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Srichairatanakool, S., Thephinlap, C., Phisalaphong, C., Porter, J. B., and Fucharoen, S. Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. Med.Chem. 2007;3(5):469-474. View abstract.

Jiao, Y., Wilkinson, J., Christine, Pietsch E., Buss, J. L., Wang, W., Planalp, R., Torti, F. M., and Torti, S. V. Iron chelation in the biological activity of curcumin. Free Radic.Biol.Med. 4-1-2006;40(7):1152-1160. View abstract.

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Jiao, Y., Wilkinson, J., Di, X., Wang, W., Hatcher, H., Kock, N. D., D'Agostino, R., Jr., Knovich, M. A., Torti, F. M., and Torti, S. V. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 1-8-2009;113(2):462-469. View abstract.

Tuntipopipat, S., Judprasong, K., Zeder, C., Wasantwisut, E., Winichagoon, P., Charoenkiatkul, S., Hurrell, R., and Walczyk, T. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. J Nutr. 2006;136(12):2970-2974. View abstract.

Junyaprasert, V. B., Soonthornchareonnon, N., Thongpraditchote, S., Murakami, T., and Takano, M. Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux. Phytother.Res 2006;20(1):79-81. View abstract.

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Hou, X. L., Takahashi, K., Tanaka, K., Tougou, K., Qiu, F., Komatsu, K., Takahashi, K., and Azuma, J. Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways. Int.J Pharm 6-24-2008;358(1-2):224-229. View abstract.

Choi, B. H., Kim, C. G., Lim, Y., Shin, S. Y., and Lee, Y. H. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 1-18-2008;259(1):111-118. View abstract.

Zhang, W., Tan, T. M., and Lim, L. Y. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Drug Metab Dispos. 2007;35(1):110-115. View abstract.

Limtrakul, P., Chearwae, W., Shukla, S., Phisalphong, C., and Ambudkar, S. V. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol.Cell Biochem. 2007;296(1-2):85-95. View abstract.

Holland, M. L., Panetta, J. A., Hoskins, J. M., Bebawy, M., Roufogalis, B. D., Allen, J. D., and Arnold, J. C. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem.Pharmacol 4-14-2006;71(8):1146-1154. View abstract.

Tang, X. Q., Bi, H., Feng, J. Q., and Cao, J. G. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol Sin. 2005;26(8):1009-1016. View abstract.

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Yue, G. G., Cheng, S. W., Yu, H., Xu, Z. S., Lee, J. K., Hon, P. M., Lee, M. Y., Kennelly, E. J., Deng, G., Yeung, S. K., Cassileth, B. R., Fung, K. P., Leung, P. C., and Lau, C. B. The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. J Med Food 2012;15(3):242-252. View abstract.

Shenouda, N. S., Zhou, C., Browning, J. D., Ansell, P. J., Sakla, M. S., Lubahn, D. B., and MacDonald, R. S. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr.Cancer 2004;49(2):200-208. View abstract.

Allen, S. W., Mueller, L., Williams, S. N., Quattrochi, L. C., and Raucy, J. The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos. 2001;29(8):1074-1079. View abstract.

Appiah-Opong, R., Commandeur, J. N., Vugt-Lussenburg, B., and Vermeulen, N. P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 6-3-2007;235(1-2):83-91. View abstract.

Hou, X. L., Takahashi, K., Kinoshita, N., Qiu, F., Tanaka, K., Komatsu, K., Takahashi, K., and Azuma, J. Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. Int.J Pharm 6-7-2007;337(1-2):169-177. View abstract.

Valentine, S. P., Le Nedelec, M. J., Menzies, A. R., Scandlyn, M. J., Goodin, M. G., and Rosengren, R. J. Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse. Life Sci. 4-11-2006;78(20):2391-2398. View abstract.

Krizkova, J., Burdova, K., Hudecek, J., Stiborova, M., and Hodek, P. Induction of cytochromes P450 in small intestine by chemopreventive compounds. Neuro.Endocrinol.Lett. 2008;29(5):717-721. View abstract.

Price, R. J., Scott, M. P., Giddings, A. M., Walters, D. G., Stierum, R. H., Meredith, C., and Lake, B. G. Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica 2008;38(6):574-586. View abstract.

Ganta, S., Devalapally, H., and Amiji, M. Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Pharm Sci 2010;99(11):4630-4641. View abstract.

Kim IG, Kang SC, Kim KC, Choung ES, Zee OP. Screening of estrogenic and antiestrogenic activities from medicinal plants. Environ Toxicol Pharmacol. 2008;25(1):75-82. View abstract.

Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res. 2006;20(11):1017-9. View abstract.

Singh M, Singh N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol Cell Biochem. 2011;347(1-2):1-11. View abstract.

Calaf GM, Echiburú-Chau C, Wen G, Balajee AS, Roy D. Effect of curcumin on irradiated and estrogen-transformed human breast cell lines. Int J Oncol. 2012;40(2):436-42. View abstract.

O'Mahony, R., Al Khtheeri, H., Weerasekera, D., Fernando, N., Vaira, D., Holton, J., and Basset, C. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol. 12-21-2005;11(47):7499-7507. View abstract.

Ho, S. C., Tsai, T. H., Tsai, P. J., and Lin, C. C. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem.Toxicol. 2008;46(3):920-928. View abstract.

Tayel, A. A. and El Tras, W. F. Possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts. J Egypt.Public Health Assoc. 2009;84(1-2):21-32. View abstract.

Yano, Y., Satomi, M., and Oikawa, H. Antimicrobial effect of spices and herbs on Vibrio parahaemolyticus. Int.J Food Microbiol. 8-15-2006;111(1):6-11. View abstract.

Srivastava, K. C. Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins Leukot.Essent.Fatty Acids 1989;37(1):57-64. View abstract.

Baliga, M. S., Jagetia, G. C., Rao, S. K., and Babu, K. Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Nahrung 2003;47(4):261-264. View abstract.

Platel, K. and Srinivasan, K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung 2000;44(1):42-46. View abstract.

Chatterjee, S., Variyar, P. S., and Sharma, A. Stability of lipid constituents in radiation processed fenugreek seeds and turmeric: role of phenolic antioxidants. J Agric.Food Chem. 10-14-2009;57(19):9226-9233. View abstract.

Thongson, C., Davidson, P. M., Mahakarnchanakul, W., and Vibulsresth, P. Antimicrobial effect of Thai spices against Listeria monocytogenes and Salmonella typhimurium DT104. J Food Prot. 2005;68(10):2054-2058. View abstract.

Chopra, A., Lavin, P., Patwardhan, B., and Chitre, D. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004;10(5):236-245. View abstract.

Molnar, V. and Garai, J. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Int.Immunopharmacol. 2005;5(5):849-856. View abstract.

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Choudhary, D., Chandra, D., and Kale, R. K. Modulation of radioresponse of glyoxalase system by curcumin. J Ethnopharmacol. 1999;64(1):1-7. View abstract.

Thresiamma, K. C., George, J., and Kuttan, R. Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. J Exp.Clin Cancer Res 1998;17(4):431-434. View abstract.

Rasyid, A. and Lelo, A. The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Aliment.Pharmacol Ther. 1999;13(2):245-249. View abstract.

Olajide, O. A. Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 1999;13(3):231-232. View abstract.

Bourne, K. Z., Bourne, N., Reising, S. F., and Stanberry, L. R. Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antiviral Res 1999;42(3):219-226. View abstract.

Park, E. J., Jeon, C. H., Ko, G., Kim, J., and Sohn, D. H. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 2000;52(4):437-440. View abstract.

Gopalan, B., Goto, M., Kodama, A., and Hirose, T. Supercritical carbon dioxide extraction of turmeric (Curcuma longa). J Agric.Food Chem. 2000;48(6):2189-2192. View abstract.

Punithavathi, D., Venkatesan, N., and Babu, M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br.J Pharmacol 2000;131(2):169-172. View abstract.

Ramirez-Bosca, A., Soler, A., Carrion, M. A., Diaz-Alperi, J., Bernd, A., Quintanilla, C., Quintanilla, Almagro E., and Miquel, J. An hydroalcoholic extract of curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech.Ageing Dev. 10-20-2000;119(1-2):41-47. View abstract.

Li, W. Q., Dehnade, F., and Zafarullah, M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol. 3-1-2001;166(5):3491-3498. View abstract.

Kim, D. S., Park, S. Y., and Kim, J. K. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci.Lett. 4-27-2001;303(1):57-61. View abstract.

Sood, A., Mathew, R., and Trachtman, H. Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin. Biochem.Biophys.Res Commun. 4-27-2001;283(1):36-41. View abstract.

Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 6-1-2001;47(4):293-303. View abstract.

Zhang, W., Liu, D., Wo, X., Zhang, Y., Jin, M., and Ding, Z. Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. Chin Med.J (Engl) 1999;112(4):308-311. View abstract.

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 11-1-2001;21(21):8370-8377. View abstract.

Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., and Hsieh, C. Y. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001;21(4B):2895-2900. View abstract.

Song, E. K., Cho, H., Kim, J. S., Kim, N. Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y. C. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med. 2001;67(9):876-877. View abstract.

Frautschy, S. A., Hu, W., Kim, P., Miller, S. A., Chu, T., Harris-White, M. E., and Cole, G. M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol.Aging 2001;22(6):993-1005. View abstract.

Arun, N. and Nalini, N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum.Nutr. 2002;57(1):41-52. View abstract.

Hergenhahn, M., Soto, U., Weninger, A., Polack, A., Hsu, C. H., Cheng, A. L., and Rosl, F. The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. Mol.Carcinog. 2002;33(3):137-145. View abstract.

Hu, Y., Du, Q., and Tang, Q. [Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry]. Se.Pu. 1998;16(6):528-529. View abstract.

Literat, A., Su, F., Norwicki, M., Durand, M., Ramanathan, R., Jones, C. A., Minoo, P., and Kwong, K. Y. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci. 12-7-2001;70(3):253-267. View abstract.

Inano, H. and Onoda, M. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int.J Radiat.Oncol.Biol.Phys. 7-1-2002;53(3):735-743. View abstract.

Quiles, J. L., Mesa, M. D., Ramirez-Tortosa, C. L., Aguilera, C. M., Battino, M., Gil, A., and Ramirez-Tortosa, M. C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler.Thromb.Vasc.Biol. 7-1-2002;22(7):1225-1231. View abstract.

Grandjean-Laquerriere, A., Gangloff, S. C., Le Naour, R., Trentesaux, C., Hornebeck, W., and Guenounou, M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 5-7-2002;18(3):168-177. View abstract.

Park, S. Y. and Kim, D. S. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease. J Nat.Prod. 2002;65(9):1227-1231. View abstract.

Yu, Z. F., Kong, L. D., and Chen, Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol. 2002;83(1-2):161-165. View abstract.

Sugimoto, K., Hanai, H., Tozawa, K., Aoshi, T., Uchijima, M., Nagata, T., and Koide, Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 2002;123(6):1912-1922. View abstract.

Meselhy, M. R. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 2003;62(2):213-218. View abstract.

Mani, H., Sidhu, G. S., Kumari, R., Gaddipati, J. P., Seth, P., and Maheshwari, R. K. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors 2002;16(1-2):29-43. View abstract.

Salh, B. S., Assi, K., Templeman, V., Parhar, K., Owen, D., Gomez-Munoz, A., and Jacobson, K. Curcumin attenuates DNB-induced murine colitis. Am.J Physiol Gastrointest.Liver Physiol 3-13-2003; View abstract.

Chainani-Wu, N. Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa). J Altern.Complement Med. 2003;9(1):161-168. View abstract.

Ukil, A., Maity, S., Karmakar, S., Datta, N., Vedasiromoni, J. R., and Das, P. K. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br.J Pharmacol 2003;139(2):209-218. View abstract.

Lamb, S. R. and Wilkinson, S. M. Contact allergy to tetrahydrocurcumin. Contact Dermatitis 2003;48(4):227. View abstract.

Ram, A., Das, M., and Ghosh, B. Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. Biol.Pharm Bull. 2003;26(7):1021-1024. View abstract.

Punithavathi, D., Venkatesan, N., and Babu, M. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br.J Pharmacol 2003;139(7):1342-1350. View abstract.

Alves, L. V., Temporal, R. M., Cysne-Finkelstein, L., and Leon, L. L. Efficacy of a diarylheptanoid derivative against Leishmania amazonensis. Mem.Inst.Oswaldo Cruz 2003;98(4):553-555. View abstract.

Soni, K. B., Rajan, A., and Kuttan, R. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett. 9-30-1992;66(2):115-121. View abstract.

Huang, H. C., Jan, T. R., and Yeh, S. F. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur.J Pharmacol. 10-20-1992;221(2-3):381-384. View abstract.

Rithaporn, T., Monga, M., and Rajasekaran, M. Curcumin: a potential vaginal contraceptive. Contraception 2003;68(3):219-223. View abstract.

Manzan, A. C., Toniolo, F. S., Bredow, E., and Povh, N. P. Extraction of essential oil and pigments from Curcuma longa [L] by steam distillation and extraction with volatile solvents. J Agric.Food Chem. 11-5-2003;51(23):6802-6807. View abstract.

Hussain, M. S. and Chandrasekhara, N. Effect on curcumin on cholesterol gall-stone induction in mice. Indian J Med.Res. 1992;96:288-291. View abstract.

Yao, Q. H., Wang, D. Q., Cui, C. C., Yuan, Z. Y., Chen, S. B., Yao, X. W., Wang, J. K., and Lian, J. F. Curcumin ameliorates left ventricular function in rabbits with pressure overload: inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression. Biol.Pharm Bull. 2004;27(2):198-202. View abstract.

Ashok, P. and Meenakshi, B. Contraceptive effect of Curcuma longa (L.) in male albino rat. Asian J Androl 2004;6(1):71-74. View abstract.

Nguyen, K. T., Shaikh, N., Shukla, K. P., Su, S. H., Eberhart, R. C., and Tang, L. Molecular responses of vascular smooth muscle cells and phagocytes to curcumin-eluting bioresorbable stent materials. Biomaterials 2004;25(23):5333-5346. View abstract.

Jayasekera, R., Freitas, M. C., and Araujo, M. F. Bulk and trace element analysis of spices: the applicability of k0-standardization and energy dispersive X-ray fluorescence. J Trace Elem.Med.Biol. 2004;17(4):221-228. View abstract.

Nemavarkar, P., Chourasia, B. K., and Pasupathy, K. Evaluation of radioprotective action of compounds using Saccharomyces cerevisiae. J Environ.Pathol.Toxicol Oncol. 2004;23(2):145-151. View abstract.

Rezvani, M. and Ross, G. A. Modification of radiation-induced acute oral mucositis in the rat. Int.J Radiat.Biol. 2004;80(2):177-182. View abstract.

Eybl, V., Kotyzova, D., and Bludovska, M. The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice. Toxicol Lett. 6-15-2004;151(1):79-85. View abstract.

Ji, M., Choi, J., Lee, J., and Lee, Y. Induction of apoptosis by ar-turmerone on various cell lines. Int.J Mol.Med. 2004;14(2):253-256. View abstract.

Gonda, R., Tomoda, M., Takada, K., Ohara, N., and Shimizu, N. The core structure of ukonan A, a phagocytosis-activating polysaccharide from the rhizome of Curcuma longa, and immunological activities of degradation products. Chem.Pharm Bull.(Tokyo) 1992;40(4):990-993. View abstract.

Joshi, J., Ghaisas, S., Vaidya, A., Vaidya, R., Kamat, D. V., Bhagwat, A. N., and Bhide, S. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J Assoc.Physicians India 2003;51:1055-1060. View abstract.

Bao, H. Y., Chen, R. H., Huang, S. M., Zhang, A. H., Guo, M., Fei, L., and Pan, X. Q. [Effect of curcumin on extracellular matrix accumulation in the glomeruli in nephrotoxic sera nephritis rats]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2004;2(1):30-32. View abstract.

Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., Marczylo, T. H., Morgan, B., Hemingway, D., Plummer, S. M., Pirmohamed, M., Gescher, A. J., and Steward, W. P. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 10-15-2004;10(20):6847-6854. View abstract.

Kalpana, C. and Menon, V. P. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. Pol.J Pharmacol 2004;56(5):581-586. View abstract.

Ramaswami, G., Chai, H., Yao, Q., Lin, P. H., Lumsden, A. B., and Chen, C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc.Surg. 2004;40(6):1216-1222. View abstract.

Rukkumani, R., Aruna, K., Varma, P. S., and Menon, V. P. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Ital.J Biochem. 2004;53(2):61-66. View abstract.

Kalpana, C. and Menon, V. P. Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats. Ital.J Biochem. 2004;53(2):82-86. View abstract.

Biswas, S. K., McClure, D., Jimenez, L. A., Megson, I. L., and Rahman, I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid.Redox.Signal. 2005;7(1-2):32-41. View abstract.

Garcea, G., Berry, D. P., Jones, D. J., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., and Gescher, A. J. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol.Biomarkers Prev. 2005;14(1):120-125. View abstract.

Bundy, R., Walker, A. F., Middleton, R. W., and Booth, J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern.Complement Med. 2004;10(6):1015-1018. View abstract.

Huang, C. Y., Chen, J. H., Tsai, C. H., Kuo, W. W., Liu, J. Y., and Chang, Y. C. Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Periodontal Res 2005;40(2):176-181. View abstract.

Nan, B., Lin, P., Lumsden, A. B., Yao, Q., and Chen, C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb.Res 2005;115(5):417-426. View abstract.

Azuine, M. A. and Bhide, S. V. Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr.Cancer 1992;17(1):77-83. View abstract.

Gonda, R., Takeda, K., Shimizu, N., and Tomoda, M. Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem.Pharm Bull.(Tokyo) 1992;40(1):185-188. View abstract.

Yeh, C. H., Lin, Y. M., Wu, Y. C., and Lin, P. J. Inhibition of NF-kappa B activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression. J Cardiovasc.Pharmacol 2005;45(4):301-309. View abstract.

Mahesh, T., Sri Balasubashini, M. M., and Menon, V. P. Photo-irradiated curcumin supplementation in streptozotocin-induced diabetic rats: effect on lipid peroxidation. Therapie 2004;59(6):639-644. View abstract.

Yuan, K., Weng, Q., Zhang, H., Xiong, J., Yang, J., and Xu, G. [Determination of curcumin in urine by capillary electrophoresis]. Se.Pu. 2004;22(6):609-612. View abstract.

Yeh, C. H., Chen, T. P., Wu, Y. C., Lin, Y. M., and Jing, Lin P. Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg.Res 5-1-2005;125(1):109-116. View abstract.

Yuan, K., Weng, Q., Zhang, H., Xiong, J., and Xu, G. Application of capillary zone electrophoresis in the separation and determination of the curcuminoids in urine. J Pharm Biomed.Anal. 6-1-2005;38(1):133-138. View abstract.

Wessler, S., Muenzner, P., Meyer, T. F., and Naumann, M. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection. Biol.Chem. 2005;386(5):481-490. View abstract.

Zahid, Ashraf M., Hussain, M. E., and Fahim, M. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci. 7-8-2005;77(8):837-857. View abstract.

Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. The effects of curcumin on depressive-like behaviors in mice. Eur.J Pharmacol 7-25-2005;518(1):40-46. View abstract.

Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-452. View abstract.

Ali, B. H., Al Wabel, N., Mahmoud, O., Mousa, H. M., and Hashad, M. Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats. Fundam.Clin Pharmacol 2005;19(4):473-477. View abstract.

Goto, H., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y., and Komatsu, K. Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat. Am.J Chin Med. 2005;33(3):449-457. View abstract.

Huang, M. T., Deschner, E. E., Newmark, H. L., Wang, Z. Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol- induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett. 6-15-1992;64(2):117-121. View abstract.

Mahesh, T., Balasubashini, M. S., and Menon, V. P. Effect of photo-irradiated curcumin treatment against oxidative stress in streptozotocin-induced diabetic rats. J Med.Food 2005;8(2):251-255. View abstract.

Romero, M. R., Efferth, T., Serrano, M. A., Castano, B., Macias, R. I., Briz, O., and Marin, J. J. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 2005;68(2):75-83. View abstract.

Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138(2):212-222. View abstract.

Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem.Behav. 2005;82(1):200-206. View abstract.

Tirkey, N., Kaur, G., Vij, G., and Chopra, K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC.Pharmacol 2005;5:15. View abstract.

Yang, X., Thomas, D. P., Zhang, X., Culver, B. W., Alexander, B. M., Murdoch, W. J., Rao, M. N., Tulis, D. A., Ren, J., and Sreejayan, N. Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler.Thromb.Vasc.Biol. 2006;26(1):85-90. View abstract.

Holt, P. R., Katz, S., and Kirshoff, R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig.Dis.Sci. 2005;50(11):2191-2193. View abstract.

Park, B. S., Kim, J. G., Kim, M. R., Lee, S. E., Takeoka, G. R., Oh, K. B., and Kim, J. H. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric.Food Chem. 11-16-2005;53(23):9005-9009. View abstract.

Fan, C., Wo, X., Qian, Y., Yin, J., and Gao, L. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol. 4-21-2006;105(1-2):251-254. View abstract.

Kuwabara, N., Tamada, S., Iwai, T., Teramoto, K., Kaneda, N., Yukimura, T., Nakatani, T., and Miura, K. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006;67(2):440-446. View abstract.

Jiang, H., Timmermann, B. N., and Gang, D. R. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromatogr.A 4-7-2006;1111(1):21-31. View abstract.

Sharma, S., Kulkarni, S. K., Agrewala, J. N., and Chopra, K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur.J Pharmacol 5-1-2006;536(3):256-261. View abstract.

Perez-Arriaga, L., Mendoza-Magana, M. L., Cortes-Zarate, R., Corona-Rivera, A., Bobadilla-Morales, L., Troyo-Sanroman, R., and Ramirez-Herrera, M. A. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop. 2006;98(2):152-161. View abstract.

Peschel, D., Koerting, R., and Nass, N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr.Biochem. 2007;18(2):113-119. View abstract.

Panchatcharam, M., Miriyala, S., Gayathri, V. S., and Suguna, L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol.Cell Biochem. 2006;290(1-2):87-96. View abstract.

Zhou, G., Wang, J. F., Niu, J. Z., Lu, Y. S., Chen, W. T., Li, Z. H., and Lin, T. X. [Experimental study on protective effects of curcumin on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31(7):570-573. View abstract.

Zhang, M., Deng, C., Zheng, J., Xia, J., and Sheng, D. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. Int.Immunopharmacol. 2006;6(8):1233-1242. View abstract.

Moon, D. O., Jin, C. Y., Lee, J. D., Choi, Y. H., Ahn, S. C., Lee, C. M., Jeong, S. C., Park, Y. M., and Kim, G. Y. Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets. Biol.Pharm Bull. 2006;29(7):1470-1475. View abstract.

Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., and Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp.Immunol. 2006;145(2):313-321. View abstract.

Qin, N. Y., Yang, F. Q., Wang, Y. T., and Li, S. P. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharm Biomed.Anal. 1-17-2007;43(2):486-492. View abstract.

Thompson, D. A. and Tan, B. B. Tetrahydracurcumin-related allergic contact dermatitis. Contact Dermatitis 2006;55(4):254-255. View abstract.

Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G., and Rosenthal, M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2006;10(1):1-7. View abstract.

Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54(11):3452-3464. View abstract.

Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4(12):1502-1506. View abstract.

Honda, S., Aoki, F., Tanaka, H., Kishida, H., Nishiyama, T., Okada, S., Matsumoto, I., Abe, K., and Mae, T. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study. J Agric.Food Chem. 11-29-2006;54(24):9055-9062. View abstract.

Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob.Agents Chemother. 2007;51(2):488-494. View abstract.

Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol.Microcirc. 2006;35(4):481-489. View abstract.

Liddle, M., Hull, C., Liu, C., and Powell, D. Contact urticaria from curcumin. Dermatitis 2006;17(4):196-197. View abstract.

Sivalingam, N., Hanumantharaya, R., Faith, M., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin reduces indomethacin-induced damage in the rat small intestine. J Appl.Toxicol 2007;27(6):551-560. View abstract.

Lian, Q., Li, X., Shang, Y., Yao, S., Ma, L., and Jin, S. Protective effect of curcumin on endotoxin-induced acute lung injury in rats. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26(6):678-681. View abstract.

Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim.Biophys.Acta 2007;1770(6):989-996. View abstract.

Kowluru, R. A. and Kanwar, M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr.Metab (Lond) 2007;4:8. View abstract.

Xu, P. H., Long, Y., Dai, F., and Liu, Z. L. The relaxant effect of curcumin on porcine coronary arterial ring segments. Vascul.Pharmacol 2007;47(1):25-30. View abstract.

Juan, H., Terhaag, B., Cong, Z., Bi-Kui, Z., Rong-Hua, Z., Feng, W., Fen-Li, S., Juan, S., Jing, T., and Wen-Xing, P. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur.J Clin Pharmacol 2007;63(7):663-668. View abstract.

Garcia-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., and Bacskai, B. J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007;102(4):1095-1104. View abstract.

Teichmann, A., Heuschkel, S., Jacobi, U., Presse, G., Neubert, R. H., Sterry, W., and Lademann, J. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur.J Pharm Biopharm. 2007;67(3):699-706. View abstract.

Zeng, Y., Qiu, F., Takahashi, K., Liang, J., Qu, G., and Yao, X. New sesquiterpenes and calebin derivatives from Curcuma longa. Chem.Pharm Bull.(Tokyo) 2007;55(6):940-943. View abstract.

Zhang, D. P., Qiu, H., Zhuang, Y., and Meng, F. Q. [The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 2007;30(3):197-201. View abstract.

Jain, V., Prasad, V., Pal, R., and Singh, S. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. J Pharm Biomed.Anal. 9-3-2007;44(5):1079-1086. View abstract.

Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104(31):12849-12854. View abstract.

Mrudula, T., Suryanarayana, P., Srinivas, P. N., and Reddy, G. B. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem.Biophys.Res Commun. 9-21-2007;361(2):528-532. View abstract.

Park, C., Moon, D. O., Choi, I. W., Choi, B. T., Nam, T. J., Rhu, C. H., Kwon, T. K., Lee, W. H., Kim, G. Y., and Choi, Y. H. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int.J Mol.Med. 2007;20(3):365-372. View abstract.

Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J Ethnopharmacol. 9-25-2007;113(3):479-486. View abstract.

Paramasivam, S., Thangaradjou, T., and Kannan, L. Effect of natural preservatives on the growth of histamine producing bacteria. J Environ.Biol. 2007;28(2):271-274. View abstract.

Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem.J 2-15-2008;410(1):147-155. View abstract.

Olszanecki, R., Gebska, A., and Korbut, R. The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin Pharmacol Toxicol 2007;101(6):411-415. View abstract.

Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227(1):115-124. View abstract.

Wan, X. H., Li, Y. W., and Luo, X. P. [Curcumin attenuated the lipid peroxidation and apoptotic liver injury in copper-overloaded rats]. Zhonghua Er.Ke.Za Zhi. 2007;45(8):604-608. View abstract.

Srinivasan, K. and Sambaiah, K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int.J Vitam.Nutr.Res 1991;61(4):364-369. View abstract.

Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373(2):239-247. View abstract.

Tikoo, K., Meena, R. L., Kabra, D. G., and Gaikwad, A. B. Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br.J Pharmacol 2008;153(6):1225-1231. View abstract.

Wei, S. M., Yan, Z. Z., and Zhou, J. Curcumin attenuates ischemia-reperfusion injury in rat testis. Fertil.Steril. 2009;91(1):271-277. View abstract.

Mukherjee, S., Roy, M., Dey, S., and Bhattacharya, R. K. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn. J Clin Biochem.Nutr. 2007;41(1):32-42. View abstract.

Seo, K. I., Choi, M. S., Jung, U. J., Kim, H. J., Yeo, J., Jeon, S. M., and Lee, M. K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol.Nutr.Food Res 2008;52(9):995-1004. View abstract.

Weisberg, S. P., Leibel, R., and Tortoriello, D. V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008;149(7):3549-3558. View abstract.

Meja, K. K., Rajendrasozhan, S., Adenuga, D., Biswas, S. K., Sundar, I. K., Spooner, G., Marwick, J. A., Chakravarty, P., Fletcher, D., Whittaker, P., Megson, I. L., Kirkham, P. A., and Rahman, I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am.J Respir.Cell Mol.Biol. 2008;39(3):312-323. View abstract.

Yuan, H. Y., Kuang, S. Y., Zheng, X., Ling, H. Y., Yang, Y. B., Yan, P. K., Li, K., and Liao, D. F. Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin. 2008;29(5):555-563. View abstract.

Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., and Brenner, D. E. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol.Biomarkers Prev. 2008;17(6):1411-1417. View abstract.

Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci.Lett. 8-8-2008;440(3):344-347. View abstract.

Kumar, A. and Singh, A. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Phytomedicine. 2008;15(8):577-586. View abstract.

Usharani, P., Mateen, A. A., Naidu, M. U., Raju, Y. S., and Chandra, N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R.D. 2008;9(4):243-250. View abstract.

Srinivasan, M., Sudheer, A. R., Rajasekaran, K. N., and Menon, V. P. Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro. Chem.Biol.Interact. 10-22-2008;176(1):1-8. View abstract.

Sotanaphun, U., Phattanawasin, P., and Sriphong, L. Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa). Phytochem.Anal. 2009;20(1):19-23. View abstract.

Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., and Sugimoto, H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 8-27-2008;19(13):1329-1333. View abstract.

Dou, X., Fan, C., Wo, L., Yan, J., Qian, Y., and Wo, X. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med. 2008;74(11):1374-1379. View abstract.

Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam.Clin Pharmacol 2008;22(4):417-427. View abstract.

Moon, D. O., Kim, M. O., Lee, H. J., Choi, Y. H., Park, Y. M., Heo, M. S., and Kim, G. Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem.Biophys.Res Commun. 10-17-2008;375(2):275-279. View abstract.

Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14(30):4753-4762. View abstract.

Kulkarni, S. K., Bhutani, M. K., and Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008;201(3):435-442. View abstract.

Tanaka, K., Kuba, Y., Sasaki, T., Hiwatashi, F., and Komatsu, K. Quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis. J Agric.Food Chem. 10-8-2008;56(19):8787-8792. View abstract.

Wang, L. Y., Zhang, M., Zhang, C. F., and Wang, Z. T. Alkaloid and sesquiterpenes from the root tuber of Curcuma longa. Yao Xue.Xue.Bao. 2008;43(7):724-727. View abstract.

Chen, D., Nie, M., Fan, M. W., and Bian, Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology 2008;82(4):264-269. View abstract.

Ahmed, T. and Gilani, A. H. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem.Behav. 2009;91(4):554-559. View abstract.

Jain, S. K., Rains, J., Croad, J., Larson, B., and Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid.Redox.Signal. 2009;11(2):241-249. View abstract.

Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 2-1-1991;51(3):813-819. View abstract.

Agrawal, D. K., Saikia, D., Tiwari, R., Ojha, S., Shanker, K., Kumar, J. K., Gupta, A. K., Tandon, S., Negi, A. S., and Khanuja, S. P. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008;74(15):1828-1831. View abstract.

Rastogi, M., Ojha, R. P., Rajamanickam, G. V., Agrawal, A., Aggarwal, A., and Dubey, G. P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. Free Radic.Res 2008;42(11-12):999-1005. View abstract.

Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., and Kondo, T. Effect of dietary turmeric on breath hydrogen. Dig.Dis.Sci. 2009;54(8):1725-1729. View abstract.

Madden, K., Flowers, L., Salani, R., Horowitz, I., Logan, S., Kowalski, K., Xie, J., and Mohammed, S. I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot.Essent.Fatty Acids 2009;80(1):9-18. View abstract.

Chen, Z., Zhu, L., Song, T., Chen, J., and Guo, Z. A novel curcumin assay with the metal ion Cu (II) as a simple probe by resonance light scattering technique. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2009;72(3):518-522. View abstract.

Cashman, J. R., Ghirmai, S., Abel, K. J., and Fiala, M. Immune defects in Alzheimer's disease: new medications development. BMC.Neurosci. 2008;9 Suppl 2:S13. View abstract.

Tian, Y. M., Zhou, D., Zhang, W., and Cheng, C. G. [Comparison and correlative analysis of trace elements in five kinds of radix curcumae]. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. 2008;28(9):2192-2195. View abstract.

Balasubramanian, K. Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease. J Agric.Food Chem. 5-17-2006;54(10):3512-3520. View abstract.

Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Odajima, N., Moriyama, C., Nasuhara, Y., and Nishimura, M. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am.J Physiol Lung Cell Mol.Physiol 2009;296(4):L614-L623. View abstract.

Yu, Y., Hu, S. K., and Yan, H. [The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42(11):818-822. View abstract.

Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N., Tungsinmunkong, K., and Bouking, P. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. Phytomedicine. 2009;16(4):342-351. View abstract.

De, R., Kundu, P., Swarnakar, S., Ramamurthy, T., Chowdhury, A., Nair, G. B., and Mukhopadhyay, A. K. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob.Agents Chemother. 2009;53(4):1592-1597. View abstract.

Al Zanbagi, N. A. and Zelai, N. T. Two methods for attenuating Toxoplasma gondii tachyzoites RH strain by using ethanol extract of Curcuma longa. J Egypt Soc.Parasitol. 2008;38(3):965-976. View abstract.

Ghosh, A. K., Kay, N. E., Secreto, C. R., and Shanafelt, T. D. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 2-15-2009;15(4):1250-1258. View abstract.

Allam, G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. Immunobiology 2009;214(8):712-727. View abstract.

Chiu, J., Khan, Z. A., Farhangkhoee, H., and Chakrabarti, S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition 2009;25(9):964-972. View abstract.

Zhang, J., Jinnai, S., Ikeda, R., Wada, M., Hayashida, S., and Nakashima, K. A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products. Anal.Sci. 2009;25(3):385-388. View abstract.

Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., and Kong, L. D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog.Neuropsychopharmacol.Biol.Psychiatry 4-30-2009;33(3):435-449. View abstract.

Ji, H. F. and Shen, L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg.Med.Chem.Lett. 5-1-2009;19(9):2453-2455. View abstract.

Bas, M., Tugcu, V., Kemahli, E., Ozbek, E., Uhri, M., Altug, T., and Tasci, A. I. Curcumin prevents shock-wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats. Urol.Res 2009;37(3):159-164. View abstract.

Cekmen, M., Ilbey, Y. O., Ozbek, E., Simsek, A., Somay, A., and Ersoz, C. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem.Toxicol 2009;47(7):1480-1484. View abstract.

Pongchaidecha, A., Lailerd, N., Boonprasert, W., and Chattipakorn, N. Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats. Nutrition 2009;25(7-8):870-878. View abstract.

Wichitnithad, W., Jongaroonngamsang, N., Pummangura, S., and Rojsitthisak, P. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochem.Anal. 2009;20(4):314-319. View abstract.

Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., Choi, H., Min, J. S., Kim, Y. S., Yoon, S. W., and Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 7-15-2009;124(2):189-196. View abstract.

Mishra, R. K. and Singh, S. K. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 2009;79(6):479-487. View abstract.

Yu, Y. M. and Lin, H. C. Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr.Metab Cardiovasc.Dis. 2010;20(2):125-132. View abstract.

Fang, X. D., Yang, F., Zhu, L., Shen, Y. L., Wang, L. L., and Chen, Y. Y. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp.Pharmacol Physiol 2009;36(12):1177-1182. View abstract.

Kim, H. J. and Jang, Y. P. Direct analysis of curcumin in turmeric by DART-MS. Phytochem.Anal. 2009;20(5):372-377. View abstract.

Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic.Biol.Med. 10-1-2009;47(7):924-931. View abstract.

Shu, J. C., He, Y. J., Lv, X., Ye, G. R., and Wang, L. X. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. J Nat.Med. 2009;63(4):415-420. View abstract.

Shahiduzzaman, M., Dyachenko, V., Khalafalla, R. E., Desouky, A. Y., and Daugschies, A. Effects of curcumin on Cryptosporidium parvum in vitro. Parasitol.Res 2009;105(4):1155-1161. View abstract.

Li, W., Wang, S., Feng, J., Xiao, Y., Xue, X., Zhang, H., Wang, Y., and Liang, X. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson.Chem. 2009;47(10):902-908. View abstract.

Sumiyoshi, M. and Kimura, Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Phytomedicine. 2009;16(12):1137-1143. View abstract.

Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2009;119(7):2113. View abstract.

Kurien, B. T. Inhibition of p300 and nuclear factor-kappaB by curcumin and its role in diabetic nephropathy. Nutrition 2009;25(9):973-974. View abstract.

Patel, S. S., Shah, R. S., and Goyal, R. K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp.Biol. 2009;47(7):564-570. View abstract.

Mun, S. H., Kim, H. S., Kim, J. W., Ko, N. Y., Kim, do K., Lee, B. Y., Kim, B., Won, H. S., Shin, H. S., Han, J. W., Lee, H. Y., Kim, Y. M., and Choi, W. S. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci. 2009;111(1):13-21. View abstract.

Wang, Y., Lu, Z., Wu, H., and Lv, F. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int.J Food Microbiol. 11-30-2009;136(1):71-74. View abstract.

Tang, Y. H., Bao, M. W., Yang, B., Zhang, Y., Zhang, B. S., Zhou, Q., Chen, J. L., and Huang, C. X. [Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure.]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 2009;37(3):262-267. View abstract.

Moghaddam, S. J., Barta, P., Mirabolfathinejad, S. G., Ammar-Aouchiche, Z., Garza, N. T., Vo, T. T., Newman, R. A., Aggarwal, B. B., Evans, C. M., Tuvim, M. J., Lotan, R., and Dickey, B. F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009;30(11):1949-1956. View abstract.

Li, W., Xiao, H., Wang, L., and Liang, X. [Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry]. Se.Pu. 2009;27(3):264-269. View abstract.

Peeyush, K. T., Gireesh, G., Jobin, M., and Paulose, C. S. Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Life Sci. 11-4-2009;85(19-20):704-710. View abstract.

Yun, S. S., Kim, S. P., Kang, M. Y., and Nam, S. H. Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock. Biotechnol.Lett. 2010;32(2):209-214. View abstract.

Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35(5):599-606. View abstract.

Vizzutti, F., Provenzano, A., Galastri, S., Milani, S., Delogu, W., Novo, E., Caligiuri, A., Zamara, E., Arena, U., Laffi, G., Parola, M., Pinzani, M., and Marra, F. Curcumin limits the fibrogenic evolution of experimental steatohepatitis. Lab Invest 2010;90(1):104-115. View abstract.

Kheradpezhouh, E., Panjehshahin, M. R., Miri, R., Javidnia, K., Noorafshan, A., Monabati, A., and Dehpour, A. R. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. Eur.J Pharmacol 2-25-2010;628(1-3):274-281. View abstract.

Pavithra, B. H., Prakash, N., and Jayakumar, K. Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. J Vet.Sci. 2009;10(4):293-297. View abstract.

Yao, J., Zhang, Q., Min, J., He, J., and Yu, Z. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorg.Med.Chem.Lett. 1-1-2010;20(1):56-59. View abstract.

Nayak, S. and Sashidhar, R. B. Metabolic intervention of aflatoxin B1 toxicity by curcumin. J Ethnopharmacol. 2-17-2010;127(3):641-644. View abstract.

Kim, K., Kim, K. H., Kim, H. Y., Cho, H. K., Sakamoto, N., and Cheong, J. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Lett. 2-19-2010;584(4):707-712. View abstract.

Tanwar, V., Sachdeva, J., Kishore, K., Mittal, R., Nag, T. C., Ray, R., Kumari, S., and Arya, D. S. Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Cell Biochem.Funct. 2010;28(1):74-82. View abstract.

Yeon, K. Y., Kim, S. A., Kim, Y. H., Lee, M. K., Ahn, D. K., Kim, H. J., Kim, J. S., Jung, S. J., and Oh, S. B. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent.Res 2010;89(2):170-174. View abstract.

Bansal, S. and Chhibber, S. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice. J Med.Microbiol. 2010;59(Pt 4):429-437. View abstract.

Smith, M. R., Gangireddy, S. R., Narala, V. R., Hogaboam, C. M., Standiford, T. J., Christensen, P. J., Kondapi, A. K., and Reddy, R. C. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am.J Physiol Lung Cell Mol.Physiol 1-8-2010; View abstract.

Varghese, K., Molnar, P., Das, M., Bhargava, N., Lambert, S., Kindy, M. S., and Hickman, J. J. A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS.One. 2010;5(1):e8643. View abstract.

Wang, B. M., Zhai, C. Y., Fang, W. L., Chen, X., Jiang, K., and Wang, Y. M. [The inhibitory effect of curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid]. Zhonghua Nei Ke.Za Zhi. 2009;48(9):760-763. View abstract.

Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., and Agarwal, M. G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric.Food Chem 2-24-2010;58(4):2095-2099. View abstract.

El Agamy, D. S. Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats. Arch.Toxicol 2010;84(5):389-396. View abstract.

Tanwar, V., Sachdeva, J., Golechha, M., Kumari, S., and Arya, D. S. Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. J Cardiovasc.Pharmacol 2010;55(4):377-384. View abstract.

Baghdasaryan, A., Claudel, T., Kosters, A., Gumhold, J., Silbert, D., Thuringer, A., Leski, K., Fickert, P., Karpen, S. J., and Trauner, M. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010;59(4):521-530. View abstract.

Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20(8):2549-2551. View abstract.

Abdel Fattah, E. A., Hashem, H. E., Ahmed, F. A., Ghallab, M. A., Varga, I., and Polak, S. Prophylactic role of curcumin against cyclosporine-induced nephrotoxicity: Histological and immunohistological study. Gen.Physiol Biophys. 2010;29(1):85-94. View abstract.

Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173(5):590-601. View abstract.

Chen, K. H., Chao, D., Liu, C. F., Chen, C. F., and Wang, D. Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. Transplant.Proc. 2010;42(3):744-747. View abstract.

Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., and Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10(7):815-818. View abstract.

Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 6-9-2010; View abstract.

Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., and Appendino, G. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010;52(2 Suppl 1):55-62. View abstract.

Yan, Y. D., Kim, D. H., Sung, J. H., Yong, C. S., and Choi, H. G. Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin. Int J Pharm 10-31-2010;399(1-2):116-120. View abstract.

Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99(12):4992-5010. View abstract.

Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., and Fathollahi, Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011;65(7):572-582. View abstract.

Voznesens'ka, T. I., Bryzhina, T. M., Sukhina, V. S., Makohon, N. V., and Aleksieieva, I. M. [Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice]. Fiziol.Zh. 2010;56(4):96-101. View abstract.

Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 2010;62(8):1137-1141. View abstract.

Madkor, H. R., Mansour, S. W., and Ramadan, G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105(8):1210-1217. View abstract.

Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., and Oguzturk, H. Antioxidative effects of curcumin, beta-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicol Ind Health 2011;27(5):447-453. View abstract.

Guimaraes, M. R., Coimbra, L. S., de Aquino, S. G., Spolidorio, L. C., Kirkwood, K. L., and Rossa, C., Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46(2):269-279. View abstract.

He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., and Wang, J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest 2011;29(3):208-213. View abstract.

Naz, R. K. Can curcumin provide an ideal contraceptive? Mol.Reprod.Dev 2011;78(2):116-123. View abstract.

Sahin, Kavakli H., Koca, C., and Alici, O. Antioxidant effects of curcumin in spinal cord injury in rats. Ulus.Travma.Acil.Cerrahi.Derg. 2011;17(1):14-18. View abstract.

Kumar, A., Purwar, B., Shrivastava, A., and Pandey, S. Effects of curcumin on the intestinal motility of albino rats. Indian J Physiol Pharmacol 2010;54(3):284-288. View abstract.

Nakmareong, S., Kukongviriyapan, U., Pakdeechote, P., Donpunha, W., Kukongviriyapan, V., Kongyingyoes, B., Sompamit, K., and Phisalaphong, C. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension. Naunyn Schmiedebergs Arch Pharmacol 2011;383(5):519-529. View abstract.

Yiu, W. F., Kwan, P. L., Wong, C. Y., Kam, T. S., Chiu, S. M., Chan, S. W., and Chan, R. Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase. J Food Sci 2011;76(3):H80-H89. View abstract.

Kanai, M., Imaizumi, A., Otsuka, Y., Sasaki, H., Hashiguchi, M., Tsujiko, K., Matsumoto, S., Ishiguro, H., and Chiba, T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother.Pharmacol 2012;69(1):65-70. View abstract.

Shubha, M. C., Reddy, R. R., and Srinivasan, K. Antilithogenic influence of dietary capsaicin and curcumin during experimental induction of cholesterol gallstone in mice. Appl Physiol Nutr Metab 2011;36(2):201-209. View abstract.

Agarwal, K. A., Tripathi, C. D., Agarwal, B. B., and Saluja, S. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surg Endosc. 6-14-2011; View abstract.

Khajehdehi, P., Zanjaninejad, B., Aflaki, E., Nazarinia, M., Azad, F., Malekmakan, L., and Dehghanzadeh, G. R. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study. J Ren Nutr 2012;22(1):50-57. View abstract.

Pungcharoenkul, K. and Thongnopnua, P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytother Res 2011;25(11):1721-1726. View abstract.

Chainani-Wu, N., Madden, E., Lozada-Nur, F., and Silverman S Jr. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol 2012;66(5):752-760. View abstract.

Wu, J. C., Lai, C. S., Badmaev, V., Nagabhushanam, K., Ho, C. T., and Pan, M. H. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol.Nutr Food Res 2011;55(11):1646-1654. View abstract.

Panahi, Y., Sahebkar, A., Amiri, M., Davoudi, S. M., Beiraghdar, F., Hoseininejad, S. L., and Kolivand, M. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 2012;108(7):1272-1279. View abstract.

Waghmare, P. F., Chaudhari, A. U., Karhadkar, V. M., and Jamkhande, A. S. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study. J Contemp.Dent Pract. 2011;12(4):221-224. View abstract.

Kusuhara, H., Furuie, H., Inano, A., Sunagawa, A., Yamada, S., Wu, C., Fukizawa, S., Morimoto, N., Ieiri, I., Morishita, M., Sumita, K., Mayahara, H., Fujita, T., Maeda, K., and Sugiyama, Y. Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br J Pharmacol 2012;166(6):1793-1803. View abstract.

Vitaglione, P., Barone, Lumaga R., Ferracane, R., Radetsky, I., Mennella, I., Schettino, R., Koder, S., Shimoni, E., and Fogliano, V. Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients. J Agric.Food Chem 4-4-2012;60(13):3357-3366. View abstract.

Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T., Sukonthasarn, A., Apaijai, N., and Chattipakorn, N. Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. Am J Cardiol 7-1-2012;110(1):40-44. View abstract.

Mohammadi, A., Sahebkar, A., Iranshahi, M., Amini, M., Khojasteh, R., Ghayour-Mobarhan, M., and Ferns, G. A. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 2013;27(3):374-379. View abstract.

Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., and Jirawatnotai, S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012;35(11):2121-2127. View abstract.

Panahi, Y., Sahebkar, A., Parvin, S., and Saadat, A. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann.Clin Biochem. 2012;49(Pt 6):580-588. View abstract.

Gonda, R., Tomoda, M., Shimizu, N., and Kanari, M. Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem.Pharm Bull.(Tokyo) 1990;38(2):482-486. View abstract.

Rafatullah, S., Tariq, M., Al Yahya, M. A., Mossa, J. S., and Ageel, A. M. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol. 1990;29(1):25-34. View abstract.

Goh, C. L. and Ng, S. K. Allergic contact dermatitis to Curcuma longa (turmeric). Contact Dermatitis 1987;17(3):186. View abstract.

Flynn, D. L., Rafferty, M. F., and Boctor, A. M. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones. Prostaglandins Leukot.Med. 1986;22(3):357-360. View abstract.

Srivastava, R., Puri, V., Srimal, R. C., and Dhawan, B. N. Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis. Arzneimittelforschung. 1986;36(4):715-717. View abstract.

Satoskar, R. R., Shah, S. J., and Shenoy, S. G. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int.J Clin Pharmacol Ther.Toxicol. 1986;24(12):651-654. View abstract.

Nagabhushan, M., Amonkar, A. J., and Bhide, S. V. In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem.Toxicol. 1987;25(7):545-547. View abstract.

Srivastava, R., Dikshit, M., Srimal, R. C., and Dhawan, B. N. Anti-thrombotic effect of curcumin. Thromb.Res 11-1-1985;40(3):413-417. View abstract.

Srinivasan, M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci 1972;26(4):269-270. View abstract.

Abraham, S. K., Sarma, L., and Kesavan, P. C. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. Mutat.Res 1993;303(3):109-112. View abstract.

Sreejayan and Rao, M. N. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 1994;46(12):1013-1016. View abstract.

Srivastava, K. C., Bordia, A., and Verma, S. K. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot.Essent.Fatty Acids 1995;52(4):223-227. View abstract.

Korutla, L. and Kumar, R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim.Biophys.Acta 12-30-1994;1224(3):597-600. View abstract.

Kositchaiwat, C., Kositchaiwat, S., and Havanondha, J. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical trial. J Med.Assoc.Thai. 1993;76(11):601-605. View abstract.

Rao, C. V., Simi, B., and Reddy, B. S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 1993;14(11):2219-2225. View abstract.

Oetari, S., Sudibyo, M., Commandeur, J. N., Samhoedi, R., and Vermeulen, N. P. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol 1-12-1996;51(1):39-45. View abstract.

Babu, P. S. and Srinivasan, K. Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mol.Cell Biochem. 11-8-1995;152(1):13-21. View abstract.

Kuo, M. L., Huang, T. S., and Lin, J. K. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim.Biophys.Acta 11-15-1996;1317(2):95-100. View abstract.

Babu, P. S. and Srinivasan, K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol.Cell Biochem. 1997;166(1-2):169-175. View abstract.

Verma S, Salamone E, and Goldin B. Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem.Biophys.Res Commun. 4-28-1997;233(3):692-696. View abstract.

Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B. B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 1997;8(5):470-481. View abstract.

Ranjan, D., Siquijor, A., Johnston, T. D., Wu, G., and Nagabhuskahn, M. The effect of curcumin on human B-cell immortalization by Epstein-Barr virus. Am Surg 1998;64(1):47-51. View abstract.

Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., and Srinivas, P. S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64(4):353-356. View abstract.

Kiec-Swierczynska, M. and Krecisz, B. Occupational allergic contact dermatitis due to curcumin food colour in a pasta factory worker. Contact Dermatitis 1998;39(1):30-31. View abstract.

Ciolino, H. P., Daschner, P. J., Wang, T. T., and Yeh, G. C. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem.Pharmacol. 7-15-1998;56(2):197-206. View abstract.

Shoskes, D. A. Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents. Transplantation 7-27-1998;66(2):147-152. View abstract.

Chen, H. W. and Huang, H. C. Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. Br.J Pharmacol. 1998;124(6):1029-1040. View abstract.

Parshad, R., Sanford, K. K., Price, F. M., Steele, V. E., Tarone, R. E., Kelloff, G. J., and Boone, C. W. Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells. Anticancer Res 1998;18(5A):3263-3266. View abstract.

Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., and Reddy, B. S. Chemopreventive effect of curcumin, a naturally occurring anti- inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 2-1-1999;59(3):597-601. View abstract.

Van Dau N, Ngoc Ham N, Huy Khac D, and et al. The effects of a traditional drug, tumeric (Curcuma longa), and placebo on the healing of duodenal ulcer. Phytomed 1998;5(1):29-34.

Srinivasan K and Sambaiah K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Internat J Vit Nutr Res 1991;61:364-369.

Benny, M and Antony B. Bioavailability of Biocurcumax (BCM - 095). Spice India 2006;11-15.

Antony B, Kizhakedath R Benny M Kuruvilla BT. Clinical Evaluation of a herbal product (Rhulief) in the management of knee osteoarthritis. Abstract 316. Osteoarthritis Cartilage 2011;19(S1):S145-S146.

Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 2013;12(1):154. View abstract.

Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med 2014 Winter;20 Suppl 1:32-7. View abstract.

Daveluy A, Géniaux H, Thibaud L, Mallaret M, Miremont-Salamé G, Haramburu F. Probable interaction between an oral vitamin K antagonist and turmeric (Curcuma longa). Therapie. 2014 Nov-Dec;69(6):519-20. View abstract.

Kizhakkedath R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep 2013;8(5):1542-8. View abstract.

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging 2014;9:451-8. View abstract.

Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology 2013;21(2):129-36. View abstract.

Pinsornsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thai 2012;95 Suppl 1:S51-8. View abstract.

Mali AM, Behal R, Gilda SS. Comparative evaluation of 0.1% turmeric mouthwash with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: A clinical and microbiological study. J Indian Soc Periodontol 2012;16(3):386-91. View abstract.

Pakfetrat M, Basiri F, Malekmakan L, Roozbeh J. Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. J Nephrol 2014;27(2):203-7. View abstract.

Pashine L, Singh JV, Vaish AK, Ojha SK, Mahdi AA. Effect of turmeric (Curcuma longa) on overweight hyperlipidemic subjects: Double blind study. Indian J Comm Health 2012;24(2):113-117.

Rao S, Dinkar C, Vaishnav LK, Rao P, Rai MP, Fayad R, Baliga MS. The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study. Integr Cancer Ther 2013;13(3):201-210. View abstract.

Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res 2014;28(4):579-85. View abstract.

Singla V, Pratap Mouli V, Garg SK, Rai T, Choudhury BN, Verma P, Deb R, Tiwari V, Rohatgi S, Dhingra R, Kedia S, Sharma PK, Makharia G, Ahuja V. Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study. J Crohns Colitis 2014;8(3):208-14. View abstract.

Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis 2014;17(2):180-6. View abstract.

Nayeri A, Wu S, Adams E, et al. Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. Transplant Proc. 2017;49(1):198-200. View abstract.

Mitchell TM. Correspondence re: Somasundaram et al., Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. 2003;63(16):5165-6; author reply 5166-7. View abstract.

Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. 2002;62(13):3868-75. View abstract.

Haroyan A, Mukuchyan V, Mkrtchyan N, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018;18(1):7. View abstract.

Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017;16(1):68. View abstract.

Amalraj A, Varma K, Jacob J, et al. A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: A randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study. J Med Food. 2017;20(10):1022-1030. View abstract.

Rainey-Smith SR, Brown BM, Sohrabi HR, et al. Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults. Br J Nutr. 2016;115(12):2106-13. View abstract.

Al-Karawi D, Al Mamoori DA, Tayyar Y. The role of curcumin administration in patients with major depressive disorder: Mini meta-analysis of clinical trials. Phytother Res. 2016;30(2):175-83. View abstract.

Mahammedi H, Planchat E, Pouget M, et al. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: A pilot phase II study. Oncology. 2016;90(2):69-78. View abstract.

Neerati P, Devde R, Gangi AK. Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytother Res. 2014;28(12):1796-800. View abstract.

Simental-Mendía LE, Pirro M, Gotto AM Jr, et al. Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2017:1-10. View abstract.

Lasoff DR, Cantrell FL, Ly BT. Death associated with intravenous turmeric (Curcumin) preparation. Clin Toxicol (Phila). 2018;56(5):384-385. View abstract.

Fung FY, Wong WH, Ang SK, et al. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017;32:88-96. View abstract.

Wu S, Xiao D. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2016;117(6):697-702.e1. View abstract.

Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL. Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol. 2015;35(4):406-10. View abstract.

Small GW, Siddarth P, Li Z, et al. Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatry. 2018;26(3):266-277. View abstract.

Belcaro G, Dugall M, Luzzi R, et al. Phytoproflex: supplementary management of osteoarthritis: a supplement registry. Minerva Med. 2018 Apr;109(2):88-94. View abstract.

Khonche A, Biglarian O, Panahi Y, et al. Adjunctive therapy with curcumin for peptic ulcer: a randomized controlled trial. Drug Res (Stuttg). 2016 Aug;66(8):444-8. View abstract.

Sterzi S, Giordani L, Morrone M, Lena E, et al. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate, and bio-circumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study. Eur J Phys Rehabil Med. 2016 Jun;52(3):321-30. View abstract.

Portincasa P, Bonfrate L, Scribano ML, et al. Curcumin and fennel essential oil improve symptoms and quality of life in patients with irritable bowel syndrome. J Gastrointestin Liver Dis. 2016 Jun;25(2):151-7. View abstract.

Lang A, Salomon N, Wu JC, et al. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1444-9. View abstract.

Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. View abstract.

Skiba MB, Luis PB, Alfarara C, Billheimer D, Schneider C, Funk JL. Curcuminoid content and safety-related markers of quality of turmeric dietary supplements sold in an urban retail marketplace in the United States. Mol Nutr Food Res. 2018 May 29:e1800143 [Epub ahead of print] View abstract.

Cruz-Correa M, Hylind LM, Marrero JH, et al. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology. 2018 May 23. Pii:S0016-5085(18)34564-5. [Epub ahead of print] View abstract.

Karlapudi V, Prasad Mungara AVV, Sengupta K, Davis BA, Rachaudhuri SP. A placebo-controlled double-blind study demonstrates the clinical efficacy of a novel herbal formulation for relieving joint discomfort in human subjects with osteoarthritis of knee. J Med Food. 2018 May;21(5):511-520. View abstract.

Bahraini P, Rajabi M, Mansouri P, Sarafian G, Chalangari R, Azizian Z. Turmeric tone as a treatment in scalp psoriasis: a randomized placebo-control clinical trial. J Cosmet Dermatol. 2018 Jun;17(3):461-466. View abstract.

Rahmani S, Asgary S, Askari G, et al. Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res. 2016 Sep;30(9):1540-8. View abstract.

Panahi Y, Kinpour P, Mohtashami R, Jafari R, Simental-Mendia LE, Sahebkar A. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res (Stuttg). 2017 Apr;67(4):244-51. View abstract.

Lopez-Villafuerte L, CLores KH. Contact dermatitis caused by turmeric in a massage oil. Contact Dermatitis. 2016 Jul;75(1):52-3. View abstract.

Khayat S, Fanaei H, Kherikhah M, Moghadam ZB, Kasaeian A, Javadimehr M. Curcumin attenuates severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2015 Jun;23(3):318-24. View abstract.

Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 2015;115(8):1769-77. View abstract.

Amin F, Islam N, Anila N, Gilani AH. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial. Complement Ther Med. 2015;23(2):165-74. View abstract.

Grammatikopoulou MG, Gkiouras K, Theodoridis X, Asteriou E, Forbes A, Bogdanos DP. Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2018;10(11). pii: E1737. View abstract.

Lukefahr AL, McEvoy S, Alfafara C, Funk JL. Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use. BMJ Case Rep. 2018. pii: bcr-2018-224611. View abstract.

Maulina T, Diana H, Cahyanto A, Amaliya A. The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial. J Oral Rehabil. 2018;45(9):677-683. View abstract.

Mohammadi E, Tamaddoni A, Qujeq D, et al. An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in ß-thalassemia major patients: A double-blind randomized controlled clinical trial. Phytother Res. 2018;32(9):1828-1835. View abstract.

Palatty PL, Azmidah A, Rao S, et al. Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study. Br J Radiol. 2014;87(1038):20130490. View abstract.

Pandaran Sudheeran S, Jacob D, Natinga Mulakal J, et al. Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. J Clin Psychopharmacol. 2016;36(3):236-43. View abstract.

Scontre VA, Martins JC, de Melo Sette CV, et al. Curcuma longa (Turmeric) for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Pilot Study. J Diet Suppl. 2018;15(5):606-612. View abstract.

Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res. 2014;28(12):1770-7. View abstract.

Manarin G, Anderson D, Silva JME, et al. Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial. J Ethnopharmacol. 2019;238:111882. View abstract.

Abidi A, Gupta S, Agarwal M, Bhalla HL, Saluja M. Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma. J Clin Diagn Res. 2014;8(8):HC19-24. View abstract.

Goodarzi R, Sabzian K, Shishehbor F, Mansoori A. Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(3):561-570. View abstract.

Saadipoor A, Razzaghdoust A, Simforoosh N, et al. Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy. Phytother Res. 2019;33(2):370-378. View abstract.

Tabrizi R, Vakili S, Akbari M, et al. The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(2):253-262. View abstract.

Zhu LN, Mei X, Zhang ZG, Xie YP, Lang F. Curcumin intervention for cognitive function in different types of people: A systematic review and meta-analysis. Phytother Res. 2019;33(3):524-533. View abstract.

Medsafe Safety Communication- Turmeric/Curcumin Interaction with Warfarin. April 30, 2018. Accessed at: https://medsafe.govt.nz/safety/EWS/2018/Turmeric.asp.

Raghava KV, Sistla KP, Narayan SJ, Yadalam U, Bose A, Mitra K. Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial. J Contemp Dent Pract. 2019;20(7):842-846. View abstract.

Srinivasan A, Selvarajan S, Kamalanathan S, Kadhiravan T, Prasanna Lakshmi NC, Adithan S. Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial. Phytother Res. 2019;33(7):1898-1911. View abstract.

Burgos-Morón E, Calderón-Montaño JM, Salvador J, Robles A, López-Lázaro M. The dark side of curcumin. Int J Cancer. 2010;126(7):1771-5. View abstract.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218. View abstract.

Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 2020;60(1):171-80. doi: 10.1080/10408398.2018.1517724. View abstract.

Imam Z, Khasawneh M, Jomaa D, Iftikhar H, Sayedahmad Z. Drug induced liver injury attributed to a curcumin supplement. Case Rep Gastrointest Med 2019 Oct 20;2019:6029403. doi: 10.1155/2019/6029403. View abstract.

Rai A, Kaur M, Gombra V, Hasan S, Kumar N. Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis. J Investig Clin Dent 2019;10(4):e12464. doi: 10.1111/jicd.12464. View abstract.

Hallajzadeh J, Milajerdi A, Kolahdooz F, Amirani E, Mirzaei H, Asemi Z. The effects of curcumin supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2019;33(11):2989-95. doi: 10.1002/ptr.6477. View abstract.

Hashemzadeh K, Davoudian N, Jaafari MR, Mirfeizi Z. The effect of nanocurcumin on the improvement symptoms of knee osteoarthritis: a randomized clinical trial. Curr Rheumatol Rev 2019 Dec 23. doi: 10.2174/1874471013666191223152658. [Epub ahead of print]. View abstract.

Ghaffari A, Rafraf M, Navekar R, Sepehri B, Asghari-Jafarabadi M, Ghavami SM. Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD). Int J Vitam Nutr Res 2019;89(5-6):293-302. doi: 10.1024/0300-9831/a000568. View abstract.

Chand S, Hair C, Beswick L. A rare case of turmeric-induced hepatotoxicity. Intern Med J. 2020;50(2):258-259. View abstract.

Jiang N, Zhang M, Meng X, Sun B. Effects of Curcumin on the Pharmacokinetics of Amlodipine in Rats and Its Potential Mechanism. Pharm Biol. 2020;58(1):465-468. View abstract.

Lee BS, Bhatia T, Chaya CT, Wen R, Taira MT, Lim BS. Autoimmune Hepatitis Associated With Turmeric Consumption. ACG Case Rep J. 2020;7(3):e00320. View abstract.

Lombardi N, Crescioli G, Maggini V, et al. Acute liver injury following turmeric use in Tuscany: an analysis of the Italian Phytovigilance database and systematic review of case reports. Br J Clin Pharmacol. 2020. View abstract.

Suhail FK, Masood U, Sharma A, John S, Dhamoon A. Turmeric supplement induced hepatotoxicity: a rare complication of a poorly regulated substance. Clin Toxicol (Phila). 2020;58(3):216-217. View abstract.

Malekzadeh M, Kia SJ, Mashaei L, Moosavi MS. Oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis. Clin Exp Dent Res. 2020. doi: 10.1002/cre2.330. Online ahead of print. View abstract.

Calderón-Pérez L, Llaurad E, Companys J, et al. Acute effects of turmeric extracts on knee joint pain: a pilot, randomized controlled trial. J Med Food. 2020. doi: 10.1089/jmf.2020.0074. Online ahead of print. View abstract.

Nakagawa Y, Mukai S, Yamada S, et al. The efficacy and safety of highly-bioavailable curcumin for treating knee osteoarthritis: a 6-month open-labeled prospective study. Clin Med Insights Arthritis Musculoskelet Disord. 2020;13:1179544120948471. View abstract.

Shafabakhsh R, Asemi Z, Reiner Z, Soleimani A, Aghadavod E, Bahmani F. The effects of nano-curcumin on metabolic status in patients with diabetes on hemodialysis, a randomized, double blind, placebo-controlled trial. Iran J Kidney Dis. 2020;14(4):290-9. View abstract.

Haines SR, McCann MJ, Grosvenor AJ, Thomas A, Noble A, Clerens S. ACE inhibitory peptides in standard and fermented deer velvet: an in silico and in vitro investigation. BMC Complement Altern Med. 2019 Dec 5;19(1):350. View abstract.

Kia SJ, Basirat M, Mortezaie T, Moosavi MS. Comparison of oral nano-curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial. BMC Complement Med Ther 2020;20(1):328. View abstract.

Raman P, Pitty R, Krithika CL, Anand SPN, Subramani GP. Topical curcumin and triamcinolone acetonide in recurrent minor aphthous ulcers: a pilot trial. J Contemp Dent Pract 2020;21(8):884-90. View abstract.

Sawangroj N, Budkaew J, Chumworathayi B. Efficacy of Curcuma longa in treatment of postprandial distress syndrome: an open-label randomized-controlled trial. F1000Res 2019;8:1827. doi: 10.12688/f1000research.20662.1. View abstract.

Jamali N, Adib-Hajbaghery M, Soleimani A. The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial. BMC Complement Med Ther 2020;20(1):305. View abstract.

Altobelli E, Angeletti PM, Marziliano C, Mastrodomenico M, Giuliani AR, Petrocelli R. Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes - a meta-analysis of randomized controlled trial. Nutrients 2021;13(2):404. doi: 10.3390/nu13020404. View abstract.

Saber-Moghaddam N, Salari S, Hejazi S, et al. Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial. Phytother Res 2021 Jan 3. doi: 10.1002/ptr.7004. View abstract.

Nerkar Rajbhoj A, Kulkarni TM, Shete A, Shete M, Gore R, Sapkal R. A comparative study to evaluate efficacy of curcumin and aloe vera gel along with oral physiotherapy in the management of oral submucous fibrosis: a randomized clinical trial. Asian Pac J Cancer Prev 2021;22(S1):107-12. doi: 10.31557/APJCP.2021.22.S1.107. View abstract.

Heshmati J, Moini A, Sepidarkish M, et al. Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Phytomedicine 2021 Jan;80:153395. doi: 10.1016/j.phymed.2020.153395. View abstract.

Shah S, Rath H, Sharma G, Senapati SN, Mishra E. Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: a triple-blind, pilot randomised controlled trial. Indian J Dent Res 2020;31(5):718-27. View abstract.

Wang Z, Singh A, Jones G, et al. Efficacy and safety of turmeric extracts for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomised controlled trials. Curr Rheumatol Rep 2021 Jan 28;23(2):11. doi: 10.1007/s11926-020-00975-8. View abstract.

Wang Z, Zhang Q, Huang H, Liu Z. The efficacy and acceptability of curcumin for the treatment of depression or depressive symptoms: a systematic review and meta-analysis. J Affect Disord 2021;282:242-51. View abstract.

Mokhtari M, Razzaghi R, Momen-Heravi M. The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Phytother Res 2020 Nov 16. doi: 10.1002/ptr.6957. View abstract.

Varma K, Amalraj A, Divya C, Gopi S. The efficacy of the novel bioavailable curcumin (Cureit) in the management of sarcopenia in healthy elderly subjects: a randomized, placebo-controlled, double-blind clinical study. J Med Food 2021;24(1):40-9. View abstract.

Karandish M, Mozaffari-Khosravi H, Mohammadi SM, Cheraghian B, Azhdari M. The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design. Phytother Res. 2021;35(8):4377-4387. View abstract.

Passildas-Jahanmohan J, Eymard JC, Pouget M, et al. Multicenter randomized phase II study comparing docetaxel plus curcumin versus docetaxel plus placebo in first-line treatment of metastatic castration-resistant prostate cancer. Cancer Med. 2021;10(7):2332-2340. View abstract.

Pawar KS, Mastud RN, Pawar SK, et al. Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial. Front Pharmacol. 2021;12:669362. View abstract.

Chien YJ, Chang CY, Wu MY, Chen CH, Horng YS, Wu HC. Effects of curcumin on glycemic control and lipid profile in polycystic ovary syndrome: Systematic review with meta-analysis and trial sequential analysis. Nutrients. 2021;13(2):684. View abstract.

Donovan EK, Kekes-Szabo S, Lin JC, et al. A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for gulf war illness: Curcumin (Curcuma longa), boswellia (Boswellia serrata), and French maritime pine bark (Pinus pinaster). Int J Environ Res Public Health. 2021;18(5):2468. View abstract.

Thanawala S, Shah R, Somepalli V, Alluri KV, Desomayanandam P, Bhuvanendran A. A multicenter, randomized, double-blind, placebo-controlled trial assessing efficacy and safety of a novel low-dose turmeric extract formulation in healthy adults with chronic knee pain. Clin Pharmacol. 2021;13:91-100. View abstract.

Saberi-Karimian M, Ghazizadeh H, Mohammadzadeh E, Ferns GA, Ghayour-Mobarhan M, Sahebkar A. Does curcumin have an effect on sleep duration in metabolic syndrome patients? Avicenna J Phytomed. 2021;11(2):190-198. View abstract.

Soni TP, Gupta AK, Sharma LM, Singhal H, Sharma S, Gothwal RS. A randomized, placebo-controlled study to evaluate the effect of bio-enhanced turmeric formulation on radiation-induced oral mucositis. ORL J Otorhinolaryngol Relat Spec. 2021:1-11. View abstract.

Rai A, Kumar N, Sharma S, Parveen S, Rasheed A. Turmeric in the management of oral submucous fibrosis: A systematic review and meta-analysis. J Cancer Res Ther. 2021;17(2):327-335. View abstract.

Bateni Z, Rahimi HR, Hedayati M, Afsharian S, Goudarzi R, Sohrab G. The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial. Phytother Res. 2021;35(7):3945-3953. View abstract.

Al-Maweri SA, Alhajj MN, Deshisha EA, et al. Curcumin mouthwashes versus chlorhexidine in controlling plaque and gingivitis: A systematic review and meta-analysis. Int J Dent Hyg. 2021. View abstract.

Sohrevardi SM, Heydari B, Azarpazhooh MR, et al. Therapeutic effect of curcumin in women with polycystic ovary syndrome receiving metformin: A randomized controlled trial. Adv Exp Med Biol. 2021;1308:109-117. View abstract.

Mirhafez SR, Azimi-Nezhad M, Dehabeh M, et al. The effect of curcumin phytosome on the treatment of patients with non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled trial. Adv Exp Med Biol. 2021;1308:25-35. View abstract.

Panahi Y, Karbasi A, Valizadegan G, et al. Effect of curcumin on severity of functional dyspepsia: a triple blinded clinical trial. Adv Exp Med Biol. 2021;1308:119-126. View abstract.

Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study. J Pharm Pharmacol. 2021;73(6):816-823. View abstract.

Zegota Z, Gozdzik J, Glogowska-Szelag J. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. Adv Orthop. 2021;2021:5589597. View abstract.

Hsiao AF, Lien YC, Tzeng IS, Liu CT, Chou SH, Horng YS. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis. Complement Ther Med 2021;63:102775. View abstract.

Ashtary-Larky D, Rezaei Kelishadi M, Bagheri R, et al. The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Antioxidants (Basel) 2021;10(7):1015. View abstract.

Ebrahimzadeh A, Abbasi F, Ebrahimzadeh A, Jibril AT, Milajerdi A. Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis. Complement Ther Med 2021;61:102773. View abstract.

Gorabi AM, Abbasifard M, Imani D, et al. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytother Res 2021. View abstract.

Tatapudi R, Abdul Samad SK, Manyam R, Dasari D, Lakshmi RV. Efficacy of curcumin in the treatment of denture stomatitis: A randomized double-blind study. J Oral Maxillofac Pathol 2021;25(2):286-291. View abstract.

Lorinczova HT, Begum G, Renshaw D, Zariwala MG. Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial. Nutrients 2021;13(7):2300. View abstract.

Qiao J, Gan Y, Gong Y, et al. Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study. Transl Androl Urol 2021;10(8):3432-3439. View abstract.

Kia SJ, Basirat M, Saedi HS, Arab SA. Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial. BMC Complement Med Ther 2021;21(1):232. View abstract.

Yongwatana K, Harinwan K, Chirapongsathorn S, et al. Curcuma longa Linn Versus Omeprazole in Treatment of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Trial. J Gastroenterol Hepatol 2021. View abstract.

Ahmadi R, Salari S, Sharifi MD, et al. Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial. Food Sci Nutr 2021;9(8):4068-4075. View abstract.

Salehi M, Mashhadi NS, Esfahani PS, Feizi A, Hadi A, Askari G. The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Int J Prev Med 2021;12:94. View abstract.

Bahrami A, Zarban A, Rezapour H, Agha Amini Fashami A, Ferns GA. Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple-blind, placebo-controlled clinical trial. Phytother Res 2021. View abstract.

Zhang T, He Q, Liu Y, Chen Z, Hu H. Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med 2021;2021:4471944. View abstract.

Terby S, Shereef M, Ramanarayanan V, Balakrishnan B. The effect of curcumin as an adjunct in the treatment of chronic periodontitis: A systematic review and meta-analysis. Saudi Dent J 2021;33(7):375-385. View abstract.

Panahi Y, Saberi-Karimian M, Valizadeh O, et al. Effects of curcuminoids on systemic inflammation and quality of life in patients with colorectal cancer undergoing chemotherapy: A randomized controlled trial. Adv Exp Med Biol 2021;1328:1-9. View abstract.

Allegri P, Rosa R, Masala A, et al. Clinical effectiveness of a new oral curcumin formulation in acute non-infectious uveitic macular edema: a 12-month observational study. Eur Rev Med Pharmacol Sci 2022;26(1):46-53. View abstract.

Panahi Y, Vahedian-Azimi A, Saadat A, et al. The effects of curcumin on the side effects of anticancer drugs in chemotherapy: A randomized controlled trial. Adv Exp Med Biol 2021;1328:255-273. View abstract.

Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. The effect of curcumin differs on individual cognitive domains across different patient populations: A systematic review and meta-analysis. Pharmaceuticals (Basel) 2021;14(12):1235. View abstract.

Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: Pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of lepidium sativum and curcuma longa. Xenobiotica 2022;1-9. View abstract.

Jie Z, Chao M, Jun A, Wei S, LiFeng M. Effect of curcumin on diabetic kidney disease: A systematic review and meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Evid Based Complement Alternat Med 2021;2021:6109406. View abstract.

Tabaee S, Sahebkar A, Aghamohammadi T, et al. The effects of curcumin plus piperine supplementation in patients with acute myocardial infarction: A randomized, double-blind, and placebo-controlled Trial. Adv Exp Med Biol 2021;1328:199-211. View abstract.

Rezaie S, Askari G, Khorvash F, Tarrahi MJ, Amani R. Effects of curcumin supplementation on clinical features and inflammation, in migraine patients: A double-blind controlled, placebo randomized clinical trial. Int J Prev Med 2021;12:161. View abstract.

Nowak KL, Farmer-Bailey H, Wang W, et al. Curcumin therapy to treat vascular dysfunction in children and young adults with ADPKD: A randomized controlled trial. Clin J Am Soc Nephrol 2022;17(2):240-250. View abstract.

Lopresti AL, Smith SJ, Jackson-Michel S, Fairchild T. An investigation into the effects of a curcumin extract (Curcugen ®) on osteoarthritis pain of the knee: A randomised, double-blind, placebo-controlled study. Nutrients 2021;14(1):41. View abstract.

Asadirad A, Nashibi R, Khodadadi A, et al. Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial. Phytother Res 2022;36(2):1023-1031. View abstract.

Mirhafez SR, Dehabeh M, Hariri M, et al. Curcumin and piperine combination for the treatment of patients with non-alcoholic fatty liver disease: A double-blind randomized placebo-controlled trial. Adv Exp Med Biol 2021;1328:11-19. View abstract.

Arabnezhad L, Mohammadifard M, Rahmani L, Majidi Z, Ferns GA, Bahrami A. Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study. BMC Complement Med Ther 2022;22(1):19. View abstract.

Sohal A, Alhankawi D, Sandhu S, Chintanaboina J. Turmeric-induced hepatotoxicity: Report of 2 cases. Int Med Case Rep J 2021;14:849-852. View abstract.

Hussaarts KGAM, Hurkmans DP, Oomen-de Hoop E, et al. Impact of curcumin (with or without piperine) on the pharmacokinetics of tamoxifen. Cancers (Basel). 2019;11(3):403. View abstract.

Saeidnia M, Fazeli P, Erfani M, Nowrouzi-Sohrabi P, Tamaddon G, Karimi M. The Effect of Curcumin on Iron Overload in Patients with Beta-Thalassemia Intermedia. Clin Lab 2022;68(3). View abstract.

Yin J, Wei L, Wang N, Li X, Miao M. Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis. J Ethnopharmacol 2022;289:115041. View abstract.

Naeini F, Tutunchi H, Razmi H, et al. Does nano-curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial. J Food Biochem 2022;46(5):e14093. View abstract.

Elyasi S, Rasta S, Taghizadeh-Kermani A, Hosseini S. Topical henna and curcumin (Alpha®) ointment efficacy for prevention of capecitabine induced hand-foot syndrome: A randomized, triple-blinded, placebo-controlled clinical. Daru 2022;30(1):117-125. View abstract.

Pourhabibi-Zarandi F, Rafraf M, Zayeni H, Asghari-Jafarabadi M, Ebrahimi AA. Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res 2022;36(4):1797-1806. View abstract.

Kalluru H, Mallayasamy SR, Kondaveeti SS, Chandrasekhar V, Kalachaveedu M. Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: A study with population pharmacokinetics approach. Phytother Res 2022;36(4):1761-1769. View abstract.

Yuan F, Wu W, Ma L, et al. Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2022;177:106121. View abstract.

Malekmakan L, Hamidianjahromi A, Sayadi M, Rezazadeh MH. Efficacy and safety of turmeric dietary supplementation on proteinuria in CKD: A systematic review and meta-analysis of RCT. Iran J Kidney Dis 2022;16(3):153-161. View abstract.

Rudrappa GH, Murthy M, Saklecha S, Kumar Kare S, Gupta A, Basu I. Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation: A randomized placebo-controlled double-blinded multicentre study. Medicine (Baltimore) 2022;101(35):e30144. View abstract.

Askari G, Sahebkar A, Soleimani D, et al. The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial. Trials 2022;23(1):472. View abstract.

Ngu MH, Norhayati MN, Rosnani Z, Zulkifli MM. Curcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysis. Complement Ther Med 2022;68:102843. View abstract.

Zeng L, Yang T, Yang K, et al. Efficacy and safety of curcumin and Curcuma longa extract in the treatment of arthritis: A systematic review and meta-analysis of randomized controlled trial. Front Immunol 2022;13:891822. View abstract.

Talakesh T, Tabatabaee N, Atoof F, et al. Effect of nano-curcumin on radiotherapy-induced skin reaction in breast cancer patients: A randomized, triple-blind, placebo-controlled trial. Curr Radiopharm 2022. View abstract.

Bakhshi M, Mahboubi A, Jaafari MR, Ebrahimi F, Tofangchiha M, Alizadeh A. Comparative efficacy of 1% curcumin nanomicelle gel and 2% curcumin gel for treatment of recurrent aphthous stomatitis: A double-blind randomized clinical trial. J Evid Based Dent Pract 2022;22(2):101708. View abstract.

Chaiworramukkul A, Seetalarom K, Saichamchan S, Prasongsook N. A double-blind, placebo-controlled randomized phase IIa study: Evaluating the effect of curcumin for treatment of cancer anorexia-cachexia syndrome in solid cancer patients. Asian Pac J Cancer Prev 2022;23(7):2333-2340. View abstract.

Sangouni AA, Taghdir M, Mirahmadi J, Sepandi M, Parastouei K. Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial. Nutr J 2022;21(1):62. View abstract.

Naseri K, Saadati S, Yari Z, et al. Curcumin offers no additional benefit to lifestyle intervention on cardiometabolic status in patients with non-alcoholic fatty liver disease. Nutrients 2022;14(15):3224. View abstract.

Bankowski S, Petr M, Rozpara M, Sadowska-Krepa E. Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners. Redox Rep 2022;27(1):186-192. View abstract.

109288 Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver injury associated with turmeric-A growing problem: Ten cases from the drug-induced liver injury network [DILIN]. Am J Med. 2022:S0002-9343(22)00740-9. View abstract.

Chitre D, Nadkarni S, Jagtap N, et al. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Phytother Res 2022. View abstract.

Arabi SM, Bahari H, Hamidipor S, et al. The effects of curcumin-containing supplements on inflammatory biomarkers in hemodialysis patients: A systematic review and meta-analysis. Phytother Res 2022;36(12):4361-4370. View abstract.

Shen W, Qu Y, Jiang H, et al. Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis. Front Endocrinol (Lausanne) 2022;13:1051111. View abstract.

Saeedi F, Farkhondeh T, Roshanravan B, Amirabadizadeh A, Ashrafizadeh M, Samarghandian S. Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials. Arch Physiol Biochem 2022;128(6):1493-1502. View abstract.

Arzallus T, Izagirre A, Castiella A, Torrente S, Garmendia M, Zapata EM. Drug induced autoimmune hepatitis after turmeric intake. Gastroenterol Hepatol 2023. View abstract.

Feng J, Li Z, Tian L, et al. Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2022;22(1):276. View abstract.

Gilad O, Rosner G, Ivancovsky-Wajcman D, et al. Efficacy of wholistic turmeric supplement on adenomatous polyps in patients with familial adenomatous polyposis-A randomized, double-blinded, placebo-controlled study. Genes (Basel) 2022;13(12):2182. View abstract.

Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry. 2022;23(6):424-455. View abstract.

Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33. View abstract.

Majeed M, Nagabhushanam K, Devarajan TV, Saklecha S, Reddy SVK, Mundkur L. A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study. Food Funct 2023;14(10):4722-4733. View abstract.

Rózanski G, Tabisz H, Zalewska M, et al. Meta-Analysis of Exploring the Effect of Curcumin Supplementation with or without Other Advice on Biochemical and Anthropometric Parameters in Patients with Metabolic-Associated Fatty Liver Disease (MAFLD). Int J Environ Res Public Health 2023;20(5):4266. View abstract.

Lukkunaprasit T, Tansawet A, Boonmanunt S, et al. An updated meta-analysis of effects of curcumin on metabolic dysfunction-associated fatty liver disease based on available evidence from Iran and Thailand. Sci Rep 2023;13(1):5824. View abstract.

Ramezani V, Ghadirian S, Shabani M, Boroumand MA, Daneshvar R, Saghafi F. Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial. BMC Cancer 2023;23(1):354. View abstract.

Unhapipatpong C, Polruang N, Shantavasinkul PC, Julanon N, Numthavaj P, Thakkinstian A. The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials. Am J Clin Nutr 2023;117(5):1005-1016. View abstract.

Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res 2023;37(4):1703-1728. View abstract.

Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Cytokine 2023;164:156144. View abstract.

Mirzaei Dahka S, Afsharfar M, Tajaddod S, et al. Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Asian Pac J Cancer Prev 2023;24(3):783-789. View abstract.

Ghanbarzadeh-Ghashti N, Ghanbari-Homaie S, Shaseb E, Abbasalizadeh S, Mirghafourvand M. The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial. BMC Endocr Disord 2023;23(1):40. View abstract.

Hansell EJ, Brett A, Škarabot J, James LJ, Clifford T. Curcumin Attenuates Delayed-Onset Muscle Soreness and Muscle Function Deficits Following a Soccer Match in Male Professional Soccer Players. Int J Sports Physiol Perform 2023;18(4):347-353. View abstract.

Mankowski RT, Sibille KT, Leeuwenburgh C, et al. Effects of Curcumin C3 Complex® on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation - A Pilot Trial. J Frailty Aging 2023;12(2):143-149. View abstract.

Long Z, Xiang W, He Q, et al. Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials. Front Immunol. 2023;14:1024120. View abstract.

Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. View abstract.

Kongkam P, Khongkha W, Lopimpisuth C, et al. Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial. BMJ Evid Based Med. 2023 Sep 11:bmjebm-2022-112231. Epub ahead of print. View abstract.

Leong XY, Gopinath D, Syeed SM, Veettil SK, Shetty NY, Menon RK. Comparative Efficacy and Safety of Interventions for the Treatment of Oral Lichen Planus: A Systematic Review and Network Meta-Analysis. J Clin Med 2023;12(8):2763. View abstract.

Pochet S, Lechon AS, Lescrainier C, et al. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Sci Rep 2022;12(1):14178. View abstract.

D'Orio M, De Vitis R, Taccardo G, et al. Clinical usefulness of nutraceutics with acetyl-L-carnitine, a-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study. Acta Biomed 2023;94(S2):e2023050. View abstract.

Tamoli SM, Harit MK, Mundhe N, Pande SP, Damle N, Chavan S, Kamde R, Pawar VA, Mahadik S. Nicotine Free Herbal Composition for Smoking De-Addiction - A Placebo Controlled, Double Blind, Randomized, Multicentric Clinical Study. J Pharm Bioallied Sci. 2023;15(2):88-94. View abstract.

Kou H, Huang L, Jin M, He Q, Zhang R, Ma J. Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis. Front Immunol 2023;14:1121655. View abstract.

Qiu L, Gao C, Wang H, et al. Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne) 2023;14:1216708. View abstract.

Dehzad MJ, Ghalandari H, Amini MR, Askarpour M. Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Complement Ther Med 2023;75:102955. View abstract.

Agarwal D, Chaudhary P. Effect of Turmeric-Boswellia-Sesame Formulation in Menstrual Cramp Pain Associated with Primary Dysmenorrhea-A Double-Blind, Randomized, Placebo-Controlled Study. J Clin Med 2023;12(12):3968. View abstract.

Mobeen S, Sv R, Jd S, et al. A novel herbal paste formulation of turmeric, tulsi, and honey for the treatment of oral submucous fibrosis. Cureus. 2023;15(10):e46608. View abstract.

Sato T, Yagi A, Yamauchi M, et al. The use of an antioxidant enables accurate evaluation of the interaction of curcumin on organic anion-transporting polypeptides 4C1 by preventing auto-oxidation. Int J Mol Sci 2024;25(2):991. View abstract.

Erol Dogan Ö, Karaca Çelik KE, Bas M, Alan EH, Çagin YF. Effects of Mediterranean diet, curcumin, and resveratrol on mild-to-moderate active ulcerative colitis: A multicenter randomized clinical trial. Nutrients 2024;16(10):1504. View abstract.

Washington O, Robinson E, Simh D, et al. Oxalate nephropathy and chronic turmeric supplementation: a case report. J Bras Nefrol 2024;46(1):99-106. View abstract.

Lustberg M, Fan-Havard P, Wong FL, et al. Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial. Breast Cancer Res Treat 2024;205(1):61-73. View abstract.

Wade U, Pascual-Figal DA, Rabbani F, et al. The possible synergistic pharmacological effect of an oral berberine (BBR) and curcumin (CUR) complementary therapy alleviates symptoms of irritable bowel syndrome (IBS): Results from a real-life, routine clinical practice settings-based study. Nutrients 2024;16(8):1204. View abstract.

Munshi R, Karande-Patil S, Kumbhar D, Deshmukh A, Hingorani L. A randomized, controlled, comparative, proof-of-concept study to evaluate the efficacy and safety of Nisha-Amalaki capsules in prediabetic patients for preventing progression to diabetes. J Ayurveda Integr Med. 2023;14(6):100806. View abstract.

Sharifi Razavi A, Mohajerani F, Niksolat F, Karimi N. Efficacy of topical curcumin on mild to moderate carpal tunnel syndrome: a randomized double-blind, placebo-controlled clinical trial. Pain Med 2024;25(5):327-333. View abstract.

Baharizade M, Ghetmiri SI, Mohammady M, Mohammadi-Samani S, Yousefi G. Revolutionizing knee osteoarthritis treatment: Innovative self-nano-emulsifying polyethylene glycol organogel of curcumin for effective topical delivery. AAPS PharmSciTech 2024;25(4):80. View abstract.

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Dehzad MJ, Ghalandari H, Askarpour M. Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Clin Nutr ESPEN 2024;59:194-207. View abstract.

Gudarzi R, Shabani F, Mohammad-Alizadeh-Charandabi S, Naghshineh E, Shaseb E, Mirghafourvand M. Effect of curcumin on painful symptoms of endometriosis: A triple-blind randomized controlled trial. Phytother Res 2024;38(1):147-155. View abstract.

Kumar S, Sharma SK, Mudgal SK, et al. Comparative effectiveness of six herbs in the management of glycemic status of type 2 diabetes mellitus patients: A systematic review and network meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2023;17(8):102826. View abstract.

Moayeri H, Rajabi A, Mohammadi M, Moghaddam SB. Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study. BMC Oral Health 2024;24(1):104. View abstract.

Saeidnia M, Ghaderi A, Erfani M, et al. Suppression of Growth Differentiation Factor 15 Gene Expression by Curcumin in Patients with Beta-Thalassemia Intermedia. Clin Lab 2024;70(1). View abstract.

Zhao J, Liang G, Zhou G, et al. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis. J Ethnopharmacol 2024;321:117493. View abstract.