Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4.
View abstract.
964
Raus I. [Clinical studies on Frubienzyme in a controlled double-blind trial]. Fortschr Med 1976;94:1579-82.
View abstract.
965
Billigmann P. [Enzyme therapy-an alternative in treatment of herpes zoster. A controlled study of 192 patients]. Fortschr Med 1995;113:43-8.
View abstract.
968
Bienen H, Raus I. [Therapeutic comparison of throat lozenges; (author's transl)]. MMW Munch Med Wochenschr 1981;123:745-7.
View abstract.
969
Reinecke M. [Treatment of inflammatory diseases of the mouth and throat with Larypront in ENT practice; (author's transl)]. MMW Munch Med Wochenschr 1976;118:1253-4.
View abstract.
6252
Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest 2000;19:15-23.
6253
Kane S, Goldberg MJ. Use of bromelain for mild ulcerative colitis. Ann Intern Med 2000;132:680.
View abstract.
10622
Stone MB, Merrick MA, Ingersoll CD, et al. Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. Clin J Sport Med 2002;12:373-8..
View abstract.
11457
Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine 2002;9:681-6.
View abstract.
18281
Cohen A, Goldman J. Bromelains therapy in rheumatoid arthritis. Pa Med J. 1964;67:27-30.
View abstract.
18284
Gerard G. [Anticancer treatment and bromelains]. Agressologie 1972;13:261-74.
View abstract.
67832
Leipner, J., Iten, F., and Saller, R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs. 2001;15(12):779-789.
View abstract.
67835
Nomura, J. T., Sato, R. L., Ahern, R. M., Snow, J. L., Kuwaye, T. T., and Yamamoto, L. G. A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings. Am J Emerg Med 2002;20(7):624-626.
View abstract.
67843
Matinian, L. A., Nagapetian, KhO, Amirian, S. S., Mkrtchian, S. R., Mirzoian, V. S., and Voskanian, R. M. [Papain phonophoresis in the treatment of suppurative wounds and inflammatory processes]. Khirurgiia (Mosk) 1990;(9):74-76.
View abstract.
67845
Ross, E. V., Jr., Badame, A. J., and Dale, S. E. Meat tenderizer in the acute treatment of imported fire ant stings. J Am Acad Dermatol. 1987;16(6):1189-1192.
View abstract.
91104
Bolten WW, Glade MJ, Raum S, et al. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis. 2015;2015:251521.
View abstract.
91105
Büttner L, Achilles N, Böhm M, et al. Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study. B-ENT. 2013;9(3):217-25.
View abstract.
91106
Conrozier T, Mathieu P, Bonjean M, et al. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20 Suppl 1:32-7.
View abstract.
91111
Müller S, März R, Schmolz M, et al. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. Phytother Res. 2013;27(2):199-204.
View abstract.
91113
Rosenberg L, Krieger Y, Bogdanov-Berezovski A, et al. A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. Burns. 2014;40(3):466-74.
View abstract.
96449
Desideri I, Francolini G, Becherini C, et al. Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol. 2017 Mar;34(3):46.
View abstract.
101516
United States Pharmacopeial Convention. Food Chemicals Codex (FCC). 11th Edition. Rockville, MD: The United States Pharmacopeial Convention; 2018.
101517
Beuth J. Proteolytic Enzyme Therapy in Evidence-Based Complementary Oncology: Fact or Fiction? Integr Cancer Ther. 2008;7(4):311-316.
View abstract.
102705
Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9.
View abstract.
102706
Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7.
View abstract.
102707
Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7.
View abstract.
102708
Mantle D, Preedy VR. Adverse and beneficial functions of proteolytic enzymes in skeletal muscle. An overview. Adverse Drug React Toxicol Rev. 2002;21(1-2):31-49.
View abstract.
102709
Sinclair RD, Ryan TJ. Proteolytic enzymes in wound healing: the role of enzymatic debridement. Australas J Dermatol. 1994;35(1):35-41.
View abstract.
102711
Tooth D, Garsed K, Singh G, et al. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit. Gut. 2014;63(5):753-60.
View abstract.
102712
Kawabata A, Matsunami M, Sekiguchi F. Gastrointestinal roles for proteinase-activated receptors in health and disease. Br J Pharmacol. 2008;153 Suppl 1(Suppl 1):S230-40.
View abstract.
102713
Hansen KK, Oikonomopoulou K, Li Y, Hollenberg MD. Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems. Naunyn Schmiedebergs Arch Pharmacol. 2008;377(4-6):377-92.
View abstract.