References
Hesperidin
2
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4919
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4956
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4959
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Ho Y, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids. Dis Colon Rectum 2000;43:66-9. View abstract.
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Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.. View abstract.
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Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997;48:77-85.. View abstract.
37478
Bouaziz, N., Michiels, C., Janssens, D., Berna, N., Eliaers, F., Panconi, E., and Remacle, J. Effect of Ruscus extract and hesperidin methylchalcone on hypoxia-induced activation of endothelial cells. Int Angiol. 1999;18(4):306-312. View abstract.
37479
Beltramino, R., Penenory, A., and Buceta, A. M. An open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Int Angiol. 1999;18(4):337-342. View abstract.
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50892
Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., and Corsi, M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb.Hemost. 2006;12(2):205-212. View abstract.
53374
Ameer, B., Weintraub, R. A., Johnson, J. V., Yost, R. A., and Rouseff, R. L. Flavanone absorption after naringin, hesperidin, and citrus administration. Clin Pharmacol Ther 1996;60(1):34-40. View abstract.
54755
Jantet, G. Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids. Angiology 2002;53(3):245-256. View abstract.
54760
Lyseng-Williamson, K. A. and Perry, C. M. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs 2003;63(1):71-100. View abstract.
54763
Manach, C., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., and Remesy, C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur.J.Clin.Nutr. 2003;57(2):235-242. View abstract.
54766
Chiba, H., Uehara, M., Wu, J., Wang, X., Masuyama, R., Suzuki, K., Kanazawa, K., and Ishimi, Y. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J.Nutr. 2003;133(6):1892-1897. View abstract.
54771
Sakata, K., Hirose, Y., Qiao, Z., Tanaka, T., and Mori, H. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett. 9-25-2003;199(2):139-145. View abstract.
54772
BOOTH, A. N., JONES, F. T., and DeEDS, F. Metabolic fate of hesperidin, eriodictyol, homoeridictyol, and diosmin. J.Biol.Chem. 1958;230(2):661-668. View abstract.
54779
Fenton, J. I. and Hord, N. G. Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. Nutr.Cancer 2004;48(2):182-188. View abstract.
54784
Jung, U. J., Lee, M. K., Jeong, K. S., and Choi, M. S. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J.Nutr. 2004;134(10):2499-2503. View abstract.
54786
Cesarone, M. R., Belcaro, G., Pellegrini, L., Ledda, A., Di Renzo, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., and Cacchio, M. HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study. Angiology 2005;56(1):1-8. View abstract.
54789
Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. View abstract.
54793
Mlakar, B. and Kosorok, P. Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial. Wien.Klin.Wochenschr. 2005;117(15-16):558-560. View abstract.
54799
Cesarone, M. R., Belcaro, G., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Di Renzo, A., Ruffini, I., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cornelli, U., Hosoi, M., and Cacchio, M. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology 2006;57(2):131-138. View abstract.
54800
Miwa, Y., Mitsuzumi, H., Sunayama, T., Yamada, M., Okada, K., Kubota, M., Chaen, H., Mishima, Y., and Kibata, M. Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality. J Nutr Sci Vitaminol.(Tokyo) 2005;51(6):460-470. View abstract.
54804
Hosseinimehr, S. J. and Nemati, A. Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells. Br.J.Radiol. 2006;79(941):415-418. View abstract.
54806
Yamada, M., Tanabe, F., Arai, N., Mitsuzumi, H., Miwa, Y., Kubota, M., Chaen, H., and Kibata, M. Bioavailability of glucosyl hesperidin in rats. Biosci.Biotechnol.Biochem. 2006;70(6):1386-1394. View abstract.
54814
Kim, J. Y., Jung, K. J., Choi, J. S., and Chung, H. Y. Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. Aging Cell 2006;5(5):401-411. View abstract.
54818
Uehara, M. [Prevention of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism]. Clin.Calcium 2006;16(10):1669-1676. View abstract.
54819
Kanaze, F. I., Bounartzi, M. I., Georgarakis, M., and Niopas, I. Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. Eur.J.Clin.Nutr. 2007;61(4):472-477. View abstract.
54822
Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 2007;194(1):144-152. View abstract.
54825
Gardana, C., Guarnieri, S., Riso, P., Simonetti, P., and Porrini, M. Flavanone plasma pharmacokinetics from blood orange juice in human subjects. Br.J.Nutr. 2007;98(1):165-172. View abstract.
54838
Pokrovsky, A. V., Saveljev, V. S., Kirienko, A. I., Bogachev, V. Y., Zolotukhin, I. A., Sapelkin, S. V., Shvalb, P. G., Zhukov, B. N., Vozlubleny, S. I., Sabelnikov, V. V., Voskanian, Y. E., Katelnitsky, I. I., Burleva, E. P., and Tolstikhin, V. Y. Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). Angiol.Sosud.Khir. 2007;13(2):47-55. View abstract.
54841
Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. View abstract.
54842
Yanez, J. A., Remsberg, C. M., Miranda, N. D., Vega-Villa, K. R., Andrews, P. K., and Davies, N. M. Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices. Biopharm.Drug Dispos. 2008;29(2):63-82. View abstract.
54844
Hwang, S. L. and Yen, G. C. Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. J.Agric.Food Chem. 2-13-2008;56(3):859-864. View abstract.
54850
Kometani, T., Fukuda, T., Kakuma, T., Kawaguchi, K., Tamura, W., Kumazawa, Y., and Nagata, K. Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans. Immunopharmacol.Immunotoxicol. 2008;30(1):117-134. View abstract.
54851
Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. View abstract.
54859
Pradeep, K., Park, S. H., and Ko, K. C. Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur.J.Pharmacol. 6-10-2008;587(1-3):273-280. View abstract.
54860
Aliev, S. A., Ibishov, K. G., and Aliev, E. S. [Certain aspects of pathogenesis of hemorheological and trophic disturbances and their pharmacological correction in patients with chronic venous insufficiency]. Vestn.Khir.Im I.I.Grek. 2008;167(2):39-43. View abstract.
54863
Li, Y. M., Li, X. M., Li, G. M., Du, W. C., Zhang, J., Li, W. X., Xu, J., Hu, M., and Zhu, Z. In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts. J.Agric.Food Chem. 7-23-2008;56(14):5550-5557. View abstract.
54867
Brett, G. M., Hollands, W., Needs, P. W., Teucher, B., Dainty, J. R., Davis, B. D., Brodbelt, J. S., and Kroon, P. A. Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion. Br.J.Nutr. 2009;101(5):664-675. View abstract.
54876
Guex, J. J., Enrici, E., Boussetta, S., Avril, L., Lis, C., and Taieb, C. Correlations between ankle circumference, symptoms, and quality of life demonstrate the clinical relevance of minimal leg swelling reduction: results of a study in 1,036 Argentinean patients. Dermatol.Surg. 2008;34(12):1666-1675. View abstract.
54888
Iqbal, M. F. and Zhu, W. Y. Bioactivation of flavonoid diglycosides by chicken cecal bacteria. FEMS Microbiol.Lett. 2009;295(1):30-41. View abstract.
54892
Saha, R. K., Takahashi, T., and Suzuki, T. Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase. Biol.Pharm.Bull. 2009;32(7):1188-1192. View abstract.
54903
Kumar, P. and Kumar, A. Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide. Behav.Brain Res. 1-5-2010;206(1):38-46. View abstract.
54908
El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145. View abstract.
54913
Akiyama, S., Katsumata, S., Suzuki, K., Nakaya, Y., Ishimi, Y., and Uehara, M. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. Biosci.Biotechnol.Biochem. 2009;73(12):2779-2782. View abstract.
54935
Cospite, M. and Dominici, A. Double blind study of the pharmacodynamic and clinical activities of 5682 SE in venous insufficiency. Advantages of the new micronized form. Int Angiol. 1989;8(4 Suppl):61-65. View abstract.
54944
Ho, Y. H., Foo, C. L., Seow-Choen, F., and Goh, H. S. Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy. Br J Surg. 1995;82(8):1034-1035. View abstract.
54950
Amato, C. Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin. Angiology 1994;45(6 Pt 2):531-536. View abstract.
54954
Godeberge, P. Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology 1994;45(6 Pt 2):574-578. View abstract.
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Galley, P. and Thiollet, M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol. 1993;12(1):69-72. View abstract.
54970
Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. View abstract.
54972
Guilhou, J. J., Fevrier, F., Debure, C., Dubeaux, D., Gillet-Terver, M. N., Guillot, B., Levesque, H., Marzin, L., Mignot, J., Ouvry, P., Pillion, G., Van, Landuyt H., Zuccarelli, F., and Nicolaides, A. N. Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial. Int.J.Microcirc.Clin.Exp. 1997;17 Suppl 1:21-26. View abstract.
54976
Kim, D. H., Jung, E. A., Sohng, I. S., Han, J. A., Kim, T. H., and Han, M. J. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch Pharm.Res. 1998;21(1):17-23. View abstract.
54977
Rizk, S. M and Sabri, N. A. Evaluation of Clinical Activity and Safety of Dalfon® 500mg in Type 2 Diabetic Femal Patients. Saudi Pharmacetical Journal 3-17-2009;199-209.
54980
Chassignolle, J. F., Amiel, M., Lanfranchi, G., and et al. Activité thérapeutique de Daflon 500 mg dans l'insuffisance veineuse fonctionnelle [in French]. J Int Med 1987;99:32-37.
54981
Gilly, R., Pillion, G., and Frileux, C. Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: a double-blind, placebo-controlled study. Phlebology. 1994;9(2):67-70.
54982
Menyhei, G., Acsady, G., Hetenyi, A., and et al. Chronobiology and clinical activity of Daflon 500 mg in chronic venous insufficiency. Phlebology. 1994;9(1):53-59.
54983
Cospite, M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Drugs Today 1995;31(Suppl E):49-55.
54984
Glinski, W, Chodynicka, B., Roszkiewicz, J., and et al. The beneficial augmentative effect of micronised purified flavonoid fraction (MPFF) on the healing of leg ulcers: an open, multicentre, controlled, randomised study. Phlebology. 1999;14(4):151-157.
91760
Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. View abstract.
91761
Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. View abstract.
91762
Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. View abstract.
93885
Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, Tafuri S, Pennisi D, Altomare DF. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Jun;19(6):339-45. View abstract.
94538
Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. View abstract.
94539
Demonty I, Lin Y, Zebregs YE, et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr. 2010;140(9):1615-20. View abstract.
94541
Martin BR, McCabe GP, McCabe L, et al. Effect of hesperidin with and without a calcium (Calcilock) supplement on bone health in postmenopausal women. J Clin Endocrinol Metab 2016;101(3):923-7. View abstract.
94542
Milenkovic D, Deval C, Dubray C, et al. Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study. PLoS One 2011;6(11):e26669. View abstract.
94543
Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. View abstract.
94544
Ohara T, Muroyama K, Yamamoto Y, et al. Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. Nutr J 2016;15:6. View abstract.
94545
Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab 2011;96(5):E782-92. View abstract.
98697
Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. View abstract.
102312
Martínez-Noguera FJ, Marín-Pagán C, Carlos-Vivas J, Rubio-Arias JA, Alcaraz PE. Acute Effects of Hesperidin in Oxidant/Antioxidant State Markers and Performance in Amateur Cyclists. Nutrients. 2019 Aug 14;11(8). pii: E1898. View abstract.
102313
Cheraghpour M, Imani H, Ommi S, et al. Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial. Phytother Res. 2019 Aug;33(8):2118-2125. View abstract.
102314
Lorzadeh E, Ramezani-Jolfaie N, Mohammadi M, Khoshbakht Y, Salehi-Abargouei A. The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials. Chem Biol Interact. 2019 Jul 1;307:8-15. View abstract.
102315
Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2019 Mar;33(3):534-545. View abstract.
105275
Yari Z, Cheraghpour M, Alavian SM, Hedayati M, Eini-Zinab H, Hekmatdoost A. The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. Eur J Clin Nutr. 2021;75(1):99-111. View abstract.
105276
Yari Z, Cheraghpour M, Hekmatdoost A. Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial. Eur J Nutr. 2021;60(1):287-298. View abstract.
105277
Martínez-Noguera FJ, Marín-Pagán C, Carlos-Vivas J, Alcaraz PE. Effects of 8 weeks of 2S-hesperidin supplementation on performance in amateur cyclists. Nutrients. 2020;12(12):3911. View abstract.
105278
Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. View abstract.
105279
Martínez Noguera FJ, Alcaraz PE, Carlos Vivas J, et al. 8 weeks of 2S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists: randomized controlled trial. Food Funct. 2021;12(9):3872-3882. View abstract.
105280
Djafari F, Shahavandi M, Amini MR, et al. The effects of hesperidin supplementation or orange juice consumption on anthropometric measures in adults: A meta-analysis of randomized controlled clinical trials. Clin Nutr ESPEN. 2021;43:148-157. View abstract.
105281
Ohara T, Muroyama K, Yamamoto Y, Murosaki S. Erratum to: Oral intake of a combination of glucosyl hesperidin and caffeine elicits an antiobesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. Nutr J. 2017;16(1):28. View abstract.
105288
Yari Z, Movahedian M, Imani H, Alavian SM, Hedayati M, Hekmatdoost A. The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. Eur J Nutr. 2020;59(6):2569-2577. View abstract.
105290
Miwa Y, Yamada M, Sunayama T, et al. Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level. J Nutr Sci Vitaminol (Tokyo). 2004;50(3):211-8. View abstract.
105292
Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin supplementation alleviates oxidative DNA damage and lipid peroxidation in type 2 diabetes: A randomized double-blind placebo-controlled clinical trial. Phytother Res. 2017;31(10):1539-1545. View abstract.
108151
Bagnati M, Puricelli C, Bauce G, et al. Short-term effects of supplemental L-arginine, diosmin, troxerutin, and hesperidin in diabetic patients: A Pilot Study. Biomed Res Int 2021;2021:3508281. View abstract.
108152
Yoshitomi R, Yamamoto M, Kumazoe M, et al. The combined effect of green tea and a-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial. Sci Rep 2021;11(1):19067. View abstract.