Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

Caraballo PJ, Heit JA, Atkinson EJ, et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 1999;159:1750-6. View abstract.

Jie KG, Bots ML, Vermeer C, et al. Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 1996;59:352-6. View abstract.

Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. View abstract.

Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. View abstract.

Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. View abstract.

Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. View abstract.

Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3. View abstract.

LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.

Breum L, Pedersen JK, Ahlstrom F, et al. Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity. A double-blind multi-centre trial in general practice. Int J Obes Relat Metab Disord 1994;18:99-103. View abstract.

Toubro S, Astrup A, Breum L, Quaade F. The acute and chronic effects of ephedrine/caffeine mixtures on energy expenditure and glucose metabolism in humans. Int J Obes Relat Metab Disord 1993;17:S73-7. View abstract.

Ascherio A, Zhang SM, Hernan MA, et al. Prospective study of caffeine intake and risk of Parkinson's disease in men and women. Proceedings 125th Ann Mtg Am Neurological Assn. Boston, MA: 2000;Oct 15-18:42 (abstract 53).

Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. View abstract.

Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.

Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. View abstract.

Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. View abstract.

Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999;70:1040-5. View abstract.

Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.

Toubro S, Astrup A. Randomised comparison of diets for maintaining obese subjects' weight after major weight loss: ad lib, low fat, high carbohydrate diet v fixed energy intake. BMJ 1997;314:29-34. View abstract.

Vandeberghe K, Gillis N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452-7. View abstract.

Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. View abstract.

Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. View abstract.

The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.

Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. View abstract.

Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. View abstract.

Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. View abstract.

Stookey JD. The diuretic effects of alcohol and caffeine and total water intake misclassification. Eur J Epidemiol 1999;15:181-8. View abstract.

Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997;18:40-6. View abstract.

Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. View abstract.

Goldstein J, Hoffman HD, Armellino JJ, et al. Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine. Cephalalgia 1999;19:684-91. View abstract.

Lipton RB, Stewart WF, Ryan RE Jr, et al. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials. Arch Neurol 1998;55:210-7. View abstract.

Silberstein SD, Armellino JJ, Hoffman HD, et al. Treatment of menstruation-associated migraine with the nonprescription combination of acetaminophen, aspirin, and caffeine: results from three randomized, placebo-controlled studies. Clin Ther 1999;21:475-91. View abstract.

Migliardi JR, Armellino JJ, Friedman M, et al. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994;56:576-86. View abstract.

Rees K, Allen D, Lader M. The influences of age and caffeine on psychomotor and cognitive function. Psychopharmacology (Berl) 1999;145:181-8. View abstract.

Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.

Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. View abstract.

Akhtar S, Wood G, Rubin JS, et al. Effect of caffeine on the vocal folds: a pilot study. J Laryngol Otol 1999;113:341-5. View abstract.

Weber JG, Klindworth JT, Arnold JJ, et al. Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures. Mayo Clin Proc 1997;72:621-6. View abstract.

Hampl KF, Schneider MC, Ruttimann U, et al. Perioperative administration of caffeine tablets for prevention of postoperative headaches. Can J Anaesth 1995;42:789-92. View abstract.

Yucel A, Ozyalcin S, Talu GK, et al. Intravenous administration of caffeine sodium benzoate for postdural puncture headache. Reg Anesth Pain Med 1999;24:51-4. View abstract.

Camann WR, Murray RS, Mushlin PS, Lambert DH. Effects of oral caffeine on postdural puncture headache. A double-blind, placebo-controlled trial. Anesth Analg 1990;70:181-4. View abstract.

FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).

Leitzmann MF, Willett WC, Rimm EB, et al. A Prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA 1999;281:2106-12. View abstract.

Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. View abstract.

Durlach PJ. The effects of a low dose of caffeine on cognitive performance. Psychopharmacology (Berl) 1998;140:116-9. View abstract.

Hindmarch I, Quinlan PT, Moore KL, Parkin C. The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacol 1998;139:230-8. View abstract.

Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.

Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. View abstract.

Ross GW, Abbott RD, Petrovitch H, et al. Association of coffee and caffeine intake with the risk of parkinson disease. JAMA 2000;283:2674-9. View abstract.

Tobias JD. Caffeine in the treatment of apnea associated with respiratory syncytial virus infection in neonates and infants. South Med J 2000;93:297-304. View abstract.

Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. View abstract.

Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. View abstract.

American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. View abstract.

Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract.

Erenberg A, Leff RD, Haack DG, et al. Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebo-controlled study. Pharmacotherapy 2000;20:644-52. View abstract.

Suleman A, Siddiqui NH. Haemodynamic and cardiovascular effects of caffeine. Medicine On Line Int J Medicine 2000. www.priory.com/pharmol/caffeine.htm (Accessed 14 April 2000).

Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.

Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. View abstract.

Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. View abstract.

Ruhl CE, Everhart JE. Association of coffee consumption with gallbladder disease. Am J Epidemiol 2000;152:1034-8. View abstract.

Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. View abstract.

Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. View abstract.

Haller CA, Jacob P 3rd, Benowitz NL. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Clin Pharmacol Ther 2002;71:421-32. View abstract.

Greenway FL, Raum WJ, DeLany JP. The effect of an herbal dietary supplement containing ephedrine and caffeine on oxygen consumption in humans. J Altern Complement Med 2000;6:553-5. View abstract.

Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.

Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604. View abstract.

Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. View abstract.

Checkoway H, Powers K, Smith-Weller T, et al. Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol 2002;155:732-8.. View abstract.

Bracken MB, Triche EW, Belanger K, et al. Association of maternal caffeine consumption with decrements in fetal growth. Am J Epidemiol 2003;157:456-66.. View abstract.

Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112.. View abstract.

McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4.. View abstract.

Warburton DM, Bersellini E, Sweeney E. An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology (Berl) 2001;158:322-8.. View abstract.

Chen JF, Xu K, Petzer JP, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci 2001;21:RC143.. View abstract.

Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. View abstract.

Greer F, Friars D, Graham TE. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. J Appl Physiol 2000;89:1837-44.. View abstract.

Dreher HM. The effect of caffeine reduction on sleep quality and well-being in persons with HIV. J Psychosom Res 2003;54:191-8.. View abstract.

Kamimori GH, Penetar DM, Headley DB, et al. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Eur J Clin Pharmacol 2000;56:537-44.. View abstract.

Grandjean AC, Reimers KJ, Bannick KE, Haven MC. The effect of caffeinated, non-caffeinated, caloric and non-caloric beverages on hydration. J Am Coll Nutr 2000;19:591-600.. View abstract.

Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.

Schechter MD, Timmons GD. Objectively measured hyperactivity--II. Caffeine and amphetamine effects. J Clin Pharmacol 1985;25:276-80.. View abstract.

Schnackenberg RC. Caffeine as a substitute for Schedule II stimulants in hyperkinetic children. Am J Psychiatry 1973;130:796-8.

Garfinkel BD, Webster CD, Sloman L. Methylphenidate and caffeine in the treatment of children with minimal brain dysfunction. Am J Psychiatry 1975;132:723-8.. View abstract.

Conners CK. The acute effects of caffeine on evoked response, vigilance, and activity level in hyperkinetic children. J Abnorm Child Psychol 1979;7:145-51.. View abstract.

Arnold LE, Christopher J, Huestis R, Smeltzer DJ. Methylphenidate vs dextroamphetamine vs caffeine in minimal brain dysfunction: controlled comparison by placebo washout design with Bayes' analysis. Arch Gen Psychiatry 1978;35:463-73.. View abstract.

Huestis RD, Arnold LE, Smeltzer DJ. Caffeine versus methylphenidate and d-amphetamine in minimal brain dysfunction: a double-blind comparison. Am J Psychiatry 1975;132:868-70. View abstract.

Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.

Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. View abstract.

Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. View abstract.

Salazar-Martinez E, Willett WC, Ascherio A, et al. Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 2004;140:1-8. View abstract.

Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. View abstract.

May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. View abstract.

Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. View abstract.

Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. View abstract.

Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. View abstract.

Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. View abstract.

Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. View abstract.

Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7. View abstract.

Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.

Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. View abstract.

Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. View abstract.

Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7. View abstract.

Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html.

Castellanos FX, Rapoport JL. Effects of caffeine on development and behavior in infancy and childhood: a review of the published literature. Food Chem Toxicol 2002;40:1235-42. View abstract.

Heseltine D, Dakkak M, woodhouse K, et al. The effect of caffeine on postprandial hypotension in the elderly. J Am Geriatr Soc 1991;39:160-4. View abstract.

Rakic V, Beilin LJ, Burke V. Effect of coffee and tea drinking on postprandial hypotension in older men and women. Clin Exp Pharmacol Physiol 1996;23:559-63. View abstract.

Howell LL, Coffin VL, Spealman RD. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology (Berl) 1997;129:1-14. View abstract.

Chou T. Wake up and smell the coffee. Caffeine, coffee, and the medical consequences. West J Med 1992;157:544-53. View abstract.

Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. View abstract.

Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. View abstract.

Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. View abstract.

Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37. View abstract.

Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust 2001;174:520-1. View abstract.

Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 2004;18:55-62. View abstract.

Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27:2047-8. View abstract.

Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr 2004;80:22-8. View abstract.

Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. View abstract.

Scholey AB, Kennedy DO. Cognitive and physiological effects of an "energy drink:" an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions. Psychopharmacology (Berl) 2004;176:320-30. View abstract.

Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr 2004;79:40-6. View abstract.

Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. View abstract.

Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. View abstract.

Anderson BJ, Gunn TR, Holford NH, Johnson R. Caffeine overdose in a premature infant: clinical course and pharmacokinetics. Anaesth Intensive Care 1999;27:307-11. View abstract.

Ergenekon E, Dalgic N, Aksoy E, et al. Caffeine intoxication in a premature neonate. Paediatr Anaesth 2001;11:737-9. View abstract.

Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. View abstract.

Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5. View abstract.

Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54. View abstract.

Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8. View abstract.

Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. View abstract.

Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. View abstract.

Robinson LE, Savani S, Battram DS, et al. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr 2004;134:2528-33. View abstract.

Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. View abstract.

Iso H, Date C, Wakai K, et al; JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 2006;144:554-62. View abstract.

Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 2008;198:279.e1-8. View abstract.

Savitz DA, Chan RL, Herring AH, et al. Caffeine and miscarriage risk. Epidemiology 2008;19:55-62. View abstract.

Ellender L, Linder MM. Sports pharmacology and ergogenic aids. Prim Care 2005;32:277-92. View abstract.

Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82. View abstract.

Phung OJ, Baker WL, Matthews LJ, et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systemic review and meta-analysis. Am J Clin Nutr 2010;91:73-81. View abstract.

Backhouse SH, Biddle SJ, Bishop NC, Williams C. Caffeine ingestion, affect and perceived exertion during prolonged cycling. Appetite 2011;57:247-52. View abstract.

Keijzers GB, De Galan BE, Tack CJ, et al. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25:364-9. View abstract.

Kynast-Gales SA, Massey LK. Effect of caffeine on circadian excretion of urinary calcium and magnesium. J Am Coll Nutr. 1994;13:467-72. View abstract.

Shet, M. S., McPhaul, M., Fisher, C. W., Stallings, N. R., and Estabrook, R. W. Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997;25(11):1298-1303. View abstract.

Staib, A. H., Stille, W., Dietlein, G., Shah, P. M., Harder, S., Mieke, S., and Beer, C. Interaction between quinolones and caffeine. Drugs 1987;34 Suppl 1:170-174. View abstract.

Stille, W., Harder, S., Mieke, S., Beer, C., Shah, P. M., Frech, K., and Staib, A. H. Decrease of caffeine elimination in man during co-administration of 4-quinolones. J.Antimicrob.Chemother. 1987;20(5):729-734. View abstract.

Fuhr, U., Strobl, G., Manaut, F., Anders, E. M., Sorgel, F., Lopez-de-Brinas, E., Chu, D. T., Pernet, A. G., Mahr, G., Sanz, F., and . Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isoform CYP1A2. Mol.Pharmacol. 1993;43(2):191-199. View abstract.

Kot, M. and Daniel, W. A. Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. Pharmacol Rep. 2009;61(6):1216-1220. View abstract.

Gasior, M., Borowicz, K., Buszewicz, G., Kleinrok, Z., and Czuczwar, S. J. Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. Epilepsia 1996;37(3):262-268. View abstract.

Jankiewicz, K., Chroscinska-Krawczyk, M., Blaszczyk, B., and Czuczwar, S. J. [Caffeine and antiepileptic drugs: experimental and clinical data]. Przegl.Lek. 2007;64(11):965-967. View abstract.

Luszczki, J. J., Zuchora, M., Sawicka, K. M., Kozinska, J., and Czuczwar, S. J. Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice. Pharmacol Rep. 2006;58(5):652-659. View abstract.

Chroscinska-Krawczyk, M., Jargiello-Baszak, M., Walek, M., Tylus, B., and Czuczwar, S. J. Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Pharmacol.Rep. 2011;63(1):12-18. View abstract.

Vaz, J., Kulkarni, C., David, J., and Joseph, T. Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. Indian J.Exp.Biol. 1998;36(1):112-114. View abstract.

Gasior, M., Swiader, M., Przybylko, M., Borowicz, K., Turski, W. A., Kleinrok, Z., and Czuczwar, S. J. Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. Eur.J Pharmacol 7-10-1998;352(2-3):207-214. View abstract.

Balogh, A., Klinger, G., Henschel, L., Borner, A., Vollanth, R., and Kuhnz, W. Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur.J.Clin.Pharmacol. 1995;48(2):161-166. View abstract.

Mohiuddin, M., Azam, A. T., Amran, M. S., and Hossain, M. A. In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats. Pak.J Biol Sci 5-1-2009;12(9):734-737. View abstract.

Mays, D. C., Camisa, C., Cheney, P., Pacula, C. M., Nawoot, S., and Gerber, N. Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans. Clin.Pharmacol.Ther. 1987;42(6):621-626. View abstract.

Wojcikowski, J. and Daniel, W. A. Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. Pharmacol Rep. 2009;61(5):851-858. View abstract.

Daniel, W. A., Syrek, M., Rylko, Z., and Kot, M. Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. Pol.J Pharmacol 2001;53(6):615-621. View abstract.

Norager, C. B., Jensen, M. B., Weimann, A., and Madsen, M. R. Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Clin Endocrinol (Oxf) 2006;65(2):223-228. View abstract.

Wang, X. and Yeung, J. H. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. J Pharm Pharmacol 2010;62(8):1077-1083. View abstract.

Gorski, J. C., Huang, S. M., Pinto, A., Hamman, M. A., Hilligoss, J. K., Zaheer, N. A., Desai, M., Miller, M., and Hall, S. D. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004;75(1):89-100. View abstract.

Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. View abstract.

Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. View abstract.

Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. View abstract.

Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. View abstract.

Liu, T. T. and Liau, J. Caffeine increases the linearity of the visual BOLD response. Neuroimage. 2-1-2010;49(3):2311-2317. View abstract.

Bailey, D. N., Weibert, R. T., Naylor, A. J., and Shaw, R. F. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J.Anal.Toxicol. 1982;6(2):64-68. View abstract.

Arya, L. A., Myers, D. L., and Jackson, N. D. Dietary caffeine intake and the risk for detrusor instability: a case-control study. Obstet.Gynecol. 2000;96(1):85-89. View abstract.

Conlisk, A. J. and Galuska, D. A. Is caffeine associated with bone mineral density in young adult women?. Prev.Med. 2000;31(5):562-568. View abstract.

Griffiths, R. R. and Chausmer, A. L. Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement. Nihon Shinkei Seishin Yakurigaku Zasshi 2000;20(5):223-231. View abstract.

Bryant, C. M., Dowell, C. J., and Fairbrother, G. Caffeine reduction education to improve urinary symptoms. Br.J.Nurs. 4-25-2002;11(8):560-565. View abstract.

ROTH, J. L. Clinical evaluation of the caffeine gastric analysis in duodenal ulcer patients. Gastroenterology 1951;19(2):199-215. View abstract.

Taylor, E. S., Smith, A. D., Cowan, J. O., Herbison, G. P., and Taylor, D. R. Effect of caffeine ingestion on exhaled nitric oxide measurements in patients with asthma. Am.J Respir.Crit Care Med. 5-1-2004;169(9):1019-1021. View abstract.

Roberts, A. T., Jonge-Levitan, L., Parker, C. C., and Greenway, F. The effect of an herbal supplement containing black tea and caffeine on metabolic parameters in humans. Altern Med Rev 2005;10(4):321-325. View abstract.

Gardner, E. J., Ruxton, C. H., and Leeds, A. R. Black tea--helpful or harmful? A review of the evidence. Eur J Clin Nutr 2007;61(1):3-18. View abstract.

Price, K. R. and Fligner, D. J. Treatment of caffeine toxicity with esmolol. Ann.Emerg.Med. 1990;19(1):44-46. View abstract.

Dagan, Y. and Doljansky, J. T. Cognitive performance during sustained wakefulness: A low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. Chronobiol.Int. 2006;23(5):973-983. View abstract.

Kohler, M., Pavy, A., and van den Heuvel, C. The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation. J Sleep Res. 2006;15(4):358-368. View abstract.

Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. View abstract.

Karacan, I., Thornby, J. I., Anch, M., Booth, G. H., Williams, R. L., and Salis, P. J. Dose-related sleep disturbances induced by coffee and caffeine. Clin Pharmacol Ther 1976;20(6):682-689. View abstract.

Quirce, G. S., Freire, P., Fernandez, R. M., Davila, I., and Losada, E. Urticaria from caffeine. J.Allergy Clin Immunol. 1991;88(4):680-681. View abstract.

Duffy, P. and Phillips, Y. Y. Caffeine consumption decreases the response to bronchoprovocation challenge with dry gas hyperventilation. Chest 1991;99(6):1374-1377. View abstract.

Hughes, J. R., Higgins, S. T., Bickel, W. K., Hunt, W. K., Fenwick, J. W., Gulliver, S. B., and Mireault, G. C. Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. Arch.Gen.Psychiatry 1991;48(7):611-617. View abstract.

Arnaud, M. J. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb.Exp.Pharmacol 2011;(200):33-91. View abstract.

Adams, B. A. and Brubaker, R. F. Caffeine has no clinically significant effect on aqueous humor flow in the normal human eye. Ophthalmology 1990;97(8):1030-1031. View abstract.

Davis, R. H. Does caffeine ingestion affect intraocular pressure?. Ophthalmology 1989;96(11):1680-1681. View abstract.

Higginbotham, E. J., Kilimanjaro, H. A., Wilensky, J. T., Batenhorst, R. L., and Hermann, D. The effect of caffeine on intraocular pressure in glaucoma patients. Ophthalmology 1989;96(5):624-626. View abstract.

Wrenn, K. D. and Oschner, I. Rhabdomyolysis induced by a caffeine overdose. Ann.Emerg.Med. 1989;18(1):94-97. View abstract.

Pola, J., Subiza, J., Armentia, A., Zapata, C., Hinojosa, M., Losada, E., and Valdivieso, R. Urticaria caused by caffeine. Ann.Allergy 1988;60(3):207-208. View abstract.

Bukowskyj, M. and Nakatsu, K. The bronchodilator effect of caffeine in adult asthmatics. Am.Rev.Respir.Dis 1987;135(1):173-175. View abstract.

Lane, J. D. and Williams, R. B., Jr. Cardiovascular effects of caffeine and stress in regular coffee drinkers. Psychophysiology 1987;24(2):157-164. View abstract.

Shirlow, M. J. and Mathers, C. D. A study of caffeine consumption and symptoms; indigestion, palpitations, tremor, headache and insomnia. Int.J.Epidemiol. 1985;14(2):239-248. View abstract.

Gong, H., Jr., Simmons, M. S., Tashkin, D. P., Hui, K. K., and Lee, E. Y. Bronchodilator effects of caffeine in coffee. A dose-response study of asthmatic subjects. Chest 1986;89(3):335-342. View abstract.

Sutherland, D. J., McPherson, D. D., Renton, K. W., Spencer, C. A., and Montague, T. J. The effect of caffeine on cardiac rate, rhythm, and ventricular repolarization. Analysis of 18 normal subjects and 18 patients with primary ventricular dysrhythmia. Chest 1985;87(3):319-324. View abstract.

Prineas, R. J., Jacobs, D. R., Jr., Crow, R. S., and Blackburn, H. Coffee, tea and VPB. J Chronic.Dis 1980;33(2):67-72. View abstract.

Stillner, V., Popkin, M. K., and Pierce, C. M. Caffeine-induced delirium during prolonged competitive stress. Am.J.Psychiatry 1978;135(7):855-856. View abstract.

Beach, C. A., Bianchine, J. R., and Gerber, N. The excretion of caffeine in the semen of men: pharmacokinetics and comparison of the concentrations in blood and semen. J Clin Pharmacol 1984;24(2-3):120-126. View abstract.

Dobmeyer, D. J., Stine, R. A., Leier, C. V., Greenberg, R., and Schaal, S. F. The arrhythmogenic effects of caffeine in human beings. N.Engl.J.Med. 4-7-1983;308(14):814-816. View abstract.

Levy, M. and Zylber-Katz, E. Caffeine metabolism and coffee-attributed sleep disturbances. Clin Pharmacol Ther 1983;33(6):770-775. View abstract.

Blanchard, J. and Sawers, S. J. Comparative pharmacokinetics of caffeine in young and elderly men. J Pharmacokinet.Biopharm. 1983;11(2):109-126. View abstract.

Newton, R., Broughton, L. J., Lind, M. J., Morrison, P. J., Rogers, H. J., and Bradbrook, I. D. Plasma and salivary pharmacokinetics of caffeine in man. Eur.J Clin Pharmacol 1981;21(1):45-52. View abstract.

Banner, W., Jr. and Czajka, P. A. Acute caffeine overdose in the neonate. Am.J Dis Child 1980;134(5):495-498. View abstract.

Brown, S. L., Salive, M. E., Pahor, M., Foley, D. J., Corti, M. C., Langlois, J. A., Wallace, R. B., and Harris, T. B. Occult caffeine as a source of sleep problems in an older population. J.Am.Geriatr.Soc. 1995;43(8):860-864. View abstract.

Sung, B. H., Whitsett, T. L., Lovallo, W. R., al'Absi, M., Pincomb, G. A., and Wilson, M. F. Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men. Am.J Hypertens. 1994;7(8):755-758. View abstract.

Tassaneeyakul, W., Birkett, D. J., McManus, M. E., Tassaneeyakul, W., Veronese, M. E., Andersson, T., Tukey, R. H., and Miners, J. O. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem.Pharmacol 5-18-1994;47(10):1767-1776. View abstract.

Caballero, T., Garcia-Ara, C., Pascual, C., Diaz-Pena, J. M., and Ojeda, A. Urticaria induced by caffeine. J.Investig.Allergol.Clin Immunol. 1993;3(3):160-162. View abstract.

Smits, P., Temme, L., and Thien, T. The cardiovascular interaction between caffeine and nicotine in humans. Clin Pharmacol Ther 1993;54(2):194-204. View abstract.

Stein, M. A., Krasowski, M., Leventhal, B. L., Phillips, W., and Bender, B. G. Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine. Arch.Pediatr.Adolesc.Med. 1996;150(3):284-288. View abstract.

Garrett, B. E. and Griffiths, R. R. Physical dependence increases the relative reinforcing effects of caffeine versus placebo. Psychopharmacology (Berl) 1998;139(3):195-202. View abstract.

Lane, J. D. and Phillips-Bute, B. G. Caffeine deprivation affects vigilance performance and mood. Physiol Behav. 1998;65(1):171-175. View abstract.

Robelin, M. and Rogers, P. J. Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence. Behav.Pharmacol 1998;9(7):611-618. View abstract.

Boekema, P. J., Samsom, M., van Berge Henegouwen, G. P., and Smout, A. J. Coffee and gastrointestinal function: facts and fiction. A review. Scand J Gastroenterol.Suppl 1999;230:35-39. View abstract.

Engels, H. J., Wirth, J. C., Celik, S., and Dorsey, J. L. Influence of caffeine on metabolic and cardiovascular functions during sustained light intensity cycling and at rest. Int.J.Sport Nutr. 1999;9(4):361-370. View abstract.

Steer, P. A. and Henderson-Smart, D. J. Caffeine versus theophylline for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2000;(2):CD000273. View abstract.

Henderson-Smart, D. J. and Steer, P. Postoperative caffeine for preventing apnea in preterm infants. Cochrane.Database.Syst.Rev. 2000;(2):CD000048. View abstract.

Henderson-Smart, D. J. and Davis, P. G. Prophylactic methylxanthine for extubation in preterm infants. Cochrane.Database.Syst.Rev. 2000;(2):CD000139. View abstract.

Henderson-Smart, D. J. and Steer, P. Methylxanthine treatment for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2000;(2):CD000140. View abstract.

Henderson-Smart, D. J. and Steer, P. A. Prophylactic methylxanthine for preventing of apnea in preterm infants. Cochrane.Database.Syst.Rev. 2000;(2):CD000432. View abstract.

Hansen, S. A., Folsom, A. R., Kushi, L. H., and Sellers, T. A. Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study. Public Health Nutr. 2000;3(3):253-261. View abstract.

Henderson-Smart, D. J. and Steer, P. Doxapram versus methylxanthine for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2000;(4):CD000075. View abstract.

Bruce, C. R., Anderson, M. E., Fraser, S. F., Stepto, N. K., Klein, R., Hopkins, W. G., and Hawley, J. A. Enhancement of 2000-m rowing performance after caffeine ingestion. Med.Sci.Sports Exerc. 2000;32(11):1958-1963. View abstract.

Anderson, M. E., Bruce, C. R., Fraser, S. F., Stepto, N. K., Klein, R., Hopkins, W. G., and Hawley, J. A. Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion. Int.J.Sport Nutr.Exerc.Metab 2000;10(4):464-475. View abstract.

Gedye, A. Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid. Med.Hypotheses 2001;56(1):91-94. View abstract.

Steele, K., Greenstone, M., and Lasserson, J. A. Oral methyl-xanthines for bronchiectasis. Cochrane.Database.Syst.Rev. 2001;(1):CD002734. View abstract.

Paton, C. D., Hopkins, W. G., and Vollebregt, L. Little effect of caffeine ingestion on repeated sprints in team-sport athletes. Med.Sci.Sports Exerc. 2001;33(5):822-825. View abstract.

Ferre, S., Popoli, P., Gimenez-Llort, L., Rimondini, R., Muller, C. E., Stromberg, I., Ogren, S. O., and Fuxe, K. Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease. Parkinsonism.Relat Disord. 2001;7(3):235-241. View abstract.

Bauer, J., Maier, K., Linderkamp, O., and Hentschel, R. Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea. Pediatrics 2001;107(4):660-663. View abstract.

Mercadante, S., Serretta, R., and Casuccio, A. Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study. J.Pain Symptom.Manage. 2001;21(5):369-372. View abstract.

al-Alaiyan, S., al-Rawithi, S., Raines, D., Yusuf, A., Legayada, E., Shoukri, M. M., and el-Yazigi, A. Caffeine metabolism in premature infants. J Clin Pharmacol 2001;41(6):620-627. View abstract.

Tyas, S. L., Manfreda, J., Strain, L. A., and Montgomery, P. R. Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada. Int J Epidemiol. 2001;30(3):590-597. View abstract.

Terry, P., Lagergren, J., Wolk, A., and Nyren, O. Reflux-inducing dietary factors and risk of adenocarcinoma of the esophagus and gastric cardia. Nutr Cancer 2000;38(2):186-191. View abstract.

Corrao, G., Zambon, A., Bagnardi, V., D'Amicis, A., and Klatsky, A. Coffee, caffeine, and the risk of liver cirrhosis. Ann.Epidemiol. 2001;11(7):458-465. View abstract.

Henderson-Smart, D. J. and Steer, P. Methylxanthine treatment for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2001;(3):CD000140. View abstract.

Henderson-Smart, D. J. and Steer, P. Prophylactic caffeine to prevent postoperative apnea following general anesthesia in preterm infants. Cochrane.Database.Syst.Rev. 2001;(4):CD000048. View abstract.

Henderson-Smart, D. J., Subramaniam, P., and Davis, P. G. Continuous positive airway pressure versus theophylline for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2001;(4):CD001072. View abstract.

Ross, G. W. and Petrovitch, H. Current evidence for neuroprotective effects of nicotine and caffeine against Parkinson's disease. Drugs Aging 2001;18(11):797-806. View abstract.

Cohen, S. and Booth, G. H., Jr. Gastric acid secretion and lower-esophageal-sphincter pressure in response to coffee and caffeine. N.Engl.J.Med. 10-30-1975;293(18):897-899. View abstract.

Bell, D. G., McLellan, T. M., and Sabiston, C. M. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med.Sci.Sports Exerc. 2002;34(2):344-349. View abstract.

Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350. View abstract.

Kiersch, T. A. and Minic, M. R. The onset of action and the analgesic efficacy of Saridon (a propyphenazone/paracetamol/ caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis). Curr.Med.Res.Opin. 2002;18(1):18-25. View abstract.

Maia, L. and de Mendonca, A. Does caffeine intake protect from Alzheimer's disease? Eur.J.Neurol. 2002;9(4):377-382. View abstract.

Lindsay, J., Laurin, D., Verreault, R., Hebert, R., Helliwell, B., Hill, G. B., and McDowell, I. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 9-1-2002;156(5):445-453. View abstract.

Brice, C. and Smith, A. The effects of caffeine on simulated driving, subjective alertness and sustained attention. Hum Psychopharmacol. 2001;16(7):523-531. View abstract.

Floran, B., Barajas, C., Floran, L., Erlij, D., and Aceves, J. Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat. Neuroscience 2002;115(3):743-751. View abstract.

Doherty, M., Smith, P. M., Davison, R. C., and Hughes, M. G. Caffeine is ergogenic after supplementation of oral creatine monohydrate. Med.Sci.Sports Exerc. 2002;34(11):1785-1792. View abstract.

Verhoef, P., Pasman, W. J., Van Vliet, T., Urgert, R., and Katan, M. B. Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. Am.J.Clin.Nutr. 2002;76(6):1244-1248. View abstract.

Hunter, A. M., St Clair, Gibson A., Collins, M., Lambert, M., and Noakes, T. D. Caffeine ingestion does not alter performance during a 100-km cycling time-trial performance. Int.J.Sport Nutr.Exerc.Metab 2002;12(4):438-452. View abstract.

Henderson-Smart, D. J. and Davis, P. G. Prophylactic methylxanthines for extubation in preterm infants. Cochrane.Database.Syst.Rev. 2003;(1):CD000139. View abstract.

Vlachopoulos, C., Hirata, K., and O'Rourke, M. F. Effect of caffeine on aortic elastic properties and wave reflection. J.Hypertens. 2003;21(3):563-570. View abstract.

DiBaise, J. K. A randomized, double-blind comparison of two different coffee-roasting processes on development of heartburn and dyspepsia in coffee-sensitive individuals. Dig.Dis.Sci 2003;48(4):652-656. View abstract.

Jacobs, I., Pasternak, H., and Bell, D. G. Effects of ephedrine, caffeine, and their combination on muscular endurance. Med.Sci.Sports Exerc. 2003;35(6):987-994. View abstract.

Tverdal, A. and Skurtveit, S. Coffee intake and mortality from liver cirrhosis. Ann Epidemiol. 2003;13(6):419-423. View abstract.

Bell, D. G. and McLellan, T. M. Effect of repeated caffeine ingestion on repeated exhaustive exercise endurance. Med.Sci.Sports Exerc. 2003;35(8):1348-1354. View abstract.

Schmitt, J. A., Hogervorst, E., Vuurman, E. F., Jolles, J., and Riedel, W. J. Memory functions and focussed attention in middle-aged and elderly subjects are unaffected by a low, acute dose of caffeine. J.Nutr.Health Aging 2003;7(5):301-303. View abstract.

McCrory, D. C. and Gray, R. N. Oral sumatriptan for acute migraine. Cochrane.Database.Syst.Rev. 2003;(3):CD002915. [RETRACTED]. View abstract.

Di, Monda, V, Nicolodi, M., Aloisio, A., Del Bianco, P., Fonzari, M., Grazioli, I., Uslenghi, C., Vecchiet, L., and Sicuteri, F. Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial. Headache 2003;43(8):835-844. View abstract.

Beaumont, M., Batejat, D., Pierard, C., Van Beers, P., Denis, J. B., Coste, O., Doireau, P., Chauffard, F., French, J., and Lagarde, D. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. J.Appl.Physiol 2004;96(1):50-58. View abstract.

Astrup, A., Breum, L., Toubro, S., Hein, P., and Quaade, F. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial. Int.J.Obes.Relat Metab Disord. 1992;16(4):269-277. View abstract.

Nehlig, A., Daval, J. L., and Debry, G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res.Brain Res.Rev. 1992;17(2):139-170. View abstract.

Aranda, J. V., Gorman, W., Bergsteinsson, H., and Gunn, T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. J.Pediatr. 1977;90(3):467-472. View abstract.

Motl, R. W., O'Connor, P. J., and Dishman, R. K. Effect of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise. J.Pain 2003;4(6):316-321. View abstract.

Schwarzschild, M. A., Xu, K., Oztas, E., Petzer, J. P., Castagnoli, K., Castagnoli, N., Jr., and Chen, J. F. Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease. Neurology 12-9-2003;61(11 Suppl 6):S55-S61. View abstract.

Gillingham, R., Keefe, A. A., Keillor, J., and Tikuisis, P. Effect of caffeine on target detection and rifle marksmanship. Ergonomics 12-15-2003;46(15):1513-1530. View abstract.

Peroutka, S. J., Lyon, J. A., Swarbrick, J., Lipton, R. B., Kolodner, K., and Goldstein, J. Efficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in migraine without aura: a randomized, double-blind, crossover study. Headache 2004;44(2):136-141. View abstract.

Jodynis-Liebert, J., Flieger, J., Matuszewska, A., and Juszczyk, J. Serum metabolite/caffeine ratios as a test for liver function. J.Clin.Pharmacol. 2004;44(4):338-347. View abstract.

Wang, J. H., Luo, J. Y., Dong, L., Gong, J., and Tong, M. Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi'an of Northwest China. World J Gastroenterol. 6-1-2004;10(11):1647-1651. View abstract.

Wyatt, J. K., Cajochen, C., Ritz-De Cecco, A., Czeisler, C. A., and Dijk, D. J. Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. Sleep 5-1-2004;27(3):374-381. View abstract.

Naliboff, B. D., Mayer, M., Fass, R., Fitzgerald, L. Z., Chang, L., Bolus, R., and Mayer, E. A. The effect of life stress on symptoms of heartburn. Psychosom.Med 2004;66(3):426-434. View abstract.

Massey, L. K. and Sutton, R. A. Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers. J.Urol. 2004;172(2):555-558. View abstract.

Horrigan, L. A., Kelly, J. P., and Connor, T. J. Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway. Int Immunopharmacol. 2004;4(10-11):1409-1417. View abstract.

Birnbaum, L. J. and Herbst, J. D. Physiologic effects of caffeine on cross-country runners. J.Strength.Cond.Res. 2004;18(3):463-465. View abstract.

Doherty, M., Smith, P., Hughes, M., and Davison, R. Caffeine lowers perceptual response and increases power output during high-intensity cycling. J Sports Sci 2004;22(7):637-643. View abstract.

Tavani, A. and La, Vecchia C. Coffee, decaffeinated coffee, tea and cancer of the colon and rectum: a review of epidemiological studies, 1990-2003. Cancer Causes Control 2004;15(8):743-757. View abstract.

Steer, P., Flenady, V., Shearman, A., Charles, B., Gray, P. H., Henderson-Smart, D., Bury, G., Fraser, S., Hegarty, J., Rogers, Y., Reid, S., Horton, L., Charlton, M., Jacklin, R., and Walsh, A. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch.Dis.Child Fetal Neonatal Ed 2004;89(6):F499-F503. View abstract.

Bishop, N. C., Fitzgerald, C., Porter, P. J., Scanlon, G. A., and Smith, A. C. Effect of caffeine ingestion on lymphocyte counts and subset activation in vivo following strenuous cycling. Eur.J Appl Physiol 2005;93(5-6):606-613. View abstract.

Doherty, M. and Smith, P. M. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc.Metab 2004;14(6):626-646. View abstract.

Meno, J. R., Nguyen, T. S., Jensen, E. M., Alexander, West G., Groysman, L., Kung, D. K., Ngai, A. C., Britz, G. W., and Winn, H. R. Effect of caffeine on cerebral blood flow response to somatosensory stimulation. J Cereb.Blood Flow Metab 2005;25(6):775-784. View abstract.

Lee, S., Hudson, R., Kilpatrick, K., Graham, T. E., and Ross, R. Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training. Diabetes Care 2005;28(3):566-572. View abstract.

Csajka, C., Haller, C. A., Benowitz, N. L., and Verotta, D. Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects. Br.J Clin Pharmacol 2005;59(3):335-345. View abstract.

Doherty, M. and Smith, P. M. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports 2005;15(2):69-78. View abstract.

Noordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., and Geleijnse, J. M. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23(5):921-928. View abstract.

Scanlon, J. E., Chin, K. C., Morgan, M. E., Durbin, G. M., Hale, K. A., and Brown, S. S. Caffeine or theophylline for neonatal apnoea? Arch.Dis.Child 1992;67(4 Spec No):425-428. View abstract.

Richardson, T., Thomas, P., Ryder, J., and Kerr, D. Influence of caffeine on frequency of hypoglycemia detected by continuous interstitial glucose monitoring system in patients with long-standing type 1 diabetes. Diabetes Care 2005;28(6):1316-1320. View abstract.

James, J. E. and Rogers, P. J. Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation. Psychopharmacology (Berl) 2005;182(1):1-8. View abstract.

Smith, A. P. Caffeine at work. Hum Psychopharmacol. 2005;20(6):441-445. View abstract.

Goldstein, J., Silberstein, S. D., Saper, J. R., Elkind, A. H., Smith, T. R., Gallagher, R. M., Battikha, J. P., Hoffman, H., and Baggish, J. Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache 2005;45(8):973-982. View abstract.

Diener, H. C., Pfaffenrath, V., Pageler, L., Peil, H., and Aicher, B. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2005;25(10):776-787. View abstract.

Chandrasekaran, S., Rochtchina, E., and Mitchell, P. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma. 2005;14(6):504-507. View abstract.

Stuart, G. R., Hopkins, W. G., Cook, C., and Cairns, S. P. Multiple effects of caffeine on simulated high-intensity team-sport performance. Med Sci Sports Exerc. 2005;37(11):1998-2005. View abstract.

Morgan, J. C. and Sethi, K. D. Drug-induced tremors. Lancet Neurol. 2005;4(12):866-876. View abstract.

Kalmar, J. M. The influence of caffeine on voluntary muscle activation. Med Sci Sports Exerc. 2005;37(12):2113-2119. View abstract.

van Dam, R. M. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc.Dis. 2006;16(1):69-77. View abstract.

Schweitzer, P. K., Randazzo, A. C., Stone, K., Erman, M., and Walsh, J. K. Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work. Sleep 1-1-2006;29(1):39-50. View abstract.

A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. Eur.Neurol. 1991;31(5):314-322. View abstract.

Horrigan, L. A., Kelly, J. P., and Connor, T. J. Immunomodulatory effects of caffeine: friend or foe? Pharmacol Ther 2006;111(3):877-892. View abstract.

Jay, S. M., Petrilli, R. M., Ferguson, S. A., Dawson, D., and Lamond, N. The suitability of a caffeinated energy drink for night-shift workers. Physiol Behav 5-30-2006;87(5):925-931. View abstract.

Schmidt, B., Roberts, R. S., Davis, P., Doyle, L. W., Barrington, K. J., Ohlsson, A., Solimano, A., and Tin, W. Caffeine therapy for apnea of prematurity. N.Engl.J Med 5-18-2006;354(20):2112-2121. View abstract.

Philip, P., Taillard, J., Moore, N., Delord, S., Valtat, C., Sagaspe, P., and Bioulac, B. The effects of coffee and napping on nighttime highway driving: a randomized trial. Ann Intern Med 6-6-2006;144(11):785-791. View abstract.

van Gelder, B. M., Buijsse, B., Tijhuis, M., Kalmijn, S., Giampaoli, S., Nissinen, A., and Kromhout, D. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur.J Clin Nutr 2007;61(2):226-232. View abstract.

Doan, B. K., Hickey, P. A., Lieberman, H. R., and Fischer, J. R. Caffeinated tube food effect on pilot performance during a 9-hour, simulated nighttime U-2 mission. Aviat.Space Environ Med 2006;77(10):1034-1040. View abstract.

Conney, A. H., Zhou, S., Lee, M. J., Xie, J. G., Yang, C. S., Lou, Y. R., and Lu, Y. Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice. Toxicol.Appl Pharmacol 11-1-2007;224(3):209-213. View abstract.

Smith, B. D., Rafferty, J., Lindgren, K., Smith, D. A., and Nespor, A. Effects of habitual caffeine use and acute ingestion: testing a biobehavioral model. Physiol Behav. 1992;51(1):131-137. View abstract.

Fernandez-Duenas, V., Sanchez, S., Planas, E., and Poveda, R. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. Eur.J Pain 2008;12(2):157-163. View abstract.

O'Rourke, M. P., O'Brien, B. J., Knez, W. L., and Paton, C. D. Caffeine has a small effect on 5-km running performance of well-trained and recreational runners. J Sci Med Sport 2008;11(2):231-233. View abstract.

Ritchie, K., Carriere, I., de, Mendonca A., Portet, F., Dartigues, J. F., Rouaud, O., Barberger-Gateau, P., and Ancelin, M. L. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 8-7-2007;69(6):536-545. View abstract.

Belza, A., Toubro, S., and Astrup, A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur.J Clin Nutr 2009;63(1):57-64. View abstract.

McLellan, T. M., Kamimori, G. H., Voss, D. M., Tate, C., and Smith, S. J. Caffeine effects on physical and cognitive performance during sustained operations. Aviat.Space Environ Med 2007;78(9):871-877. View abstract.

Barry, R. J., Johnstone, S. J., Clarke, A. R., Rushby, J. A., Brown, C. R., and McKenzie, D. N. Caffeine effects on ERPs and performance in an auditory Go/NoGo task. Clin Neurophysiol. 2007;118(12):2692-2699. View abstract.

Lohi, J. J., Huttunen, K. H., Lahtinen, T. M., Kilpelainen, A. A., Muhli, A. A., and Leino, T. K. Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. Mil.Med 2007;172(9):982-987. View abstract.

Whalen, D. J., Silk, J. S., Semel, M., Forbes, E. E., Ryan, N. D., Axelson, D. A., Birmaher, B., and Dahl, R. E. Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls. J Pediatr.Psychol. 2008;33(4):358-367. View abstract.

Desbrow, B. and Leveritt, M. Well-trained endurance athletes' knowledge, insight, and experience of caffeine use. Int J Sport Nutr Exerc.Metab 2007;17(4):328-339. View abstract.

Legrand, D. and Scheen, A. J. [Does coffee protect against type 2 diabetes?]. Rev.Med Liege 2007;62(9):554-559. View abstract.

Ferre, S., Ciruela, F., Borycz, J., Solinas, M., Quarta, D., Antoniou, K., Quiroz, C., Justinova, Z., Lluis, C., Franco, R., and Goldberg, S. R. Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. Front Biosci. 2008;13:2391-2399. View abstract.

Schmidt, B., Roberts, R. S., Davis, P., Doyle, L. W., Barrington, K. J., Ohlsson, A., Solimano, A., and Tin, W. Long-term effects of caffeine therapy for apnea of prematurity. N.Engl.J Med 11-8-2007;357(19):1893-1902. View abstract.

Norman, D., Bardwell, W. A., Loredo, J. S., Ancoli-Israel, S., Heaton, R. K., and Dimsdale, J. E. Caffeine intake is independently associated with neuropsychological performance in patients with obstructive sleep apnea. Sleep Breath. 2008;12(3):199-205. View abstract.

MacKenzie, T., Comi, R., Sluss, P., Keisari, R., Manwar, S., Kim, J., Larson, R., and Baron, J. A. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism 2007;56(12):1694-1698. View abstract.

Peeling, P. and Dawson, B. Influence of caffeine ingestion on perceived mood states, concentration, and arousal levels during a 75-min university lecture. Adv.Physiol Educ. 2007;31(4):332-335. View abstract.

Biggs, S. N., Smith, A., Dorrian, J., Reid, K., Dawson, D., van den Heuvel, C., and Baulk, S. Perception of simulated driving performance after sleep restriction and caffeine. J Psychosom.Res 2007;63(6):573-577. View abstract.

Turley, K. R., Desisso, T., and Gerst, J. W. Effects of caffeine on physiological responses to exercise: boys versus men. Pediatr Exerc.Sci 2007;19(4):481-492. View abstract.

Foad, A. J., Beedie, C. J., and Coleman, D. A. Pharmacological and psychological effects of caffeine ingestion in 40-km cycling performance. Med Sci Sports Exerc. 2008;40(1):158-165. View abstract.

Mort, J. R. and Kruse, H. R. Timing of blood pressure measurement related to caffeine consumption. Ann Pharmacother. 2008;42(1):105-110. View abstract.

Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y. Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition 2008;24(3):233-238. View abstract.

Conney, A. H., Kramata, P., Lou, Y. R., and Lu, Y. P. Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice. Photochem.Photobiol. 2008;84(2):330-338. View abstract.

Ganmaa, D., Willett, W. C., Li, T. Y., Feskanich, D., van Dam, R. M., Lopez-Garcia, E., Hunter, D. J., and Holmes, M. D. Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer 5-1-2008;122(9):2071-2076. View abstract.

Perthen, J. E., Lansing, A. E., Liau, J., Liu, T. T., and Buxton, R. B. Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study. Neuroimage. 3-1-2008;40(1):237-247. View abstract.

Sedlacik, J., Helm, K., Rauscher, A., Stadler, J., Mentzel, H. J., and Reichenbach, J. R. Investigations on the effect of caffeine on cerebral venous vessel contrast by using susceptibility-weighted imaging (SWI) at 1.5, 3 and 7 T. Neuroimage. 3-1-2008;40(1):11-18. View abstract.

Childs, E. and de, Wit H. Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals. Exp.Clin Psychopharmacol. 2008;16(1):13-21. View abstract.

Huck, N. O., McBride, S. A., Kendall, A. P., Grugle, N. L., and Killgore, W. D. The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. Int J Neurosci. 2008;118(4):487-502. View abstract.

Walker, G. J., Dziubak, A., Houghton, L., Prendergast, C., Lim, L., and Bishop, N. C. The effect of caffeine ingestion on human neutrophil oxidative burst responses following time-trial cycling. J Sports Sci 2008;26(6):611-619. View abstract.

Turley, K. R., Bland, J. R., and Evans, W. J. Effects of different doses of caffeine on exercise responses in young children. Med Sci Sports Exerc. 2008;40(5):871-878. View abstract.

Li, Z., Liu, W., Mo, B., Hu, C., Liu, H., Qi, H., Wang, X., and Xu, J. Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells. Nutr Cancer 2008;60(3):382-388. View abstract.

Gliottoni, R. C. and Motl, R. W. Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity. Int J Sport Nutr Exerc.Metab 2008;18(2):103-115. View abstract.

Pruscino, C. L., Ross, M. L., Gregory, J. R., Savage, B., and Flanagan, T. R. Effects of sodium bicarbonate, caffeine, and their combination on repeated 200-m freestyle performance. Int J Sport Nutr Exerc.Metab 2008;18(2):116-130. View abstract.

Chapman, R. F. and Stager, J. M. Caffeine stimulates ventilation in athletes with exercise-induced hypoxemia. Med Sci Sports Exerc. 2008;40(6):1080-1086. View abstract.

Pedersen, D. J., Lessard, S. J., Coffey, V. G., Churchley, E. G., Wootton, A. M., Ng, T., Watt, M. J., and Hawley, J. A. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol 2008;105(1):7-13. View abstract.

Killgore, W. D., Rupp, T. L., Grugle, N. L., Reichardt, R. M., Lipizzi, E. L., and Balkin, T. J. Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. J Sleep Res 2008;17(3):309-321. View abstract.

Waugh, E. J., Lam, M. A., Hawker, G. A., McGowan, J., Papaioannou, A., Cheung, A. M., Hodsman, A. B., Leslie, W. D., Siminoski, K., and Jamal, S. A. Risk factors for low bone mass in healthy 40-60 year old women: a systematic review of the literature. Osteoporos.Int. 2009;20(1):1-21. View abstract.

Michael, N., Johns, M., Owen, C., and Patterson, J. Effects of caffeine on alertness as measured by infrared reflectance oculography. Psychopharmacology (Berl) 2008;200(2):255-260. View abstract.

Williams, A. D., Cribb, P. J., Cooke, M. B., and Hayes, A. The effect of ephedra and caffeine on maximal strength and power in resistance-trained athletes. J Strength.Cond.Res 2008;22(2):464-470. View abstract.

Mednick, S. C., Cai, D. J., Kanady, J., and Drummond, S. P. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res 11-3-2008;193(1):79-86. View abstract.

Jenkins, N. T., Trilk, J. L., Singhal, A., O'Connor, P. J., and Cureton, K. J. Ergogenic effects of low doses of caffeine on cycling performance. Int J Sport Nutr Exerc.Metab 2008;18(3):328-342. View abstract.

Ng, T. P., Feng, L., Niti, M., Kua, E. H., and Yap, K. B. Tea consumption and cognitive impairment and decline in older Chinese adults. Am J Clin Nutr 2008;88(1):224-231. View abstract.

Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., and Foxe, J. J. L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. J Nutr 2008;138(8):1572S-1577S. View abstract.

Woolf, K., Bidwell, W. K., and Carlson, A. G. The effect of caffeine as an ergogenic aid in anaerobic exercise. Int J Sport Nutr Exerc.Metab 2008;18(4):412-429. View abstract.

Beck, T. W., Housh, T. J., Malek, M. H., Mielke, M., and Hendrix, R. The acute effects of a caffeine-containing supplement on bench press strength and time to running exhaustion. J Strength.Cond.Res 2008;22(5):1654-1658. View abstract.

Ozsungur, S., Brenner, D., and El-Sohemy, A. Fourteen well-described caffeine withdrawal symptoms factor into three clusters. Psychopharmacology (Berl) 2009;201(4):541-548. View abstract.

Ozkan, B., Yuksel, N., Anik, Y., Altintas, O., Demirci, A., and Caglar, Y. The effect of caffeine on retrobulbar hemodynamics. Curr.Eye Res 2008;33(9):804-809. View abstract.

Glaister, M., Howatson, G., Abraham, C. S., Lockey, R. A., Goodwin, J. E., Foley, P., and McInnes, G. Caffeine supplementation and multiple sprint running performance. Med Sci Sports Exerc. 2008;40(10):1835-1840. View abstract.

Hogervorst, E., Bandelow, S., Schmitt, J., Jentjens, R., Oliveira, M., Allgrove, J., Carter, T., and Gleeson, M. Caffeine improves physical and cognitive performance during exhaustive exercise. Med Sci Sports Exerc. 2008;40(10):1841-1851. View abstract.

Pini, L. A., Del, Bene E., Zanchin, G., Sarchielli, P., Di, Trapani G., Prudenzano, M. P., LaPegna, G., Savi, L., Di, Loreto G., Dionisio, P., and Granella, F. Tolerability and efficacy of a combination of paracetamol and caffeine in the treatment of tension-type headache: a randomised, double-blind, double-dummy, cross-over study versus placebo and naproxen sodium. J Headache Pain 2008;9(6):367-373. View abstract.

Hudson, G. M., Green, J. M., Bishop, P. A., and Richardson, M. T. Effects of caffeine and aspirin on light resistance training performance, perceived exertion, and pain perception. J Strength.Cond.Res 2008;22(6):1950-1957. View abstract.

Ishitani, K., Lin, J., Manson, J. E., Buring, J. E., and Zhang, S. M. Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. Arch Intern Med 10-13-2008;168(18):2022-2031. View abstract.

Mc Naughton, L. R., Lovell, R. J., Siegler, J. C., Midgley, A. W., Sandstrom, M., and Bentley, D. J. The effects of caffeine ingestion on time trial cycling performance. J Sports Med Phys.Fitness 2008;48(3):320-325. View abstract.

Carr, A., Dawson, B., Schneiker, K., Goodman, C., and Lay, B. Effect of caffeine supplementation on repeated sprint running performance. J Sports Med Phys.Fitness 2008;48(4):472-478. View abstract.

Smith, A. P. Caffeine, cognitive failures and health in a non-working community sample. Hum Psychopharmacol. 2009;24(1):29-34. View abstract.

Soloveychik, V., Bin-Nun, A., Ionchev, A., Sriram, S., and Meadow, W. Acute hemodynamic effects of caffeine administration in premature infants. J Perinatol. 2009;29(3):205-208. View abstract.

Reyes, E., Loong, C. Y., Harbinson, M., Donovan, J., Anagnostopoulos, C., and Underwood, S. R. High-dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine. J Am Coll.Cardiol. 12-9-2008;52(24):2008-2016. View abstract.

Ganio, M. S., Klau, J. F., Casa, D. J., Armstrong, L. E., and Maresh, C. M. Effect of caffeine on sport-specific endurance performance: a systematic review. J Strength Cond.Res 2009;23(1):315-324. View abstract.

Tarnopolsky, M. A. Effect of caffeine on the neuromuscular system--potential as an ergogenic aid. Appl Physiol Nutr Metab 2008;33(6):1284-1289. View abstract.

Tunnicliffe, J. M., Erdman, K. A., Reimer, R. A., Lun, V., and Shearer, J. Consumption of dietary caffeine and coffee in physically active populations: physiological interactions. Appl Physiol Nutr Metab 2008;33(6):1301-1310. View abstract.

Sin, C. W., Ho, J. S., and Chung, J. W. Systematic review on the effectiveness of caffeine abstinence on the quality of sleep. J Clin Nurs. 2009;18(1):13-21. View abstract.

Seng, K. Y., Fun, C. Y., Law, Y. L., Lim, W. M., Fan, W., and Lim, C. L. Population pharmacokinetics of caffeine in healthy male adults using mixed-effects models. J Clin Pharm Ther 2009;34(1):103-114. View abstract.

Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., and Kivipelto, M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers.Dis. 2009;16(1):85-91. View abstract.

McNaughton, L. R., Lovell, R. J., Siegler, J., Midgley, A. W., Moore, L., and Bentley, D. J. The effects of caffeine ingestion on time trial cycling performance. Int J Sports Physiol Perform. 2008;3(2):157-163. View abstract.

Addicott, M. A., Yang, L. L., Peiffer, A. M., Burnett, L. R., Burdette, J. H., Chen, M. Y., Hayasaka, S., Kraft, R. A., Maldjian, J. A., and Laurienti, P. J. The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate? Hum Brain Mapp. 2009;30(10):3102-3114. View abstract.

Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of stroke in women. Circulation 3-3-2009;119(8):1116-1123. View abstract.

Zhang, W., Lopez-Garcia, E., Li, T. Y., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of cardiovascular diseases and all-cause mortality among men with type 2 diabetes. Diabetes Care 2009;32(6):1043-1045. View abstract.

Killgore, W. D., Kahn-Greene, E. T., Grugle, N. L., Killgore, D. B., and Balkin, T. J. Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. Sleep 2-1-2009;32(2):205-216. View abstract.

Heffernan, T. P., Kawasumi, M., Blasina, A., Anderes, K., Conney, A. H., and Nghiem, P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129(7):1805-1815. View abstract.

Lesk, V. E., Honey, T. E., and de Jager, C. A. The effect of recent consumption of caffeine-containing foodstuffs on neuropsychological tests in the elderly. Dement.Geriatr.Cogn Disord. 2009;27(4):322-328. View abstract.

Hagen, K., Thoresen, K., Stovner, L. J., and Zwart, J. A. High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study. J Headache Pain 2009;10(3):153-159. View abstract.

Share, B., Sanders, N., and Kemp, J. Caffeine and performance in clay target shooting. J Sports Sci 2009;27(6):661-666. View abstract.

Ryan, E. D., Beck, T. W., Herda, T. J., Smith, A. E., Walter, A. A., Stout, J. R., and Cramer, J. T. Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise. J Strength Cond.Res 2009;23(3):807-817. View abstract.

Ivy, J. L., Kammer, L., Ding, Z., Wang, B., Bernard, J. R., Liao, Y. H., and Hwang, J. Improved cycling time-trial performance after ingestion of a caffeine energy drink. Int J Sport Nutr Exerc Metab 2009;19(1):61-78. View abstract.

Pfaffenrath, V., Diener, H. C., Pageler, L., Peil, H., and Aicher, B. OTC analgesics in headache treatment: open-label phase vs randomized double-blind phase of a large clinical trial. Headache 2009;49(5):638-645. View abstract.

Gliottoni, R. C., Meyers, J. R., Arngrimsson, S. A., Broglio, S. P., and Motl, R. W. Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. Int J Sport Nutr Exerc.Metab 2009;19(2):150-161. View abstract.

Natale, F., Cirillo, C., Di Marco, G. M., di Vetta, L. S., Aronne, L., Siciliano, A., Mocerino, R., Tedesco, M. A., Golino, P., and Calabro, R. When chewing gum is more than just a bad habit. Lancet 5-30-2009;373(9678):1918. View abstract.

Calamaro, C. J., Mason, T. B., and Ratcliffe, S. J. Adolescents living the 24/7 lifestyle: effects of caffeine and technology on sleep duration and daytime functioning. Pediatrics 2009;123(6):e1005-e1010. View abstract.

Robinson, L. E., Spafford, C., Graham, T. E., and Smith, G. N. Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus. J Obstet.Gynaecol.Can 2009;31(4):304-312. View abstract.

Candow, D. G., Kleisinger, A. K., Grenier, S., and Dorsch, K. D. Effect of sugar-free Red Bull energy drink on high-intensity run time-to-exhaustion in young adults. J Strength.Cond.Res 2009;23(4):1271-1275. View abstract.

Tabaton, M. Coffee "breaks" Alzheimer's disease. J Alzheimers.Dis. 2009;17(3):699-700. View abstract.

Duncan, M. J., Lyons, M., and Hankey, J. Placebo effects of caffeine on short-term resistance exercise to failure. Int J Sports Physiol Perform. 2009;4(2):244-253. View abstract.

Sonneson, G. J. and Horn, J. R. Hapten-induced dimerization of a single-domain VHH camelid antibody. Biochemistry 7-28-2009;48(29):6693-6695. View abstract.

Verder, H., Bohlin, K., Kamper, J., Lindwall, R., and Jonsson, B. Nasal CPAP and surfactant for treatment of respiratory distress syndrome and prevention of bronchopulmonary dysplasia. Acta Paediatr. 2009;98(9):1400-1408. View abstract.

Koran, L. M., Aboujaoude, E., and Gamel, N. N. Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 2009;70(11):1530-1535. View abstract.

Hasani-Ranjbar, S., Nayebi, N., Larijani, B., and Abdollahi, M. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol. 7-7-2009;15(25):3073-3085. View abstract.

Laitala, V. S., Kaprio, J., Koskenvuo, M., Raiha, I., Rinne, J. O., and Silventoinen, K. Coffee drinking in middle age is not associated with cognitive performance in old age. Am J Clin Nutr 2009;90(3):640-646. View abstract.

Walter, A. A., Herda, T. J., Ryan, E. D., Costa, P. B., Hoge, K. M., Beck, T. W., Stout, J. R., and Cramer, J. T. Acute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged men. J Int Soc Sports Nutr 2009;6:15. View abstract.

Scher, A. I., Lipton, R. B., Stewart, W. F., and Bigal, M. Patterns of medication use by chronic and episodic headache sufferers in the general population: results from the frequent headache epidemiology study. Cephalalgia 2010;30(3):321-328. View abstract.

Woolf, K., Bidwell, W. K., and Carlson, A. G. Effect of caffeine as an ergogenic aid during anaerobic exercise performance in caffeine naive collegiate football players. J Strength Cond.Res 2009;23(5):1363-1369. View abstract.

Luebbe, A. M. and Bell, D. J. Mountain Dew or mountain don't?: a pilot investigation of caffeine use parameters and relations to depression and anxiety symptoms in 5th- and 10th-grade students. J Sch Health 2009;79(8):380-387. View abstract.

Desbrow, B., Barrett, C. M., Minahan, C. L., Grant, G. D., and Leveritt, M. D. Caffeine, cycling performance, and exogenous CHO oxidation: a dose-response study. Med Sci Sports Exerc. 2009;41(9):1744-1751. View abstract.

Olmos, V., Bardoni, N., Ridolfi, A. S., and Villaamil Lepori, E. C. Caffeine levels in beverages from Argentina's market: application to caffeine dietary intake assessment. Food Addit.Contam Part A Chem.Anal Control Expo.Risk Assess. 2009;26(3):275-281. View abstract.

Dworetzky, B. A., Bromfield, E. B., Townsend, M. K., and Kang, J. H. A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II. Epilepsia 2010;51(2):198-205. View abstract.

Capek, S. and Guenther, R. K. Caffeine's effects on true and false memory. Psychol.Rep. 2009;104(3):787-795. View abstract.

Deakins, K. M. Bronchopulmonary dysplasia. Respir.Care 2009;54(9):1252-1262. View abstract.

Chik, Y., Hoesch, R. E., Lazaridis, C., Weisman, C. J., and Llinas, R. H. A case of postpartum cerebral angiopathy with subarachnoid hemorrhage. Nat.Rev.Neurol. 2009;5(9):512-516. View abstract.

van, Dieren S., Uiterwaal, C. S., van der Schouw, Y. T., van der, A. DL, Boer, J. M., Spijkerman, A., Grobbee, D. E., and Beulens, J. W. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia 2009;52(12):2561-2569. View abstract.

Wnuk, M., Lewinska, A., Oklejewicz, B., Bugno, M., Slota, E., and Bartosz, G. Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro. Mutat.Res 2009;679(1-2):18-23. View abstract.

Laughon, M. M., Smith, P. B., and Bose, C. Prevention of bronchopulmonary dysplasia. Semin.Fetal Neonatal Med 2009;14(6):374-382. View abstract.

Harrington, B. E. and Schmitt, A. M. Meningeal (postdural) puncture headache, unintentional dural puncture, and the epidural blood patch: a national survey of United States practice. Reg Anesth.Pain Med 2009;34(5):430-437. View abstract.

Skouroliakou, M., Bacopoulou, F., and Markantonis, S. L. Caffeine versus theophylline for apnea of prematurity: a randomised controlled trial. J Paediatr.Child Health 2009;45(10):587-592. View abstract.

Harrell, P. T. and Juliano, L. M. Caffeine expectancies influence the subjective and behavioral effects of caffeine. Psychopharmacology (Berl) 2009;207(2):335-342. View abstract.

Stevenson, E. J., Hayes, P. R., and Allison, S. J. The effect of a carbohydrate-caffeine sports drink on simulated golf performance. Appl Physiol Nutr Metab 2009;34(4):681-688. View abstract.

Arciero, P. J. and Ormsbee, M. J. Relationship of blood pressure, behavioral mood state, and physical activity following caffeine ingestion in younger and older women. Appl Physiol Nutr Metab 2009;34(4):754-762. View abstract.

Urade, Y. [Molecular mechanisms of insomnia]. Nippon Rinsho 2009;67(8):1489-1493. View abstract.

Montandon, G., Horner, R. L., Kinkead, R., and Bairam, A. Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats. J Physiol 11-15-2009;587(Pt 22):5493-5507. View abstract.

Addicott, M. A. and Laurienti, P. J. A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology (Berl) 2009;207(3):423-431. View abstract.

Van Marter, L. J. Epidemiology of bronchopulmonary dysplasia. Semin.Fetal Neonatal Med 2009;14(6):358-366. View abstract.

Puangpraphant, S. and de Mejia, E. G. Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. J Agric.Food Chem. 10-14-2009;57(19):8873-8883. View abstract.

Oba, S., Nagata, C., Nakamura, K., Fujii, K., Kawachi, T., Takatsuka, N., and Shimizu, H. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Br.J Nutr 2010;103(3):453-459. View abstract.

Pimentel, G. D., Zemdegs, J. C., Theodoro, J. A., and Mota, J. F. Does long-term coffee intake reduce type 2 diabetes mellitus risk? Diabetol.Metab Syndr. 2009;1(1):6. View abstract.

Foskett, A., Ali, A., and Gant, N. Caffeine enhances cognitive function and skill performance during simulated soccer activity. Int J Sport Nutr Exerc.Metab 2009;19(4):410-423. View abstract.

Hendrix, C. R., Housh, T. J., Mielke, M., Zuniga, J. M., Camic, C. L., Johnson, G. O., Schmidt, R. J., and Housh, D. J. Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion during cycle ergometry. J Strength.Cond.Res 2010;24(3):859-865. View abstract.

Hashim, H. and Al, Mousa R. Management of fluid intake in patients with overactive bladder. Curr.Urol.Rep. 2009;10(6):428-433. View abstract.

Reznikov, L. R., Pasumarthi, R. K., and Fadel, J. R. Caffeine elicits c-Fos expression in horizontal diagonal band cholinergic neurons. Neuroreport 12-9-2009;20(18):1609-1612. View abstract.

Yagi, K., Goto, K., and Nanjo, F. Identification of a major polyphenol and polyphenolic composition in leaves of Camellia irrawadiensis. Chem.Pharm Bull (Tokyo) 2009;57(11):1284-1288. View abstract.

Moisey, L. L., Robinson, L. E., and Graham, T. E. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Br.J Nutr. 2010;103(6):833-841. View abstract.

Hoffman, M. S., Golder, F. J., Mahamed, S., and Mitchell, G. S. Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia. J Physiol 1-1-2010;588(Pt 1):255-266. View abstract.

Chroscinska-Krawczyk, M., Ratnaraj, N., Patsalos, P. N., and Czuczwar, S. J. Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures. Pharmacol Rep. 2009;61(5):819-826. View abstract.

Strupp, M. and Katsarava, Z. [Post-lumbar puncture syndrome and spontaneous low CSF pressure syndrome]. Nervenarzt 2009;80(12):1509-1519. View abstract.

Maridakis, V., O'Connor, P. J., and Tomporowski, P. D. Sensitivity to change in cognitive performance and mood measures of energy and fatigue in response to morning caffeine alone or in combination with carbohydrate. Int J Neurosci. 2009;119(8):1239-1258. View abstract.

Astorino, T. A. and Roberson, D. W. Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review. J Strength Cond.Res 2010;24(1):257-265. View abstract.

Davis, P. G., Schmidt, B., Roberts, R. S., Doyle, L. W., Asztalos, E., Haslam, R., Sinha, S., and Tin, W. Caffeine for Apnea of Prematurity trial: benefits may vary in subgroups. J Pediatr 2010;156(3):382-387. View abstract.

Attwood, A., Terry, P., and Higgs, S. Conditioned effects of caffeine on performance in humans. Physiol Behav 3-3-2010;99(3):286-293. View abstract.

Skinner, T. L., Jenkins, D. G., Coombes, J. S., Taaffe, D. R., and Leveritt, M. D. Dose response of caffeine on 2000-m rowing performance. Med Sci Sports Exerc. 2010;42(3):571-576. View abstract.

Corley, J., Jia, X., Kyle, J. A., Gow, A. J., Brett, C. E., Starr, J. M., McNeill, G., and Deary, I. J. Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study. Psychosom.Med 2010;72(2):206-214. View abstract.

Xie, X. K., Yang, D. S., Ye, Z. M., and Tao, H. M. Enhancement effect of adenovirus-mediated antisense c-myc and caffeine on the cytotoxicity of cisplatin in osteosarcoma cell lines. Chemotherapy 2009;55(6):433-440. View abstract.

Kumada, T., Nishii, R., Higashi, T., Oda, N., and Fujii, T. Epileptic apnea in a trisomy 18 infant. Pediatr.Neurol. 2010;42(1):61-64. View abstract.

Warren, G. L., Park, N. D., Maresca, R. D., McKibans, K. I., and Millard-Stafford, M. L. Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis. Med Sci Sports Exerc. 2010;42(7):1375-1387. View abstract.

Dusitanond, P. and Young, W. B. Neuroleptics and migraine. Cent.Nerv Syst.Agents Med Chem. 2009;9(1):63-70. View abstract.

Modi, A. A., Feld, J. J., Park, Y., Kleiner, D. E., Everhart, J. E., Liang, T. J., and Hoofnagle, J. H. Increased caffeine consumption is associated with reduced hepatic fibrosis. Hepatology 2010;51(1):201-209. View abstract.

Holick, C. N., Smith, S. G., Giovannucci, E., and Michaud, D. S. Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies. Cancer Epidemiol.Biomarkers Prev 2010;19(1):39-47. View abstract.

Vandenbogaerde, T. J. and Hopkins, W. G. Monitoring acute effects on athletic performance with mixed linear modeling. Med Sci Sports Exerc. 2010;42(7):1339-1344. View abstract.

Einother, S. J., Martens, V. E., Rycroft, J. A., and De Bruin, E. A. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite 2010;54(2):406-409. View abstract.

Borel, J. F., Deschaumes, C., Devoize, L., Huard, C., Orliaguet, T., Dubray, C., Baudet-Pommel, M., and Dallel, R. [Treating pain after dental surgery: a randomised, controlled, double-blind trial to assess a new formulation of paracetamol, opium powder and caffeine versus tramadol or placebo]. Presse Med 2010;39(5):e103-e111. View abstract.

Simmonds, M. J., Minahan, C. L., and Sabapathy, S. Caffeine improves supramaximal cycling but not the rate of anaerobic energy release. Eur.J Appl Physiol 2010;109(2):287-295. View abstract.

Henderson-Smart, D. J. and Steer, P. A. Caffeine versus theophylline for apnea in preterm infants. Cochrane.Database.Syst.Rev. 2010;(1):CD000273. View abstract.

Welsh, E. J., Bara, A., Barley, E., and Cates, C. J. Caffeine for asthma. Cochrane.Database.Syst.Rev. 2010;(1):CD001112. View abstract.

Rudolph, T. and Knudsen, K. A case of fatal caffeine poisoning. Acta Anaesthesiol.Scand 2010;54(4):521-523. View abstract.

Sinn, B., Tallen, G., Schroeder, G., Grassl, B., Schulze, J., Budach, V., and Tinhofer, I. Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation. Mol.Cancer Ther. 2010;9(2):480-488. View abstract.

Kang, S. S., Han, K. S., Ku, B. M., Lee, Y. K., Hong, J., Shin, H. Y., Almonte, A. G., Woo, D. H., Brat, D. J., Hwang, E. M., Yoo, S. H., Chung, C. K., Park, S. H., Paek, S. H., Roh, E. J., Lee, S. J., Park, J. Y., Traynelis, S. F., and Lee, C. J. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res 2-1-2010;70(3):1173-1183. View abstract.

Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., and Cerasola, G. Acute effects of coffee on endothelial function in healthy subjects. Eur.J Clin Nutr. 2010;64(5):483-489. View abstract.

Sartorelli, D. S., Fagherazzi, G., Balkau, B., Touillaud, M. S., Boutron-Ruault, M. C., de Lauzon-Guillain, B., and Clavel-Chapelon, F. Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. Am J Clin Nutr 2010;91(4):1002-1012. View abstract.

VanHaitsma, T. A., Mickleborough, T., Stager, J. M., Koceja, D. M., Lindley, M. R., and Chapman, R. Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes. Int J Sports Med 2010;31(4):231-236. View abstract.

Kumral, A., Yesilirmak, D. C., Aykan, S., Genc, S., Tugyan, K., Cilaker, S., Akhisaroglu, M., Aksu, I., Sutcuoglu, S., Yilmaz, O., Duman, N., and Ozkan, H. Protective effects of methylxanthines on hypoxia-induced apoptotic neurodegeneration and long-term cognitive functions in the developing rat brain. Neonatology. 2010;98(2):128-136. View abstract.

Chen, X., Ghribi, O., and Geiger, J. D. Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers.Dis. 2010;20 Suppl 1:S127-S141. View abstract.

Lara, D. R. Caffeine, mental health, and psychiatric disorders. J Alzheimers.Dis. 2010;20 Suppl 1:S239-S248. View abstract.

Xu, K., Xu, Y. H., Chen, J. F., and Schwarzschild, M. A. Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease. Neuroscience 5-5-2010;167(2):475-481. View abstract.

Mattioli, A. V., Farinetti, A., Miloro, C., Pedrazzi, P., and Mattioli, G. Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients. Nutr Metab Cardiovasc.Dis. 2-16-2010; View abstract.

Thelander, G., Jonsson, A. K., Personne, M., Forsberg, G. S., Lundqvist, K. M., and Ahlner, J. Caffeine fatalities--do sales restrictions prevent intentional intoxications? Clin Toxicol.(Phila) 2010;48(4):354-358. View abstract.

Dean, S., Braakhuis, A., and Paton, C. The effects of EGCG on fat oxidation and endurance performance in male cyclists. Int J Sport Nutr Exerc.Metab 2009;19(6):624-644. View abstract.

Ahmed, I. Malignant hypertension and acute aortic dissection associated with caffeine-based ephedra-free dietary supplements: a case report. Cases.J 2009;2:6612. View abstract.

Costa, J., Lunet, N., Santos, C., Santos, J., and Vaz-Carneiro, A. Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies. J Alzheimers.Dis. 2010;20 Suppl 1:S221-S238. View abstract.

Santos, C., Costa, J., Santos, J., Vaz-Carneiro, A., and Lunet, N. Caffeine intake and dementia: systematic review and meta-analysis. J Alzheimers.Dis. 2010;20 Suppl 1:S187-S204. View abstract.

Nehlig, A. Is caffeine a cognitive enhancer? J Alzheimers.Dis. 2010;20 Suppl 1:S85-S94. View abstract.

Santos, C., Lunet, N., Azevedo, A., de, Mendonca A., Ritchie, K., and Barros, H. Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. J Alzheimers.Dis. 2010;20 Suppl 1:S175-S185. View abstract.

Arendash, G. W. and Cao, C. Caffeine and coffee as therapeutics against Alzheimer's disease. J Alzheimers.Dis. 2010;20 Suppl 1:S117-S126. View abstract.

Biessels, G. J. Caffeine, diabetes, cognition, and dementia. J Alzheimers.Dis. 2010;20 Suppl 1:S143-S150. View abstract.

Cunha, R. A. and Agostinho, P. M. Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. J Alzheimers.Dis. 2010;20 Suppl 1:S95-116. View abstract.

Ferre, S. Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine. J Alzheimers.Dis. 2010;20 Suppl 1:S35-S49. View abstract.

Kachroo, A., Irizarry, M. C., and Schwarzschild, M. A. Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Exp.Neurol. 2010;223(2):657-661. View abstract.

Barbour, K. E., Zmuda, J. M., Strotmeyer, E. S., Horwitz, M. J., Boudreau, R., Evans, R. W., Ensrud, K. E., Petit, M. A., Gordon, C. L., and Cauley, J. A. Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study. J Bone Miner.Res 2010;25(5):1017-1028. View abstract.

Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., Wildman, R., Ivy, J. L., Spano, M., Smith, A. E., and Antonio, J. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 2010;7(1):5. View abstract.

Rigato, I., Blarasin, L., and Kette, F. Severe hypokalemia in 2 young bicycle riders due to massive caffeine intake. Clin J Sport Med. 2010;20(2):128-130. View abstract.

Ruangkittisakul, A., Panaitescu, B., Kuribayashi, J., and Ballanyi, K. Caffeine reversal of opioid-evoked and endogenous inspiratory depression in perinatal rat en bloc medullas and slices. Adv.Exp.Med Biol 2010;669:123-127. View abstract.

Lv, X., Chen, Z., Li, J., Zhang, L., Liu, H., Huang, C., and Zhu, P. Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflamm.Res 2010;59(8):635-645. View abstract.

Jha, R. M., Mithal, A., Malhotra, N., and Brown, E. M. Pilot case-control investigation of risk factors for hip fractures in the urban Indian population. BMC.Musculoskelet.Disord. 2010;11:49. View abstract.

Greenwood, D. C., Alwan, N., Boylan, S., Cade, J. E., Charvill, J., Chipps, K. C., Cooke, M. S., Dolby, V. A., Hay, A. W., Kassam, S., Kirk, S. F., Konje, J. C., Potdar, N., Shires, S., Simpson, N., Taub, N., Thomas, J. D., Walker, J., White, K. L., and Wild, C. P. Caffeine intake during pregnancy, late miscarriage and stillbirth. Eur.J Epidemiol. 2010;25(4):275-280. View abstract.

Mevcha, A., Gulur, D. M., and Gillatt, D. Diagnosing urological disorders in ageing men. Practitioner 2010;254(1726):25-9, 2. View abstract.

Ling, T. J., Wan, X. C., Ling, W. W., Zhang, Z. Z., Xia, T., Li, D. X., and Hou, R. Y. New triterpenoids and other constituents from a special microbial-fermented tea-Fuzhuan brick tea. J Agric.Food Chem. 4-28-2010;58(8):4945-4950. View abstract.

Brick, C. A., Seely, D. L., and Palermo, T. M. Association between sleep hygiene and sleep quality in medical students. Behav Sleep Med 2010;8(2):113-121. View abstract.

Ruusunen, A., Lehto, S. M., Tolmunen, T., Mursu, J., Kaplan, G. A., and Voutilainen, S. Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Public Health Nutr 2010;13(8):1215-1220. View abstract.

Digdon, N. L. Circadian preference and college students' beliefs about sleep education. Chronobiol.Int 2010;27(2):297-317. View abstract.

Elliman, N. A., Ash, J., and Green, M. W. Pre-existent expectancy effects in the relationship between caffeine and performance. Appetite 2010;55(2):355-358. View abstract.

Wang, T. J., Liu, Z. S., Zeng, Z. C., Du, S. S., Qiang, M., Zhang, S. M., Zhang, Z. Y., Tang, Z. Y., Wu, W. Z., and Zeng, H. Y. Caffeine enhances radiosensitization to orthotopic transplant LM3 hepatocellular carcinoma in vivo. Cancer Sci 2010;101(6):1440-1446. View abstract.

Karydes, H. C. and Bryant, S. M. Adenosine and caffeine-induced paroxysmal supraventricular tachycardia. Acad.Emerg.Med 2010;17(5):570. View abstract.

Antonelli-Ushirobira, T. M., Kaneshima, E. N., Gabriel, M., Audi, E. A., Marques, L. C., and Mello, J. C. Acute and subchronic toxicological evaluation of the semipurified extract of seeds of guarana (Paullinia cupana) in rodents. Food Chem.Toxicol. 2010;48(7):1817-1820. View abstract.

Truter, I. Prescribing for migraine with the focus on selective 5HT1-receptor agonists: a pharmacy database analysis. Int J Clin Pharmacol Ther. 2010;48(5):319-326. View abstract.

Astorino, T. A., Terzi, M. N., Roberson, D. W., and Burnett, T. R. Effect of Two Doses of Caffeine on Muscular Function during Isokinetic Exercise. Med Sci Sports Exerc. 4-22-2010; View abstract.

Liu, W. H. and Chang, L. S. Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway. J Cell Physiol 2010;224(3):775-785. View abstract.

Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. View abstract.

Julien, C. A., Joseph, V., and Bairam, A. Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia. Pediatr Res 2010;68(2):105-111. View abstract.

Kramer, B. W., Lievense, S., Been, J. V., and Zimmermann, L. J. [From classic to new bronchopulmonary dysplasia]. Ned.Tijdschr.Geneeskd. 2010;154(14):A1024. View abstract.

Casiglia, E., Bongiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study. J.Intern.Med. 1991;229(6):501-504. View abstract.

Aguggia, M. and Saracco, M. G. Pathophysiology of migraine chronification. Neurol.Sci 2010;31 Suppl 1:S15-S17. View abstract.

Ker, K., Edwards, P. J., Felix, L. M., Blackhall, K., and Roberts, I. Caffeine for the prevention of injuries and errors in shift workers. Cochrane.Database.Syst.Rev. 2010;(5):CD008508. View abstract.

Kato, M., Kitao, N., Ishida, M., Morimoto, H., Irino, F., and Mizuno, K. Expression for caffeine biosynthesis and related enzymes in Camellia sinensis. Z.Naturforsch.C. 2010;65(3-4):245-256. View abstract.

Goldstein, E., Jacobs, P. L., Whitehurst, M., Penhollow, T., and Antonio, J. Caffeine enhances upper body strength in resistance-trained women. J Int Soc Sports Nutr 2010;7:18. View abstract.

Ganio, M. S., Klau, J. F., Lee, E. C., Yeargin, S. W., McDermott, B. P., Buyckx, M., Maresh, C. M., and Armstrong, L. E. Effect of various carbohydrate-electrolyte fluids on cycling performance and maximal voluntary contraction. Int J Sport Nutr Exerc.Metab 2010;20(2):104-114. View abstract.

Park, Y. S., Lee, M. K., Heo, B. G., Ham, K. S., Kang, S. G., Cho, J. Y., and Gorinstein, S. Comparison of the nutrient and chemical contents of traditional Korean Chungtaejeon and green teas. Plant Foods Hum Nutr 2010;65(2):186-191. View abstract.

Torelli, P. and Manzoni, G. C. Fasting headache. Curr Pain Headache Rep. 2010;14(4):284-291. View abstract.

Heckman, M. A., Weil, J., and Gonzalez de, Mejia E. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci 2010;75(3):R77-R87. View abstract.

Farag, N. H., Whitsett, T. L., McKey, B. S., Wilson, M. F., Vincent, A. S., Everson-Rose, S. A., and Lovallo, W. R. Caffeine and blood pressure response: sex, age, and hormonal status. J Womens Health (Larchmt.) 2010;19(6):1171-1176. View abstract.

Ernest, D., Chia, M., and Corallo, C. E. Profound hypokalaemia due to Nurofen Plus and Red Bull misuse. Crit Care Resusc. 2010;12(2):109-110. View abstract.

Suen, L. K., Tam, W. W., and Hon, K. L. Association of sleep hygiene-related factors and sleep quality among university students in Hong Kong. Hong.Kong.Med.J 2010;16(3):180-185. View abstract.

Roberts, S. P., Stokes, K. A., Trewartha, G., Doyle, J., Hogben, P., and Thompson, D. Effects of carbohydrate and caffeine ingestion on performance during a rugby union simulation protocol. J Sports Sci 2010;28(8):833-842. View abstract.

Adan, A. and Serra-Grabulosa, J. M. Effects of caffeine and glucose, alone and combined, on cognitive performance. Hum Psychopharmacol. 2010;25(4):310-317. View abstract.

Elie, D., Gagnon, P., Gagnon, B., and Giguere, A. [Using psychostimulants in end-of-life patients with hypoactive delirium and cognitive disorders: A literature review]. Can J Psychiatry 2010;55(6):386-393. View abstract.

Brothers, H. M., Marchalant, Y., and Wenk, G. L. Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neurosci.Lett. 8-16-2010;480(2):97-100. View abstract.

Botton, P. H., Costa, M. S., Ardais, A. P., Mioranzza, S., Souza, D. O., da Rocha, J. B., and Porciuncula, L. O. Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice. Behav Brain Res 12-25-2010;214(2):254-259. View abstract.

Stafford, L. D., Wright, C., and Yeomans, M. R. The drink remains the same: implicit positive associations in high but not moderate or non-caffeine users. Psychol.Addict.Behav. 2010;24(2):274-281. View abstract.

Conen, D., Chiuve, S. E., Everett, B. M., Zhang, S. M., Buring, J. E., and Albert, C. M. Caffeine consumption and incident atrial fibrillation in women. Am J Clin Nutr 2010;92(3):509-514. View abstract.

Napolitano, G., Amente, S., Castiglia, V., Gargano, B., Ruda, V., Darzacq, X., Bensaude, O., Majello, B., and Lania, L. Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage. PLoS.One. 2010;5(6):e11245. View abstract.

Xu, Y. and Venton, B. J. Rapid determination of adenosine deaminase kinetics using fast-scan cyclic voltammetry. Phys.Chem.Chem.Phys. 9-14-2010;12(34):10027-10032. View abstract.

Meyer, F. P., Canzler, E., Giers, H., and Walther, H. [Time course of inhibition of caffeine elimination in response to the oral depot contraceptive agent Deposiston. Hormonal contraceptives and caffeine elimination]. Zentralbl.Gynakol. 1991;113(6):297-302. View abstract.

Lisotto, C., Rossi, P., Tassorelli, C., Ferrante, E., and Nappi, G. Focus on therapy of hypnic headache. J Headache Pain 2010;11(4):349-354. View abstract.

Freire, R. C., Perna, G., and Nardi, A. E. Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment. Harv.Rev.Psychiatry 2010;18(4):220-229. View abstract.

Bracesco, N., Sanchez, A. G., Contreras, V., Menini, T., and Gugliucci, A. Recent advances on Ilex paraguariensis research: Minireview. J Ethnopharmacol. 6-26-2010; View abstract.

Pires, V. A., Pamplona, F. A., Pandolfo, P., Prediger, R. D., and Takahashi, R. N. Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD). Behav Brain Res 12-20-2010;215(1):39-44. View abstract.

Gant, N., Ali, A., and Foskett, A. The influence of caffeine and carbohydrate coingestion on simulated soccer performance. Int J Sport Nutr Exerc.Metab 2010;20(3):191-197. View abstract.

Reis, J. P., Loria, C. M., Steffen, L. M., Zhou, X., van, Horn L., Siscovick, D. S., Jacobs, D. R., Jr., and Carr, J. J. Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study. Arterioscler.Thromb.Vasc.Biol 2010;30(10):2059-2066. View abstract.

Clausen, T. Hormonal and pharmacological modification of plasma potassium homeostasis. Fundam.Clin Pharmacol 2010;24(5):595-605. View abstract.

Gevins, A., Smith, M. E., McEvoy, L. K., Ilan, A. B., Chan, C. S., Jiang, A., Sam-Vargas, L., and Abraham, G. A cognitive and neurophysiological test of change from an individual's baseline. Clin.Neurophysiol. 2011;122(1):114-120. View abstract.

Palmer, H., Graham, G., Williams, K., and Day, R. A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. Pain Med 2010;11(6):951-965. View abstract.

Momsen, A. H., Jensen, M. B., Norager, C. B., Madsen, M. R., Vestersgaard-Andersen, T., and Lindholt, J. S. Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication. Br.J Surg. 2010;97(10):1503-1510. View abstract.

Szeto, Y. T. and Tong, H. H. Caffeine as a photoprotective agent for diminishing phototoxicity. Toxicol.Ind.Health 2010;26(10):667-670. View abstract.

Artin, B., Singh, M., Richeh, C., Jawad, E., Arora, R., and Khosla, S. Caffeine-related atrial fibrillation. Am J Ther 2010;17(5):e169-e171. View abstract.

Prasanthi, J. R., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D., and Ghribi, O. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic.Biol Med 10-15-2010;49(7):1212-1220. View abstract.

Kujawa-Hadrys, M., Tosik, D., and Bartel, H. Changes in thickness of each layer of developing chicken cornea after administration of caffeine. Folia Histochem.Cytobiol. 2010;48(2):273-277. View abstract.

Mueni, E., Opiyo, N., and English, M. Caffeine for the management of apnea in preterm infants. Int Health 2009;1(2):190-195. View abstract.

Boggs, D. A., Palmer, J. R., Stampfer, M. J., Spiegelman, D., Adams-Campbell, L. L., and Rosenberg, L. Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study. Cancer Causes Control 2010;21(11):1941-1948. View abstract.

Chavez, Valdez R., Ahlawat, R., Wills-Karp, M., Nathan, A., Ezell, T., and Gauda, E. B. Correlation between Serum Caffeine Levels and Changes in Cytokine Profile in a Cohort of Preterm Infants. J Pediatr. 2011 Jan;158(1):57-64.

View abstract.

Schulzke, S. M. and Pillow, J. J. The management of evolving bronchopulmonary dysplasia. Paediatr.Respir.Rev. 2010;11(3):143-148. View abstract.

Ping, W. C., Keong, C. C., and Bandyopadhyay, A. Effects of acute supplementation of caffeine on cardiorespiratory responses during endurance running in a hot & humid climate. Indian J Med Res 2010;132:36-41. View abstract.

Paton, C. D., Lowe, T., and Irvine, A. Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. Eur.J Appl.Physiol 2010;110(6):1243-1250. View abstract.

Dostal, V., Roberts, C. M., and Link, C. D. Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of {beta}-Amyloid Peptide Toxicity. Genetics 2010;186(3):857-866. View abstract.

Nebes, R. D., Pollock, B. G., Halligan, E. M., Houck, P., and Saxton, J. A. Cognitive Slowing Associated With Elevated Serum Anticholinergic Activity in Older Individuals is Decreased by Caffeine Use. Am J Geriatr.Psychiatry 6-10-2010; View abstract.

Olson, C. A., Thornton, J. A., Adam, G. E., and Lieberman, H. R. Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood. J Clin Psychopharmacol. 2010;30(5):573-578. View abstract.

Smillie, L. D. and Gokcen, E. Caffeine enhances working memory for extraverts. Biol Psychol. 2010;85(3):496-498. View abstract.

Li, S., Zhu, S., Jin, X., Yan, C., Wu, S., Jiang, F., and Shen, X. Risk factors associated with short sleep duration among Chinese school-aged children. Sleep Med. 2010;11(9):907-916. View abstract.

Lee, J. E., Lee, B. J., Chung, J. O., Hwang, J. A., Lee, S. J., Lee, C. H., and Hong, Y. S. Geographical and climatic dependencies of green tea (Camellia sinensis) metabolites: a (1)H NMR-based metabolomics study. J Agric.Food Chem. 10-13-2010;58(19):10582-10589. View abstract.

Xiao, D., Cassin, J. J., Healy, B., Burdett, T. C., Chen, J. F., Fredholm, B. B., and Schwarzschild, M. A. Deletion of adenosine A(1) or A(2A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease. Brain Res 9-6-2010; View abstract.

Brunye, T. T., Mahoney, C. R., Lieberman, H. R., Giles, G. E., and Taylor, H. A. Acute caffeine consumption enhances the executive control of visual attention in habitual consumers. Brain Cogn 2010;74(3):186-192. View abstract.

Gronroos, N. N. and Alonso, A. Diet and risk of atrial fibrillation - epidemiologic and clinical evidence -. Circ.J 2010;74(10):2029-2038. View abstract.

Obermann, M. and Holle, D. Hypnic headache. Expert.Rev.Neurother. 2010;10(9):1391-1397. View abstract.

Knight, J. M., Avery, E. F., Janssen, I., and Powell, L. H. Cortisol and depressive symptoms in a population-based cohort of midlife women. Psychosom.Med. 2010;72(9):855-861. View abstract.

Magalhaes, S. T., Fernandes, F. L., Demuner, A. J., Picanco, M. C., and Guedes, R. N. Leaf alkaloids, phenolics, and coffee resistance to the leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). J Econ.Entomol. 2010;103(4):1438-1443. View abstract.

Muller, C. E. and Jacobson, K. A. Xanthines as adenosine receptor antagonists. Handb.Exp.Pharmacol 2011;(200):151-199. View abstract.

Smit, H. J. Theobromine and the pharmacology of cocoa. Handb.Exp.Pharmacol 2011;(200):201-234. View abstract.

Chen, J. F. and Chern, Y. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Handb.Exp.Pharmacol 2011;(200):267-310. View abstract.

Sawynok, J. Methylxanthines and pain. Handb.Exp.Pharmacol 2011;(200):311-329. View abstract.

Porkka-Heiskanen, T. Methylxanthines and sleep. Handb.Exp.Pharmacol 2011;(200):331-348. View abstract.

Osswald, H. and Schnermann, J. Methylxanthines and the kidney. Handb.Exp.Pharmacol 2011;(200):391-412. View abstract.

Hasko, G. and Cronstein, B. Methylxanthines and inflammatory cells. Handb.Exp.Pharmacol 2011;(200):457-468. View abstract.

Aranda, J. V., Beharry, K., Valencia, G. B., Natarajan, G., and Davis, J. Caffeine impact on neonatal morbidities. J Matern.Fetal Neonatal Med 2010;23 Suppl 3:20-23. View abstract.

Castro, J., Pregibon, T., Chumanov, K., and Marcus, R. K. Determination of catechins and caffeine in proposed green tea standard reference materials by liquid chromatography-particle beam/electron ionization mass spectrometry (LC-PB/EIMS). Talanta 10-15-2010;82(5):1687-1695. View abstract.

Mostofsky, E., Schlaug, G., Mukamal, K. J., Rosamond, W. D., and Mittleman, M. A. Coffee and acute ischemic stroke onset: the Stroke Onset Study. Neurology 11-2-2010;75(18):1583-1588. View abstract.

Vaglio, J. C., Schoenhard, J. A., Saavedra, P. J., Williams, S. R., and Raj, S. R. Arrhythmogenic Munchausen syndrome culminating in caffeine-induced ventricular tachycardia. J Electrocardiol. 9-29-2010; View abstract.

Glade, M. J. Caffeine-Not just a stimulant. Nutrition 2010;26(10):932-938. View abstract.

Shinohara, T., Park, H. W., Han, S., Shen, M. J., Maruyama, M., Kim, D., Chen, P. S., and Lin, S. F. Ca2+ clock malfunction in a canine model of pacing-induced heart failure. Am.J Physiol Heart Circ.Physiol 2010;299(6):H1805-H1811. View abstract.

Orozco-Gregorio, H., Mota-Rojas, D., Bonilla-Jaime, H., Trujillo-Ortega, M. E., Becerril-Herrera, M., Hernandez-Gonzalez, R., and Villanueva-Garcia, D. Effects of administration of caffeine on metabolic variables in neonatal pigs with peripartum asphyxia. Am.J Vet.Res. 2010;71(10):1214-1219. View abstract.

Killgore, W. D., Kamimori, G. H., and Balkin, T. J. Caffeine protects against increased risk-taking propensity during severe sleep deprivation. J Sleep Res 10-14-2010; View abstract.

Vanattou-Saifoudine, N., Gossen, A., and Harkin, A. A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release. Eur.J Pharmacol. 1-10-2011;650(1):220-228. View abstract.

Goto, A., Song, Y., Chen, B. H., Manson, J. E., Buring, J. E., and Liu, S. Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. Diabetes 2011;60(1):269-275. View abstract.

Doyle, L. W., Cheong, J., Hunt, R. W., Lee, K. J., Thompson, D. K., Davis, P. G., Rees, S., Anderson, P. J., and Inder, T. E. Caffeine and brain development in very preterm infants. Ann Neurol. 2010;68(5):734-742. View abstract.

Li, G. Z., Zhang, N., Du, P., Yang, Y., Wu, S. L., Xiao, Y. X., Jin, R., Liu, L., Shen, H., and Dai, Y. Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study. Chin Med J (Engl.) 2010;123(20):2842-2846. View abstract.

Giesbrecht, T., Rycroft, J. A., Rowson, M. J., and De Bruin, E. A. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010;13(6):283-290. View abstract.

Mets, M. A., Ketzer, S., Blom, C., van Gerven, M. H., van Willigenburg, G. M., Olivier, B., and Verster, J. C. Positive effects of Red Bull(R) Energy Drink on driving performance during prolonged driving. Psychopharmacology (Berl) 2011;214(3):737-745. View abstract.

Hammami, M. M., Al-Gaai, E. A., Alvi, S., and Hammami, M. B. Interaction between drug and placebo effects: a cross-over balanced placebo design trial. Trials 2010;11:110. View abstract.

Ganio, M. S., Johnson, E. C., Klau, J. F., Anderson, J. M., Casa, D. J., Maresh, C. M., Volek, J. S., and Armstrong, L. E. Effect of ambient temperature on caffeine ergogenicity during endurance exercise. Eur.J Appl.Physiol 2011;111(6):1135-1146. View abstract.

Mathew, O. P. Apnea of prematurity: pathogenesis and management strategies. J Perinatol. 2011;31(5):302-310. View abstract.

Howland, J., Rohsenow, D. J., Arnedt, J. T., Bliss, C. A., Hunt, S. K., Calise, T. V., Heeren, T., Winter, M., Littlefield, C., and Gottlieb, D. J. The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time. Addiction 2011;106(2):335-341. View abstract.

Henderson-Smart, D. J. and Davis, P. G. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane.Database.Syst.Rev. 2010;(12):CD000139. View abstract.

Henderson-Smart, D. J. and De Paoli, A. G. Methylxanthine treatment for apnoea in preterm infants. Cochrane.Database.Syst.Rev. 2010;(12):CD000140. View abstract.

Henderson-Smart, D. J. and De Paoli, A. G. Prophylactic methylxanthine for prevention of apnoea in preterm infants. Cochrane.Database.Syst.Rev. 2010;(12):CD000432. View abstract.

Duncan, M. J. and Oxford, S. W. The effect of caffeine ingestion on mood state and bench press performance to failure. J Strength.Cond.Res 2011;25(1):178-185. View abstract.

Pontifex, K. J., Wallman, K. E., Dawson, B. T., and Goodman, C. Effects of caffeine on repeated sprint ability, reactive agility time, sleep and next day performance. J Sports Med.Phys.Fitness 2010;50(4):455-464. View abstract.

Howard, M. A. and Marczinski, C. A. Acute effects of a glucose energy drink on behavioral control. Exp.Clin.Psychopharmacol. 2010;18(6):553-561. View abstract.

Walker, T. B., Balldin, U., Fischer, J., Storm, W., and Warren, G. L. Acceleration tolerance after ingestion of a commercial energy drink. Aviat.Space Environ.Med. 2010;81(12):1100-1106. View abstract.

Lee, C. L., Lin, J. C., and Cheng, C. F. Effect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance. Eur.J Appl.Physiol 2011;111(8):1669-1677. View abstract.

Ramakers, B. P., Riksen, N. P., van den Broek, P., Franke, B., Peters, W. H., van der Hoeven, J. G., Smits, P., and Pickkers, P. Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury. Crit Care 2011;15(1):R3. View abstract.

Hunt, M. G., Momjian, A. J., and Wong, K. K. Effects of diurnal variation and caffeine consumption on Test of Variables of Attention (TOVA) performance in healthy young adults. Psychol.Assess. 2011;23(1):226-233. View abstract.

Gray, P. H., Flenady, V. J., Charles, B. G., and Steer, P. A. Caffeine citrate for very preterm infants: Effects on development, temperament and behaviour. J Paediatr.Child Health 2011;47(4):167-172. View abstract.

Kennedy, D. O. and Haskell, C. F. Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: a near infrared spectroscopy study. Biol.Psychol. 2011;86(3):298-306. View abstract.

Duvnjak-Zaknich, D. M., Dawson, B. T., Wallman, K. E., and Henry, G. Effect of caffeine on reactive agility time when fresh and fatigued. Med.Sci.Sports Exerc. 2011;43(8):1523-1530. View abstract.

Irwin, C., Desbrow, B., Ellis, A., O'Keeffe, B., Grant, G., and Leveritt, M. Caffeine withdrawal and high-intensity endurance cycling performance. J Sports Sci. 2011;29(5):509-515. View abstract.

Astorino, T. A., Martin, B. J., Schachtsiek, L., Wong, K., and Ng, K. Minimal effect of acute caffeine ingestion on intense resistance training performance. J Strength.Cond.Res 2011;25(6):1752-1758. View abstract.

Serra-Grabulosa, J. M., Adan, A., Falcon, C., and Bargallo, N. Glucose and caffeine effects on sustained attention: an exploratory fMRI study. Hum.Psychopharmacol. 2010;25(7-8):543-552. View abstract.

Shechter, M., Shalmon, G., Scheinowitz, M., Koren-Morag, N., Feinberg, M. S., Harats, D., Sela, B. A., Sharabi, Y., and Chouraqui, P. Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease. Am J Cardiol 5-1-2011;107(9):1255-1261. View abstract.

Astorino, T. A., Terzi, M. N., Roberson, D. W., and Burnett, T. R. Effect of caffeine intake on pain perception during high-intensity exercise. Int.J Sport Nutr.Exerc.Metab 2011;21(1):27-32. View abstract.

Broe, G. A., Henderson, A. S., Creasey, H., McCusker, E., Korten, A. E., Jorm, A. F., Longley, W., and Anthony, J. C. A case-control study of Alzheimer's disease in Australia. Neurology 1990;40(11):1698-1707. View abstract.

Bazzucchi, I., Felici, F., Montini, M., Figura, F., and Sacchetti, M. Caffeine improves neuromuscular function during maximal dynamic exercise. Muscle Nerve 2011;43(6):839-844. View abstract.

Pappa, H. M., Saslowsky, T. M., Filip-Dhima, R., DiFabio, D., Lahsinoui, H. H., Akkad, A., Grand, R. J., and Gordon, C. M. Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial. Am J Gastroenterol. 2011;106(8):1527-1543. View abstract.

Bellar, D., Kamimori, G. H., and Glickman, E. L. The effects of low-dose caffeine on perceived pain during a grip to exhaustion task. J Strength.Cond.Res 2011;25(5):1225-1228. View abstract.

Erol, D. D. The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache. Adv.Med.Sci. 2011;56(1):25-29. View abstract.

Fletcher, D. K. and Bishop, N. C. Effect of a high and low dose of caffeine on antigen-stimulated activation of human natural killer cells after prolonged cycling. Int.J Sport Nutr.Exerc.Metab 2011;21(2):155-165. View abstract.

Yurach, M. T., Davis, B. E., and Cockcroft, D. W. The effect of caffeinated coffee on airway response to methacholine and exhaled nitric oxide. Respir.Med. 2011;105(11):1606-1610. View abstract.

Aggarwal, R., Mishra, A., Crochet, P., Sirimanna, P., and Darzi, A. Effect of caffeine and taurine on simulated laparoscopy performed following sleep deprivation. Br J Surg 2011;98(11):1666-1672. View abstract.

Carr, A. J., Gore, C. J., and Dawson, B. Induced alkalosis and caffeine supplementation: effects on 2,000-m rowing performance. Int.J Sport Nutr.Exerc.Metab 2011;21(5):357-364. View abstract.

Peliowski, A. and Finer, N. N. A blinded, randomized, placebo-controlled trial to compare theophylline and doxapram for the treatment of apnea of prematurity. J Pediatr 1990;116(4):648-653. View abstract.

Dawkins, L., Shahzad, F. Z., Ahmed, S. S., and Edmonds, C. J. Expectation of having consumed caffeine can improve performance and mood. Appetite 2011;57(3):597-600. View abstract.

Taylor, C., Higham, D., Close, G. L., and Morton, J. P. The effect of adding caffeine to postexercise carbohydrate feeding on subsequent high-intensity interval-running capacity compared with carbohydrate alone. Int.J Sport Nutr.Exerc.Metab 2011;21(5):410-416. View abstract.

Kivity, S., Ben Aharon, Y., Man, A., and Topilsky, M. The effect of caffeine on exercise-induced bronchoconstriction. Chest 1990;97(5):1083-1085. View abstract.

Benko, C. R., Farias, A. C., Farias, L. G., Pereira, E. F., Louzada, F. M., and Cordeiro, M. L. Potential link between caffeine consumption and pediatric depression: A case-control study. BMC.Pediatr 2011;11:73. View abstract.

Diener, H. C., Peil, H., and Aicher, B. The efficacy and tolerability of a fixed combination of acetylsalicylic acid, paracetamol, and caffeine in patients with severe headache: a post-hoc subgroup analysis from a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2011;31(14):1466-1476. View abstract.

Lucas, M., Mirzaei, F., Pan, A., Okereke, O. I., Willett, W. C., O'Reilly, E. J., Koenen, K., and Ascherio, A. Coffee, caffeine, and risk of depression among women. Arch.Intern.Med. 9-26-2011;171(17):1571-1578. View abstract.

Colacone, A., Bertolo, L., Wolkove, N., Cohen, C., and Kreisman, H. Effect of caffeine on histamine bronchoprovocation in asthma. Thorax 1990;45(8):630-632. View abstract.

Lubin, F. and Ron, E. Consumption of methylxanthine-containing beverages and the risk of breast cancer. Cancer Lett. 1990;53(2-3):81-90. View abstract.

Khaliq, S., Haider, S., Naqvi, F., Perveen, T., Saleem, S., and Haleem, D. J. Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. Pak.J Pharm.Sci. 2012;25(1):21-25. View abstract.

Schmidt, B., Anderson, P. J., Doyle, L. W., Dewey, D., Grunau, R. E., Asztalos, E. V., Davis, P. G., Tin, W., Moddemann, D., Solimano, A., Ohlsson, A., Barrington, K. J., and Roberts, R. S. Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA 1-18-2012;307(3):275-282. View abstract.

Smits, P., Lenders, J. W., and Thien, T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clin.Pharmacol.Ther. 1990;48(4):410-418. View abstract.

Floegel, A., Pischon, T., Bergmann, M. M., Teucher, B., Kaaks, R., and Boeing, H. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am J Clin.Nutr. 2012;95(4):901-908. View abstract.

Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., and Madsen, J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am.J.Clin.Nutr. 1990;51(5):759-767. View abstract.

Rossignol, A. M. and Bonnlander, H. Caffeine-containing beverages, total fluid consumption, and premenstrual syndrome. Am.J.Public Health 1990;80(9):1106-1110. View abstract.

Levitt, G. A., Mushin, A., Bellman, S., and Harvey, D. R. Outcome of preterm infants who suffered neonatal apnoeic attacks. Early Hum.Dev. 1988;16(2-3):235-243. View abstract.

Lammi, U. K., Kivela, S. L., Nissinen, A., Punsar, S., Puska, P., and Karvonen, M. Mental disability among elderly men in Finland: prevalence, predictors and correlates. Acta Psychiatr.Scand 1989;80(5):459-468. View abstract.

Rogers, A. S., Spencer, M. B., Stone, B. M., and Nicholson, A. N. The influence of a 1 h nap on performance overnight. Ergonomics 1989;32(10):1193-1205. View abstract.

Welborn, L. G., Hannallah, R. S., Fink, R., Ruttimann, U. E., and Hicks, J. M. High-dose caffeine suppresses postoperative apnea in former preterm infants. Anesthesiology 1989;71(3):347-349. View abstract.

Fuglsang, G., Nielsen, K., Kjaer, Nielsen L., Sennels, F., Jakobsen, P., and Thelle, T. The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants. Acta Paediatr.Scand. 1989;78(5):786-788. View abstract.

Green, R. M. and Stiles, G. L. Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex. J Clin Invest 1986;77(1):222-227. View abstract.

Somani, S. M. and Gupta, P. Caffeine: a new look at an age-old drug. Int.J.Clin.Pharmacol.Ther.Toxicol. 1988;26(11):521-533. View abstract.

Birkett, N. J. and Logan, A. G. Caffeine-containing beverages and the prevalence of hypertension. J Hypertens.Suppl 1988;6(4):S620-S622. View abstract.

Welborn, L. G., de Soto, H., Hannallah, R. S., Fink, R., Ruttimann, U. E., and Boeckx, R. The use of caffeine in the control of post-anesthetic apnea in former premature infants. Anesthesiology 1988;68(5):796-798. View abstract.

Bucher, H. U. and Duc, G. Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial. Eur.J.Pediatr. 1988;147(3):288-291. View abstract.

Durand, D. J., Goodman, A., Ray, P., Ballard, R. A., and Clyman, R. I. Theophylline treatment in the extubation of infants weighing less than 1,250 grams: a controlled trial. Pediatrics 1987;80(5):684-688. View abstract.

Stavchansky, S., Combs, A., Sagraves, R., Delgado, M., and Joshi, A. Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers. Biopharm.Drug Dispos. 1988;9(3):285-299. View abstract.

Harvey, D. H. and Marsh, R. W. The effects of de-caffeinated coffee versus whole coffee on hyperactive children. Dev.Med Child Neurol. 1978;20(1):81-86. View abstract.

Bairam, A., Boutroy, M. J., Badonnel, Y., and Vert, P. Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant. J.Pediatr. 1987;110(4):636-639. View abstract.

Watanabe, H. and Uramoto, H. Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors. Neuropharmacology 1986;25(6):577-581. View abstract.

Crivelli, M., Wahllander, A., Jost, G., Preisig, R., and Bachofen, H. Effect of dietary caffeine on airway reactivity in asthma. Respiration 1986;50(4):258-264. View abstract.

Sims, M. E., Yau, G., Rambhatla, S., Cabal, L., and Wu, P. Y. Limitations of theophylline in the treatment of apnea of prematurity. Am J Dis Child 1985;139(6):567-570. View abstract.

Viscardi, R. M., Faix, R. G., Nicks, J. J., and Grasela, T. H. Efficacy of theophylline for prevention of post-extubation respiratory failure in very low birth weight infants. J Pediatr 1985;107(3):469-472. View abstract.

Greenough, A., Elias-Jones, A., Pool, J., Morley, C. J., and Davis, J. A. The therapeutic actions of theophylline in preterm ventilated infants. Early Hum.Dev. 1985;12(1):15-22. View abstract.

Brouard, C., Moriette, G., Murat, I., Flouvat, B., Pajot, N., Walti, H., de Gamarra, E., and Relier, J. P. Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants. Am.J.Dis.Child 1985;139(7):698-700. View abstract.

Ryu, J. E. Caffeine in human milk and in serum of breast-fed infants. Dev.Pharmacol.Ther. 1985;8(6):329-337. View abstract.

Ryu, J. E. Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Dev.Pharmacol.Ther. 1985;8(6):355-363. View abstract.

Ortweiler, W., Simon, H. U., Splinter, F. K., Peiker, G., Siegert, C., and Traeger, A. [Determination of caffeine and metamizole elimination in pregnancy and after delivery as an in vivo method for characterization of various cytochrome p-450 dependent biotransformation reactions]. Biomed.Biochim.Acta 1985;44(7-8):1189-1199. View abstract.

Fraumeni, J. F., Jr., Scotto, J., and Dunham, L. J. Coffee-drinking and bladder cancer. Lancet 11-27-1971;2(7735):1204. View abstract.

Greden, J. F. Anxiety or caffeinism: a diagnostic dilemma. Am J Psychiatry 1974;131(10):1089-1092. View abstract.

Johnsen, O., Eliasson, R., and Kader, M. M. Effects of caffeine on the motility and metabolism of human spermatozoa. Andrologia 1974;6(1):53-58. View abstract.

Schnackenberg, R. C. Caffeine as a substitute for Schedule II stimulants in hyperkinetic children. Am.J.Psychiatry 1973;130(7):796-798. View abstract.

Schoenfeld, C., Amelar, R. D., and Dubin, L. Stimulation of ejaculated human spermatozoa by caffeine. A preliminary report. Fertil.Steril. 1973;24(10):772-775. View abstract.

Alstott, R. L., Miller, A. J., and Forney, R. B. Report of a human fatality due to caffeine. J.Forensic Sci. 1973;18(2):135-137. View abstract.

Dimaio, V. J. and Garriott, J. C. Lethal caffeine poisoning in a child. Forensic Sci. 1974;3(3):275-278. View abstract.

Rapoport, J. L., Berg, C. J., Ismond, D. R., Zahn, T. P., and Neims, A. Behavioral effects of caffeine in children. Relationship between dietary choice and effects of caffeine challenge. Arch.Gen.Psychiatry 1984;41(11):1073-1079. View abstract.

Hildebrandt, R. and Gundert-Remy, U. Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Pediatr.Pharmacol.(New York.) 1983;3(3-4):237-244. View abstract.

Becker, A. B., Simons, K. J., Gillespie, C. A., and Simons, F. E. The bronchodilator effects and pharmacokinetics of caffeine in asthma. N.Engl.J.Med. 3-22-1984;310(12):743-746. View abstract.

Whitsett, T. L., Manion, C. V., and Christensen, H. D. Cardiovascular effects of coffee and caffeine. Am.J.Cardiol. 3-15-1984;53(7):918-922. View abstract.

Firestone, P., Poitras-Wright, H., and Douglas, V. The effects of caffeine on hyperactive children. J.Learn.Disabil. 1978;11(3):133-141. View abstract.

Blanchard, J. and Sawers, S. J. The absolute bioavailability of caffeine in man. Eur.J.Clin.Pharmacol. 1983;24(1):93-98. View abstract.

Blanchard, J. and Sawers, S. J. Relationship between urine flow rate and renal clearance of caffeine in man. J.Clin.Pharmacol. 1983;23(4):134-138. View abstract.

Ammon, H. P., Bieck, P. R., Mandalaz, D., and Verspohl, E. J. Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double-blind crossover study. Br.J Clin Pharmacol 1983;15(6):701-706. View abstract.

Firestone, P., Davey, J., Goodman, J. T., and Peters, S. The effects of caffeine and methylphenidate on hyperactive children. J.Am.Acad.Child Psychiatry 1978;17(3):445-456. View abstract.

Knutti, R., Rothweiler, H., and Schlatter, C. The effect of pregnancy on the pharmacokinetics of caffeine. Arch.Toxicol.Suppl 1982;5:187-192. View abstract.

Thomas, F. B., Steinbaugh, J. T., Fromkes, J. J., Mekhjian, H. S., and Caldwell, J. H. Inhibitory effect of coffee on lower esophageal sphincter pressure. Gastroenterology 1980;79(6):1262-1266. View abstract.

Linn, S., Schoenbaum, S. C., Monson, R. R., Rosner, B., Stubblefield, P. G., and Ryan, K. J. No association between coffee consumption and adverse outcomes of pregnancy. N.Engl.J Med 1-21-1982;306(3):141-145. View abstract.

Aldridge, A., Bailey, J., and Neims, A. H. The disposition of caffeine during and after pregnancy. Semin.Perinatol. 1981;5(4):310-314. View abstract.

Murat, I., Moriette, G., Blin, M. C., Couchard, M., Flouvat, B., de Gamarra, E., Relier, J. P., and Dreyfus-Brisac, C. The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants. J.Pediatr. 1981;99(6):984-989. View abstract.

Gupta, J. M., Mercer, H. P., and Koo, W. W. Theophylline in treatment of apnoea of prematurity. Aust Paediatr.J 1981;17(4):290-291. View abstract.

Cohen, S. Pathogenesis of coffee-induced gastrointestinal symptoms. N.Engl.J Med 7-17-1980;303(3):122-124. View abstract.

Haleem, D. J., Yasmeen, A., Haleem, M. A., and Zafar, A. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life Sci 1995;57(19):L285-L292. View abstract.

Muehlbach, M. J. and Walsh, J. K. The effects of caffeine on simulated night-shift work and subsequent daytime sleep. Sleep 1995;18(1):22-29. View abstract.

Feldman, M. and Barnett, C. Relationships between the acidity and osmolality of popular beverages and reported postprandial heartburn. Gastroenterology 1995;108(1):125-131. View abstract.

Chen, M. D., Lin, W. H., Song, Y. M., Lin, P. Y., and Ho, L. T. Effect of caffeine on the levels of brain serotonin and catecholamine in the genetically obese mice. Zhonghua Yi.Xue.Za Zhi.(Taipei) 1994;53(5):257-261. View abstract.

Barrington, K. J. and Finer, N. N. A randomized, controlled trial of aminophylline in ventilatory weaning of premature infants. Crit Care Med. 1993;21(6):846-850. View abstract.

Golgeli, A., Ozesmi, C., and Ozesmi, M. The effects of theophylline and caffeine on the isolated rat diaphragm. Acta Physiol Pharmacol Ther Latinoam. 1995;45(2):105-113. View abstract.

Jeppesen, U., Loft, S., Poulsen, H. E., and Brsen, K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996;6(3):213-222. View abstract.

Riedel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., and Jolles, J. Caffeine attenuates scopolamine-induced memory impairment in humans. Psychopharmacology (Berl) 1995;122(2):158-168. View abstract.

Sicard, B. A., Perault, M. C., Enslen, M., Chauffard, F., Vandel, B., and Tachon, P. The effects of 600 mg of slow release caffeine on mood and alertness. Aviat.Space Environ.Med. 1996;67(9):859-862. View abstract.

Lloyd, T., Rollings, N., Eggli, D. F., Kieselhorst, K., and Chinchilli, V. M. Dietary caffeine intake and bone status of postmenopausal women. Am.J.Clin.Nutr. 1997;65(6):1826-1830. View abstract.

Weinmann, S., Siscovick, D. S., Raghunathan, T. E., Arbogast, P., Smith, H., Bovbjerg, V. E., Cobb, L. A., and Psaty, B. M. Caffeine intake in relation to the risk of primary cardiac arrest. Epidemiology 1997;8(5):505-508. View abstract.

Liguori, A., Hughes, J. R., and Grass, J. A. Absorption and subjective effects of caffeine from coffee, cola and capsules. Pharmacol Biochem.Behav 1997;58(3):721-726. View abstract.

Quinlan, P., Lane, J., and Aspinall, L. Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology (Berl) 1997;134(2):164-173. View abstract.

Ferrauti, A., Weber, K., and Struder, H. K. Metabolic and ergogenic effects of carbohydrate and caffeine beverages in tennis. J.Sports Med.Phys.Fitness 1997;37(4):258-266. View abstract.

Po, A. L. and Zhang, W. Y. Analgesic efficacy of ibuprofen alone and in combination with codeine or caffeine in post-surgical pain: a meta-analysis. Eur.J.Clin.Pharmacol. 1998;53(5):303-311. View abstract.

Youngstedt, S. D., O'Connor, P. J., Crabbe, J. B., and Dishman, R. K. Acute exercise reduces caffeine-induced anxiogenesis. Med.Sci Sports Exerc. 1998;30(5):740-745. View abstract.

Doherty, M. The effects of caffeine on the maximal accumulated oxygen deficit and short-term running performance. Int.J.Sport Nutr. 1998;8(2):95-104. View abstract.

Kaminsky, L. A., Martin, C. A., and Whaley, M. H. Caffeine consumption habits do not influence the exercise blood pressure response following caffeine ingestion. J.Sports Med.Phys.Fitness 1998;38(1):53-58. View abstract.

FitzSimmons, C. R. and Kidner, N. Caffeine toxicity in a bodybuilder. J.Accid.Emerg.Med. 1998;15(3):196-197. View abstract.

Le, Jeunne C., Gomez, J. P., Pradalier, A., Albareda, F., Joffroy, A., Liano, H., Henry, P., Lainez, J. M., and Geraud, G. Comparative efficacy and safety of calcium carbasalate plus metoclopramide versus ergotamine tartrate plus caffeine in the treatment of acute migraine attacks. Eur.Neurol. 1999;41(1):37-43. View abstract.

Zhang, S., Zeng, Z., and Tang, Z. Caffeine Enhances MHCC97H Cell Line Radiosensitization by Shortening G2-Phase Arrest In Vitro. J Caffeine Res 2011;1(1):59-65.

Fimland, M. S. and Saeterbakken, A. H. No Effects of Caffeine on Muscle Hypertrophy-Style Resistance Exercise. J Caffeine Res 2011;1(2):117-121.

Astorino, T. A., Cottrel, I., Lozano, A. T., Pratt, K. A., and Duhon, J. Ergogenic Effects of Caffeine on Simulated Time-Trial Performance Are Independent of Fitness Level. J Caffeine Res 2011;1(3):179-185.

Jensen, M. B., Norager, C. B., Fenger-Gron, M., Weimann, A., Moller, N., Mogens Madsen, R., and Laurberg, S. Caffeine Supplementation Had No Effect on Endurance Capacity in Elderly Subjects Who Had Abstained from Caffeine-Containing Nutrition for 8 Hours. J Caffeine Res 2011;1(2):109-116.

Sechzer, P. H. and Able, L. Post-spinal anesthesia headache treated with caffeine. Evaluation with demand method. Part I. Curr Ther Res 1978;70:729-731.

Kumar, S. P., Mehta, P. N., Bradley, B. S., and Ezhuthachan, S. G. Documented monitoring (DM) shows theophylline (T) to be more effective than caffeine (C) in prematurity apnea (PA). Pediatric Research 1992;31:208A.

McManamy, M. C. and Schube, P. G. Caffeine intoxication: report of a case the symptoms of which amounted to a psychosis. New England Journal of Medicine 1936;215:616-620.

Richter, J. E., Katz, P. O., and Waring, J. P. Gastroesophageal Reflux Disease. IFFGD 2000;

Hsu, C., Harden, R. N., and Houle, T. Nicotine and caffeine intake in complex regional pain syndrome. Journal of Back and Musculoskeletal Rehabilitation 2002;16(1):33-38.

Luebbe, A. M. Child and Adolescent Anxiety Sensitivity, Perceived Subjective Effects of Caffeine and Caffeine Consumption. J Caffeine Res 2011;1(4):213-218.

Machado, M., Zovico, P. V. C., da Silvia, D. P., Pereira, L. N., Barreto, J. G., and Pereira, R. Caffeine does not increase resistance exercise-induced microdamage. Journal of Exercise Science & Fitness 2008;6(2):115-120.

Li-Neng, Y., Greenstadt, L., and Shapiro, D. Effects of caffeine on blood pressure:A cross-cultural comparison. Psychophysiology 1983;20

Fotherby, M. D., Ghandi, C., Haigh, R. A., Macdonald, T. A., and Potter, J. F. Sustained caffeine use has no pressor effect in the elderly. Cardiology in the Elderly 1994;2(6):499-503.

Bolton and Sanford, G. N. Caffeine: Phsychological Effects, Use and Abuse. Othomolecular Psychiatry 1981;10(3):202-211.

Henderson-Smart, D. J. and Steer, P. A. Prophylactic caffeine to prevent postoperative apnoea following general anaesthesia in preterm infants. The Cochrane Library 2012;

LeBard, S. E., Kurth, C. D., Spitzer, A. R., and Downes, J. J. Preventing postoperative apnea by neuromodulator antagonists. Anesthesiology 1989;71:A1026.

Muro, M. Pharmacological treatment during the weaning of mechanical ventilation in preterm infants. Effects on pulmonary mechanics [Tratamiento farmacológico en la retirada de la ventilación mecánica del recién nacido pretérmino. Repercusión sobre la función pulmonar]. 1992;

Pearlman, S. A., Kepler, J. A., and Stefano, J. L. Comparative efficacy of theophylline and caffeine in facilitating extubation of preterm infants with respiratory distress syndrome. 1991;

Erenberg, A., Leff, R., and Wynne, B. Results of the First Double Blind Placebo (Pl) Controlled Study of Caffeine Citrate (Cc) for the Treatment of Apnea of Prematurity (Aop). Journal of Investigative Medicine 1998;46(1):157A.

Mortaz-Hedjiri, S., Yousefi-Nooraie, R., and Akbari-Kamrani, M. Caffeine for cognition (Protocol). Cochrane.Database.Syst.Rev. 2007;2

Rahnama, N., Gaeini, A. A., and Kazemi, F. The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes. JRMS 2010;15(3):127-132.

Diamond, S. Caffeine as an analgesic adjuvant in the treatment of headache. Current Treatment & Research 1999;10(2):119-125.

Lane, J. D. Caffeine, Glucose Metabolism, and Type 2 Diabetes. J Caffeine Res 2011;1(1):23-28.

Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.

Avci S, Sarikaya R, Büyükcam F. Death of a young man after overuse of energy drink. Am J Emerg Med. 2013;31(11):1624.e3-4. doi: 10.1016/j.ajem.2013.06.031. Epub 2013 27. View abstract.

Basurto Ona X, Uriona Tuma SM, Martínez García L, Solà I, Bonfill Cosp X. Drug therapy for preventing post-dural puncture headache. Cochrane Database Syst Rev. 2013 28;2:CD001792. doi: 10.1002/14651858.CD001792.pub3. Review. View abstract.

Beaudoin MS, Allen B, Mazzetti G, Sullivan PJ, Graham TE. Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women. Appl Physiol Nutr Metab. 2013;38(2):140-7. doi: 10.1139/apnm-2012-0201. Epub 2012 9. View abstract.

Bioh G, Gallagher MM, Prasad U. Survival of a highly toxic dose of caffeine. BMJ Case Rep. 2013 8;2013. pii: bcr2012007454. doi: 10.1136/bcr-2012-007454. View abstract.

Bonsignore A, Sblano S, Pozzi F, Ventura F, Dell'Erba A, Palmiere C. A case of suicide by ingestion of caffeine. Forensic Sci Med Pathol. 2014 Sep;10(3):448-51. doi: 10.1007/s12024-014-9571-6. Epub 2014 27. View abstract.

Bottoms L, Greenhalgh A, Gregory K. The effect of caffeine ingestion on skill maintenance and fatigue in epee fencers. J Sports Sci. 2013;31(10):1091-9. doi: 10.1080/02640414.2013.764466. Epub 2013 5. View abstract.

Calabrò RS, Italiano D, Gervasi G, Bramanti P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav. 2012;23(3):384-5. doi: 10.1016/j.yebeh.2011.12.010. Epub 2012 26. View abstract.

Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 2013;99(19):1383-9. doi: 10.1136/heartjnl-2013-303950. Review. View abstract.

Campana C, Griffin PL, Simon EL. Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure. Am J Emerg Med. 2014 Jan;32(1):111.e3-4. doi: 10.1016/j.ajem.2013.08.042. Epub 2013 27. View abstract.

Carol ML. Hydroxycut weight loss dietary supplements: a contributing factor in the development of exertional rhabdomyolysis in three U.S. Army soldiers. Mil Med. 2013;178(9):e1039-42. doi: 10.7205/MILMED-D-13-00133. View abstract.

Chen L, Bell EM, Browne ML, Druschel CM, Romitti PA, Schmidt RJ, Burns TL, Moslehi R, Olney RS; National Birth Defects Prevention Study. Maternal caffeine consumption and risk of congenital limb deficiencies. Birth Defects Res A Clin Mol Teratol. 2012 Dec;94(12):1033-43. doi: 10.1002/bdra.23050. Epub 2012 18. View abstract.

Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM. Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. BMC Med. 2014 19;12:174. doi: 10.1186/s12916-014-0174-6. View abstract.

Cheng M, Hu Z, Lu X, Huang J, Gu D. Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Can J Cardiol. 2014 Apr;30(4):448-54. doi: 10.1016/j.cjca.2013.12.026. Epub 2014 2. Review. View abstract.

Chiaffarino F, Bravi F, Cipriani S, Parazzini F, Ricci E, Viganò P, La Vecchia C. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur J Nutr. 2014 Oct;53(7):1573-9. doi: 10.1007/s00394-014-0662-7. Epub 2014 31. View abstract.

Del Coso J, Portillo J, Muñoz G, Abián-Vicén J, Gonzalez-Millán C, Muñoz-Guerra J. Caffeine-containing energy drink improves sprint performance during an international rugby sevens competition. Amino Acids. 2013 ;44(6):1511-9. doi: 10.1007/s00726-013-1473-5. Epub 2013 5. View abstract.

Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. 2014 Dec 11;12:CD009281. doi: 10.1002/14651858.CD009281.pub3. Review. View abstract.

Dikici S, Saritas A, Kilinc S, Guneysu S, Gunes H. Does an energy drink cause a transient ischemic attack? Am J Emerg Med. 2015;33(1):129.e5-6. doi: 10.1016/j.ajem.2014.06.037. Epub 2014 1. View abstract.

Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care. 2014 ;37(2):569-86. doi: 10.2337/dc13-1203. Review. View abstract.

Foxe JJ, Morie KP, Laud PJ, Rowson MJ, de Bruin EA, Kelly SP. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology. 2012;62(7):2320-7. doi: 10.1016/j.neuropharm.2012.01.020. Epub 2012 2. View abstract.

Gavrieli A, Karfopoulou E, Kardatou E, Spyreli E, Fragopoulou E, Mantzoros CS, Yannakoulia M. Effect of different amounts of coffee on dietary intake and appetite of normal-weight and overweight/obese individuals. Obesity (Silver Spring). 2013 Jun;21(6):1127-32. doi: 10.1002/oby.20190. Epub 2013 13. View abstract.

González W, Altieri PI, Alvarado E, Banchs HL, Colón E, Escobales N, Crespo M. Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature. Bol Asoc Med P R. 2015;107(1):38-40. Review. View abstract.

Greenwood DC, Thatcher NJ, Ye J, Garrard L, Keogh G, King LG, Cade JE. Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis. Eur J Epidemiol. 2014;29(10):725-34. doi: 10.1007/s10654-014-9944-x. Epub 2014 2. View abstract.

Hartley SL, Barbot F, Machou M, Lejaille M, Moreau B, Vaugier I, Lofaso F, Quera-Salva MA. Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. Neurophysiol Clin. 2013;43(3):161-9. doi: 10.1016/j.neucli.2013.04.001. Epub 2013 26. View abstract.

Hurley CF, Hatfield DL, Riebe DA. The effect of caffeine ingestion on delayed onset muscle soreness. J Strength Cond Res. 2013 Nov;27(11):3101-9. doi: 10.1519/JSC.0b013e3182a99477. View abstract.

Ishigaki S, Fukasawa H, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R. Caffeine intoxication successfully treated by hemoperfusion and hemodialysis. Intern Med. 2014;53(23):2745-7. Epub 2014 1. View abstract.

Jabbar SB, Hanly MG. Fatal caffeine overdose: a case report and review of literature. Am J Forensic Med Pathol. 2013;34(4):321-4. doi: 10.1097/PAF.0000000000000058. Review. View abstract.

Jantos R, Stein KM, Flechtenmacher C, Skopp G. A fatal case involving a caffeine-containing fat burner. Drug Test Anal. 2013 Sep-Oct;5(9-10):773-6. doi: 10.1002/dta.1485. Epub 2013 9. No abstract available. View abstract.

Jiang W, Wu Y, Jiang X. Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol Oncol. 2013 Jun;129(3):620-9. doi: 10.1016/j.ygyno.2013.03.014. Epub 2013 25. Review. View abstract.

Jiang X, Zhang D, Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur J Nutr. 2014 Feb;53(1):25-38. doi: 10.1007/s00394-013-0603-x. Epub 2013 23. Review. View abstract.

Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ, Chen SH, Grosskreutz CL, Chang KK, Kloek CE, Greenstein SH, Borboli-Gerogiannis S, Pasquale DL, Chaudhry S, Loomis S, Wiggs JL, Pasquale LR, Turalba AV. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond). 2012;26(8):1122-30. doi: 10.1038/eye.2012.113. Epub 2012 Jun 8. View abstract.

Kim SW, Bae KY, Shin HY, Kim JM, Shin IS, Kim JK, Kang G, Yoon JS. Caffeine counteracts impairments in task-oriented psychomotor performance induced by chlorpheniramine: a double-blind placebo-controlled crossover study. J Psychopharmacol. 2013 Jan;27(1):62-70. doi: 10.1177/0269881112450784. Epub 2012 20. View abstract.

Lee SM, Choi NK, Lee BC, Cho KH, Yoon BW, Park BJ. Caffeine-containing medicines increase the risk of hemorrhagic stroke. Stroke. 2013 Aug;44(8):2139-43. doi: 10.1161/STROKEAHA.111.674077. Epub 2013 6. View abstract.

Liu R, Guo X, Park Y, Huang X, Sinha R, Freedman ND, Hollenbeck AR, Blair A, Chen H. Caffeine intake, smoking, and risk of Parkinson disease in men and women. Am J Epidemiol. 2012 Jun 1;175(11):1200-7. doi: 10.1093/aje/kwr451. Epub 2012 13. View abstract.

Miller B, O'Connor H, Orr R, Ruell P, Cheng HL, Chow CM. Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes. Eur J Appl Physiol. 2014 Dec;114(12):2529-37. doi: 10.1007/s00421-014-2973-z. Epub 2014 13. View abstract.

Müller SA, Rahbari NN, Schmied BM, Büchler MW. Can postoperative coffee perk up recovery time after colon surgery? Expert Rev Gastroenterol Hepatol. 2013 Feb;7(2):91-3. doi: 10.1586/egh.12.78. No abstract available. View abstract.

Pendleton M, Brown S, Thomas C, Odle B. Potential toxicity of caffeine when used as a dietary supplement for weight loss. J Diet Suppl. 2012 Dec;9(4):293-8. doi: 10.3109/19390211.2012.736460. View abstract.

Pendleton M, Brown S, Thomas CM, Odle B. Potential toxicity of caffeine when used as a dietary supplement for weight loss. J Diet Suppl. 2013 Mar;10(1):1-5. doi: 10.3109/19390211.2012.758215. Epub 2013 4. View abstract.

Peng PJ, Chiang KT, Liang CS. Low-dose caffeine may exacerbate psychotic symptoms in people with schizophrenia. J Neuropsychiatry Clin Neurosci. 2014 Apr 1;26(2):E41. doi: 10.1176/appi.neuropsych.13040098. No abstract available. View abstract.

Pham NM, Nanri A, Kurotani K, Kuwahara K, Kume A, Sato M, Hayabuchi H, Mizoue T. Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population. Public Health Nutr. 2014 Mar;17(3):625-33. doi: 10.1017/S1368980013000360. Epub 2013 4. Erratum in: Public Health Nutr. 2014 Mar;17(3):715. View abstract.

Pini LA, Guerzoni S, Cainazzo M, Ciccarese M, Prudenzano MP, Livrea P. Comparison of tolerability and efficacy of a combination of paracetamol +caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study. J Headache Pain. 2012 Nov;13(8):669-75. doi: 10.1007/s10194-012-0484-z. Epub 2012 2. View abstract.

Postuma RB, Lang AE, Munhoz RP, Charland K, Pelletier A, Moscovich M, Filla L, Zanatta D, Rios Romenets S, Altman R, Chuang R, Shah B. Caffeine for treatment of Parkinson disease: a randomized controlled trial. Neurology. 2012 Aug 14;79(7):651-8. doi: 10.1212/WNL.0b013e318263570d. Epub 2012 Aug 1. Erratum in: Neurology. 2012 16;79(16):1744. View abstract.

Poussel M, Kimmoun A, Levy B, Gambier N, Dudek F, Puskarczyk E, Poussel JF, Chenuel B. Fatal cardiac arrhythmia following voluntary caffeine overdose in an amateur body-builder athlete. Int J Cardiol. 2013 1;166(3):e41-2. doi: 10.1016/j.ijcard.2013.01.238. Epub 2013 7. No abstract available. View abstract.

Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int. 2014 Apr;14(2):430-9. doi: 10.1111/ggi.12123. Epub 2013 23. View abstract.

Reyner LA, Horne JA. Sleep restriction and serving accuracy in performance tennis players, and effects ofcaffeine. Physiol Behav. 2013 Aug 15;120:93-6. doi: 10.1016/j.physbeh.2013.07.002. Epub 2013 31. View abstract.

Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC, Poets CF, McEntire BL, Hunt CE;Caffeine Pilot Study Group. Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial. JAMA Pediatr. 2014;168(3):250-7. doi: 10.1001/jamapediatrics.2013.4371. View abstract.

Rogers PJ, Heatherley SV, Mullings EL, Smith JE. Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance. Psychopharmacology (Berl). 2013 Mar;226(2):229-40. doi: 10.1007/s00213-012-2889-4. Epub 2012 30. View abstract.

Ronen A, Oron-Gilad T, Gershon P. The combination of short rest and energy drink consumption as fatigue countermeasures during a prolonged drive of professional truck drivers. J Safety Res. 2014 Jun;49:39-43. doi: 10.1016/j.jsr.2014.02.006. Epub 2014 24. View abstract.

Sanikini H, Dik VK, Siersema PD, Bhoo-Pathy N, Uiterwaal CS, Peeters PH, González CA, Zamora-Ros R, Overvad K, Tjønneland A, Roswall N, Boutron-Ruault MC, Fagherazzi G, Racine A, Kühn T, Katzke V, Boeing H, Trichopoulou A, Trichopoulos D, Lagiou P, Palli D, Grioni S, Vineis P, Tumino R, Panico S, Weiderpass E, Skeie G, Braaten T, Huerta JM, Sánchez-Cantalejo E, Barricarte A, Sonestedt E, Wallstrom P, Nilsson LM, Johansson I, Bradbury KE, Khaw KT, Wareham N, Huybrechts I, Freisling H, Cross AJ, Riboli E, Bueno-de-Mesquita HB. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: results from the EPIC cohort study. Int J Cancer. 2015 15;136(6):E720-30. doi: 10.1002/ijc.29223. Epub 2014 29. View abstract.

Schrader P, Panek LM, Temple JL. Acute and chronic caffeine administration increases physical activity in sedentary adults. Nutr Res. 2013 Jun;33(6):457-63. doi: 10.1016/j.nutres.2013.04.003. Epub 2013 10. View abstract.

Simonin C, Duru C, Salleron J, Hincker P, Charles P, Delval A, Youssov K, Burnouf S, Azulay JP, Verny C, Scherer C, Tranchant C, Goizet C, Debruxelles S, Defebvre L, Sablonnière B, Romon-Rousseaux M, Buée L, Destée A, Godefroy O, Dürr A, Landwehrmeyer B; REGISTRY Study of the European Huntington's Disease Network, Bachoud-Levi AC, Richard F, Blum D, Krystkowiak P; Huntington French Speaking Network. Association between caffeine intake and age at onset in Huntington's disease. Neurobiol Dis. 2013;58:179-82. doi: 10.1016/j.nbd.2013.05.013. Epub 2013 31. View abstract.

Smith AP. Caffeine, extraversion and working memory. J Psychopharmacol. 2013 ;27(1):71-6. doi: 10.1177/0269881112460111. Epub 2012 26. View abstract.

Suh SY, Choi YS, Oh SC, Kim YS, Cho K, Bae WK, Lee JH, Seo AR, Ahn HY. Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manage. 2013 Oct;46(4):474-82. doi: 10.1016/j.jpainsymman.2012.10.232. Epub 2013 13. View abstract.

Szpak A, Allen D. A case of acute suicidality following excessive caffeine intake. J Psychopharmacol. 2012 Nov;26(11):1502-10. doi: 10.1177/0269881112442788. Epub 2012 2. View abstract.

Tejani FH, Thompson RC, Kristy R, Bukofzer S. Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: a prospective, randomized, multicenter study. Int J Cardiovasc Imaging. 2014 Jun;30(5):979-89. doi: 10.1007/s10554-014-0419-7. Epub 2014 17. View abstract.

Ulanovsky I, Haleluya NS, Blazer S, Weissman A. The effects of caffeine on heart rate variability in newborns with apnea of prematurity. J Perinatol. 2014 Aug;34(8):620-3. doi: 10.1038/jp.2014.60. Epub 2014 10. View abstract.

Usman A, Jawaid A. Hypertension in a young boy: an energy drink effect. BMC Res Notes. 2012 29;5:591. doi: 10.1186/1756-0500-5-591. View abstract.

van der Hoeven N, Visser I, Schene A, van den Born BJ. Severe hypertension related to caffeinated coffee and tranylcypromine: a case report. Ann Intern Med. 2014 May 6;160(9):657-8. doi: 10.7326/L14-5009-8. No abstract available. View abstract.

Vatlach S, Arand J, Engel C, Poets CF. Safety profile comparison between extemporaneous and a licensed preparation of caffeine citrate in preterm infants with apnea of prematurity. Neonatology. 2014;105(2):108-11. doi: 10.1159/000355715. Epub 2013 6. View abstract.

Vercambre MN, Berr C, Ritchie K, Kang JH. Caffeine and cognitive decline in elderly women at high vascular risk. J Alzheimers Dis. 2013;35(2):413-21. doi: 10.3233/JAD-122371. View abstract.

Vukcevic NP, Babic G, Segrt Z, Ercegovic GV, Jankovic S, Acimovic L. Severe acute caffeine poisoning due to intradermal injections: mesotherapy hazard. Vojnosanit Pregl. 2012 Aug;69(8):707-13. Erratum in: Vojnosanit Pregl. 2012;69(10):929. View abstract.

Wills AM, Eberly S, Tennis M, Lang AE, Messing S, Togasaki D, Tanner CM, Kamp C, Chen JF, Oakes D, McDermott MP, Schwarzschild MA; Parkinson Study Group. Caffeine consumption and risk of dyskinesia in CALM-PD. Mov Disord. 2013 Mar;28(3):380-3. doi: 10.1002/mds.25319. Epub 2013 21. View abstract.

Wilson RE, Kado HS, Samson R, Miller AB. A case of caffeine-induced coronary artery vasospasm of a 17-year-old male. Cardiovasc Toxicol. 2012;12(2):175-9. doi: 10.1007/s12012-011-9152-9. View abstract.

Young C, Oladipo O, Frasier S, Putko R, Chronister S, Marovich M. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Mil Med. 2012;177(12):1450-4. View abstract.

Young HA, Benton D. Caffeine can decrease subjective energy depending on the vehicle with which it is consumed and when it is measured. Psychopharmacology (Berl). 2013 Jul;228(2):243-54. doi: 10.1007/s00213-013-3025-9. Epub 2013 2. View abstract.

McCusker RR, Goldberger BA, Cone EJ. Caffeine content of energy drinks, carbonated sodas, and other beverages. J Anal Toxicol. 2006;30(2):112-4. View abstract.

Dixit S, Stein PK, Dewland TA, Dukes JW, Vittinghoff E, Heckbert SR, Marcus GM. Consumption of Caffeinated Products and Cardiac Ectopy. J Am Heart Assoc. 2016 26;5(1). pii: e002503. doi: 10.1161/JAHA.115.002503. View abstract.

Sheppard SG. A preliminary investigation of ibogaine: case reports and recommendations for further study. J Subst Abuse Treat. 1994 Jul-Aug;11(4):379-85. View abstract.

FDA takes step to protect consumers against dietary supplements containing dangerously high levels of extremely concentrated or pure caffeine. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm604485.htm (Accessed 10 May 2018).

Wijarnpreecha K, Thongprayoon C, Ungprasert P. Impact of caffeine in Hepatitis C virus infection: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017 Jan;29(1):17-22. View abstract.

Zuchinali P, Riberio PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace 2016 Feb;18(2):257-66. View abstract.

Rhee J, Kim R, Kim Y, et al. Maternal caffeine consumption during pregnancy and risk of low birth weight: a dose-response meta-analysis of observational studies. PLoS One. 2015 Jul 20;10(7):e0132334. View abstract.

Zuchinali P, Souza GC, Pimentel M, et al. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: a randomized clinical trial. JAMA Intern Med. 2016 Dec 1;176(12):1752-59. View abstract.

Simon DK, Wu C, Tilly BC, et al. Caffeine and progression of Parkinson Disease: a deleterious interaction with creatine. Clin Neuropharmacol. 2015 Sep-Oct;38(5):163-9. View abstract.

Lystrup RM, Leggit JC. Caffeine toxicity due to supplement use in caffeine - naïve individual: a cautionary tale. Mil Med. 2015 Aug;180(8):e936-40.

Gbadebo S, Colpus S, Felstead D. Case on caffeine toxicity and learning points. J Intensive Care Soc. 2017 Nov;18(4):354. View abstract.

Postuma RB, Anang J, Pelletier A, et al. Caffeine as symptomatic treatment for Parkinson Disease (Café-PD): a randomized trial. Neurology. 2017 Oct 24;89(17):1795-1803. View abstract.

Beaumont R, Cordery P, Funnell M, Maers S, James L, Watson P. Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. J Sports Sci. 2017 Oct;35(19):1920-27. View abstract.

Magdalan J, Zawadzki M, Skowronek R, et al. Nonfatal and fata intoxications with pure caffeine - report of three different cases. Forensic Sci Med Pathol. 2017 Sep;13(3):355-58. View abstract.

Trexler ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, Persky AM, Mock AG. Effects of coffee and caffeine anhydrous intake during creatine loading. J Strength Cond Res. 2016 May;30(5):1438-46. View abstract.

Pacchiarotti A, Carlomagno G. Antonini G, Pacchiarotti A. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol. 2016;32(1):69-73. View abstract.

Lagier D, Nee L, Guieu R, et al. Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass: a randomized controlled clinical trial. Eur J Anaesthesiol. 2018 Apr 26. [Epub ahead of print] View abstract.

Murner-Lavanchy IM, Doyle LW, Schmidt B, et al. Neurobehavioral outcomes 11 years after neonatal caffeine therapy for apnea of prematurity. Moddemann D, Nelson H, Ohlsson A, te al. Pediatrics. 2018 May;141(5). pii: e20174047. View abstract.

Voskoboinik A, Kalman JM, Kistler PM. Caffeine and arrhythmias: time to grind the data. JACC: Clin Electrophysiol. 2018;4(4):425-32.

Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipollini L, Aromatario M. Caffeine-related deaths: manner of deaths and categories of risk. Nutrients. 2018 May 14;10(5). pii: E611. View abstract.

Vandenberghe C, St-Pierre V, Courchesne-Loyer A, Hennebelle M, Castellano CA, Cunnane SC. Caffeine intake increases plasma ketones: an acute metabolic study in humans. Can J Physiol Pharmacol. 2017 Apr;95(4):455-458. View abstract.

Boyett JC, Giersch GE, Womack CJ, et al. Time of day and training status both impact the efficacy of caffeine for short duration cycling performance. Nutrients. 2016 Oct 14;8(10). View abstract.

Driscoll I, Shumaker SA, Snively BM, et al. Relationships between caffeine intake and risk for probably dementia or global cognitive impairment: the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1596-1602. View abstract.

Souza DB, Del Coso J, Casonatto J, Polito MD. Acute effects of caffeine-containing drinks on physical performance: a systematic review and meta-analysis. Eur J Nutr. 2017 Feb;56(1):13-27. View abstract.

Amaro CM, Bello JA, Jain D, et al. Early caffeine and weaning from mechanical ventilation in preterm infants: a randomized, placebo-controlled trial. J Pediatr. 2018 May;196:52-57. View abstract.

Pakvasa MA, Saroha V, Patel RM. Optimizing caffeine use and risk of bronchopulmonary dysplasia in preterm infants: a systematic review, meta-analysis, and application of grading of recommendations assessment, development, and evaluation methodology. Clin Perinatol. 2018 Jun;45(2):273-291. View abstract.

Hashimoto Y, Tanaka M, Yamazaki M, et al. Caffeine intake enhances the benefits of sodium glucose transporter 2 inhibitor. Diabetes Metab Res Rev. 2016 Oct;32(7):694-699. View abstract.

Wang HR, Woo YS, Bahk WM. Caffeine-induced psychiatric manifestations: a review. Int Clin Psychopharmacol. 2015 Jul;30(4):179-82. View abstract.

Caini S, Cattaruzza S, Bendinelli B, et al. Coffee, tea, and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. Eur J Nutr. 2017Feb;56(1):1-12. View abstract.

Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 2017;109:585-648. View abstract.

Vliegenthart R, Miedema M, Hutten GJ, van Kaam AH, Onland W. High versus standard dose caffeine for apnoea: a systematic review. Arch Dis Child Fetal Neonatal Ed 2018;103(6):F523-9. doi: 10.1136/archdischild-2017-313556. View abstract.

Southward K, Rutherfurd-Markwick KJ, Ali A. The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Med 2018;48(10):2425-41. doi: 10.1007/s40279-018-0967-4. View abstract.

Anderson JR, Hagerdorn PL, Gunstad J, Spitznagel MB. Using coffee to compensate for poor sleep: Impact on vigilance and implications for workplace performance. Appl Ergon 2018;70:142-7. doi: 10.1016/j.apergo.2018.02.026. View abstract.

Glaister M, Gissane C. Caffeine and physiological responses to submaximal exercise: a meta-analysis. Int J Sports Physiol Perform 2018;13(4):402-11. doi: 10.1123/ijspp.2017-0312. View abstract.

Apostolidis A, Mougios V, Smilios I, Rodosthenous J, Hadjicharalambous M. Caffeine Supplementation: Ergogenic in Both High and Low Caffeine Responders. Int J Sports Physiol Perform. 2019;14(5):650-657. View abstract.

Chen J, Jin L, Chen X. Efficacy and Safety of Different Maintenance Doses of Caffeine Citrate for Treatment of Apnea in Premature Infants: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018;2018:9061234. View abstract.

Grgic J, Pickering C. The effects of caffeine ingestion on isokinetic muscular strength: A meta-analysis. J Sci Med Sport. 2019;22(3):353-360. View abstract.

Iranpour S, Sabour S. Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006. Psychiatry Res. 2019;271:732-739. View abstract.

Mirmiran P, Carlström M, Bahadoran Z, Azizi F. Long-term effects of coffee and caffeine intake on the risk of pre-diabetes and type 2 diabetes: Findings from a population with low coffee consumption. Nutr Metab Cardiovasc Dis. 2018;28(12):1261-1266. View abstract.

Modzelewska D, Bellocco R, Elfvin A, et al. Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome - results from the Norwegian Mother and Child Cohort Study. BMC Pregnancy Childbirth. 2019;19(1):80. View abstract.

Rahimi R. The effect of CYP1A2 genotype on the ergogenic properties of caffeine during resistance exercise: a randomized, double-blind, placebo-controlled, crossover study. Ir J Med Sci. 2019;188(1):337-345. View abstract.

Shen JG, Brooks MB, Cincotta J, Manjourides JD. Establishing a relationship between the effect of caffeine and duration of endurance athletic time trial events: A systematic review and meta-analysis. J Sci Med Sport. 2019;22(2):232-238. View abstract.

Yoshihara T, Zaitsu M, Shiraishi F, et al. Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers. J Pharmacol Sci. 2019;139(3):209-214. View abstract.

Rao SS. Current and emerging treatment options for fecal incontinence. J Clin Gastroenterol. 2014;48(9):752-64. View abstract.

Cozma-Petrut A, Loghin F, Miere D, Dumitrascu DL.Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771-3783. View abstract.

Aldosari MS, Olaish AH, Nashwan SZ, Abulmeaty MMA, BaHammam AS. The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study. Sleep Breath. 2020. View abstract.

Berglundh S, Vollrath M, Brantsæter AL, et al. Maternal caffeine intake during pregnancy and child neurodevelopment up to eight years of age-Results from the Norwegian Mother, Father and Child Cohort Study. Eur J Nutr. 2020. View abstract.

Ferreira TT, da Silva JVF, Bueno NB. Effects of caffeine supplementation on muscle endurance, maximum strength, and perceived exertion in adults submitted to strength training: a systematic review and meta-analyses. Crit Rev Food Sci Nutr. 2020:1-14. View abstract.

Grgic J, Diaz-Lara FJ, Coso JD, et al. The Effects of Caffeine Ingestion on Measures of Rowing Performance: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(2):434. View abstract.

Gupta N, Padidam S, Tewari A. Acute macular neuroretinopathy (AMN) related to energy drink consumption. BMJ Case Rep. 2019;12(12):e232144. View abstract.

Hong CT, Chan L, Bai CH. The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis. Nutrients. 2020;12(6):E1860. View abstract.

Irwin C, Khalesi S, Desbrow B, McCartney D. Effects of acute caffeine consumption following sleep loss on cognitive, physical, occupational and driving performance: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2020;108:877-888. View abstract.

Jin F, Qiao C. Association of maternal caffeine intake during pregnancy with low birth weight, childhood overweight, and obesity: a meta-analysis of cohort studies. Int J Obes (Lond). 2020. View abstract.

Krittanawong C, Tunhasiriwet A, Wang Z, et al. Is caffeine or coffee consumption a risk for new-onset atrial fibrillation? A systematic review and meta-analysis. Eur J Prev Cardiol. 2020:2047487320908385. View abstract.

Marinho AH, Mendes EV, Vilela RA, Bastos-Silva VJ, Araujo GG, Balikian P. Caffeine mouth rinse has no effects on anaerobic energy yield during a Wingate Test. Sports Med Phys Fitness. 2020;60(1):69-74. View abstract.

Pak İE, Cuğ M, Volpe SL, Beaven CM. The effect of carbohydrate and caffeine mouth rinsing on kicking performance in competitive Taekwondo athletes during Ramadan. J Sports Sci. 2020;38(7):795-800. View abstract.

Jagim AR, Harty PS, Fischer KM, Kerksick CM, Erickson JL. Adverse events reported to the United States Food and Drug Administration related to caffeine-containing products. Mayo Clin Proc. 2020;95(8):1594-1603. View abstract.

Kromhout MA, Rius Ottenheim N, Putter H, Numans ME, Achterberg WP. Caffeine consumption and behavioral symptoms in nursing home residents: A cross-sectional analysis. J Nutr Health Aging. 2021;25(1):100-107. View abstract.

Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Coso JD. Effect of acute caffeine intake on the fat oxidation rate during exercise: A systematic review and meta-analysis. Nutrients. 2020;12(12):3603. View abstract.

Morales AP, Sampaio-Jorge F, Barth T, Pierucci APTR, Ribeiro BG. Caffeine supplementation for 4 days does not induce tolerance to the ergogenic effects promoted by acute intake on physiological, metabolic, and performance parameters of cyclists: A randomized, double-blind, crossover, placebo-controlled study. Nutrients. 2020;12(7):2101. View abstract.

Harty PS, Zabriskie HA, Stecker RA, et al. Caffeine timing improves lower-body muscular performance: A randomized trial. Front Nutr. 2020;7:585900. View abstract.

Muñoz A, López-Samanes Á, Aguilar-Navarro M, et al. Effects of CYP1A2 and ADORA2A genotypes on the ergogenic response to caffeine in professional handball players. Genes (Basel). 2020;11(8):933. View abstract.

Zhang H, Lee ZX, Qiu A. Caffeine intake and cognitive functions in children. Psychopharmacology (Berl). 2020;237(10):3109-3116. View abstract.

Stojanovic E, Scanlan AT, Milanovic Z, Fox JL, Stankovic R, Dalbo VJ. Acute caffeine supplementation improves jumping, sprinting, and change-of-direction performance in basketball players when ingested in the morning but not evening. Eur J Sport Sci. 2021:1-20. View abstract.

Pereira PEA, Azevedo P, Azevedo K, Azevedo W, Machado M. Caffeine supplementation or carbohydrate mouth rinse improves performance. Int J Sports Med. 2020. View abstract.

Lorenzo Calvo J, Fei X, Domínguez R, Pareja-Galeano H. Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis. Nutrients 2021;13(3):868. View abstract.

Grgic J, Del Coso J. Ergogenic Effects of Acute Caffeine Intake on Muscular Endurance and Muscular Strength in Women: A Meta-Analysis. Int J Environ Res Public Health 2021;18(11):5773. View abstract.

Gomez-Bruton A, Marin-Puyalto J, Muñiz-Pardos B, et al. Does Acute Caffeine Supplementation Improve Physical Performance in Female Team-Sport Athletes? Evidence from a Systematic Review and Meta-Analysis. Nutrients 2021;13(10):3663. View abstract.

Nabuco LL, Saunders B, Sousa da Silva RA, Molina GE, Reis CEG. Caffeine Mouth Rinse Does Not Improve Time to Exhaustion in Male Trained Cyclists. Int J Sport Nutr Exerc Metab 2021;31(5):412-419. View abstract.

Karayigit R, Koz M, Sánchez-Gómez A, et al. High Dose of Caffeine Mouth Rinse Increases Resistance Training Performance in Men. Nutrients 2021;13(11):3800. View abstract.

Wong O, Marshall K, Sicova M, Guest NS, García-Bailo B, El-Sohemy A. CYP1A2 Genotype Modifies the Effects of Caffeine Compared With Placebo on Muscle Strength in Competitive Male Athletes. Int J Sport Nutr Exerc Metab 2021;31(5):420-426. View abstract.

de Salles Painelli V, Teixeira EL, Tardone B, et al. Habitual Caffeine Consumption Does Not Interfere With the Acute Caffeine Supplementation Effects on Strength Endurance and Jumping Performance in Trained Individuals. Int J Sport Nutr Exerc Metab 2021;31(4):321-328. View abstract.

Ledesma ALL, Leite Rodrigues D, Monteiro de Castro Silva I, Oliveira CA, Bahmad F Jr. The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial. PLoS One 2021;16(9):e0256275. View abstract.

Zheng KH, Zhu K, Wactawski-Wende J, et al. Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. Int J Cancer 2021;149(12):2032-2044. View abstract.

Wang S, Li X, Yang Y, et al. Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis. Public Health Nutr 2021;24(18):6377-6389. View abstract.

Parnasa SY, Marom G, Bdolah-Abram T, et al. Does caffeine enhance bowel recovery after elective colorectal resection? A prospective double-blinded randomized clinical trial. Tech Coloproctol 2021;25(7):831-839. View abstract.

Vlisides PE, Li D, McKinney A, et al. The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial. Anesth Analg 2021;133(1):233-242. View abstract.

Cornelis MC, Bennett DA, Weintraub S, Schneider JA, Morris MC. Caffeine Consumption and Dementia: Are Lewy Bodies the Link?. Ann Neurol 2022;91(6):834-846. View abstract.

Alshabi AM, Alkahtani SA, Shaikh IA, Habeeb MS. Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics. Saudi Med J 2021;42(2):151-160. View abstract.

Horikawa Y, Yatsuga S, Okamatsu Y. Caffeine Intoxication Due to Antipyretic Analgesic Overdose in an Adolescent. Cureus 2021;13(9):e17922. View abstract.

Hinkle SN, Gleason JL, Yisahak SF, et al. Assessment of Caffeine Consumption and Maternal Cardiometabolic Pregnancy Complications. JAMA Netw Open 2021;4(11):e2133401. View abstract.

Arhinful JS, Arhinful B, Akins TA, Hossain S. Caffeine-Induced Severe Erosive Esophagitis. Cureus 2021;13(7):e16253. View abstract.

Yartsev A, Peisah C. Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC Psychiatry 2021;21(1):192. View abstract.

Tinawi M. Severe Rhabdomyolysis Due to Strenuous Exercise With a Potential Role of a High-Caffeine Energy Drink. Cureus 2022;14(1):e20867. View abstract.

Gleason JL, Sundaram R, Mitro SD, et al. Association of maternal caffeine consumption during pregnancy with child growth. JAMA Netw Open. 2022;5(10):e2239609. View abstract.

Kruszewski M, Merchelski M, Kruszewski A,Tabecki R, Aksenov MO, and Pagowski L. Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study. Nutrients 2022;14(9):1750.

Abbassi F, Müller SA, Steffen T, et al. Caffeine for intestinal transit after laparoscopic colectomy: randomized clinical trial (CaCo trial). Br J Surg 2022;109(12):1216-1223. View abstract.

Chen B, Zhang M, He Y, et al. The association between caffeine exposure during pregnancy and risk of gestational hypertension/preeclampsia: A meta-analysis and systematical review. J Obstet Gynaecol Res 2022;48(12):3045-3055. View abstract.

Conger SA, Tuthill LM, Millard-Stafford ML. Does Caffeine Increase Fat Metabolism? A Systematic Review and Meta-Analysis. Int J Sport Nutr Exerc Metab 2022;33(2):112-120. View abstract.

Gardiner C, Weakley J, Burke LM, et al. The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep Med Rev 2023;69:101764. View abstract.

Grgic J, Varovic D. Ergogenic Effects of Caffeine on Ballistic (Throwing) Performance: A Meta-Analytical Review. Nutrients 2022;14(19):4155. View abstract.

Ismail RIH, Awad HA, Saber M, Shehata BM. Bone mineral content for preterm neonates treated with caffeine using dual energy X-ray absorptiometry: An observational study. J Neonatal Perinatal Med 2023;16(1):129-135. View abstract.

Larsson SC, Woolf B, Gill D. Appraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease: two sample mendelian randomisation study. BMJ Med 2023;2(1):1-8. doi:10.1136/bmjmed-2022-000335. View abstract.

Miao Y, Liu W, Zhao S, et al. Effect of prophylactic caffeine in the treatment of apnea in very low birth weight infants: a meta-analysis. J Matern Fetal Neonatal Med 2023;36(1):2214659. View abstract.

Miao Y, Zhou Y, Zhao S, et al. Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis. PLoS One 2022;17(9):e0274882. View abstract.

Oliphant EA, McKinlay CJ, McNamara D, Cavadino A, Alsweiler JM. Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial. Arch Dis Child Fetal Neonatal Ed 2023;108(2):106-113. View abstract.

Rao W, Li Y, Li N, Yao Q, Li Y. The association between caffeine and alcohol consumption and IVF/ICSI outcomes: A systematic review and dose-response meta-analysis. Acta Obstet Gynecol Scand 2022;101(12):1351-1363. View abstract.

Rezakhaniha S, Rezakhaniha B, Siroosbakht S. Limited caffeine consumption as first-line treatment in managing primary monosymptomatic enuresis in children: how effective is it? A randomised clinical trial. BMJ Paediatr Open 2023;7(1):e001899. View abstract.

Wall BT, Machin D, Dunlop MV, Stephens FB. Caffeine ingestion stimulates plasma carnitine clearance in humans. Physiol Rep 2023;11(4):e15615. View abstract.

Wang Z, Qiu B, Gao J, Del Coso J. Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis. Nutrients 2022;15(1):148. View abstract.

Zhao J, Huang Y, Yu X. Caffeine intake and the risk of incident kidney stones: a systematic review and meta-analysis. Int Urol Nephrol 2022;54(10):2457-2466. View abstract.