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35526
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35557
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35562
Wilson, C. J., Myer, M., Darlow, B. A., Stanley, T., Thomson, G., Baumgartner, E. R., Kirby, D. M., and Thorburn, D. R. Severe holocarboxylase synthetase deficiency with incomplete biotin responsiveness resulting in antenatal insult in samoan neonates. J Pediatr. 2005;147(1):115-118. View abstract.
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35573
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35576
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35582
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35583
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35586
Wolf, B. Clinical issues and frequent questions about biotinidase deficiency. Mol.Genet.Metab 2010;100(1):6-13. View abstract.
35590
Daniells, S. and Hardy, G. Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Curr.Opin.Clin.Nutr.Metab Care 2010;13(6):690-697. View abstract.
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Colombo, V. E., Gerber, F., Bronhofer, M., and Floersheim, G. L. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am.Acad.Dermatol. 1990;23(6 Pt 1):1127-1132. View abstract.
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Michalski, A. J., Berry, G. T., and Segal, S. Holocarboxylase synthetase deficiency: 9-year follow-up of a patient on chronic biotin therapy and a review of the literature. J Inherit.Metab Dis. 1989;12(3):312-316. View abstract.
35595
Miller, S. J. Nutritional deficiency and the skin. J Am.Acad.Dermatol. 1989;21(1):1-30. View abstract.
35597
Brenner, S. and Horwitz, C. Possible nutrient mediators in psoriasis and seborrheic dermatitis. II. Nutrient mediators: essential fatty acids; vitamins A, E and D; vitamins B1, B2, B6, niacin and biotin; vitamin C selenium; zinc; iron. World Rev.Nutr.Diet. 1988;55:165-182. View abstract.
35598
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35600
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35601
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35602
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35604
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35605
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35606
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35607
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35610
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35611
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35613
Zempleni, J., McCormick, D. B., and Mock, D. M. Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. Am.J Clin.Nutr. 1997;65(2):508-511. View abstract.
35615
Zempleni, J., Green, G. M., Spannagel, A. W., and Mock, D. M. Biliary excretion of biotin and biotin metabolites is quantitatively minor in rats and pigs. J Nutr. 1997;127(8):1496-1500. View abstract.
35616
Wallace, J. C., Jitrapakdee, S., and Chapman-Smith, A. Pyruvate carboxylase. Int J Biochem.Cell Biol. 1998;30(1):1-5. View abstract.
35617
Ozand, P. T., Gascon, G. G., Al Essa, M., Joshi, S., Al Jishi, E., Bakheet, S., Al Watban, J., Al Kawi, M. Z., and Dabbagh, O. Biotin-responsive basal ganglia disease: a novel entity. Brain 1998;121 ( Pt 7):1267-1279. View abstract.
35620
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89471
Pacheco-Alvarez D, Solórzano-Vargas RS, Del Río AL. Biotin in Metabolism and Its Relationship to Human Disease. Arch Med Res 2002;33(5):439-47. View abstract.
89472
Vadlapudi AD, Vadlapatla RK, Mitra AK. Sodium dependent multivitamin transporter (SMVT): a potential target for drug delivery. Curr Drug Targets 2012;13(7):994-1003. View abstract.
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Kwok JS, Chan IH, Chan MH. Biotin interference on TSH and free thyroid hormone measurement. Pathology. 2012;44(3):278-80. View abstract.
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Waghray A, Milas M, Nyalakonda K, Siperstein AE. Falsely low parathyroid hormone secondary to biotin interference: a case series. Endocr Pract 2013;19(3):451-5. View abstract.
89475
Oguma S, Ando I, Hirose T, et al. Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial. Tohoku J Exp Med 2012;227(3):217-23. View abstract.
94636
Minkovsky A, Lee MN, Dowlatshahi M, et al. High-dose biotin treatment for secondary progressive multiple sclerosis may interfere with thyroid assays. AACE Clin Case Rep 2016;2(4):e370-e373. View abstract.
94637
Bülow Pedersen I, Laurberg P. Biochemical Hyperthyroidism in a Newborn Baby Caused by Assay Interaction from Biotin Intake. Eur Thyroid J 2016;5(3):212-15. View abstract.
94638
Sulaiman RA. Biotin treatment causing erroneous immunoassay results: A word of caution for clinicians. Drug Discov Ther 2016;10(6):338-9. View abstract.
94639
Barbesino G. Misdiagnosis of Graves' disease with apparent severe hyperthyroidism in a patient taking biotin megadoses. Thyroid 2016;26(6):860-3. View abstract.
94640
Kummer S, Hermsen D, Distelmaier F. Biotin treatment mimicking Graves' disease. N Engl J Med 2016;375(7):704-6. View abstract.
94641
Elston MS, Sehgal S, Du Toit S, Yarndley T, Conaglen JV. Factitious Graves' disease due to biotin immunoassay interference-a case and review of the literature. J Clin Endocrinol Metab 2016;101(9):3251-5. View abstract.
94642
Trambas CM, Sikaris KA, Lu ZX. More on Biotin Treatment Mimicking Graves' Disease. N Engl J Med 2016;375(17):1698. View abstract.
94649
Piketty ML, Prie D, Sedel F, et al. High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference. Clin Chem Lab Med 2017;55(6):817-25. View abstract.
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Biscolla RPM, Chiamolera MI, Kanashiro I, Maciel RMB, Vieira JGH. A Single 10?mg Oral Dose of Biotin Interferes with Thyroid Function Tests. Thyroid 2017;27(8):1099-1100. View abstract.
95386
The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication. https://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm586505.htm. Updated November 28, 2017. Accessed November 28, 2017.
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Tabarki B, Alfadhel M, AlShahwan S, Hundallah K, AlShafi S, AlHashem A. Treatment of biotin-responsive basal ganglia disease: open comparative study between the combination of biotin plus thiamine versus thiamine alone. Eur J Paediatr Neurol. 2015;19(5):547-52. doi: 10.1016/j.ejpn.2015.05.008. View abstract.
95662
Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. View abstract.
98790
Trambas CM, Sikaris KA, Lu ZX. A caution regarding high-dose biotin therapy: misdiagnosis of hyperthyroidism in euthyroid patients. Med J Aust. 2016;205(4):192. View abstract.
102962
Elecsys Anti-SARS-CoV-2 - Cobas. Roche Diagnostics GmbH. Available at: https://www.fda.gov/media/137605/download.
102963
Couloume L, Barbin L, Leray E, et al. High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice. Mult Scler. 2019:1352458519894713. View abstract.
102964
Demas A, Cochin JP, Hardy C, Vaschalde Y, Bourre B, Labauge P. Tardive Reactivation of Progressive Multiple Sclerosis During Treatment with Biotin. Neurol Ther. 2019;9(1):181-185. View abstract.
102965
Juntas-Morales R, Pageot N, Bendarraz A, et al. High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study. EClinicalMedicine. 2020;19:100254. View abstract.
102966
Tourbah A, Lebrun-Frenay C, Edan G, et al. MD1003 (High-Dose Biotin) for the Treatment of Progressive Multiple Sclerosis: A Randomised, Double-Blind, Placebo-Controlled Study. Mult Scler. 2016;22(13):1719-1731. View abstract.
104000
Branger P, Parienti JJ, Derache N, Kassis N, Assouad R, Maillart E, Defer G. Relapses During High-Dose Biotin Treatment in Progressive Multiple Sclerosis: a Case-Crossover and Propensity Score-Adjusted Prospective Cohort. Neurotherapeutics. 2020. View abstract.
104001
Kodani M, Poe A, Drobeniuc J, Mixson-Hayden T. Determination of potential biotin interference on accuracy of results of serologic assays for various viral hepatitis markers. J Med Virol. View abstract.
104002
Li D, Ferguson A, Cervinski MA, Lynch KL, Kyle PB. AACC Guidance Document on Biotin Interference in Laboratory Tests. J Appl Lab Med. 2020;5(3):575-587. View abstract.
104011
Cree BAC, Cutter G, Wolinsky JS, et al. Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2020.
105716
Mathais S, Moisset X, Pereira B, et al. Relapses in patients treated with high-dose biotin for progressive multiple sclerosis. Neurotherapeutics. 2020 Sep 22. View abstract.
105717
Garbers LEFM, Miola AC, Dias PCR, Miot LDB, Miot HA, Schmitt JV. Efficacy of 2.5 mg oral biotin versus 5% topical minoxidil in increasing nail growth rate. Exp Dermatol. 2021 Mar 4. View abstract.
109534
Scheib N, Bauersachs D, Pogorelov D, et al. Biotin interference can cause false-negative specific IgE results in patients with anaphylaxis. J Allergy Clin Immunol Pract. 2022;10(9):2459-2462.e2. View abstract.
110044
Zhang Y, Ding Y, Fan Y, et al. Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Front Nutr 2022;9:1046800. View abstract.
111365
Takahashi N, Shoji H, Arai H, et al. Effect of biotin supplementation in infant formula: A multi-center study in Japan. Pediatr Int 2023;65(1):e15359. View abstract.
111366
Samadi A, Ketabi Y, Firooz R, Firooz A. Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands. Dermatol Ther. 2022;35(9):e15695. View abstract.
112038
Shimmaru K, Inami M, Hamaoka A, et al. Elevated free thyroxine and free triiodothyronine probably caused by high-dose biotin intake in a patient with Graves' disease: a case report. Endocr J 2023;70(8):833-837. View abstract.
112039
James A, Stalan J, Kuzhively J. Biotin induced biochemical hyperthyroidism: a case report and review of the literature. J Med Case Rep 2023;17(1):266. View abstract.