References
Stevia
11
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
3300
Tomita T, Sato N, Arai T, et al. Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria. Microbiol Immunol 1997;41:1005-9. View abstract.
3301
Curi R, Alvarez M, Bazotte RB, et al. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Braz J Med Biol Res 1986;19:771-4. View abstract.
3745
Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. View abstract.
3746
Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75. View abstract.
3747
Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. View abstract.
3748
Matsui M, Matsui K, Kawasaki Y, et al. Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis 1996;11:573-9. View abstract.
3749
Pezzuto JM, Compadre CM, Swanson SM, et al. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc Natl Acad Sci USA 1985;82:2478-82. View abstract.
3750
Hubler MO, Bracht A, Kelmer-Bracht AM. Influence of stevioside on hepatic glycogen levels in fasted rats. Res Commun Chem Pathol Pharmacol 1994;84:111-8. View abstract.
5031
Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. View abstract.
5032
Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism 2000;49:208-14. View abstract.
5033
Melis MS. Effects of chronic administration of Stevia rebaudiana on fertility in rats. J Ethnopharmacol 1999;67:157-61. View abstract.
5035
Toskulkao C, Sutheerawatananon M, Wanichanon C, et al. Effects of stevioside and steviol on intestinal glucose absorption in hamsters. J Nutr Sci Vitaminol (Tokyo) 1995;41:105-13. View abstract.
5036
Wasuntarawat C, Temcharoen P, Toskulkao C, et al. Developmental toxicity of steviol, a metabolite of stevioside, in the hamster. Drug Chem Toxicol 1998;21:207-22. View abstract.
11808
FDA. Office of Regulatory Affairs. Automatic detention of stevia leaves, extract of stevia leaves, and food containing stevia. http://www.fda.gov/ora/fiars/ora_import_ia4506.html (Accessed 21 April 2004).
11809
Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. View abstract.
11810
Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. View abstract.
11811
Geuns JM. Stevioside. Phytochemistry 2003;64:913-21. View abstract.
11812
Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. View abstract.
11813
Lailerd N, Saengsirisuwan V, Sloniger JA, et al. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. Metabolism 2004;53:101-7. View abstract.
16699
CFSAN/Office of Food Additive Safety. GRAS Notices Received in 2008. GRN No. 252. U.S. Food and Drug Administration, December 2008. Available at: http://www.cfsan.fda.gov/~rdb/opa-gn08.html.
16700
CFSAN/Office of Food Additive Safety. Agency Response Letter: GRAS Notice No. 000252. U.S. Food and Drug Administration, December 17, 2008. Available at: http://www.cfsan.fda.gov/~rdb/opa-g252.html.
16701
Brusick DJ. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem Toxicol 2008;46 Suppl 7:S83-91. View abstract.
16702
Maki KC, Curry LL, Carakostas MC, et al. The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. Food Chem Toxicol 2008;46 Suppl 7:S40-6. View abstract.
16703
Prakash I, Dubois GE, Clos JF, et al. Development of rebiana, a natural, non-caloric sweetener. Food Chem Toxicol 2008;46 Suppl 7:S75-82. View abstract.
16704
Boonkaewwan C, Ao M, Toskulkao C, Rao MC. Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells. J Agric Food Chem 2008;56:3777-84. View abstract.
16705
Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Regul Toxicol Pharmacol 2008;51:37-41. View abstract.
16706
Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. View abstract.
76308
Lee, C. N., Wong, K. L., Liu, J. C., Chen, Y. J., Cheng, J. T., and Chan, P. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Med 2001;67(9):796-799. View abstract.
76309
Jeppesen, P. B., Gregersen, S., Alstrup, K. K., and Hermansen, K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine 2002;9(1):9-14. View abstract.
76313
Yasukawa, K., Kitanaka, S., and Seo, S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol Pharm Bull. 2002;25(11):1488-1490. View abstract.
76314
Koyama, E., Kitazawa, K., Ohori, Y., Izawa, O., Kakegawa, K., Fujino, A., and Ui, M. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food Chem.Toxicol. 2003;41(3):359-374. View abstract.
76316
Jeppesen, P. B., Gregersen, S., Rolfsen, S. E., Jepsen, M., Colombo, M., Agger, A., Xiao, J., Kruhoffer, M., Orntoft, T., and Hermansen, K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism 2003;52(3):372-378. View abstract.
76320
Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., and Pietta, P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J.Agric.Food Chem. 10-22-2003;51(22):6618-6622. View abstract.
76327
Abudula, R., Jeppesen, P. B., Rolfsen, S. E., Xiao, J., and Hermansen, K. Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependency. Metabolism 2004;53(10):1378-1381. View abstract.
76329
Chen, T. H., Chen, S. C., Chan, P., Chu, Y. L., Yang, H. Y., and Cheng, J. T. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med 2005;71(2):108-113. View abstract.
76331
Boonkaewwan, C., Toskulkao, C., and Vongsakul, M. Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. J Agric.Food Chem 2-8-2006;54(3):785-789. View abstract.
76332
Geuns, J. M., Buyse, J., Vankeirsbilck, A., and Temme, E. H. Metabolism of stevioside by healthy subjects. Exp Biol Med (Maywood.) 2007;232(1):164-173. View abstract.
76336
Takasaki, M., Konoshima, T., Kozuka, M., Tokuda, H., Takayasu, J., Nishino, H., Miyakoshi, M., Mizutani, K., and Lee, K. H. Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds. Bioorg.Med.Chem. 1-15-2009;17(2):600-605. View abstract.
76341
Yang, P. S., Lee, J. J., Tsao, C. W., Wu, H. T., and Cheng, J. T. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Neurosci.Lett 4-17-2009;454(1):72-75. View abstract.
76345
Li, J., Jiang, H., and Shi, R. A new acylated quercetin glycoside from the leaves of Stevia rebaudiana Bertoni. Nat.Prod Res 2009;23(15):1378-1383. View abstract.
76361
Chaturvedula, V. S., Rhea, J., Milanowski, D., Mocek, U., and Prakash, I. Two minor diterpene glycosides from the leaves of Stevia rebaudiana. Nat.Prod Commun 2011;6(2):175-178. View abstract.
76366
Chaturvedula, V. S. and Prakash, I. Structures of the novel diterpene glycosides from Stevia rebaudiana. Carbohydr.Res 6-1-2011;346(8):1057-1060. View abstract.
76383
Kinghorn, A. D., Soejarto, D. D., Nanayakkara, N. P., Compadre, C. M., Makapugay, H. C., Hovanec-Brown, J. M., Medon, P. J., and Kamath, S. K. A phytochemical screening procedure for sweet ent-kaurene glycosides in the genus Stevia. J Nat Prod. 1984;47(3):439-444. View abstract.
76384
D'Agostino, M., De Simone, F., Pizza, C., and Aquino, R. [Sterols in Stevia rebaudiana Bertoni]. Boll.Soc Ital Biol Sper. 12-30-1984;60(12):2237-2240. View abstract.
76391
Klongpanichpak, S., Temcharoen, P., Toskulkao, C., Apibal, S., and Glinsukon, T. Lack of mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100. J Med Assoc Thai. 1997;80 Suppl 1:S121-S128. View abstract.
76393
Yadav, A. A review on the improvement of stevia [Stevia rebaudiana (Bertoni). Canadian Journal of Plant Science 2011;91(1):1-27.
76394
Taware, A. S., Mukadam, D. S., and Chavan, A. M. Antimicrobial Activity of Different Extracts of Callus and Tissue Cultured Plantlets of Stevia Rebaudiana (Bertoni). Journal of Applied Science Research 2010;6(7):883-887.
90907
Lemus-Mondaca R, Vega-Galvez A, Zura-Bravo L, Ah-Hen K. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chem. 2012;132(3):1121-1132.
103695
Ajami M, Seyfi M, Abdollah Pouri Hosseini F, et al. Effects of stevia on glycemic and lipid profile of type 2 diabetic patients: A randomized controlled trial. Avicenna J Phytomed. 2020;10(2):118-127. View abstract.
103696
Farhat G, Berset V, Moore L. Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial. Nutrients. 2019;11(12):3036. View abstract.
103697
Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Stevia Beverage Consumption prior to Lunch Reduces Appetite and Total Energy Intake without Affecting Glycemia or Attentional Bias to Food Cues: A Double-Blind Randomized Controlled Trial in Healthy Adults. J Nutr. 2020;150(5):1126-1134. View abstract.
106456
EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, et al. Safety of a proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: to expand the list of steviol glycosides to all those identified in the leaves of Stevia Rebaudiana Bertoni. EFSA J 2020;18(4):e06106. View abstract.
106458
Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. Effects of the Daily Consumption of Stevia on Glucose Homeostasis, Body Weight, and Energy Intake: A Randomised Open-Label 12-Week Trial in Healthy Adults. Nutrients 2020;12(10):3049. View abstract.
106459
Abdel-Aal RA, Abdel-Rahman MS, Al Bayoumi S, Ali LA. Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. J Ethnopharmacol 2021;265:113188. View abstract.
108049
US Food and Drug Administration. Import Alert 45-06: Detention without Physical Examination of Stevia Leaves, Crude Extracts of Stevia Leaves and foods Containing Stevia Leaves and/or Stevia Extracts. October 4, 2021. Available at: https://www.accessdata.fda.gov/cms_ia/importalert_119.html. Accessed on: May 6, 2022.
110124
Sambra V, Vicuña IA, Priken KM, et al. Acute responses of stevia and d-tagatose intake on metabolic parameters and appetite/satiety in insulin resistance. Clin Nutr ESPEN 2022;49:217-224. View abstract.
110125
Simoens C, Philippaert K, Wuyts C, et al. Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. Eur J Drug Metab Pharmacokinet 2022;47(6):827-839. View abstract.