References
Bromelain
11
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Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial. Urol 1999;54:960-3. View abstract.
957
Hotz G, Frank T, Zoller J, Wiebelt H. [Antiphlogistic effect of bromelaine following third molar removal]. Dtsch Zahnarztl Z 1989;44:830-2. View abstract.
958
Valueva TA, Revina TA, Mosolov VV. Potato tuber protein proteinase inhibitors belonging to the Kunitz soybean inhibitor family. Biochemistry (Mosc) 1997;62:1367-74. View abstract.
959
Tanabe S, Tesaki S, Watanabe M, Yanagihara Y. [Cross-reactivity between bromelain and soluble fraction from wheat flour]. Arerugi 1997;46:1170-3. View abstract.
960
Masson M. [Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice]. Fortschr Med 1995;113:303-6. View abstract.
961
Zimacheva AV, Mosolov VV. [Cysteine proteinase inhibitors from soy seeds]. Biokhimiia 1995;60:118-23. View abstract.
962
Zavadova E, Desser L, Mohr T. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation. Cancer Biother 1995;10:147-52. View abstract.
6252
Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest 2000;19:15-23.
6253
Kane S, Goldberg MJ. Use of bromelain for mild ulcerative colitis. Ann Intern Med 2000;132:680. View abstract.
9183
Hale LP, Greer PK, Sempowski GD. Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. Clin Immunol 2002;104:183-90. View abstract.
9184
Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. View abstract.
10622
Stone MB, Merrick MA, Ingersoll CD, et al. Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. Clin J Sport Med 2002;12:373-8.. View abstract.
10639
Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. View abstract.
11457
Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine 2002;9:681-6. View abstract.
14296
Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. View abstract.
14806
Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5. View abstract.
18274
Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. View abstract.
18275
Rosenberg L, Lapid O, Bogdanov-Berezovsky A, et al. Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report. Burns 2004;30:843-50. View abstract.
18276
Ryan RE. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13-17. View abstract.
18277
Taub SJ. The use of bromelains in sinusitis: a double-blind clinical evaluation. Eye Ear Nose Throat Mon 1967;46:361-2. View abstract.
18278
Seltzer AP. Adjunctive use of bromelains in sinusitis: a controlled study. Eye Ear Nose Throat Mon 1967;46:1281, 1284, 1286-8. View abstract.
18279
Taub SJ. The use of Ananase in sinusitis. A study of 60 patients. Eye Ear Nose Throat Mon 1966;45:96, 98. View abstract.
18280
Massimiliano R, Pietro R, Paolo S, et al. Role of bromelain in the treatment of patients with pityriasis lichenoides chronica. J DermatologTreat 2007;18:219-22. View abstract.
18281
Cohen A, Goldman J. Bromelains therapy in rheumatoid arthritis. Pa Med J. 1964;67:27-30. View abstract.
18282
Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53. View abstract.
18283
Gylling U, Rintala A, Taipale S, Tammisto T. The effect of a proteolytic enzyme combinate (bromelain) on the postoperative oedema by oral application. A clinical and experimental study. Acta Chir Scand 1966;131:193-6. View abstract.
18284
Gerard G. [Anticancer treatment and bromelains]. Agressologie 1972;13:261-74. View abstract.
18285
Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. View abstract.
18286
Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. View abstract.
18288
Perez-Camo I, Quirce S, Duran MA, et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51:48.
19321
Notarnicola A, Pesce V, Vicenti G, et al. SWAAT study: extracorporeal shock wave therapy and arginine supplementation and other nutraceuticals for insertional Achilles tendinopathy. Adv Ther. 2012 Sep;29:799-814. View abstract.
19322
Gumina S, Passaretti D, Gurzì MD, et al. Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study. Curr Med Res Opin. 2012 Nov;28:1767-74. View abstract.
24560
Korpan MI, Fialka V. [Wobenzyme and diuretic therapy in lymphedema after breast operation]. Wien Med Wochenschr 1996;146(4):67-72. View abstract.
37190
Seltzer, A. P. Minimizing post-operative edema and ecchymoses by the use of an oral enzyme preparation (bromelain). A controlled study of 53 rhinoplasty cases. Eye Ear Nose Throat Mon. 1962;41:813-817. View abstract.
37192
Hou, R. C., Chen, Y. S., Huang, J. R., and Jeng, K. C. Cross-linked bromelain inhibits lipopolysaccharide-induced cytokine production involving cellular signaling suppression in rats. J Agric.Food Chem 3-22-2006;54(6):2193-2198. View abstract.
37193
Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30. View abstract.
37194
Sideris, C. P. and Young, H. Y. GROWTH OF ANANAS COMOSUS (L.) MERR. AT DIFFERENT LEVELS OF MINERAL NUTRITION UNDER GREENHOUSE AND FIELD CONDITIONS. I. PLANT AND FRUIT WEIGHTS AND ABSORPTION OF NITRATE AND POTASSIUM AT DIFFERENT GROWTH INTERVALS. Plant Physiol 1950;25(4):594-616. View abstract.
37195
Lotz-Winter, H. On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Planta Med 1990;56(3):249-253. View abstract.
37196
Kumakura, S., Yamashita, M., and Tsurufuji, S. Effect of bromelain on kaolin-induced inflammation in rats. Eur.J Pharmacol 6-10-1988;150(3):295-301. View abstract.
37197
Maurer, H. R., Hozumi, M., Honma, Y., and Okabe-Kado, J. Bromelain induces the differentiation of leukemic cells in vitro: an explanation for its cytostatic effects? Planta Med 1988;54(5):377-381. View abstract.
37198
Felton, G. E. Does kinin released by pineapple stem bromelain stimulate production of prostaglandin E1-like compounds? Hawaii Med J 1977;36(2):39-47. View abstract.
37199
Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. View abstract.
37200
Ito, C., Yamaguchi, K., Shibutani, Y., Suzuki, K., Yamazaki, Y., Komachi, H., Ohnishi, H., and Fujimura, H. [Anti-inflammatory actions of proteases, bromelain, trypsin and their mixed preparation (author's transl)]. Nippon Yakurigaku Zasshi 4-20-1979;75(3):227-237. View abstract.
37201
Levine, N., Seifter, E., Connerton, C., and Levenson, S. M. Debridement of experimental skin burns of pigs with bromelain, a pineapple-stem enzyme. Plast.Reconstr.Surg. 1973;52(4):413-424. View abstract.
37202
Izaka, K. I., Yamada, M., Kawano, T., and Suyama, T. Gastrointestinal absorption and antiinflammatory effect of bromelain. Jpn J Pharmacol 1972;22(4):519-534. View abstract.
37203
Weiss, S. and Scherrer, M. [Crossed double-blind trial of potassium iodide and bromelain (Traumanase) in chronic bronchitis]. Schweiz.Rundsch.Med Prax. 10-24-1972;61(43):1331-1333. View abstract.
37204
Howat, R. C. and Lewis, G. D. The effect of bromelain therapy on episiotomy wounds--a double blind controlled clinical trial. J Obstet.Gynaecol.Br.Commonw. 1972;79(10):951-953. View abstract.
37205
Mader, H. [Comparative studies on the effect of bromelin and oxyphenbutazone in episiotomy pains]. Schweiz Rundsch.Med Prax. 8-28-1973;62(35):1064-1068. View abstract.
37206
Spaeth, G. L. The effect of bromelains on the inflammatory response caused by cataract extraction: a double-blind study. Eye Ear Nose Throat Mon. 1968;47(12):634-639. View abstract.
37207
Seligman, B. Oral bromelains as adjuncts in the treatment of acute thrombophlebitis. Angiology 1969;20(1):22-26. View abstract.
37208
Korlof, B., Ponten, B., and Ugland, O. Bromelain--a proteolytic enzyme. Scand.J.Plast.Reconstr.Surg. 1969;3(1):27-29. View abstract.
37209
Cowie, D. H., Fairweather, D. V., and Newell, D. J. A double-blind trial of bromelains as an adjunct to vaginal plastic repair operations. J Obstet Gynaecol Br Commonw. 1970;77(4):365-368. View abstract.
37210
Koshiishi, T., Furusawa, Y., Iseki, H., and Iwasaki, Y. A double blind study of the effects of Kimotab on engorgement of the breast. Acta Obstet.Gynaecol.Jpn. 1971;18(4):222-228. View abstract.
37211
Zatuchni, G. I. and Colombi, D. J. Bromelains therapy for the prevention of episiotomy pain. Obstet Gynecol. 1967;29(2):275-278. View abstract.
37212
Kagitomi, T. and Shozuka, K. [Effect of bromelain in chronic sinusitis]. Jibiinkoka 1966;38(4):433-437. View abstract.
37213
Hine, S. and Tamura, N. [Clinical use of bromelain (Ananase) in chronic rhino-sinusitis]. Jibiinkoka 1966;38(4):439-442. View abstract.
37214
Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409. View abstract.
37215
Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. View abstract.
37217
Balakrishnan, V., Hareendran, A., and Nair, C. S. Double-blind cross-over trial of an enzyme preparation in pancreatic steatorrhoea. J Assoc Physicians India 1981;29(3):207-209. View abstract.
37218
Ako, H., Cheung, A. H., and Matsuura, P. K. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn.Ther 1981;254(1):157-167. View abstract.
37219
Desser, L., Rehberger, A., Kokron, E., and Paukovits, W. Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations. Oncology 1993;50(6):403-407. View abstract.
37221
Mynott, T. L., Luke, R. K., and Chandler, D. S. Oral administration of protease inhibits enterotoxigenic Escherichia coli receptor activity in piglet small intestine. Gut 1996;38(1):28-32. View abstract.
37222
Kleef, R., Delohery, T. M., and Bovbjerg, D. H. Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5. Pathobiology 1996;64(6):339-346. View abstract.
37223
Mudrak, J., Bobak, L., and Sebova, I. Adjuvant therapy with hydrolytic enzymes in recurrent laryngeal papillomatosis. Acta Otolaryngol.Suppl 1997;527:128-130. View abstract.
37224
Mynott, T. L., Guandalini, S., Raimondi, F., and Fasano, A. Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro. Gastroenterology 1997;113(1):175-184. View abstract.
37225
Castell, J. V., Friedrich, G., Kuhn, C. S., and Poppe, G. E. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Am.J Physiol 1997;273(1 Pt 1):G139-G146. View abstract.
37226
Hunter RG, Henry GW, and Heinicke RM. The action of papain and bromelain on the uterus. Part I. Mucolytic properties of papain and bromelain, effect on cervical mucus. Am J Obst & Gynec 1957;73(4):867-874.
37227
Seligman B. Bromelain: an anti-inflammatory agent. Angiology 1962;13:508-510.
37229
Morrison AW and Morrison MC. Bromelain - a clinical assessment in the post-operative treatment of arthrotomies of the knee and facial injuries. Brit J Clin Pract 1965;19(4):207-210.
37230
Cohen A and Goldman J. Bromelains therapy in rheumatoid arthritis. Pennsylvania Med J 1964;67:27-30.
37231
Nasciuti M and Benini P. Sperimentazione clinica in doppio cieco della bromelina in pazienti con fratture recenti degli arti inferiori. Gaz Med It 1977;136:535-546.
37232
Kelly GS. Bromelain: a literature review and discussion of its therapeutic applications. Alternative Medicine Review 1996;1(4):243-257.
37233
Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
37234
Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
37235
Tassman GC, Zafran JN, and Zayon GM. Evaluation of a plant proteolytic enzyme for the control of inflammation and pain. Journal of Dental Medicine 1964;19(2):73-77.
37236
Anonymous. Bromelain. Alternative Medicine Review 1998;3(4):302-305.
37239
Kleine MW. Introduction to oral enzyme therapy. Int J Immunotherapy 1997;13(3-4):59-65.
37240
Kolac C, Streichhan P, and Lehr CM. Oral bioavailability of proteolytic enzymes. Eur J Pharm Biopharm 1996;42(222):232.
37241
Klein GK. Enzymatic debridement of third degree burns in animals with bromelains - a preliminary report. J Maine Med Assoc 1964;55:169-171.
37242
Klaue P, Dilbert G, Hinke G, and et al. [Experiments on the local treatment of subdermal burns with bromelain]. Therapiewoche 1979;29:796-797.
37243
Kugener H, Bergmann D, and Beck K. [Efficacy of bromelain in pancreatogenic digestive insufficiency]. Zeitschrift fur Gastroenterologie 1968;6:430-433.
37244
Ferrari A, Pifarotti G, Dindelli M, and et al. Clinical trial of the efficacy and safety of seaprose S in patients with benign breast disease. Controlled trial vs bromeline. Gironale Italiano Di Ricerche Cliniche e Terapeutiche 1995;16(1):1-6.
37245
Tassman GC, Zafran JN, and Zayon GM. A double-blind crossover study of a plant proteolytic enzyme in oral surgery. J Dent Med 1965;20(2):51-54.
37246
Cirelli MG. Five years of clinical experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clinical Medicine 1967;74(6):55-59.
37247
Miller JM, Ginsberg M, McElfatrick GC, and et al. The administration of bromelain orally in the treatment of inflammation and edema. Exper Med & Surg 1964;22:293-299.
67838
Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. View abstract.
91104
Bolten WW, Glade MJ, Raum S, et al. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis. 2015;2015:251521. View abstract.
91105
Büttner L, Achilles N, Böhm M, et al. Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study. B-ENT. 2013;9(3):217-25. View abstract.
91106
Conrozier T, Mathieu P, Bonjean M, et al. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20 Suppl 1:32-7. View abstract.
91107
de la Barrera-Núñez MC, Yáñez-Vico RM, Batista-Cruzado A, et al. Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period. Med Oral Patol Oral Cir Bucal. 2014;19(2):e157-62. View abstract.
91109
Inchingolo F, Tatullo M, Marrelli M, Inchingolo AM, Picciariello V, Inchingolo AD, Dipalma G, Vermesan D, Cagiano R. Clinical trial with bromelain in third molar exodontia. Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):771-4. View abstract.
91110
Majid OW, Al-Mashhadani BA. Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial. J Oral Maxillofac Surg. 2014;72(6):1043-8. View abstract.
91111
Müller S, März R, Schmolz M, et al. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. Phytother Res. 2013;27(2):199-204. View abstract.
91113
Rosenberg L, Krieger Y, Bogdanov-Berezovski A, et al. A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. Burns. 2014;40(3):466-74. View abstract.
92235
Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. View abstract.
96214
Ghensi P, Cucchi A, Creminelli L, Tomasi C, Zavan B, Maiorana C. Effect of oral administration of bromelain on postoperative discomfort after third molar surgery. J Craniofac Surg. 2017 Mar;28(2):e191-e197. View abstract.
96215
Bormann KH, Weber K, Kloppenburg H, et al. Perioperative bromelain therapy after wisdom teeth extraction - a randomized, placebo-controlled, double-blinded, three-armed, cross-over dose-finding study. Phytother Res. 2016 Dec;30(12):2012-19. View abstract.
96216
Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. View abstract.
96449
Desideri I, Francolini G, Becherini C, et al. Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol. 2017 Mar;34(3):46. View abstract.
96766
Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. View abstract.
99467
Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-5. View abstract.
99468
Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. View abstract.
99472
Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. View abstract.
99473
Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. View abstract.
99476
Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac Surg. 2013;71(7):1261-7. View abstract.
99477
Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial. J Assoc Physicians India. 2001;49:617-21. View abstract.
100750
de Souza GM, Fernandes IA, Dos Santos CRR, Falci SGM. Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis. Phytother Res. 2019;33(3):473-481. View abstract.
100751
Mendes ML, do Nascimento-Júnior EM, Reinheimer DM, Martins-Filho PR. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e61-e69. View abstract.
100752
Palmisano F, Spinelli MG, Luzzago S, et al. Medical Expulsive Therapy for Symptomatic Distal Ureter Stones: Is the Combination of Bromelain and Tamsulosin More Effective than Tamsulosin Alone? Preliminary Results of a Single-Center Study. Urol Int. 2019;102(2):145-152. View abstract.
103297
Harats M, Haik J, Cleary M, Vashurin I, Aviv U, Kornhaber R. A retrospective review of an off-label bromelain-based selective enzymatic debridement (Nexobrid®) in the treatment of deep, partial, and full thickness burns and hard to heal wounds. Isr Med Assoc J 2020;22(2):83-8. View abstract.
103298
Michelini S, Fiorentino A, Cardone M. Melilotus, rutin and bromelain in primary and secondary lymphedema. Lymphology 2019;52(4):177-86. View abstract.
103299
Naeem H, Naqvi SN, Perveen R, et al. Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes. Pak J Pharm Sci 2020;33(1(Supplementary)):371-8. View abstract.
103300
Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. View abstract.
108148
Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. View abstract.
108149
Claes KEY, Amar S, Hoeksema H, et al. Pain management during a bromelain-based selective enzymatic debridement in paediatric and adult burn patients. Burns 2021. View abstract.
109570
Desideri I, Lucidi S, Francolini G, et al. Use of an alfa-lipoic, methylsulfonylmethane, Boswellia serrata and bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management (AIA): a prospective phase II trial (NCT04161833). Med Oncol 2022;39(8):113. View abstract.
110546
Gupta AA, Kambala R, Bhola N, Jadhav A. Comparative efficacy of bromelain and aceclofenac in limiting post-operative inflammatory sequelae in surgical removal of lower impacted third molar: a randomized controlled, triple blind clinical trial. J Dent Anesth Pain Med 2022;22(1):29-37. View abstract.
110547
Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. View abstract.