C. A., Sever, L. E., Miller, L. A., Meaney, F. J., and Levitt, M. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States. Teratology 2002;66(1):33-39. View abstract.

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The nutrition of expectant and nursing mothers in relation to maternal and infant mortality and morbidity. J Obstet.Gynaecol.Br Emp. 1946;53(6):498-509. View abstract.

Sharp, L., Little, J., Schofield, A. C., Pavlidou, E., Cotton, S. C., Miedzybrodzka, Z., Baird, J. O., Haites, N. E., Heys, S. D., and Grubb, D. A. Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett. 7-8-2002;181(1):65-71. View abstract.

Hirsch, S., Pia, De la Maza, Yanez, P., Glasinovic, A., Petermann, M., Barrera, G., Gattas, V., Escobar, E., and Bunout, D. Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation. Clin Cardiol 2002;25(11):495-501. View abstract.

Wald, D. S., Law, M., and Morris, J. K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 11-23-2002;325(7374):1202. View abstract.

Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., Van Swieten, J. C., Hofman, A., Witteman, J. C., and Breteler, M. M. Diet and risk of dementia: Does fat matter?: The Rotterdam Study. Neurology 12-24-2002;59(12):1915-1921. View abstract.

Feigelson, H. S., Jonas, C. R., Robertson, A. S., McCullough, M. L., Thun, M. J., and Calle, E. E. Alcohol, folate, methionine, and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol.Biomarkers Prev. 2003;12(2):161-164. View abstract.

Zhang, S. M., Willett, W. C., Selhub, J., Hunter, D. J., Giovannucci, E. L., Holmes, M. D., Colditz, G. A., and Hankinson, S. E. Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J.Natl.Cancer Inst. 3-5-2003;95(5):373-380. View abstract.

Sandler, R. S., Halabi, S., Baron, J. A., Budinger, S., Paskett, E., Keresztes, R., Petrelli, N., Pipas, J. M., Karp, D. D., Loprinzi, C. L., Steinbach, G., and Schilsky, R. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N.Engl.J Med 3-6-2003;348(10):883-890. View abstract.

Baron, J. A., Cole, B. F., Sandler, R. S., Haile, R. W., Ahnen, D., Bresalier, R., McKeown-Eyssen, G., Summers, R. W., Rothstein, R., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Beach, M., Beck, G. J., Bond, J. H., Byers, T., Greenberg, E. R., Mandel, J. S., Marcon, N., Mott, L. A., Pearson, L., Saibil, F., and van Stolk, R. U. A randomized trial of aspirin to prevent colorectal adenomas. N.Engl.J Med 3-6-2003;348(10):891-899. View abstract.

Clarke, R., Lewington, S., and Landray, M. Homocysteine, renal function, and risk of cardiovascular disease. Kidney Int Suppl 2003;(84):S131-S133. View abstract.

Righetti, M., Ferrario, G. M., Milani, S., Serbelloni, P., La, Rosa L., Uccellini, M., and Sessa, A. Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients. Med Sci Monit. 2003;9(4):I19-I24. View abstract.

Sellers, T. A., Alberts, S. R., Vierkant, R. A., Grabrick, D. M., Cerhan, J. R., Vachon, C. M., Olson, J. E., Kushi, L. H., and Potter, J. D. High-folate diets and breast cancer survival in a prospective cohort study. Nutr.Cancer 2002;44(2):139-144. View abstract.

Marcucci, R., Zanazzi, M., Bertoni, E., Rosati, A., Fedi, S., Lenti, M., Prisco, D., Castellani, S., Abbate, R., and Salvadori, M. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Transplantation 5-15-2003;75(9):1551-1555. View abstract.

Clarke, R., Harrison, G., and Richards, S. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern.Med 2003;254(1):67-75. View abstract.

Thompson, S. J., Torres, M. E., Stevenson, R. E., Dean, J. H., and Best, R. G. Periconceptional multivitamin folic acid use, dietary folate, total folate and risk of neural tube defects in South Carolina. Ann.Epidemiol. 2003;13(6):412-418. View abstract.

Benamouzig, R., Deyra, J., Martin, A., Girard, B., Jullian, E., Piednoir, B., Couturier, D., Coste, T., Little, J., and Chaussade, S. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 2003;125(2):328-336. View abstract.

Cho, E., Spiegelman, D., Hunter, D. J., Chen, W. Y., Zhang, S. M., Colditz, G. A., and Willett, W. C. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiol.Biomarkers Prev. 2003;12(8):713-720. View abstract.

Sommer, B. R., Hoff, A. L., and Costa, M. Folic acid supplementation in dementia: a preliminary report. J Geriatr.Psychiatry Neurol. 2003;16(3):156-159. View abstract.

Deijen, J. B., van der Beek, E. J., Orlebeke, J. F., and van den Berg, H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl) 1992;109(4):489-496. View abstract.

Batu, A. T., Toe, T., Pe, H., and Nyunt, K. K. A prophylactic trial of iron and folic acid supplements in pregnant Burmese women. Isr.J.Med.Sci. 1976;12(12):1410-1417. View abstract.

Shen, H., Wei, Q., Pillow, P. C., Amos, C. I., Hong, W. K., and Spitz, M. R. Dietary folate intake and lung cancer risk in former smokers: a case-control analysis. Cancer Epidemiol.Biomarkers Prev. 2003;12(10):980-986. View abstract.

Malouf, M., Grimley, E. J., and Areosa, S. A. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane.Database.Syst.Rev 2003;(4):CD004514. View abstract.

Wilson, R. D., Davies, G., Desilets, V., Reid, G. J., Summers, A., Wyatt, P., and Young, D. The use of folic acid for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can 2003;25(11):959-973. View abstract.

Dinckal, M. H., Aksoy, N., Aksoy, M., Davutoglu, V., Soydinc, S., Kirilmaz, A., Dinckal, N., and Akdemir, I. Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia. Acta Cardiol 2003;58(5):389-396. View abstract.

Laurin, D., Verreault, R., Lindsay, J., Dewailly, E., and Holub, B. J. Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers.Dis. 2003;5(4):315-322. View abstract.

Bellisarii, F. I., Gallina, S., Zimarino, M., and De, Caterina R. Mechanisms of nitrate tolerance: potential roles of folate. Eur J Clin Invest 2003;33(11):933-940. View abstract.

Woodman, R. J., Celermajer, D. E., Thompson, P. L., and Hung, J. Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects. Clin Sci (Lond) 2004;106(4):353-358. View abstract.

Spence, J. D., Blake, C., Landry, A., and Fenster, A. Measurement of carotid plaque and effect of vitamin therapy for total homocysteine. Clin.Chem.Lab Med 2003;41(11):1498-1504. View abstract.

Ray, J. G., Meier, C., Vermeulen, M. J., Wyatt, P. R., and Cole, D. E. Association between folic acid food fortification and congenital orofacial clefts. J Pediatr 2003;143(6):805-807. View abstract.

Zhu, K., Davidson, N. E., Hunter, S., Yang, X., Payne-Wilks, K., Roland, C. L., Phillips, D., Bentley, C., Dai, M., and Williams, S. M. Methyl-group dietary intake and risk of breast cancer among African-American women: a case-control study by methylation status of the estrogen receptor alpha genes. Cancer Causes Control 2003;14(9):827-836. View abstract.

Adzersen, K. H., Jess, P., Freivogel, K. W., Gerhard, I., and Bastert, G. Raw and cooked vegetables, fruits, selected micronutrients, and breast cancer risk: a case-control study in Germany. Nutr.Cancer 2003;46(2):131-137. View abstract.

Ratanachu-Ek, S. Effects of multivitamin and folic acid supplementation in malnourished children. J.Med.Assoc.Thai. 2003;86 Suppl 3:S537-S542. View abstract.

Diculescu, M., Ciocirlan, M., Ciocirlan, M., Pitigoi, D., Becheanu, G., Croitoru, A., and Spanache, S. Folic acid and sulfasalazine for colorectal carcinoma chemoprevention in patients with ulcerative colitis: the old and new evidence. Rom.J Gastroenterol 2003;12(4):283-286. View abstract.

De, Wals P., Rusen, I. D., Lee, N. S., Morin, P., and Niyonsenga, T. Trend in prevalence of neural tube defects in Quebec. Birth Defects Res A Clin Mol.Teratol. 2003;67(11):919-923. View abstract.

Wrone, E. M., Hornberger, J. M., Zehnder, J. L., McCann, L. M., Coplon, N. S., and Fortmann, S. P. Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. J.Am.Soc.Nephrol. 2004;15(2):420-426. View abstract.

Kirke, P. N., Daly, L. E., and Elwood, J. H. A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group. Arch Dis.Child 1992;67(12):1442-1446. View abstract.

Shrubsole, M. J., Gao, Y. T., Cai, Q., Shu, X. O., Dai, Q., Hebert, J. R., Jin, F., and Zheng, W. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol.Biomarkers Prev. 2004;13(2):190-196. View abstract.

Liem, A. H., van Boven, A. J., Veeger, N. J., Withagen, A. J., Robles de Medina, R. M., Tijssen, J. G., and van Veldhuisen, D. J. Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial. Int J Cardiol 2004;93(2-3):175-179. View abstract.

Melse-Boonstra, A., West, C. E., Katan, M. B., Kok, F. J., and Verhoef, P. Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults. Am J Clin Nutr 2004;79(3):424-429. View abstract.

Pena, A. S., Wiltshire, E., Gent, R., Hirte, C., and Couper, J. Folic acid improves endothelial function in children and adolescents with type 1 diabetes. J Pediatr 2004;144(4):500-504. View abstract.

Beilby, J., Ingram, D., Hahnel, R., and Rossi, E. Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. Eur.J.Cancer 2004;40(8):1250-1254. View abstract.

Luchsinger, J. A., Tang, M. X., Shea, S., Miller, J., Green, R., and Mayeux, R. Plasma homocysteine levels and risk of Alzheimer disease. Neurology 6-8-2004;62(11):1972-1976. View abstract.

Ellinson, M., Thomas, J., and Patterson, A. A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly. J Hum Nutr Diet 2004;17(4):371-383. View abstract.

Taylor, M. J., Carney, S. M., Goodwin, G. M., and Geddes, J. R. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol 2004;18(2):251-256. View abstract.

Schwammenthal, Y. and Tanne, D. Homocysteine, B-vitamin supplementation, and stroke prevention: from observational to interventional trials. Lancet Neurol. 2004;3(8):493-495. View abstract.

Takamura, N., Kondoh, T., Ohgi, S., Arisawa, K., Mine, M., Yamashita, S., and Aoyagi, K. Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. Eur J Nutr 2004;43(5):285-287. View abstract.

Melse-Boonstra, A., Lievers, K. J., Blom, H. J., and Verhoef, P. Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene. Am J Clin Nutr 2004;80(3):700-704. View abstract.

Hvas, A. M., Juul, S., Lauritzen, L., Nexo, E., and Ellegaard, J. No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study. J Affect.Disord. 2004;81(3):269-273. View abstract.

Carlsson, C. M., Pharo, L. M., Aeschlimann, S. E., Mitchell, C., Underbakke, G., and Stein, J. H. Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults. Am Heart J 2004;148(3):E11. View abstract.

Ramos, M. I., Allen, L. H., Haan, M. N., Green, R., and Miller, J. W. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am J Clin Nutr 2004;80(4):1024-1028. View abstract.

Liu, S., West, R., Randell, E., Longerich, L., O'connor, K. S., Scott, H., Crowley, M., Lam, A., Prabhakaran, V., and McCourt, C. A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects. BMC.Pregnancy.Childbirth. 9-27-2004;4(1):20. View abstract.

Schmiegel, W., Pox, C., and Kroesen, A. [Ulcerative colitis. Cancer prevention]. Z Gastroenterol 2004;42(9):1014-1018. View abstract.

Deol, P. S., Barnes, T. A., Dampier, K., John, Pasi K., Oppenheimer, C., and Pavord, S. R. The effects of folic acid supplements on coagulation status in pregnancy. Br.J.Haematol. 2004;127(2):204-208. View abstract.

Sanjoaquin, M. A., Allen, N., Couto, E., Roddam, A. W., and Key, T. J. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer 2-20-2005;113(5):825-828. View abstract.

Czeizel, A. E., Dobo, M., and Vargha, P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Res A Clin Mol.Teratol. 2004;70(11):853-861. View abstract.

Spoelstra-de, M. A., Brouwer, C. B., Terheggen, F., Bollen, J. M., Stehouwer, C. D., and Smulders, Y. M. No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia. Neth.J Med 2004;62(7):246-253. View abstract.

Connor, S. L., Ojeda, L. S., Sexton, G., Weidner, G., and Connor, W. E. Diets lower in folic acid and carotenoids are associated with the coronary disease epidemic in Central and Eastern Europe. J Am Diet Assoc 2004;104(12):1793-1799. View abstract.

Lekakis, J. P., Papamichael, C. M., Papaioannou, T. G., Dagre, A. G., Stamatelopoulos, K. S., Tryfonopoulos, D., Protogerou, A. D., Stamatelopoulos, S. F., and Mavrikakis, M. Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statins. Eur J Cardiovasc.Prev.Rehabil 2004;11(5):416-420. View abstract.

Ziegler, S., Mittermayer, F., Plank, C., Minar, E., Wolzt, M., and Schernthaner, G. H. Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease. J Clin Endocrinol.Metab 2005;90(4):2175-2178. View abstract.

Chen, J., Gammon, M. D., Chan, W., Palomeque, C., Wetmur, J. G., Kabat, G. C., Teitelbaum, S. L., Britton, J. A., Terry, M. B., Neugut, A. I., and Santella, R. M. One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 2-15-2005;65(4):1606-1614. View abstract.

Mangoni, A. A., Sherwood, R. A., Asonganyi, B., Swift, C. G., Thomas, S., and Jackson, S. H. Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes. Am J Hypertens. 2005;18(2 Pt 1):220-226. View abstract.

Charles, D. H., Ness, A. R., Campbell, D., Smith, G. D., Whitley, E., and Hall, M. H. Folic acid supplements in pregnancy and birth outcome: re-analysis of a large randomised controlled trial and update of Cochrane review. Paediatr.Perinat.Epidemiol. 2005;19(2):112-124. View abstract.

Brattstrom, L., Lindgren, A., Israelsson, B., Malinow, M. R., Norrving, B., Upson, B., and Hamfelt, A. Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 1992;22(3):214-221. View abstract.

Ranganathan, L. N. and Ramaratnam, S. Vitamins for epilepsy. Cochrane.Database.Syst.Rev 2005;(2):CD004304. View abstract.

Lopez-Camelo, J. S., Orioli, I. M., da Graca, Dutra M., Nazer-Herrera, J., Rivera, N., Ojeda, M. E., Canessa, A., Wettig, E., Fontannaz, A. M., Mellado, C., and Castilla, E. E. Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile. Am.J.Med.Genet.A 6-1-2005;135(2):120-125. View abstract.

Felkner, M., Suarez, L., Hendricks, K., and Larsen, R. Implementation and outcomes of recommended folic acid supplementation in Mexican-American women with prior neural tube defect-affected pregnancies. Prev.Med 2005;40(6):867-871. View abstract.

Sachdev, P. S., Parslow, R. A., Lux, O., Salonikas, C., Wen, W., Naidoo, D., Christensen, H., and Jorm, A. F. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol.Med 2005;35(4):529-538. View abstract.

Lewerin, C., Matousek, M., Steen, G., Johansson, B., Steen, B., and Nilsson-Ehle, H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am.J Clin.Nutr 2005;81(5):1155-1162. View abstract.

Garcia-Closas, R., Castellsague, X., Bosch, X., and Gonzalez, C. A. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int.J.Cancer 11-20-2005;117(4):629-637. View abstract.

Carrero, J. J., Lopez-Huertas, E., Salmeron, L. M., Baro, L., and Ros, E. Daily supplementation with (n-3) PUFAs, oleic acid, folic acid, and vitamins B-6 and E increases pain-free walking distance and improves risk factors in men with peripheral vascular disease. J.Nutr. 2005;135(6):1393-1399. View abstract.

Till, U., Rohl, P., Jentsch, A., Till, H., Muller, A., Bellstedt, K., Plonne, D., Fink, H. S., Vollandt, R., Sliwka, U., Herrmann, F. H., Petermann, H., and Riezler, R. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12. Atherosclerosis 2005;181(1):131-135. View abstract.

Cronin, S., Furie, K. L., and Kelly, P. J. Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005;36(7):1581-1587. View abstract.

Cook, N. R., Lee, I. M., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., and Buring, J. E. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 7-6-2005;294(1):47-55. View abstract.

Williams, C., Kingwell, B. A., Burke, K., McPherson, J., and Dart, A. M. Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr 2005;82(1):26-31. View abstract.

Virdis, A., Ghiadoni, L., Versari, D., Salvetti, G., Pinto, S., Favilla, S., Taddei, S., and Salvetti, A. Is Hyperhomocyst(e)inemia a humoral predictor of coronary heart disease? Curr Pharm Des 2005;11(17):2187-2197. View abstract.

Baglietto, L., English, D. R., Gertig, D. M., Hopper, J. L., and Giles, G. G. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ 10-8-2005;331(7520):807. View abstract.

Potena, L., Grigioni, F., Magnani, G., Ortolani, P., Coccolo, F., Sassi, S., Kessels, K., Marrozzini, C., Marzocchi, A., Carigi, S., Musuraca, A. C., Russo, A., Magelli, C., and Branzi, A. Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study. Am.J Transplant. 2005;5(9):2258-2264. View abstract.

Liem, A., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., and van Veldhuisen, D. J. Secondary prevention with folic acid: results of the Goes extension study. Heart 2005;91(9):1213-1214. View abstract.

Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., and Licastro, F. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005;82(3):636-643. View abstract.

Kuo, H. K., Sorond, F. A., Chen, J. H., Hashmi, A., Milberg, W. P., and Lipsitz, L. A. The role of homocysteine in multisystem age-related problems: a systematic review. J Gerontol.A Biol.Sci Med Sci 2005;60(9):1190-1201. View abstract.

Huemer, M., Ausserer, B., Graninger, G., Hubmann, M., Huemer, C., Schlachter, K., Tscharre, A., Ulmer, H., and Simma, B. Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation. Epilepsia 2005;46(10):1677-1683. View abstract.

Bailey, L. B. Do low doses of folic acid result in maximum lowering of homocysteine? Am.J Clin.Nutr 2005;82(4):717-718. View abstract.

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am.J Clin.Nutr 2005;82(4):806-812. View abstract.

Mooijaart, S. P., Gussekloo, J., Frolich, M., Jolles, J., Stott, D. J., Westendorp, R. G., and de Craen, A. J. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study. Am J Clin Nutr 2005;82(4):866-871. View abstract.

Tjonneland, A., Christensen, J., Olsen, A., Stripp, C., Nissen, S. B., Overvad, K., and Thomsen, B. L. Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. Eur.J.Clin Nutr. 2006;60(2):280-286. View abstract.

Huang, T. L., Zandi, P. P., Tucker, K. L., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., Burke, G. L., and Carlson, M. C. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 11-8-2005;65(9):1409-1414. View abstract.

Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Pantieri, G., and Mariani, E. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement.Geriatr Cogn Disord. 2006;21(1):51-58. View abstract.

Stott, D. J., MacIntosh, G., Lowe, G. D., Rumley, A., McMahon, A. D., Langhorne, P., Tait, R. C., O'Reilly, D. S., Spilg, E. G., MacDonald, J. B., MacFarlane, P. W., and Westendorp, R. G. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am.J Clin.Nutr 2005;82(6):1320-1326. View abstract.

Rossi, E., Hung, J., Beilby, J. P., Knuiman, M. W., Divitini, M. L., and Bartholomew, H. Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia. Ann.Epidemiol. 2006;16(3):206-212. View abstract.

Pathansali, R., Mangoni, A. A., Creagh-Brown, B., Lan, Z. C., Ngow, G. L., Yuan, X. F., Ouldred, E. L., Sherwood, R. A., Swift, C. G., and Jackson, S. H. Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Arch Gerontol.Geriatr 2006;43(1):127-137. View abstract.

Pastore, A., De, Angelis S., Casciani, S., Ruggia, R., Di, Giovamberardino G., Noce, A., Splendiani, G., Cortese, C., Federici, G., and Dessi', M. Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes. Clin Chem. 2006;52(1):145-148. View abstract.

Lewis, S. J., Lawlor, D. A., Davey, Smith G., Araya, R., Timpson, N., Day, I. N., and Ebrahim, S. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol.Psychiatry 2006;11(4):352-360. View abstract.

Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006;151(2):282-287. View abstract.

Lonn, E., Held, C., Arnold, J. M., Probstfield, J., McQueen, M., Micks, M., Pogue, J., Sheridan, P., Bosch, J., Genest, J., and Yusuf, S. Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial. Can.J Cardiol 2006;22(1):47-53. View abstract.

Labayle, D., Fischer, D., Vielh, P., Drouhin, F., Pariente, A., Bories, C., Duhamel, O., Trousset, M., and Attali, P. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991;101(3):635-639. View abstract.

Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C., and Genest, J., Jr. Homocysteine lowering with folic acid and B vitamins in vascular disease. N.Engl.J Med 4-13-2006;354(15):1567-1577. View abstract.

Lajous, M., Lazcano-Ponce, E., Hernandez-Avila, M., Willett, W., and Romieu, I. Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol.Biomarkers Prev. 2006;15(3):443-448. View abstract.

Shrubsole, M. J., Gao, Y. T., Cai, Q., Shu, X. O., Dai, Q., Jin, F., and Zheng, W. MTR and MTRR polymorphisms, dietary intake, and breast cancer risk. Cancer Epidemiol.Biomarkers Prev. 2006;15(3):586-588. View abstract.

Zoungas, S., McGrath, B. P., Branley, P., Kerr, P. G., Muske, C., Wolfe, R., Atkins, R. C., Nicholls, K., Fraenkel, M., Hutchison, B. G., Walker, R., and McNeil, J. J. Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial. J Am Coll Cardiol 3-21-2006;47(6):1108-1116. View abstract.

Stolzenberg-Solomon, R. Z., Chang, S. C., Leitzmann, M. F., Johnson, K. A., Johnson, C., Buys, S. S., Hoover, R. N., and Ziegler, R. G. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am.J.Clin Nutr. 2006;83(4):895-904. View abstract.

Iwama, T., Akasu, T., Utsunomiya, J., and Muto, T. Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial. Int J Clin Oncol. 2006;11(2):133-139. View abstract.

Schernthaner, G. H., Plank, C., Minar, E., Bieglmayer, C., Koppensteiner, R., and Schernthaner, G. No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease. Eur J Clin Invest 2006;36(5):333-339. View abstract.

Solfrizzi, V., Colacicco, A. M., D'Introno, A., Capurso, C., Del, Parigi A., Capurso, S. A., Argentieri, G., Capurso, A., and Panza, F. Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging. Exp.Gerontol. 2006;41(6):619-627. View abstract.

Salim, A., Tan, E., Ilchyshyn, A., and Berth-Jones, J. Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol. 2006;154(6):1169-1174. View abstract.

Laitinen, M. H., Ngandu, T., Rovio, S., Helkala, E. L., Uusitalo, U., Viitanen, M., Nissinen, A., Tuomilehto, J., Soininen, H., and Kivipelto, M. Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study. Dement.Geriatr Cogn Disord. 2006;22(1):99-107. View abstract.

Barrios, M. and Alliot, C. Venous thrombosis associated with pernicious anaemia. A report of two cases and review. Hematology. 2006;11(2):135-138. View abstract.

Righetti, M., Serbelloni, P., Milani, S., and Ferrario, G. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif. 2006;24(4):379-386. View abstract.

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 7-20-1991;338(8760):131-137. View abstract.

Chou, Y. C., Wu, M. H., Yu, J. C., Lee, M. S., Yang, T., Shih, H. L., Wu, T. Y., and Sun, C. A. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis 2006;27(11):2295-2300. View abstract.

MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., and Couper, J. J. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics 2006;118(1):242-253. View abstract.

McKillop, D. J., McNulty, H., Scott, J. M., McPartlin, J. M., Strain, J. J., Bradbury, I., Girvan, J., Hoey, L., McCreedy, R., Alexander, J., Patterson, B. K., Hannon-Fletcher, M., and Pentieva, K. The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Am J Clin Nutr 2006;84(1):167-173. View abstract.

Pena-Rosas, J. P. and Viteri, F. E. Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane.Database.Syst.Rev 2006;3:CD004736. View abstract.

Annerbo, S., Wahlund, L. O., and Lokk, J. The significance of thyroid-stimulating hormone and homocysteine in the development of Alzheimer's disease in mild cognitive impairment: a 6-year follow-up study. Am J Alzheimers.Dis.Other Demen. 2006;21(3):182-188. View abstract.

Klingler, M., Blaschitz, A., Campoy, C., Cano, A., Molloy, A. M., Scott, J. M., Dohr, G., Demmelmair, H., Koletzko, B., and Desoye, G. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. Br J Nutr 2006;96(1):182-190. View abstract.

Olthof, M. R., Bots, M. L., Katan, M. B., and Verhoef, P. Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. PLoS.Clin Trials 2006;1(2):e10. View abstract.

Title, L. M., Ur, E., Giddens, K., McQueen, M. J., and Nassar, B. A. Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering. Vasc.Med 2006;11(2):101-109. View abstract.

Eussen, S. J., de Groot, L. C., Joosten, L. W., Bloo, R. J., Clarke, R., Ueland, P. M., Schneede, J., Blom, H. J., Hoefnagels, W. H., and van Staveren, W. A. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am.J Clin.Nutr 2006;84(2):361-370. View abstract.

Morris, M. C., Evans, D. A., Schneider, J. A., Tangney, C. C., Bienias, J. L., and Aggarwal, N. T. Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease. J Alzheimers.Dis. 2006;9(4):435-443. View abstract.

Bertagnolli, M. M., Eagle, C. J., Zauber, A. G., Redston, M., Solomon, S. D., Kim, K., Tang, J., Rosenstein, R. B., Wittes, J., Corle, D., Hess, T. M., Woloj, G. M., Boisserie, F., Anderson, W. F., Viner, J. L., Bagheri, D., Burn, J., Chung, D. C., Dewar, T., Foley, T. R., Hoffman, N., Macrae, F., Pruitt, R. E., Saltzman, J. R., Salzberg, B., Sylwestrowicz, T., Gordon, G. B., and Hawk, E. T. Celecoxib for the prevention of sporadic colorectal adenomas. N.Engl.J Med 8-31-2006;355(9):873-884. View abstract.

Arber, N., Eagle, C. J., Spicak, J., Racz, I., Dite, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., Rosenstein, R. B., Macdonald, K., Bhadra, P., Fowler, R., Wittes, J., Zauber, A. G., Solomon, S. D., and Levin, B. Celecoxib for the prevention of colorectal adenomatous polyps. N.Engl.J Med 8-31-2006;355(9):885-895. View abstract.

Herrmann, W. Significance of hyperhomocysteinemia. Clin Lab 2006;52(7-8):367-374. View abstract.

den, Heijer M., Willems, H. P., Blom, H. J., Gerrits, W. B., Cattaneo, M., Eichinger, S., Rosendaal, F. R., and Bos, G. M. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. Blood 1-1-2007;109(1):139-144. View abstract.

Hubner, R. A., Muir, K. R., Liu, J. F., Sellick, G. S., Logan, R. F., Grainge, M., Armitage, N., Chau, I., and Houlston, R. S. Folate metabolism polymorphisms influence risk of colorectal adenoma recurrence. Cancer Epidemiol.Biomarkers Prev. 2006;15(9):1607-1613. View abstract.

Lajous, M., Romieu, I., Sabia, S., Boutron-Ruault, M. C., and Clavel-Chapelon, F. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes Control 2006;17(9):1209-1213. View abstract.

Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006;28(8):680-689. View abstract.

Larsson, S. C., Giovannucci, E., and Wolk, A. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 2006;131(4):1271-1283. View abstract.

Meijer, W. M., Werler, M. M., Louik, C., Hernandez-Diaz, S., de Jong-van den Berg LT, and Mitchell, A. A. Can folic acid protect against congenital heart defects in Down syndrome? Birth Defects Res A Clin Mol.Teratol. 2006;76(10):714-717. View abstract.

Fernandez-Miranda, C., Yebra, M., Aranda, J. L., Gomez, P., Martinez, J., Nunez, V., and Gomez, de la Camara. Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease. Int J Cardiol 6-12-2007;118(3):345-349. View abstract.

Haider, B. A. and Bhutta, Z. A. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database.Syst.Rev 2006;(4):CD004905. View abstract.

Berry-Kravis, E., Krause, S. E., Block, S. S., Guter, S., Wuu, J., Leurgans, S., Decle, P., Potanos, K., Cook, E., Salt, J., Maino, D., Weinberg, D., Lara, R., Jardini, T., Cogswell, J., Johnson, S. A., and Hagerman, R. Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. J Child Adolesc.Psychopharmacol 2006;16(5):525-540. View abstract.

Melse-Boonstra, A., Verhoef, P., West, C. E., van Rhijn, J. A., van Breemen, R. B., Lasaroms, J. J., Garbis, S. D., Katan, M. B., and Kok, F. J. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr 2006;84(5):1128-1133. View abstract.

Lewis, S. J., Harbord, R. M., Harris, R., and Smith, G. D. Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J Natl Cancer Inst. 11-15-2006;98(22):1607-1622. View abstract.

Sombolos, K., Papaioannou, A., Christidou, F., Natse, T., Bamichas, G., Gionanlis, L., Katsaris, G., and Progia, E. The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients. Int.Urol.Nephrol. 2006;38(3-4):725-730. View abstract.

Badovinac, R. L., Werler, M. M., Williams, P. L., Kelsey, K. T., and Hayes, C. Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Birth Defects Res A Clin Mol.Teratol. 2007;79(1):8-15. View abstract.

Austen, S. K., Fassett, R. G., Geraghty, D. P., and Coombes, J. S. Folate supplementation fails to affect vascular function and carotid artery intima media thickness in cyclosporin A-treated renal transplant recipients. Clin Nephrol. 2006;66(5):373-379. View abstract.

Clarke, R., Lewington, S., Sherliker, P., and Armitage, J. Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia. Curr Opin.Clin Nutr Metab Care 2007;10(1):32-39. View abstract.

Bazzano, L. A., Reynolds, K., Holder, K. N., and He, J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA 12-13-2006;296(22):2720-2726. View abstract.

Larsson, S. C., Giovannucci, E., and Wolk, A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 1-3-2007;99(1):64-76. View abstract.

Balk, E. M., Raman, G., Tatsioni, A., Chung, M., Lau, J., and Rosenberg, I. H. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch.Intern.Med 1-8-2007;167(1):21-30. View abstract.

Winkels, R. M., Brouwer, I. A., Siebelink, E., Katan, M. B., and Verhoef, P. Bioavailability of food folates is 80% of that of folic acid. Am J Clin Nutr 2007;85(2):465-473. View abstract.

Haan, M. N., Miller, J. W., Aiello, A. E., Whitmer, R. A., Jagust, W. J., Mungas, D. M., Allen, L. H., and Green, R. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2007;85(2):511-517. View abstract.

Moens, A. L., Claeys, M. J., Wuyts, F. L., Goovaerts, I., Van, Hertbruggen E., Wendelen, L. C., Van Hoof, V. O., and Vrints, C. J. Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol 2-15-2007;99(4):476-481. View abstract.

Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol.Ther 2007;81(5):685-691. View abstract.

Vianna, A. C., Mocelin, A. J., Matsuo, T., Morais-Filho, D., Largura, A., Delfino, V. A., Soares, A. E., and Matni, A. M. Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events. Hemodial.Int 2007;11(2):210-216. View abstract.

Shirodaria, C., Antoniades, C., Lee, J., Jackson, C. E., Robson, M. D., Francis, J. M., Moat, S. J., Ratnatunga, C., Pillai, R., Refsum, H., Neubauer, S., and Channon, K. M. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 5-1-2007;115(17):2262-2270. View abstract.

Ray, J. G., Kearon, C., Yi, Q., Sheridan, P., and Lonn, E. Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann.Intern.Med. 6-5-2007;146(11):761-767. View abstract.

McNeill, G., Avenell, A., Campbell, M. K., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., and Vale, L. D. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. Nutr J 2007;6:10. View abstract.

Pena, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., and Couper, J. Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care 2007;30(8):2122-2127. View abstract.

Wang, X., Qin, X., Demirtas, H., Li, J., Mao, G., Huo, Y., Sun, N., Liu, L., and Xu, X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 6-2-2007;369(9576):1876-1882. View abstract.

Cole, B. F., Baron, J. A., Sandler, R. S., Haile, R. W., Ahnen, D. J., Bresalier, R. S., McKeown-Eyssen, G., Summers, R. W., Rothstein, R. I., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Robertson, D. J., Beck, G. J., Bond, J. H., Byers, T., Mandel, J. S., Mott, L. A., Pearson, L. H., Barry, E. L., Rees, J. R., Marcon, N., Saibil, F., Ueland, P. M., and Greenberg, E. R. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 6-6-2007;297(21):2351-2359. View abstract.

Gilbody, S., Lightfoot, T., and Sheldon, T. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol.Community Health 2007;61(7):631-637. View abstract.

Raman, G., Tatsioni, A., Chung, M., Rosenberg, I. H., Lau, J., Lichtenstein, A. H., and Balk, E. M. Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function. J Nutr 2007;137(7):1789-1794. View abstract.

Nanayakkara, P. W., van, Guldener C., ter Wee, P. M., Scheffer, P. G., van Ittersum, F. J., Twisk, J. W., Teerlink, T., van, Dorp W., and Stehouwer, C. D. Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study. Arch.Intern.Med. 6-25-2007;167(12):1262-1270. View abstract.

Connelly, P. J., Prentice, N. P., Cousland, G., and Bonham, J. A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. Int J Geriatr Psychiatry 2008;23(2):155-160. View abstract.

Dockerty, J. D., Herbison, P., Skegg, D. C., and Elwood, M. Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study. BMC.Public Health 2007;7:136. View abstract.

De, Wals P., Tairou, F., Van Allen, M. I., Uh, S. H., Lowry, R. B., Sibbald, B., Evans, J. A., Van den Hof, M. C., Zimmer, P., Crowley, M., Fernandez, B., Lee, N. S., and Niyonsenga, T. Reduction in neural-tube defects after folic acid fortification in Canada. N.Engl.J Med 7-12-2007;357(2):135-142. View abstract.

Joyce, D. A., Will, R. K., Hoffman, D. M., Laing, B., and Blackbourn, S. J. Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid. Ann.Rheum.Dis. 1991;50(12):913-914. View abstract.

Ericson, U., Sonestedt, E., Gullberg, B., Olsson, H., and Wirfalt, E. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. Am.J.Clin Nutr. 2007;86(2):434-443. View abstract.

de, Bree A., van Mierlo, L. A., and Draijer, R. Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2007;86(3):610-617. View abstract.

Farrell, B., Godwin, J., Richards, S., and Warlow, C. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol.Neurosurg.Psychiatry 1991;54(12):1044-1054. View abstract.

Jamison, R. L., Hartigan, P., Kaufman, J. S., Goldfarb, D. S., Warren, S. R., Guarino, P. D., and Gaziano, J. M. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 9-12-2007;298(10):1163-1170. View abstract.

Kaisar, M., Isbel, N., and Johnson, D. W. Cardiovascular disease in patients with chronic kidney disease. A clinical review. Minerva Urol.Nefrol. 2007;59(3):281-297. View abstract.

Zintzaras, E. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. J Hum Genet. 2007;52(11):943-953. View abstract.

Bowman, L., Armitage, J., Bulbulia, R., Parish, S., and Collins, R. Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors. Am Heart J 2007;154(5):815-23, 823. View abstract.

Grosse, S. D. and Collins, J. S. Folic acid supplementation and neural tube defect recurrence prevention. Birth Defects Res A Clin Mol.Teratol. 2007;79(11):737-742. View abstract.

Mann, J. F., Sheridan, P., McQueen, M. J., Held, C., Arnold, J. M., Fodor, G., Yusuf, S., and Lonn, E. M. Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study. Nephrol.Dial.Transplant. 2008;23(2):645-653. View abstract.

Logan, R. F., Grainge, M. J., Shepherd, V. C., Armitage, N. C., and Muir, K. R. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 2008;134(1):29-38. View abstract.

Suzuki, T., Matsuo, K., Hirose, K., Hiraki, A., Kawase, T., Watanabe, M., Yamashita, T., Iwata, H., and Tajima, K. One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 2008;29(2):356-362. View abstract.

Clarke, R. B-vitamins and prevention of dementia. Proc Nutr Soc 2008;67(1):75-81. View abstract.

Torrioli, M. G., Vernacotola, S., Peruzzi, L., Tabolacci, E., Mila, M., Militerni, R., Musumeci, S., Ramos, F. J., Frontera, M., Sorge, G., Marzullo, E., Romeo, G., Vallee, L., Veneselli, E., Cocchi, E., Garbarino, E., Moscato, U., Chiurazzi, P., D'Iddio, S., Calvani, M., and Neri, G. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Am.J Med.Genet.A 4-1-2008;146(7):803-812. View abstract.

Ellis, J. M., Tan, H. K., Gilbert, R. E., Muller, D. P., Henley, W., Moy, R., Pumphrey, R., Ani, C., Davies, S., Edwards, V., Green, H., Salt, A., and Logan, S. Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial. BMJ 3-15-2008;336(7644):594-597. View abstract.

Hotoleanu, C., Porojan-Iuga, M., Rusu, M. L., and Andercou, A. Hyperhomocysteinemia: clinical and therapeutical involvement in venous thrombosis. Rom.J Intern Med 2007;45(2):159-164. View abstract.

Sayed, A. R., Bourne, D., Pattinson, R., Nixon, J., and Henderson, B. Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. Birth Defects Res A Clin Mol.Teratol. 2008;82(4):211-216. View abstract.

Soliman, E. Z. and Shalash, O. A. Homocysteine, vitamins, and vascular disease prevention: more negative results. Am J Clin Nutr 2008;87(4):1069-1070. View abstract.

McNulty, H., Pentieva, K., Hoey, L., and Ward, M. Homocysteine, B-vitamins and CVD. Proc.Nutr Soc. 2008;67(2):232-237. View abstract.

Potena, L., Grigioni, F., Masetti, M., Magnani, G., Coccolo, F., Fallani, F., Russo, A., Pizzuti, M., Scalone, A., Bianchi, I. G., and Branzi, A. Long-term effect of folic acid therapy in heart transplant recipients: follow-up analysis of a randomized study. Transplantation 4-27-2008;85(8):1146-1150. View abstract.

Stockley, L. and Lund, V. Use of folic acid supplements, particularly by low-income and young women: a series of systematic reviews to inform public health policy in the UK. Public Health Nutr 2008;11(8):807-821. View abstract.

Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 5-7-2008;299(17):2027-2036. View abstract.

Kaisar, M. O., Isbel, N. M., and Johnson, D. W. Recent clinical trials of pharmacologic cardiovascular interventions in patients with chronic kidney disease. Rev Recent Clin Trials 2008;3(2):79-88. View abstract.

Van, Dam F. and Van Gool, W. A. Hyperhomocysteinemia and Alzheimer's disease: A systematic review. Arch.Gerontol.Geriatr. 2009;48(3):425-430. View abstract.

Chen, B. H., Carmichael, S. L., Selvin, S., Abrams, B., and Shaw, G. M. NTD prevalences in central California before and after folic acid fortification. Birth Defects Res A Clin Mol.Teratol. 2008;82(8):547-552. View abstract.

Szczurko, O. and Boon, H. S. A systematic review of natural health product treatment for vitiligo. BMC.Dermatol. 2008;8:2. View abstract.

Kile, M. L. and Ronnenberg, A. G. Can folate intake reduce arsenic toxicity? Nutr Rev 2008;66(6):349-353. View abstract.

Ford, A. H., Flicker, L., Thomas, J., Norman, P., Jamrozik, K., and Almeida, O. P. Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial. J Clin.Psychiatry 2008;69(8):1203-1209. View abstract.

Johnson, C. Y. and Little, J. Folate intake, markers of folate status and oral clefts: is the evidence converging? Int J Epidemiol. 2008;37(5):1041-1058. View abstract.

Wolpin, B. M., Wei, E. K., Ng, K., Meyerhardt, J. A., Chan, J. A., Selhub, J., Giovannucci, E. L., and Fuchs, C. S. Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J.Clin Oncol. 7-1-2008;26(19):3222-3228. View abstract.

Chen, G., Song, X., Ji, Y., Zhang, L., Pei, L., Chen, J., Liu, J., Li, C., and Zheng, X. Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China. Birth Defects Res A Clin Mol.Teratol. 2008;82(8):592-596. View abstract.

Fioravanti, M., Ferrario, E., Massaia, M., Cappa, G., Rivolta, G., Grossi, E., and Buckley, A. E. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch.Gerontol.Geriatr. 1998;26(1):1-13. View abstract.

Mao, G., Hong, X., Xing, H., Liu, P., Liu, H., Yu, Y., Zhang, S., Jiang, S., Wang, X., and Xu, X. Efficacy of folic acid and enalapril combined therapy on reduction of blood pressure and plasma glucose: a multicenter, randomized, double-blind, parallel-controlled, clinical trial. Nutrition 2008;24(11-12):1088-1096. View abstract.

Kabat, G. C., Miller, A. B., Jain, M., and Rohan, T. E. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br.J.Cancer 9-2-2008;99(5):816-821. View abstract.

Hadler, M. C., Sigulem, D. M., Alves, Mde F., and Torres, V. M. Treatment and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiania, Goias State, Brazil: a randomized controlled trial. Cad.Saude Publica 2008;24 Suppl 2:S259-S271. View abstract.

Jaszewski, R., Misra, S., Tobi, M., Ullah, N., Naumoff, J. A., Kucuk, O., Levi, E., Axelrod, B. N., Patel, B. B., and Majumdar, A. P. Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial. World J Gastroenterol 7-28-2008;14(28):4492-4498. View abstract.

Strozzi, G. P. and Mogna, L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol 2008;42 Suppl 3 Pt 2:S179-S184. View abstract.

Ebbing, M., Bleie, O., Ueland, P. M., Nordrehaug, J. E., Nilsen, D. W., Vollset, S. E., Refsum, H., Pedersen, E. K., and Nygard, O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 8-20-2008;300(7):795-804. View abstract.

Levine, A. J., Wallace, K., Tsang, S., Haile, R. W., Saibil, F., Ahnen, D., Cole, B. F., Barry, E. L., Munroe, D. J., Ali, I. U., Ueland, P., and Baron, J. A. MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. Cancer Epidemiol.Biomarkers Prev. 2008;17(9):2409-2415. View abstract.

Duffy, C. M., Assaf, A., Cyr, M., Burkholder, G., Coccio, E., Rohan, T., McTiernan, A., Paskett, E., Lane, D., and Chetty, V. K. Alcohol and folate intake and breast cancer risk in the WHI Observational Study. Breast Cancer Res Treat. 2009;116(3):551-562. View abstract.

Potter, K., Hankey, G. J., Green, D. J., Eikelboom, J., Jamrozik, K., and Arnolda, L. F. The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis. BMC.Cardiovasc.Disord. 2008;8:24. View abstract.

Kendrick, J. and Chonchol, M. B. Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease. Nat.Clin Pract.Nephrol. 2008;4(12):672-681. View abstract.

Figueiredo, J. C., Levine, A. J., Grau, M. V., Barry, E. L., Ueland, P. M., Ahnen, D. J., Byers, T., Bresalier, R. S., Summers, R. W., Bond, J., McKeown-Eyssen, G. E., Sandler, R. S., Haile, R. W., and Baron, J. A. Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels. Cancer Epidemiol.Biomarkers Prev. 2008;17(10):2625-2631. View abstract.

Malouf, R. and Grimley, Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane.Database.Syst.Rev 2008;(4):CD004514. View abstract.

Aisen, P. S., Schneider, L. S., Sano, M., Diaz-Arrastia, R., van Dyck, C. H., Weiner, M. F., Bottiglieri, T., Jin, S., Stokes, K. T., Thomas, R. G., and Thal, L. J. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 10-15-2008;300(15):1774-1783. View abstract.

Prey, S. and Paul, C. Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. Br J Dermatol. 2009;160(3):622-628. View abstract.

Almeida, O. P., McCaul, K., Hankey, G. J., Norman, P., Jamrozik, K., and Flicker, L. Homocysteine and depression in later life. Arch.Gen.Psychiatry 2008;65(11):1286-1294. View abstract.

Zhang, S. M., Cook, N. R., Albert, C. M., Gaziano, J. M., Buring, J. E., and Manson, J. E. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA 11-5-2008;300(17):2012-2021. View abstract.

Kalmbach, R. D., Choumenkovitch, S. F., Troen, A. P., Jacques, P. F., D'Agostino, R., and Selhub, J. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr 2008;138(12):2323-2327. View abstract.

Haberg, S. E., London, S. J., Stigum, H., Nafstad, P., and Nystad, W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis.Child 2009;94(3):180-184. View abstract.

Houghton, L. A., Yang, J., and O'Connor, D. L. Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements. Am J Clin Nutr 2009;89(1):216-220. View abstract.

Kang, J. H., Cook, N., Manson, J., Buring, J. E., Albert, C. M., and Grodstein, F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am.J.Clin.Nutr. 2008;88(6):1602-1610. View abstract.

Larsson, S. C., Bergkvist, L., and Wolk, A. Folate intake and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Epidemiol.Biomarkers Prev. 2008;17(12):3444-3449. View abstract.

Burn, J., Bishop, D. T., Mecklin, J. P., Macrae, F., Moslein, G., Olschwang, S., Bisgaard, M. L., Ramesar, R., Eccles, D., Maher, E. R., Bertario, L., Jarvinen, H. J., Lindblom, A., Evans, D. G., Lubinski, J., Morrison, P. J., Ho, J. W., Vasen, H. F., Side, L., Thomas, H. J., Scott, R. J., Dunlop, M., Barker, G., Elliott, F., Jass, J. R., Fodde, R., Lynch, H. T., and Mathers, J. C. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N.Engl.J Med 12-11-2008;359(24):2567-2578. View abstract.

Weir, D. G. and Scott, J. M. Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications. Nutr Res.Rev 1998;11(2):311-338. View abstract.

Ganji, V. and Kafai, M. R. Demographic, lifestyle, and health characteristics and serum B vitamin status are determinants of plasma total homocysteine concentration in the post-folic acid fortification period, 1999-2004. J Nutr 2009;139(2):345-352. View abstract.

Calvo, E. B. and Biglieri, A. [Impact of folic acid fortification on women's nutritional status and on the prevalence of neural tube defects]. Arch.Argent Pediatr. 2008;106(6):492-498. View abstract.

Maruti, S. S., Ulrich, C. M., and White, E. Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am.J.Clin Nutr. 2009;89(2):624-633. View abstract.

Hodis, H. N., Mack, W. J., Dustin, L., Mahrer, P. R., Azen, S. P., Detrano, R., Selhub, J., Alaupovic, P., Liu, C. R., Liu, C. H., Hwang, J., Wilcox, A. G., and Selzer, R. H. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke 2009;40(3):730-736. View abstract.

Bower, C., D'Antoine, H., and Stanley, F. J. Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. Birth Defects Res A Clin Mol.Teratol. 2009;85(4):269-273. View abstract.

Hirsch, S., Sanchez, H., Albala, C., de la Maza, M. P., Barrera, G., Leiva, L., and Bunout, D. Colon cancer in Chile before and after the start of the flour fortification program with folic acid. Eur J Gastroenterol Hepatol. 2009;21(4):436-439. View abstract.

Ntaios, G., Savopoulos, C., Karamitsos, D., Economou, I., Destanis, E., Chryssogonidis, I., Pidonia, I., Zebekakis, P., Polatides, C., Sion, M., Grekas, D., and Hatzitolios, A. The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial. Int.J.Cardiol. 8-6-2010;143(1):16-19. View abstract.

Blom, H. J. Folic acid, methylation and neural tube closure in humans. Birth Defects Res A Clin Mol.Teratol. 2009;85(4):295-302. View abstract.

Allen, L. H., Peerson, J. M., and Olney, D. K. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. J Nutr 2009;139(5):1022-1030. View abstract.

Ericson, U., Sonestedt, E., Ivarsson, M. I., Gullberg, B., Carlson, J., Olsson, H., and Wirfalt, E. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmo Diet and Cancer cohort. Cancer Epidemiol.Biomarkers Prev. 2009;18(4):1101-1110. View abstract.

Oakley, G. P., Jr. The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology. Ann.Epidemiol. 2009;19(4):226-230. View abstract.

Heinz, J., Kropf, S., Luley, C., and Dierkes, J. Homocysteine as a risk factor for cardiovascular disease in patients treated by dialysis: a meta-analysis. Am J Kidney Dis. 2009;54(3):478-489. View abstract.

Nafar, M., Khatami, F., Kardavani, B., Farjad, R., Pour-Reza-Gholi, F., Firouzan, A., Kalantar, A., Farhangi, S., and Einollahi, B. Role of folic acid in atherosclerosis after kidney transplant: a double-blind, randomized, placebo-controlled clinical trial. Exp.Clin Transplant. 2009;7(1):33-39. View abstract.

Ma, E., Iwasaki, M., Junko, I., Hamada, G. S., Nishimoto, I. N., Carvalho, S. M., Motola, J., Jr., Laginha, F. M., and Tsugane, S. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC.Cancer 2009;9:122. View abstract.

Behzadi, A. H., Omrani, Z., Chalian, M., Asadi, S., and Ghadiri, M. Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial. Acta Psychiatr.Scand. 2009;120(6):441-445. View abstract.

Wolff, T., Witkop, C. T., Miller, T., and Syed, S. B. Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force. Ann.Intern Med 5-5-2009;150(9):632-639. View abstract.

Yakoob, M. Y., Menezes, E. V., Soomro, T., Haws, R. A., Darmstadt, G. L., and Bhutta, Z. A. Reducing stillbirths: behavioural and nutritional interventions before and during pregnancy. BMC.Pregnancy Childbirth. 2009;9 Suppl 1:S3. View abstract.

Ionescu-Ittu, R., Marelli, A. J., Mackie, A. S., and Pilote, L. Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada. BMJ 2009;338:b1673. View abstract.

Imasa, M. S., Gomez, N. T., and Nevado, J. B., Jr. Folic acid-based intervention in non-ST elevation acute coronary syndromes. Asian Cardiovasc.Thorac.Ann. 2009;17(1):13-21. View abstract.

Khandanpour, N., Loke, Y. K., Meyer, F. J., Jennings, B., and Armon, M. P. Homocysteine and peripheral arterial disease: systematic review and meta-analysis. Eur J Vasc.Endovasc.Surg 2009;38(3):316-322. View abstract.

McRae, M. P. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials. J Chiropr.Med 2009;8(1):15-24. View abstract.

Azadibakhsh, N., Hosseini, R. S., Atabak, S., Nateghiyan, N., Golestan, B., and Rad, A. H. Efficacy of folate and vitamin B12 in lowering homocysteine concentrations in hemodialysis patients. Saudi.J.Kidney Dis.Transpl. 2009;20(5):779-788. View abstract.

Ibrahim, E. M. and Zekri, J. M. Folic acid supplementation for the prevention of recurrence of colorectal adenomas: metaanalysis of interventional trials. Med Oncol. 2010;27(3):915-918. View abstract.

Ericson, U. C., Ivarsson, M. I., Sonestedt, E., Gullberg, B., Carlson, J., Olsson, H., and Wirfalt, E. Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele. Am.J.Clin Nutr. 2009;90(5):1380-1389. View abstract.

Koppen, I. J., Hermans, F. J., and Kaspers, G. J. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol. 2010;148(1):3-14. View abstract.

Marti-Carvajal, A. J., Sola, I., Lathyris, D., and Salanti, G. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane.Database.Syst.Rev 2009;(4):CD006612. View abstract.

Rueda, J. R., Ballesteros, J., and Tejada, M. I. Systematic review of pharmacological treatments in fragile X syndrome. BMC.Neurol. 2009;9:53. View abstract.

Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., and Tsugane, S. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer 2009;61(4):447-456. View abstract.

Fife, J., Raniga, S., Hider, P. N., and Frizelle, F. A. Folic acid supplementation and colorectal cancer risk: a meta-analysis. Colorectal Dis. 2011;13(2):132-137. View abstract.

Wu, K., Platz, E. A., Willett, W. C., Fuchs, C. S., Selhub, J., Rosner, B. A., Hunter, D. J., and Giovannucci, E. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr 2009;90(6):1623-1631. View abstract.

Whitrow, M. J., Moore, V. M., Rumbold, A. R., and Davies, M. J. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 12-15-2009;170(12):1486-1493. View abstract.

Mei, W., Rong, Y., Jinming, L., Yongjun, L., and Hui, Z. Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials. Int J Clin Pract. 2010;64(2):208-215. View abstract.

Papandreou, D., Malindretos, P., Arvanitidou, M., Makedou, A., and Rousso, I. Homocysteine lowering with folic acid supplements in children: effects on blood pressure. Int J Food Sci Nutr 2010;61(1):11-17. View abstract.

Oaks, B. M., Dodd, K. W., Meinhold, C. L., Jiao, L., Church, T. R., and Stolzenberg-Solomon, R. Z. Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 2010;91(2):449-455. View abstract.

Jian, M., Wang, J., and Sun, H. [Meta-analysis of effect of intervention with folic acid on neural tube defects]. Wei Sheng Yan.Jiu. 2009;38(6):682-684. View abstract.

Bin, Q., Li, J., Liao, C., Cao, Y., and Gao, F. Oral uracil-tegafur Plus Leucovorin versus Fluorouracil Bolus Plus Leucovorin For Advanced Colorectal Cancer: A Meta-analysis of Five Randomized Controlled Trials. Colorectal Dis. 12-28-2009; View abstract.

Poppell, T. D., Keeling, S. D., Collins, J. F., and Hassell, T. M. Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. J Clin Periodontol. 1991;18(2):134-139. View abstract.

Montagnani, F., Chiriatti, A., Turrisi, G., Francini, G., and Fiorentini, G. A systematic review of FOLFOXIRI chemotherapy for the first-line treatment of metastatic colorectal cancer: improved efficacy at the cost of increased toxicity. Colorectal Dis. 2011;13(8):846-852. View abstract.

Blehaut, H., Mircher, C., Ravel, A., Conte, M., de, Portzamparc, V, Poret, G., de Kermadec, F. H., Rethore, M. O., and Sturtz, F. G. Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status. PLoS.One. 2010;5(1):e8394. View abstract.

Carroll, C., Cooper, K., Papaioannou, D., Hind, D., Tappenden, P., Pilgrim, H., and Booth, A. Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer. Aliment.Pharmacol.Ther 2010;31(7):708-718. View abstract.

Hemminki, E. and Rimpela, U. A randomized comparison of routine versus selective iron supplementation during pregnancy. J.Am.Coll.Nutr. 1991;10(1):3-10. View abstract.

Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., and Graham, I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N.Engl.J Med 4-25-1991;324(17):1149-1155. View abstract.

Allen, L. H. and Peerson, J. M. Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food Nutr Bull. 2009;30(4 Suppl):S527-S532. View abstract.

Shrimpton, R., Huffman, S. L., Zehner, E. R., Darnton-Hill, I., and Dalmiya, N. Multiple micronutrient supplementation during pregnancy in developing-country settings: policy and program implications of the results of a meta-analysis. Food Nutr Bull 2009;30(4 Suppl):S556-S573. View abstract.

Lin, J., Lee, I. M., Song, Y., Cook, N. R., Selhub, J., Manson, J. E., Buring, J. E., and Zhang, S. M. Plasma homocysteine and cysteine and risk of breast cancer in women. Cancer Res 3-15-2010;70(6):2397-2405. View abstract.

Mendez-Gonzalez, J., Rodriguez-Millan, E., Julve, J., and Blanco-Vaca, F. [Vitamin treatments that lower homocysteine concentration: can they decrease cerebrovascular disease in primary prevention?]. Rev Neurol. 2-16-2010;50(4):235-244. View abstract.

Heinz, J., Kropf, S., Domrose, U., Westphal, S., Borucki, K., Luley, C., Neumann, K. H., and Dierkes, J. B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial. Circulation 3-30-2010;121(12):1432-1438. View abstract.

Blencowe, H., Cousens, S., Modell, B., and Lawn, J. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol. 2010;39 Suppl 1:i110-i121. View abstract.

Oakley, G. P., Jr. Folic acid-preventable spina bifida: a good start but much to be done. Am J Prev.Med 2010;38(5):569-570. View abstract.

Stevens, V. L., McCullough, M. L., Sun, J., and Gapstur, S. M. Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort. Am.J.Clin Nutr. 2010;91(6):1708-1715. View abstract.

Lee, M., Hong, K. S., Chang, S. C., and Saver, J. L. Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis. Stroke 2010;41(6):1205-1212. View abstract.

Christian, P. Micronutrients, birth weight, and survival. Annu.Rev Nutr 8-21-2010;30:83-104. View abstract.

House, A. A., Eliasziw, M., Cattran, D. C., Churchill, D. N., Oliver, M. J., Fine, A., Dresser, G. K., and Spence, J. D. Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial. JAMA 4-28-2010;303(16):1603-1609. View abstract.

Hoch, A. Z., Lynch, S. L., Jurva, J. W., Schimke, J. E., and Gutterman, D. D. Folic acid supplementation improves vascular function in amenorrheic runners. Clin J Sport Med 2010;20(3):205-210. View abstract.

Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Neal, D. E., Hamdy, F. C., Smith, A. D., and Martin, R. M. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol.Biomarkers Prev. 2010;19(6):1632-1642. View abstract.

Wald, D. S., Kasturiratne, A., and Simmonds, M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am J Med 2010;123(6):522-527. View abstract.

Armitage, J. M., Bowman, L., Clarke, R. J., Wallendszus, K., Bulbulia, R., Rahimi, K., Haynes, R., Parish, S., Sleight, P., Peto, R., and Collins, R. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA 6-23-2010;303(24):2486-2494. View abstract.

Ericson, U., Borgquist, S., Ivarsson, M. I., Sonestedt, E., Gullberg, B., Carlson, J., Olsson, H., Jirstrom, K., and Wirfalt, E. Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study. J.Nutr. 2010;140(9):1661-1668. View abstract.

Lazarou, C. and Kapsou, M. The role of folic acid in prevention and treatment of depression: an overview of existing evidence and implications for practice. Complement Ther Clin Pract. 2010;16(3):161-166. View abstract.

Simmer, K., Lort-Phillips, L., James, C., and Thompson, R. P. A double-blind trial of zinc supplementation in pregnancy. Eur J Clin Nutr 1991;45(3):139-144. View abstract.

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol. 2010;9(9):855-865. View abstract.

Miller, E. R., III, Juraschek, S., Pastor-Barriuso, R., Bazzano, L. A., Appel, L. J., and Guallar, E. Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels. Am J Cardiol 8-15-2010;106(4):517-527. View abstract.

Roswall, N., Olsen, A., Christensen, J., Dragsted, L. O., Overvad, K., and Tjonneland, A. Micronutrient intake and breast cancer characteristics among postmenopausal women. Eur.J.Cancer Prev. 2010;19(5):360-365. View abstract.

Ebbing, M., Bonaa, K. H., Arnesen, E., Ueland, P. M., Nordrehaug, J. E., Rasmussen, K., Njolstad, I., Nilsen, D. W., Refsum, H., Tverdal, A., Vollset, S. E., Schirmer, H., Bleie, O., Steigen, T., Midttun, O., Fredriksen, A., Pedersen, E. R., and Nygard, O. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern.Med 2010;268(4):367-382. View abstract.

Saposnik, G. Meta analysis suggests that folic acid supplementation does not reduce risk of stroke, but there may be some benefit when given in combination with vitamins B6 and B12 and in primary prevention. Evid.Based Med 2010;15(6):168-170. View abstract.

Kim, D. H., Smith-Warner, S. A., Spiegelman, D., Yaun, S. S., Colditz, G. A., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Graham, S., Harnack, L., Jacobs, E. J., Leitzmann, M., Mannisto, S., Miller, A. B., Potter, J. D., Rohan, T. E., Schatzkin, A., Speizer, F. E., Stevens, V. L., Stolzenberg-Solomon, R., Terry, P., Toniolo, P., Weijenberg, M. P., Willett, W. C., Wolk, A., Zeleniuch-Jacquotte, A., and Hunter, D. J. Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control 2010;21(11):1919-1930. View abstract.

Hogeveen, M., den, Heijer M., Schonbeck, Y., Ijland, M., van, Oppenraaij D., Gunnewiek, J. K., and Blom, H. J. The effect of folinic acid supplementation on homocysteine concentrations in newborns. Eur.J.Clin Nutr. 2010;64(11):1266-1271. View abstract.

Chiaffarino, F., Ascone, G. B., Bortolus, R., Mastroia-Covo, P., Ricci, E., Cipriani, S., and Parazzini, F. [Effects of folic acid supplementation on pregnancy outcomes: a review of randomized clinical trials]. Minerva Ginecol. 2010;62(4):293-301. View abstract.

Obeid, R., Kasoha, M., Kirsch, S. H., Munz, W., and Herrmann, W. Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Am J Clin Nutr 2010;92(6):1416-1422. View abstract.

Dangour, A. D., Whitehouse, P. J., Rafferty, K., Mitchell, S. A., Smith, L., Hawkesworth, S., and Vellas, B. B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review. J Alzheimers.Dis. 2010;22(1):205-224. View abstract.

Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., and Almeida, O. P. Vitamins B(12), B(6), and folic acid for cognition in older men. Neurology 10-26-2010;75(17):1540-1547. View abstract.

Rosado, J. L., Gonzalez, K. E., Caamano, Mdel C., Garcia, O. P., Preciado, R., and Odio, M. Efficacy of different strategies to treat anemia in children: a randomized clinical trial. Nutr.J. 2010;9:40. View abstract.

De-Regil, L. M., Fernandez-Gaxiola, A. C., Dowswell, T., and Pena-Rosas, J. P. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane.Database.Syst.Rev 2010;(10):CD007950. View abstract.

Ling, W., Fan, J., Ma, Y., Ma, Y., and Wang, H. Capecitabine-based chemotherapy for metastatic colorectal cancer. J.Cancer Res Clin Oncol. 2011;137(6):927-938. View abstract.

Clarke, R., Halsey, J., Lewington, S., Lonn, E., Armitage, J., Manson, J. E., Bonaa, K. H., Spence, J. D., Nygard, O., Jamison, R., Gaziano, J. M., Guarino, P., Bennett, D., Mir, F., Peto, R., and Collins, R. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch.Intern.Med 10-11-2010;170(18):1622-1631. View abstract.

Tighe, P., Ward, M., McNulty, H., Finnegan, O., Dunne, A., Strain, J., Molloy, A. M., Duffy, M., Pentieva, K., and Scott, J. M. A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy. Am J Clin Nutr 2011;93(1):11-18. View abstract.

Clarke, R., Halsey, J., Bennett, D., and Lewington, S. Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. J.Inherit.Metab Dis. 2011;34(1):83-91. View abstract.

DiFabio, J. M., Gori, T., Thomas, G., Jedrzkiewicz, S., and Parker, J. D. Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study. Can.J Cardiol 2010;26(9):461-465. View abstract.

Qin, X., Huo, Y., Langman, C. B., Hou, F., Chen, Y., Matossian, D., Xu, X., and Wang, X. Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis. Clin J Am Soc Nephrol. 2011;6(3):482-488. View abstract.

Figueiredo, J. C., Mott, L. A., Giovannucci, E., Wu, K., Cole, B., Grainge, M. J., Logan, R. F., and Baron, J. A. Folic acid and prevention of colorectal adenomas: a combined analysis of randomized clinical trials. Int J Cancer 7-1-2011;129(1):192-203. View abstract.

Kennedy, D. A., Stern, S. J., Moretti, M., Matok, I., Sarkar, M., Nickel, C., and Koren, G. Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis. Cancer Epidemiol. 2011;35(1):2-10. View abstract.

Kwok, T., Lee, J., Law, C. B., Pan, P. C., Yung, C. Y., Choi, K. C., and Lam, L. C. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr. 2011;30(3):297-302. View abstract.

Singh, J. A., Reddy, S. G., and Kundukulam, J. Risk factors for gout and prevention: a systematic review of the literature. Curr Opin.Rheumatol. 2011;23(2):192-202. View abstract.

Luhmann, D., Schramm, S., and Raspe, H. The role of Homocysteine as a predictor for coronary heart disease. GMS.Health Technol Assess. 2007;3:Doc11. View abstract.

Wald, D. S., Morris, J. K., and Wald, N. J. Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis. PLoS.One. 2011;6(2):e16473. View abstract.

Buckley, L. M., Vacek, P. M., and Cooper, S. M. Administration of folinic acid after low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol 1990;17(9):1158-1161. View abstract.

Durga, J., Bots, M. L., Schouten, E. G., Grobbee, D. E., Kok, F. J., and Verhoef, P. Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults. Am.J.Clin Nutr. 2011;93(5):941-949. View abstract.

Shrubsole, M. J., Shu, X. O., Li, H. L., Cai, H., Yang, G., Gao, Y. T., Gao, J., and Zheng, W. Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women. Am.J.Epidemiol. 5-15-2011;173(10):1171-1182. View abstract.

Arya, R., Gulati, S., Kabra, M., Sahu, J. K., and Kalra, V. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. Neurology 4-12-2011;76(15):1338-1343. View abstract.

Bostom, A. G., Carpenter, M. A., Kusek, J. W., Levey, A. S., Hunsicker, L., Pfeffer, M. A., Selhub, J., Jacques, P. F., Cole, E., Gravens-Mueller, L., House, A. A., Kew, C., McKenney, J. L., Pacheco-Silva, A., Pesavento, T., Pirsch, J., Smith, S., Solomon, S., and Weir, M. Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation 4-26-2011;123(16):1763-1770. View abstract.

Bhutta, Z. A., Yakoob, M. Y., Lawn, J. E., Rizvi, A., Friberg, I. K., Weissman, E., Buchmann, E., and Goldenberg, R. L. Stillbirths: what difference can we make and at what cost? Lancet 4-30-2011;377(9776):1523-1538. View abstract.

Haider, B. A., Yakoob, M. Y., and Bhutta, Z. A. Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. BMC.Public Health 2011;11 Suppl 3:S19. View abstract.

Yakoob, M. Y. and Bhutta, Z. A. Effect of routine iron supplementation with or without folic acid on anemia during pregnancy. BMC Public Health 2011;11 Suppl 3:S21. View abstract.

Imdad, A., Yakoob, M. Y., and Bhutta, Z. A. The effect of folic acid, protein energy and multiple micronutrient supplements in pregnancy on stillbirths. BMC.Public Health 2011;11 Suppl 3:S4. View abstract.

Van, Loon K. and Venook, A. P. Adjuvant treatment of colon cancer: what is next? Curr Opin.Oncol. 2011;23(4):403-409. View abstract.

Toriello, H. V. Policy statement on folic acid and neural tube defects. Genet.Med. 2011;13(6):593-596. View abstract.

Daviglus, M. L., Plassman, B. L., Pirzada, A., Bell, C. C., Bowen, P. E., Burke, J. R., Connolly, E. S., Jr., Dunbar-Jacob, J. M., Granieri, E. C., McGarry, K., Patel, D., Trevisan, M., and Williams, J. W., Jr. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch.Neurol. 2011;68(9):1185-1190. View abstract.

Rueda, J. R., Ballesteros, J., Guillen, V., Tejada, M. I., and Sola, I. Folic acid for fragile X syndrome. Cochrane.Database.Syst.Rev. 2011;(5):CD008476. View abstract.

Zhu, Y., He, Z. Y., and Liu, H. N. Meta-analysis of the relationship between homocysteine, vitamin B(1)(2), folate, and multiple sclerosis. J.Clin Neurosci. 2011;18(7):933-938. View abstract.

Wang, Z. P., Shang, X. X., and Zhao, Z. T. Low maternal vitamin B(12) is a risk factor for neural tube defects: a meta-analysis. J.Matern.Fetal Neonatal Med. 2012;25(4):389-394. View abstract.

Kawai, K., Spiegelman, D., Shankar, A. H., and Fawzi, W. W. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression. Bull.World Health Organ 6-1-2011;89(6):402-411B. View abstract.

Ho, R. C., Cheung, M. W., Fu, E., Win, H. H., Zaw, M. H., Ng, A., and Mak, A. Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression. Am.J.Geriatr.Psychiatry 2011;19(7):607-617. View abstract.

Green, R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am.J.Clin Nutr. 2011;94(2):666S-672S. View abstract.

de Jager, C. A., Oulhaj, A., Jacoby, R., Refsum, H., and Smith, A. D. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int.J.Geriatr.Psychiatry 2012;27(6):592-600. View abstract.

Wald, D. S., Kasturiratne, A., and Simmonds, M. Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants. Alzheimers.Dement. 2011;7(4):412-417. View abstract.

Gargari, B. P., Aghamohammadi, V., and Aliasgharzadeh, A. Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes. Diabetes Res Clin Pract. 2011;94(1):33-38. View abstract.

Holmes, M. V., Newcombe, P., Hubacek, J. A., Sofat, R., Ricketts, S. L., Cooper, J., Breteler, M. M., Bautista, L. E., Sharma, P., Whittaker, J. C., Smeeth, L., Fowkes, F. G., Algra, A., Shmeleva, V., Szolnoki, Z., Roest, M., Linnebank, M., Zacho, J., Nalls, M. A., Singleton, A. B., Ferrucci, L., Hardy, J., Worrall, B. B., Rich, S. S., Matarin, M., Norman, P. E., Flicker, L., Almeida, O. P., van Bockxmeer, F. M., Shimokata, H., Khaw, K. T., Wareham, N. J., Bobak, M., Sterne, J. A., Smith, G. D., Talmud, P. J., van, Duijn C., Humphries, S. E., Price, J. F., Ebrahim, S., Lawlor, D. A., Hankey, G. J., Meschia, J. F., Sandhu, M. S., Hingorani, A. D., and Casas, J. P. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet 8-13-2011;378(9791):584-594. View abstract.

Debreceni, B. and Debreceni, L. Why do homocysteine-lowering B vitamin and antioxidant E vitamin supplementations appear to be ineffective in the prevention of cardiovascular diseases? Cardiovasc.Ther. 2012;30(4):227-233. View abstract.

Aghamohammadi, V., Gargari, B. P., and Aliasgharzadeh, A. Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus. J.Am.Coll.Nutr. 2011;30(3):210-215. View abstract.

Lam, V. W., Spiro, C., Laurence, J. M., Johnston, E., Hollands, M. J., Pleass, H. C., and Richardson, A. J. A systematic review of clinical response and survival outcomes of downsizing systemic chemotherapy and rescue liver surgery in patients with initially unresectable colorectal liver metastases. Ann.Surg.Oncol. 2012;19(4):1292-1301. View abstract.

Wang, Z. M., Zhou, B., Nie, Z. L., Gao, W., Wang, Y. S., Zhao, H., Zhu, J., Yan, J. J., Yang, Z. J., and Wang, L. S. Folate and risk of coronary heart disease: a meta-analysis of prospective studies. Nutr.Metab Cardiovasc.Dis. 2012;22(10):890-899. View abstract.

O'Donnell, E., Goodman, J. M., and Harvey, P. J. Clinical review: Cardiovascular consequences of ovarian disruption: a focus on functional hypothalamic amenorrhea in physically active women. J.Clin Endocrinol.Metab 2011;96(12):3638-3648. View abstract.

Ramakrishnan, U., Goldenberg, T., and Allen, L. H. Do multiple micronutrient interventions improve child health, growth, and development? J.Nutr. 2011;141(11):2066-2075. View abstract.

Zhou, Y. H., Tang, J. Y., Wu, M. J., Lu, J., Wei, X., Qin, Y. Y., Wang, C., Xu, J. F., and He, J. Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis. PLoS.One. 2011;6(9):e25142. View abstract.

Lazzeroni, M., Gandini, S., Puntoni, M., Bonanni, B., Gennari, A., and Decensi, A. The science behind vitamins and natural compounds for breast cancer prevention. Getting the most prevention out of it. Breast 2011;20 Suppl 3:S36-S41. View abstract.

Sarris, J., Mischoulon, D., and Schweitzer, I. Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: a systematic review of clinical trials. Bipolar.Disord. 2011;13(5-6):454-465. View abstract.

Baggott, J. E., Oster, R. A., and Tamura, T. Meta-analysis of cancer risk in folic acid supplementation trials. Cancer Epidemiol. 2012;36(1):78-81. View abstract.

Bao, Y., Michaud, D. S., Spiegelman, D., Albanes, D., Anderson, K. E., Bernstein, L., van den Brandt, P. A., English, D. R., Freudenheim, J. L., Fuchs, C. S., Giles, G. G., Giovannucci, E., Goldbohm, R. A., Hakansson, N., Horn-Ross, P. L., Jacobs, E. J., Kitahara, C. M., Marshall, J. R., Miller, A. B., Robien, K., Rohan, T. E., Schatzkin, A., Stevens, V. L., Stolzenberg-Solomon, R. Z., Virtamo, J., Wolk, A., Ziegler, R. G., and Smith-Warner, S. A. Folate intake and risk of pancreatic cancer: pooled analysis of prospective cohort studies. J.Natl.Cancer Inst. 12-21-2011;103(24):1840-1850. View abstract.

Morris, M. C. Nutritional determinants of cognitive aging and dementia. Proc.Nutr.Soc. 2012;71(1):1-13. View abstract.

Vieitez, J. M., Garcia-Carbonero, R., Aparicio, J., Feliu, J., Gonzalez-Flores, E., Grande, E., Perez-Hoyos, T., Salud, A., Torres, E., Valero, M., Valladares-Ayerbes, M., and Diaz-Rubio, E. Recommendations and expert opinion on the adjuvant treatment of colon cancer in Spain. Clin Transl.Oncol. 2011;13(11):798-804. View abstract.

Solimando, R., Bazzoli, F., and Ricciardiello, L. Chemoprevention of colorectal cancer: a role for ursodeoxycholic acid, folate and hormone replacement treatment? Best.Pract.Res Clin Gastroenterol. 2011;25(4-5):555-568. View abstract.

Czeizel, A. E. Periconceptional folic acid-containing multivitamin supplementation for the prevention of neural tube defects and cardiovascular malformations. Ann.Nutr.Metab 2011;59(1):38-40. View abstract.

Xu, F., Zhang, L., and Li, M. Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. Graefes Arch.Clin Exp.Ophthalmol. 2012;250(7):1067-1074. View abstract.

Fruzzetti, F. Beyaz(R): an oral contraceptive fortified with folate. Womens Health (Lond Engl.) 2012;8(1):13-19. View abstract.

Zhao, Z., Pelletier, E., Barber, B., Bhosle, M., Wang, S., Gao, S., and Klingman, D. Patterns of treatment with chemotherapy and monoclonal antibodies for metastatic colorectal cancer in Western Europe. Curr Med.Res Opin. 2012;28(2):221-229. View abstract.

Qin, X., Xu, M., Zhang, Y., Li, J., Xu, X., Wang, X., Xu, X., and Huo, Y. Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials. Atherosclerosis 2012;222(2):307-313. View abstract.

Ford, A. H. and Almeida, O. P. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J.Alzheimers.Dis. 2012;29(1):133-149. View abstract.

Pan, Y., Guo, L. L., Cai, L. L., Zhu, X. J., Shu, J. L., Liu, X. L., and Jin, H. M. Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: a meta-analysis of randomised, controlled trials. Br.J.Nutr. 2012;108(3):400-407. View abstract.

Lin, R. J., Krall, R., Westerberg, B. D., Chadha, N. K., and Chau, J. K. Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. Laryngoscope 2012;122(3):624-635. View abstract.

Marik, P. E. and Flemmer, M. Do dietary supplements have beneficial health effects in industrialized nations: what is the evidence? JPEN J.Parenter.Enteral Nutr. 2012;36(2):159-168. View abstract.

Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dotsch-Klerk, M., Lathrop, M., Xu, P., Nordestgaard, B. G., Holm, H., Hopewell, J. C., Saleheen, D., Tanaka, T., Anand, S. S., Chambers, J. C., Kleber, M. E., Ouwehand, W. H., Yamada, Y., Elbers, C., Peters, B., Stewart, A. F., Reilly, M. M., Thorand, B., Yusuf, S., Engert, J. C., Assimes, T. L., Kooner, J., Danesh, J., Watkins, H., Samani, N. J., Collins, R., and Peto, R. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS.Med. 2012;9(2):e1001177. View abstract.

Perez, L., Heim, L., Sherzai, A., Jaceldo-Siegl, K., and Sherzai, A. Nutrition and vascular dementia. J.Nutr.Health Aging 2012;16(4):319-324. View abstract.

Mayne, S. T., Ferrucci, L. M., and Cartmel, B. Lessons learned from randomized clinical trials of micronutrient supplementation for cancer prevention. Annu.Rev.Nutr. 8-21-2012;32:369-390. View abstract.

Castillo-Lancellotti, C., Tur Mari, J. A., and Uauy, Dagach R. [Folic acid supplementation and colorrectal adenoma recurrence: systematic review]. Nutr.Hosp. 2012;27(1):13-21. View abstract.

Castillo, Lancellotti C., Tur Mari, J. A., and Uauy, Dagach R. [Effect of folate and related nutrients on cognitive function in older people; systematic review]. Nutr.Hosp. 2012;27(1):90-102. View abstract.

Lohner, S., Fekete, K., Berti, C., Hermoso, M., Cetin, I., Koletzko, B., and Decsi, T. Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. Int.J.Food Sci.Nutr. 2012;63(8):1014-1020. View abstract.

Huo, Y., Qin, X., Wang, J., Sun, N., Zeng, Q., Xu, X., Liu, L., Xu, X., and Wang, X. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int.J.Clin Pract. 2012;66(6):544-551. View abstract.

Wu, C. C., Zheng, C. M., Lin, Y. F., Lo, L., Liao, M. T., and Lu, K. C. Role of homocysteine in end-stage renal disease. Clin Biochem. 2012;45(16-17):1286-1294. View abstract.

Jardine, M. J., Kang, A., Zoungas, S., Navaneethan, S. D., Ninomiya, T., Nigwekar, S. U., Gallagher, M. P., Cass, A., Strippoli, G., and Perkovic, V. The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ 2012;344:e3533. View abstract.

Sudchada, P., Saokaew, S., Sridetch, S., Incampa, S., Jaiyen, S., and Khaithong, W. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2012;98(1):151-158. View abstract.

Castillo, L., Tur, J. A., and Uauy, R. [Folate and breast cancer risk: a systematic review]. Rev.Med.Chil. 2012;140(2):251-260. View abstract.

Bhutta, Z. A., Imdad, A., Ramakrishnan, U., and Martorell, R. Is it time to replace iron folate supplements in pregnancy with multiple micronutrients? Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:27-35. View abstract.

Ramakrishnan, U., Grant, F. K., Goldenberg, T., Bui, V., Imdad, A., and Bhutta, Z. A. Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: a systematic review. Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:153-167. View abstract.

Ramakrishnan, U., Grant, F., Goldenberg, T., Zongrone, A., and Martorell, R. Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:285-301. View abstract.

Zhou, K., Zhao, R., Geng, Z., Jiang, L., Cao, Y., Xu, D., Liu, Y., Huang, L., and Zhou, J. Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies. J.Thromb.Thrombolysis. 2012;34(4):459-467. View abstract.

Papakostas, G. I., Cassiello, C. F., and Iovieno, N. Folates and S-adenosylmethionine for major depressive disorder. Can.J.Psychiatry 2012;57(7):406-413. View abstract.

Skorka, A., Gieruszczak-Bialek, D., Piescik, M., and Szajewska, H. Effects of prenatal and/or postnatal (maternal and/or child) folic acid supplementation on the mental performance of children. Crit Rev.Food Sci.Nutr. 2012;52(11):959-964. View abstract.

Morse, N. L. Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. Nutrients. 2012;4(7):799-840. View abstract.

Yang, H. T., Lee, M., Hong, K. S., Ovbiagele, B., and Saver, J. L. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur.J.Intern.Med. 2012;23(8):745-754. View abstract.

Vargas, A. J. and Thompson, P. A. Diet and nutrient factors in colorectal cancer risk. Nutr.Clin Pract. 2012;27(5):613-623. View abstract.

Xu, F., Zhao, X., Zeng, S. M., Li, L., Zhong, H. B., and Li, M. Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis. Ophthalmology 2012;119(12):2493-2499. View abstract.

Fekete, K., Berti, C., Trovato, M., Lohner, S., Dullemeijer, C., Souverein, O. W., Cetin, I., and Decsi, T. Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr.J. 2012;11:75. View abstract.

Chuang, V. T. and Suno, M. Levoleucovorin as replacement for leucovorin in cancer treatment. Ann.Pharmacother. 2012;46(10):1349-1357. View abstract.

Haider, B. A. and Bhutta, Z. A. Multiple-micronutrient supplementation for women during pregnancy. Cochrane.Database.Syst.Rev. 2012;11:CD004905. View abstract.

Pena-Rosas, J. P., De-Regil, L. M., Dowswell, T., and Viteri, F. E. Daily oral iron supplementation during pregnancy. Cochrane.Database.Syst.Rev. 2012;12:CD004736. View abstract.

Coull, B. M., Malinow, M. R., Beamer, N., Sexton, G., Nordt, F., and de, Garmo P. Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke. Stroke 1990;21(4):572-576. View abstract.

Vergel, R. G., Sanchez, L. R., Heredero, B. L., Rodriguez, P. L., and Martinez, A. J. Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat.Diagn. 1990;10(3):149-152. View abstract.

Brattstrom, L., Israelsson, B., Norrving, B., Bergqvist, D., Thorne, J., Hultberg, B., and Hamfelt, A. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 1990;81(1):51-60. View abstract.

Fuller, N. J., Bates, C. J., Hayes, R. J., Bradley, A. K., Greenwood, A. M., Tulloch, S., and Greenwood, B. M. The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Ann.Trop.Paediatr. 1988;8(2):61-67. View abstract.

Milunsky, A., Jick, H., Jick, S. S., Bruell, C. L., MacLaughlin, D. S., Rothman, K. J., and Willett, W. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 11-24-1989;262(20):2847-2852. View abstract.

Mahomed, K., James, D. K., Golding, J., and McCabe, R. Zinc supplementation during pregnancy: a double blind randomised controlled trial. BMJ 9-30-1989;299(6703):826-830. View abstract.

Araki, A., Sako, Y., Fukushima, Y., Matsumoto, M., Asada, T., and Kita, T. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects. Atherosclerosis 1989;79(2-3):139-146. View abstract.

Sibai, B. M., Villar, M. A., and Bray, E. Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial. Am J Obstet.Gynecol. 1989;161(1):115-119. View abstract.

Foged, N., Lillquist, K., Rolschau, J., and Blaabjerg, O. Effect of folic acid supplementation on small-for-gestational-age infants born at term. Eur.J.Pediatr. 1989;149(1):65-67. View abstract.

Lira, P., Barrena, N., Foradori, A., Gormaz, G., and Grebe, G. [Deficiency of folates in pregnancy: effect of supplementary folic acid]. Sangre (Barc.) 1989;34(1):24-27. View abstract.

Backman, N., Holm, A. K., Hanstrom, L., Blomquist, H. K., Heijbel, J., and Safstrom, G. Folate treatment of diphenylhydantoin-induced gingival hyperplasia. Scand J Dent Res 1989;97(3):222-232. View abstract.

Coppen, A., Chaudhry, S., and Swade, C. Folic acid enhances lithium prophylaxis. J.Affect.Disord. 1986;10(1):9-13. View abstract.

Charoenlarp, P., Dhanamitta, S., Kaewvichit, R., Silprasert, A., Suwanaradd, C., Na-Nakorn, S., Prawatmuang, P., Vatanavicharn, S., Nutcharas, U., Pootrakul, P., and . A WHO collaborative study on iron supplementation in Burma and in Thailand. Am.J.Clin.Nutr. 1988;47(2):280-297. View abstract.

Hanrahan, P. S. and Russell, A. S. Concurrent use of folinic acid and methotrexate in rheumatoid arthritis. J Rheumatol 1988;15(7):1078-1080. View abstract.

Hagerman, R. J., Murphy, M. A., and Wittenberger, M. D. A controlled trial of stimulant medication in children with the fragile X syndrome. Am J Med Genet. 1988;30(1-2):377-392. View abstract.

Peto, R., Gray, R., Collins, R., Wheatley, K., Hennekens, C., Jamrozik, K., Warlow, C., Hafner, B., Thompson, E., Norton, S., and . Randomised trial of prophylactic daily aspirin in British male doctors. Br Med J (Clin Res Ed) 1-30-1988;296(6618):313-316. View abstract.

Mardones-Santander, F., Rosso, P., Stekel, A., Ahumada, E., Llaguno, S., Pizarro, F., Salinas, J., Vial, I., and Walter, T. Effect of a milk-based food supplement on maternal nutritional status and fetal growth in underweight Chilean women. Am J Clin Nutr 1988;47(3):413-419. View abstract.

Erlichman, C., Fine, S., Wong, A., and Elhakim, T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol. 1988;6(3):469-475. View abstract.

Heimburger, D. C., Alexander, C. B., Birch, R., Butterworth, C. E., Jr., Bailey, W. C., and Krumdieck, C. L. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. JAMA 3-11-1988;259(10):1525-1530. View abstract.

Spatling, L. and Spatling, G. Magnesium supplementation in pregnancy. A double-blind study. Br J Obstet.Gynaecol. 1988;95(2):120-125. View abstract.

Froster-Iskenius, U., Bodeker, K., Oepen, T., Matthes, R., Piper, U., and Schwinger, E. Folic acid treatment in males and females with fragile-(X)-syndrome. Am J Med Genet. 1986;23(1-2):273-289. View abstract.

Madison, L. S., Wells, T. E., Fristo, T. E., and Benesch, C. G. A controlled study of folic acid treatment in three fragile X syndrome males. J Dev.Behav.Pediatr 1986;7(4):253-256. View abstract.

Fleming, A. F., Ghatoura, G. B., Harrison, K. A., Briggs, N. D., and Dunn, D. T. The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria. Ann Trop Med Parasitol. 1986;80(2):211-233. View abstract.

Boers, G. H., Smals, A. G., Trijbels, F. J., Fowler, B., Bakkeren, J. A., Schoonderwaldt, H. C., Kleijer, W. J., and Kloppenborg, P. W. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N.Engl.J Med 9-19-1985;313(12):709-715. View abstract.

Harrison, K. A. Child-bearing, health and social priorities: a survey of 22 774 consecutive hospital births in Zaria, Northern Nigeria. Br J Obstet.Gynaecol. 1985;92 Suppl 5:1-119. View abstract.

Horwitz, S. J., Klipstein, F. A., and Lovelace, R. E. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Lancet 3-16-1968;1(7542):563-565. View abstract.

Ralston, A. J., Snaith, R. P., and Hinley, J. B. Effects of folic acid on fit-frequency and behaviour in epileptics on anticonvulsants. Lancet 4-25-1970;1(7652):867-868. View abstract.

Fleming, A. F., Martin, J. D., Hahnel, R., and Westlake, A. J. Effects of iron and folic acid antenatal supplements on maternal haematology and fetal wellbeing. Med.J.Aust. 9-21-1974;2(12):429-436. View abstract.

Basu, R. N., Sood, S. K., Ramachandran, K., Mathur, M., and Ramalingaswami, V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Am.J Clin.Nutr 1973;26(6):591-594. View abstract.

Mattson, R. H., Gallagher, B. B., Reynolds, E. H., and Glass, D. Folate therapy in epilepsy. A controlled study. Arch Neurol. 1973;29(2):78-81. View abstract.

Kendall, A. C., Jones, E. E., Wilson, C. I., Shinton, N. K., and Elwood, P. C. Folic acid in low birthweight infants. Arch.Dis.Child 1974;49(9):736-738. View abstract.

Christiansen, C., Rodbro, P., and Lund, M. Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial. Br Med J 12-22-1973;4(5894):695-701. View abstract.

Samuel, P. D., Burland, W. L., and Simpson, K. Response to oral administration of pteroylmonoglutamic acid or pteroylpolyglutamate in newborn infants of low birth weight. Br.J.Nutr. 1973;30(2):165-169. View abstract.

Stevens, D., Burman, D., Strelling, M. K., and Morris, A. Folic acid supplementation in low birth weight infants. Pediatrics 1979;64(3):333-335. View abstract.

Jensen, O. N. and Olesen, O. V. Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates. Arch Neurol. 1970;22(2):181-182. View abstract.

Grant, R. H. and Stores, O. P. Folic acid in folate-deficient patients with epilepsy. Br Med J 12-12-1970;4(5736):644-648. View abstract.

Bowe, J. C., Cornish, E. J., and Dawson, M. Evaluation of folic acid supplements in children taking phenytoin. Dev.Med Child Neurol. 1971;13(3):343-354. View abstract.

Hall, M. H. Folic acid deficiency and abruptio placentae. J Obstet.Gynaecol.Br Commonw. 1972;79(3):222-225. View abstract.

Roberts, P. M., Arrowsmith, D. E., Lloyd, A. V., and Monk-Jones, M. E. Effect of folic acid treatment on premature infants. Arch.Dis.Child 1972;47(254):631-634. View abstract.

Iyengar, L. Folic acid requirements of Indian pregnant women. Am.J.Obstet.Gynecol. 1971;111(1):13-16. View abstract.

Fletcher, J., Gurr, A., Fellingham, F. R., Prankerd, T. A., Brant, H. A., and Menzies, D. N. The value of folic acid supplements in pregnancy. J Obstet.Gynaecol.Br Commonw. 1971;78(9):781-785. View abstract.

Burland, W. L., Simpson, K., and Lord, J. Response of low birthweight infant to treatment with folic acid. Arch.Dis.Child 1971;46(246):189-194. View abstract.

Shaw, D. M., Macsweeney, D. A., Johnson, A. L., O'Keeffe, R., Naidoo, D., Macleod, D. M., Jog, S., Preece, J. M., and Crowley, J. M. Folate and amine metabolites in senile dementia: a combined trial and biochemical study. Psychol.Med 1971;1(2):166-171. View abstract.

Matoth, Y., Zehavi, I., Topper, E., and Klein, T. Folate nutrition and growth in infancy. Arch.Dis.Child 1979;54(9):699-702. View abstract.

Rolschau, J., Date, J., and Kristoffersen, K. Folic acid supplement and intrauterine growth. Acta Obstet.Gynecol.Scand. 1979;58(4):343-346. View abstract.

Kral, V. A., Solyom, L., Enesco, H., and Ledwidge, B. Relationship of vitamin B12 and folic acid to memory function. Biol.Psychiatry 1970;2(1):19-26. View abstract.

Iyengar, L. and Apte, S. V. Prophylaxis of anemia in pregnancy. Am.J Clin.Nutr 1970;23(6):725-730. View abstract.

Baumslag, N., Edelstein, T., and Metz, J. Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Br.Med.J. 1-3-1970;1(5687):16-17. View abstract.

Osifo, B. O. The effect of folic acid and iron in the prevention of nutritional anaemias in pregnancy in Nigeria. Br J Nutr 1970;24(3):689-694. View abstract.

Gandy, G. and Jacobson, W. Influence of folic acid on birthweight and growth of the erythroblastotic infant. III. Effect of folic acid supplementation. Arch.Dis.Child 1977;52(1):16-21. View abstract.

Fleming, A. F., Hendrickse, J. P., and Allan, N. C. The prevention of megaloblastic anaemia in pregnancy in Nigeria. J Obstet.Gynaecol.Br Commonw. 1968;75(4):425-432. View abstract.

Asfour, R., Wahbeh, N., Waslien, C. I., Guindi, S., and Darby, W. J. Folacin requirement of children. III. Normal infants. Am.J.Clin Nutr. 1977;30(7):1098-1105. View abstract.

Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., and Fielding, D. W. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 2-16-1980;1(8164):339-340. View abstract.

Smithells, R. W., Nevin, N. C., Seller, M. J., Sheppard, S., Harris, R., Read, A. P., Fielding, D. W., Walker, S., Schorah, C. J., and Wild, J. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 5-7-1983;1(8332):1027-1031. View abstract.

Ek, J., Behncke, L., Halvorsen, K. S., and Magnus, E. Plasma and red cell folate values and folate requirements in formula-fed premature infants. Eur.J.Pediatr. 1984;142(2):78-82. View abstract.

Seller, M. J. and Nevin, N. C. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. J Med Genet. 1984;21(5):325-330. View abstract.

Brattstrom, L. E., Hardebo, J. E., and Hultberg, B. L. Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke 1984;15(6):1012-1016. View abstract.

Srisupandit, S., Pootrakul, P., Areekul, S., Neungton, S., Mokkaves, J., Kiriwat, O., and Kanokpongsukdi, S. A prophylactic supplementation of iron and folate in pregnancy. Southeast Asian J Trop Med Public Health 1983;14(3):317-323. View abstract.

Brown, W. T., Jenkins, E. C., Friedman, E., Brooks, J., Cohen, I. L., Duncan, C., Hill, A. L., Malik, M. N., Morris, V., Wolf, E., and . Folic acid therapy in the fragile X syndrome. Am J Med Genet. 1984;17(1):289-297. View abstract.

Smithells, R. W. Can vitamins prevent neural tube defects? Can.Med Assoc J 8-15-1984;131(4):273-4, 276. View abstract.

Laurence, K. M., James, N., Miller, M. H., Tennant, G. B., and Campbell, H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J (Clin Res Ed) 5-9-1981;282(6275):1509-1511. View abstract.

Hunt, I. F., Murphy, N. J., Cleaver, A. E., Faraji, B., Swendseid, M. E., Coulson, A. H., Clark, V. A., Laine, N., Davis, C. A., and Smith, J. C., Jr. Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of Mexican descent. Am J Clin Nutr 1983;37(4):572-582. View abstract.

Rush, D., Stein, Z., and Susser, M. A randomized controlled trial of prenatal nutritional supplementation in New York City. Pediatrics 1980;65(4):683-697. View abstract.

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