Comparison of Common Commercial Probiotic Products

Product Contents Promoted Use Labeled Dose or Dose Used in Studies Indications For Which This Product Has Been Rated

AB Yogurt

(Mlekara Subotica)

Bifidobacterium BB12 plus Lactobacillus acidophilus

At least 1 million colony-forming units of each strain per gram

To stimulate the use of minerals and the regeneration of intestinal microflora For antibiotic-associated diarrhea: 125 grams twice daily for four weeks before and one week during Helicobacter pylori triple therapy

 

POSSIBLY INEFFECTIVE for...

  • Antibiotic-associated diarrhea

 

Activia yogurt

(Dannon/Danone [Canada])

Bifidobacterium animalis lactis DN-173 010/CNCM I-2494

At least 100 million live & active bacteria per gram

Regulates digestive system Consume daily for two weeks as part of balanced diet and healthy lifestyle This product has not been studied in clinical research for any specific indication.

Align with Bifantis

(Procter & Gamble)

Bifidobacterium longum subsp. infantis 35624 (Bifantis)

4 mg/capsule (1 billion colony-forming units)

Promotes digestive health One capsule daily POSSIBLY EFFECTIVE for…
  • Irritable bowel syndrome.

Bacid

(Erfa Canada Inc.)(Canada)

(Keep refrigerated)

Lactobacillus rhamnosus

One billion bacteria per capsule

Restore and maintain normal gastrointestinal flora; prevent/treat oral candidiasis and diarrhea due to antibiotics; management of aphthous and herpes stomatitis Two capsules two to four times daily, preferably with milk or lactose This product has not been studied in clinical research for any specific indication.

Bio-K+

(Bio-K+ International)

Lactobacillus acidophilus CL 1285, L. casei LBC80R, L. rhamnosus CLR2

12.5 billion (light), 25 billion (regular), or 50 billion (strong) live bacteria per capsule

50 billion active bacteria/98 g bottle fermented beverage

Promotes and maintains a healthy and balanced digestive system

For digestive health:  one to two capsules daily or one bottle (beverage) daily for a month, then ½ to one bottle daily (children one to 12 years, one tablespoon to ½ bottle daily)(U.S.); ½ to one bottle daily one year and older (Canada)

To prevent antibiotic-associated diarrhea:  one bottle or two extra-strength capsules daily within 24 to 48 hours of starting antibiotic. Continue until five days after stopping antibiotic

Take two hours after antibiotics

POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea.
  • Clostridium-difficile diarrhea.

BioGaia Chewable Tablets

(Ferring Inc.)

Lactobacillus reuteri DSM 17938

100 million live bacteria per tablet

Restores natural balance in the gut, calms digestive distress, promotes gut health, and strengthens immune defenses For general gut health or temporary stomach discomfort: 1 tablet daily POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea.
  • Functional constipation.

Culturelle

(Amerifit Nutrition)

Lactobacillus rhamnosus GG (Lactobacillus GG)

Culturelle Digestive Health and Culturelle Vegetarian Health & Wellness:  10 billion bacteria plus inulin 200 mg per capsule

Culturelle Health & Wellness:  10 billion bacteria per capsule

Culturelle Kids Packets:  1.5 billion bacteria per packet

Culturelle Kids Chewables:  2.5 billion bacteria per tablet

Culturelle Digestive Health:  Improve digestion and digestive health, prevent gas and bloating, support immune system and well-being, and reduce travel-associated digestive complaints

Culturelle Health and Wellness and Vegetarian Health & Wellness:  supports immune system and digestive health

Culturelle Kids products:  Promote health, support immune system, and alleviate occasional digestive complaints

Culturelle Digestive Health and Culturelle Vegetarian Health & Wellness:

  • To support immune and digestive health:  one capsule daily
  • For digestive discomfort:  two capsules daily until resolved
  • During travel (Digestive Health product):  two capsules daily beginning two to three days before travel
  • Children over one year old:  one capsule daily

Culturelle Health & Wellness:  one capsule daily (adults and children over one year old)

Culturelle Kids Packets (for children 25 to 50 lbs):

  • To support immune and digestive health:  one packet daily
  • For digestive discomfort:  up to seven packets daily, spaced regularly through the day

Culturelle Kids Chewables (for children 50 to 100 lbs):

  • To support immune and digestive health:  one tablet daily
  • For digestive discomfort:  two tablets twice daily

To prevent antibiotic-associated diarrhea in children:  10 to 20 billion bacteria once daily OR 20 billion bacteria twice daily during treatment

LIKELY EFFECTIVE for...
  • Rotaviral diarrhea.

POSSIBLY EFFECTIVE for...

  • Antibiotic-associated diarrhea.
  • Atopic dermatitis (eczema).
  • Atopic disease.
  • Diarrhea.
  • Necrotizing enterocolitis (NEC).
  • Traveler's diarrhea.
  • Upper respiratory tract infection (URTI).

POSSIBLY INEFFECTIVE for...

  • Clostridium difficile diarrhea.
  • Crohn's disease.
  • Irritable bowel syndrome.

DanActive

(Dannon/Danone [Canada])

Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus casei (strain used in product is trademarked L. casei Immunitas [Defensis in Canada])

Over 10 billion live and active L. casei per bottle

Strengthen the body’s defenses

Strengthen defenses:  at least one bottle daily

Prevention of antibiotic-associated diarrhea (hospitalized adults):  one bottle twice daily during treatment and for one week afterward

Prevention of Clostridium difficile diarrhea: one bottle twice daily for one week 

POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea.
  • Clostridium difficile diarrhea.

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Upper respiratory tract infection (URTI).

Dicloflor 60

(Dicofarm)

Lactobacillus rhamnosus GG (ATCC 53103)

6 billion colony-forming units per sachet

To balance the intestinal bacterial flora

General use: Dissolve 1 sachet is water and take with meals once daily

For necrotizing enterocolitis: Dissolve ½ sachet in human milk daily
POSSIBLY EFFECTIVE for...
  • Necrotizing enterocolitis (NEC).

Duolac Care

(Cell Biotech)

Streptococcus thermophilus CBT ST3, Lactobacillus acidophilus CBT LA1, Bifidobacterium animalis subsp. lactis CBT BL3, Lactobacillus rhamnosus CBT LR5, Bifidobacterium longum CBT BG7, Bifidobacterium bifidum CBT BF3

5 billion colony-forming units per capsule

To maintain intestinal microflora balance for a healthy gut

For a healthy gut: one capsule twice a day taken with water

For irritable bowel syndrome: 2 capsules daily for 4 weeks
 

POSSIBLY EFFECTIVE for...

  • Irritable bowel syndrome.

EcologicAAD

(Winclove Bio Industries)

Bifidobacterium bifidum NIZO 3804 plus Bifidobacterium lactis NIZO 3680 plus Enterococcus faecium NIZO 3886 plus Lactobacillus acidophilus NIZO 3678 and NIZO 3887 plus Lactobacillus paracasei NIZO 3672 plus Lactobacillusplantarum NIZO 3684 plus Lactobacillusrhamnosus NIZO 3689 plus Lactobacillus salivarius NIZO 3675

100 million colony-forming units of each species per gram

To accelerate the recovery of the intestinal flora during and after antibiotic use For antibiotic-associated diarrhea: one sachet twice daily during and for one week following antibiotic treatment.

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Antibiotic-associated diarrhea
Fem-dophilus: see RepHresh, below        

Florajen

(American Lifeline, Inc.)(U.S.)(Refrigeration recommended when possible.)

FlorajenLactobacillus acidophilus

20 billion live bacteria per capsule

Florajen 3 Lactobacillus acidophilus, Bifidobacterium lactis, B. longum

15 billion live bacteria per capsule

Florajen4KidsLactobacillus acidophilus, L. rhamnosus, Bifidobacterium lactis

6 billion live bacteria per capsule

Florajen Bifido BlendBifidobacterium bifidum, B. longum

10 billion live bacteria per capsule

Florajen:  restore and maintain vaginal flora; benefit intestinal health; maintain immune system

Florajen 3:  restore and maintain gastrointestinal health; support immune system; benefit vaginal flora

Florajen4Kids:  maintain healthy intestinal flora balance

Florajen Bifidoblend:  maintain healthy intestinal flora balance

General use:  One capsule daily

Prevention of antibiotic-associated diarrhea (hospitalized adults):  one capsule three times daily during treatment and for 14 days after the last dose of antibiotic

Take one to two hours before or after antibiotic (product labeling).

(Note:  Other sources recommend separating from antibiotics by at least two hours.)
POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea.
Florastor

(Biocodex)

(Do not refrigerate.)

Saccharomyces boulardii lyo CNCM I-745 250 mg per capsule or packet (5 billion colony-forming units) Protect against digestive imbalance due to antibiotics, travel, stress, diet, or other digestive issues

Digestive health (two months of age and older):  one capsule or packet twice daily

Prevention of antibiotic-associated diarrhea:  two capsules twice daily beginning within two days of antibiotics, and continuing for three days after discontinuation

Prevention of traveler’s diarrhea:  one or two capsules daily beginning five days before travel and continued for duration of trip

To prevent C. difficile recurrence:  two capsules twice daily for four weeks (with appropriate antibiotics)

HIV-associated diarrhea:  1 gram three times daily, tapered to 1 gram daily to control diarrhea

Tube-feed diarrhea:  500 mg four times daily; has been used for up to 28 days

LIKELY EFFECTIVE for...
  • Antibiotic-associated diarrhea.

POSSIBLY EFFECTIVE for...

  • Clostridium difficile diarrhea.
  • Helicobacter pylori (H. pylori).
  • HIV-related diarrhea.
  • Traveler’s diarrhea.

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Crohn’s disease.
  • Irritable bowel syndrome (IBS).
  • Ulcerative colitis.
Hexbio (B-Crobes)

Lactobacillus acidophilus BCMC 12130, Lactobacillus casei BCMC 12313, Lactobacillus lactis BCMC 12451, Bifidobacterium bifidum BCMC 02290, Bifidobacterium infantis BCMC 02129, Bifidobacterium longum BCMC 02120


30 billion colony-forming units per sachet

Dietary supplement

General use: 1 sachet twice daily for adults; 1 sachet once daily for children

For functional constipation: 1 sachet twice daily for 7 days

POSSIBLY EFFECTIVE for...

  • Functional constipation.

Howaru Protect

(Danisco)

(Refrigeration recommended when possible.)

Howaru Protect Kids: Lactobacillus acidophilus NCFM, Bifidobacterium lactis Bi-07

10 billion live bacteria per capsule or stick

5 billion live bacteria per tablet

Howaru Protect Adult: Bifidobacterium lactis Bi-04

2 billion live bacteria

Howaru Protect Sport:  Bifidobacterium lactis Bi-07 and Lactobacillus acidophilus NCFM

10 billion CFU

Strengthen natural defenses

Capsules or sticks:  one daily

Tablets:  two tablets per day

Respiratory infection in children:  5 billion bacteria twice daily

POSSIBLY EFFECTIVE for...

  • Respiratory infection.

Infloran

(Laboratorio Farmaceutico S.I.T.)

Lactobacillus acidophilus, Bifidobacterium bifidum

At least 2 billion colony-forming units per capsule

   

POSSIBLY EFFECTIVE for...

  • Necrotizing enterocolitis (NEC).
  • Upper respiratory tract infection (URTI).
Jamieson Probiotic Sticks

(Jamieson Natural Sources)

(Canada)

Lactobacillus helveticus and Bifidobacterium longum

1 billion colony-forming units per powder stick

Balances gut flora to maintain health, decreases stress-related digestive symptoms One powder stick daily with a meal This product has not been studied in clinical research for any specific indication.

Lacteol Forte

(Mirren Pty Ltd.)

Lactobacillus acidophilus

5 billion colony-forming units per powder stick.

    POSSIBLY EFFECTIVE for...
  • Irritable bowel syndrome (IBS).
Lactinex

(Becton, Dickinson and Company)

(Refrigeration strongly recommended.)

Lactobacillus acidophilus, L. bulgaricus (or helveticus)

1 million colony-forming unit/tablet; 1 billion colony-forming unit/packet

Not specified Four tablets three or four times daily or one packet three or four times daily

POSSIBLY INEFFECTIVE for...

  • Antibiotic-associated diarrhea.

Lactobac powder

(Nutrition Care)

Lactobacillus rhamanosus and Bifidobacterium longum

5 billion cells per gram of powder

  For vaginal candidiasis: ½ teaspoon of powder twice daily before meals

POSSIBLY INEFFECTIVE for...

  • Vaginal candidiasis.
Original Kefir

(Lifeway)

Lactobacillus lactis, L. rhamnosus, L. plantarum, L. casei, L. acidophilus, L. reuteri, Leuconostoc cremoris, Streptococcus diacetilactis, Saccharomyces florentinus, Bifidobacterium longum, B. breve, B. lactis

7 to 10 billion colony-forming units per cup

Keep harmful bacteria in check Not stated This product has not been studied in clinical research for any specific indication.
Probaclac

(Nicar Laboratories, Inc.)

Adult, children’s (Canada), and mild (Canada) formulas:  Lactobacillus acidophilus, L. rhamnosus, L. bulgaricus, L. casei, Streptococcus thermophilus, Bifidobacterium bifidum, B. longum (U.S. products also contain inulin.)

B. breve added to extra strength formula,substituted for L. acidophilus in senior formula (U.S.) and for L. casei in 50+ formula (Canada); B. breve and L. plantarum added to traveler formula (U.S.); B. breve and Saccharomyces boulardii added to traveler formula Canada)

Probaclac SB Medic (Canada):  Saccharomyces boulardii, Lactobacillus bulgaricus, L. helveticus, Streptococcus thermophilus

3 billion active bacteria per capsule (children’s and mild formulas, [Canada]), 5 billion active yeast per capsule (SB Medic and traveler formulas, Canada), 6 billion active bacteria per capsule (adult formula, Canada), 8 billion active bacteria per capsule (50+ formula, Canada), 10 billion active bacteria per capsule (traveler formula [U.S.] and extra strength formula [Canada]), 12 billion active bacteria per capsule (adult formula, U.S.), 15 billion active bacteria per capsule (senior formula), 20 billion active bacteria per capsule (extra strength formula, U.S.)

Probaclac vaginal (Canada): Lactobacillus rhamnosus, L. acidophilus, Streptococcus thermophilus

8 billion active bacteria per capsule

U.S.:  Balance intestinal flora, digestive health, normal digestive function, and support body’s defenses

Canada (adult, children’s, 50+, traveler’s, extra-strength formulas):  Provide bacteria that contribute to healthy intestinal flora

SB Medic formula (Canada):  for diarrhea

Adult, senior, extra-strength formulas, U.S.:

  • Maintenance:  one capsule daily with a meal
  • To restore flora balance:  one capsule two or three times daily

Traveler’s formula:  Beginning a week before travel and while traveling, take one capsule twice daily with a meal

Adult, children’s, 50+ formulas, Canada:  one capsule once or twice daily before breakfast and/or supper

SB Medic formula, Canada:  one capsule twice daily with breakfast and supper, or two hours after taking antibiotic. Continue for at least a week after antibiotic use

Extra-strength formula, Canada:  one capsule two or three times daily

Mild formula, Canada:  one capsule daily with breakfast

Take two hours after antibiotics.

Vaginal formula, Canada: apply one capsule at bedtime for 2 weeks
There is insufficient available evidence to rate this product for any indication.

 ProViva

(Skanemejerier)

Fermented Oat Gruel based on Lactobacillus plantarum 299v.     

POSSIBLY EFFECTIVE for...

  • Antibiotic-associated diarrhea.
  • Clostridum difficile diarrhea.

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Irritable bowel syndrome.

 

RepHresh Pro-B

(Lil’ Drug Store Products, Inc.)

Fem-dophilus 

(Jarrow Formulas) (Also called Urex-Cap-5.) (Keep refrigerated.)

Lactobacillus rhamnosus GR-1, L. reuteri RC-1461

5 billion colony-forming units per capsule

Promote vaginal health and balance flora (RepHresh Pro-B and Fem-dophilus)

Support urinary tract health (Fem-dophilus)

Maintain vaginal health:  One capsule daily

Support urinary tract health (Fem-dophilus):  One (increased to two, if needed) capsule daily

Bacterial vaginosis:  One capsule twice daily

UTI prevention:  One capsule twice daily
POSSIBLY EFFECTIVE for...
  • Bacterial vaginosis.
  • Urinary tract infection.

VSL#3

(Sigma-Tau Pharmaceuticals)

(Requires refrigeration, but can be kept at room temperature for up to a week with no potency loss.)

Lactobacillus acidophilus SD5212, L. casei SD5218, L. plantarum SD5209, L. paracasei, L. bulgaricus SD5210, Bifidobacterium longum SD5219, B. breve SD5206, B. infantis SD5220, Streptococcusthermophilus SD5207

450 billion live bacteria per packet

225 billion live bacteria per two capsules

NOTE: Dosing for children based on age, weight, and number of bowel movements daily. See product information.
Provide probiotics to protect the gastrointestinal tract and modulate intestinal inflammation to aid in the management of ulcerative colitis, irritable bowel syndrome, and ileal pouch Bloating and gas associated with diarrhea-predominant irritable bowel syndrome:  ½ to one packet or two to four capsules daily

Pouchitis, remission (maintenance):  two to four packets or six to 18 capsules daily

Ulcerative colitis, remission (maintenance):  one to two packets or four to eight capsules daily

Ulcerative colitis, active (adjunct):  four to eight packets or 16 to 32 capsules daily

(In studies, total daily dose divided [i.e., BID].)

POSSIBLY EFFECTIVE for...
  • Pouchitis.
  • Ulcerative colitis.

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Clostridium difficile diarrhea.
  • Irritable bowel syndrome (IBS).

Yakult

(Yakult U.S.A. Inc.)

Lactobacillus casei Shirota

8 billion active bacteria per 80 mL bottle

Balance digestive system and maintain health

Balance digestive system/maintain health:  One to two bottles daily

Functional constipation:  One bottle daily
INSUFFICIENT RELIABLE EVIDENCE to RATE for…
  • Functional constipation.