Comparison of Common Commercial Probiotic Products

Product Contents Promoted Use Labeled Dose (May Differ from Studied Dose) Indications For Which This Product Has Been Rated

Activia yogurt

(Dannon/Danone [Canada])

Lactobacillus delbrueckii subsp. bulgaricus

Streptococcus thermophilus

Bifidobacterium animalis subsp. lactis DN-173 010

At least 100 million live & active bacteria per gram

Regulates digestive system Consume at least two containers daily for two weeks as part of balanced diet and healthy lifestyle

This product has not been studied in clinical research for any specific indication.

Align with Bifantis

(Procter & Gamble)

Bifidobacterium longum subsp. infantis 35624 (Bifantis)

4 mg/capsule (1 billion colony-forming units)

Promotes digestive health One capsule daily INSUFFICIENT RELIABLE EVIDENCE to RATE for…
  • Irritable bowel syndrome

Bio-K+

(Bio-K+ International)

Lactobacillus acidophilus CL 1285, Lacticaseibacillus casei LBC80R, Lacticaseibacillus rhamnosus CLR2

30 billion (DailyCare), 50 billion (DailyCare+), or 85 billion (ExtraCare) live bacteria per capsule

50 billion active bacteria/104 mL bottle fermented beverage

Promotes and maintains a healthy and balanced digestive system

One capsule daily or ¼-1 bottle (beverage) daily

Take two hours after antibiotics

POSSIBLY EFFECTIVE for…
  • Clostridioides difficile infection
INSUFFICIENT RELIABLE EVIDENCE to RATE for…
  • Antibiotic-associated diarrhea

BioGaia Protectis

(Ferring Inc.)

Limosilactobacillus reuteri DSM 17938

Chewable Tablets: 100 million live bacteria per tablet

Baby Drops: 100 million live bacteria per 5 drops

Restores natural balance in the gut, calms digestive distress, promotes gut health, and strengthens immune defenses

Chewable Tablets:

  • One to two tablets daily

Baby Drops:

  • Five drops daily
POSSIBLY EFFECTIVE for...
  • Colic
  • Diarrhea

Culturelle

(DSM)

Lacticaseibacillus rhamnosus GG (Lacticaseibacillus GG)

Culturelle Digestive Daily:  10 billion bacteria plus inulin 200 mg per capsule or chewable tablet

Culturelle Ultimate Strength:  20 billion bacteria plus inulin 200 mg per capsule

Culturelle Health & Wellness:  15 billion bacteria per capsule

Culturelle Kids Packets:  5 billion bacteria per packet

Culturelle Kids Chewables:  5 billion bacteria per tablet

Culturelle Digestive Health:  Improve digestion and digestive health, prevent gas and bloating, support immune system and well-being, and restore the natural balance of good bacteria

Culturelle Health and Wellness:  supports immune system and digestive health

Culturelle Kids products:  Promote health, support immune system, and alleviate occasional digestive complaints

Culturelle Digestive Health

  • To support immune and digestive health: One capsule daily
  • For digestive discomfort: Two capsules daily until resolved
  • During travel (Digestive Health product): Two capsules daily beginning 2-3 days before travel

Culturelle Health & Wellness (Adults and children over 12 years old)

  • One capsule daily

Culturelle Ultimate Strength (Adults and children over 12 years old):

  • One capsule daily. If travelling, start 2-3 days before travel

Culturelle Kids Packets (Children 1 year and older):

  • To support immune and digestive health: One packet daily
  • For digestive discomfort: Two packets daily
  • Mix entire contents into cool (not hot) food or drink

Culturelle Kids Chewables (Children 3-12 years old):

  • To support immune and digestive health: One tablet daily
  • For digestive discomfort: Two tablets daily
POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea
  • Atopic dermatitis (eczema)
  • Atopic disease
  • Respiratory tract infections

POSSIBLY INEFFECTIVE for...

  • Ventilator-associated pneumonia (VAP)

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Cognitive impairment
  • Crohn disease
  • Diarrhea
  • Otitis media
  • Rotaviral diarrhea
  • Travelers' diarrhea

DanActive

(The Dannon Company/Danone [Canada])

Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophilus, Lacticaseibacillus casei (strain used in product is trademarked L. casei Immunitas [Defensis in Canada])

Over 10 billion live and active L. casei per bottle

Strengthen the body’s defenses Daily as part of a balanced diet POSSIBLY EFFECTIVE for...
  • Diarrhea

Dicloflor 60

(Dicofarm)

Lacticaseibacillus rhamnosus GG

6 billion colony-forming units per capsule or sachet

To balance the intestinal bacterial flora

Take 1 sachet or capsule with a meal once daily

There is insufficient available evidence to rate this product for any indication.

Fem-dophilus: see RepHresh, below

 

 

 

 

Florajen

(American Lifeline, Inc.)

(Refrigeration recommended when possible.)

Florajen Acidophilus: Lactobacillus acidophilus

20 billion live bacteria per capsule

Florajen Digestion (formerly Florajen3): Lactobacillus acidophilus LA-14, Bifidobacterium animalis subsp. lactis BI-07, B. animalis subsp. lactis HN019, Lactobacillus acidophilus NCFM, B. longum BL-05

15 billion live bacteria per capsule

Florajen Kids: Bifidobacterium animalis subsp. lactis HN019, Lacticaseibacillus rhamnosus HN001, B. animalis subsp. lactis BI-07, Lactobacillus acidophilus NCFM

6 billion live bacteria per capsule

Florajen Women: Lactobacillus acidophilus LA-14, Lacticaseibacillus rhamnosus HN001, Lactobacillus acidophilus NCFM

15 billion live bacteria per capsule

Florajen Acidophilus: Supports immune, digestive, vaginal, and urinary health

Florajen Digestion: Restore and maintain gastrointestinal health

Florajen Kids: Maintain healthy intestinal flora balance and regularity in digestive system

Florajen Women: Restore and maintain the natural balance of vaginal flora

One capsule daily

Take one to two hours before or after antibiotic
POSSIBLY EFFECTIVE for...
  • Antibiotic-associated diarrhea

Florastor

(Biocodex)

(Do not refrigerate)

Saccharomyces boulardii lyo CNCM I-745

Florastor Original: 250 mg per capsule or packet (5 billion colony-forming units)

Florastor Kids: 250 mg per packet (5 billion colony-forming units)

Florastor Baby: 250 mg per stick (5 billion colony-forming units)

Protect against digestive imbalance due to antibiotics, travel, stress, diet, or other digestive issues

Florastor Original: Two capsules or packets 1-2 times daily

Florastor Kids: One packet 2 times daily. Mix contents into soft food or beverage

Florastor Baby: One stick 1-2 times daily. Mix into milk/formula or soft food

LIKELY EFFECTIVE for... 

  • Diarrhea

POSSIBLY EFFECTIVE for...

  • Clostridium difficile diarrhea.
  • Helicobacter pylori (H. pylori)
  • Travelers' diarrhea

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Irritable bowel syndrome (IBS)

Hexbio

(B-Crobes)

Lactobacillus acidophilus BCMC 12130, Lacticaseibacillus casei BCMC 12313, Lactobacillus lactis BCMC 12451, Bifidobacterium bifidum BCMC 02290, Bifidobacterium infantis BCMC 02129, Bifidobacterium longum BCMC 02120

30 billion colony-forming units per sachet

Improving gut health

General use: 1 sachet daily for adults; 1 sachet every other day for children

For functional constipation: 1 sachet twice daily for 7 days

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Constipation

Infloran

(Laboratorio Farmaceutico S.I.T.)

(Keep refrigerated)

Lactobacillus acidophilus, Bifidobacterium bifidum

At least 2 billion colony-forming units per capsule

Promote healthy gut flora and digestive health; support immune system function Infants: One capsule three times daily

POSSIBLY EFFECTIVE for...

  • Respiratory tract infections

Jamieson Probiotic Sticks

(Jamieson Natural Sources)

(Canada)

Lactobacillus helveticus R0052 and Bifidobacterium longum R0175

3 billion colony-forming units per powder stick

Supports the maintenance of digestive health

3 years and older: One powder stick daily with a meal

Take at least 2-3 hours before or after taking antibiotics

INSUFFICIENT RELIABLE EVIDENCE to RATE for...
  • Constipation
  • Depression

Lactinex

(Becton, Dickinson and Company)

(Refrigeration strongly recommended)

Lactobacillus acidophilus

1 million colony-forming unit/tablet; 1 billion colony-forming unit/packet

Not specified Four tablets three or four times daily or one packet three or four times daily POSSIBLY INEFFECTIVE for...
  • Antibiotic-associated diarrhea.
Original Kefir

(Lifeway)

Lactobacillus lactis, Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum, Lacticaseibacillus casei, Lactobacillus acidophilus, Limosilactobacillus reuteri, Leuconostoc cremoris, Streptococcus diacetilactis, Saccharomyces florentinus, Bifidobacterium longum, B. breve, B. animalis subsp. lactis

7 to 10 billion colony-forming units per cup

Keep harmful bacteria in check Not stated This product has not been studied in clinical research for any specific indication.

Probiotic 10

(Nature's Bounty)

Lactiplantibacillus plantarum 299v and HEAL9, Lacticaseibacillus paracasei Lpc-37 and 8700:2, Lactobacillus acidophilus La-14, Levilactobacillus brevis Lbr-35, Lacticaseibacillus casei Lc-11, Bifidobacterium lactis BI-04, Lactobacillus delbrueckii subsp. bulgaricus Lb-87, Ligilactobacillus salivarius Ls-33

20 billion colony-forming units per capsule

Supports digestive health and immune function One capsule daily

INSUFFICIENT RELIABLE EVIDENCE to RATE for...

  • Pregnancy-related nausea and vomiting

Probaclac

(Nicar Laboratories, Inc.)

Probaclac Adults: Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Lactobacillus delbrueckii subsp. bulgaricus, Lacticaseibacillus casei, Streptococcus thermophilus, Bifidobacterium bifidum, B. longum

6.5 billion active cells per capsule

Probaclac Toddlers: Bifidobacterium bifidum, B. animalis subsp. infantis, Lactobacillus acidophilus, Limosilactobacillus reuteri, Lacticaseibacillus rhamnosus

2 billion active cells per capsule

Probaclac Children’s: Bifidobacterium breve B. longum, Lactobacillus acidophilus, Lacticaseibacillus casei, Lacticaseibacillus paracasei, Lacticaseibacillus rhamnosus

3 billion active cells per capsule

Probaclac Medic: Saccharomyces boulardii

5 billion active cells per capsule

Probaclac Vaginal: Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Streptococcus thermophilus

8 billion active bacteria per capsule

Balance intestinal flora, digestive health, normal digestive function, and support body’s defenses

Medic formula: Reducing diarrhea associated with antibiotics

Probaclac Adults: One capsule twice daily at breakfast and dinner

Probaclac Toddlers (children 1 year or older): One capsule once daily

Probaclac Children (3 years and older): One table twice daily at breakfast and at supper

Probaclac Medic formula (Adults and Children 6 years and older): One capsule twice daily with breakfast and supper (take simultaneously with antibiotic treatment; take at least 2-3 hours before or after antifungal)

Probaclac Vaginal: Apply one capsule at bedtime for 2 weeks

There is insufficient available evidence to rate this product for any indication.

RepHresh Pro-B

(Lil’ Drug Store Products, Inc.)

Fem-dophilus

(Jarrow Formulas) (Also called Urex-Cap-5.) 

(Keep refrigerated)

Lacticaseibacillus rhamnosus GR-1, Limosilactobacillus reuteri RC-14

5 billion colony-forming units per capsule

Promote vaginal health and balance flora (RepHresh Pro-B and Fem-dophilus)

Support urinary tract health (Fem-dophilus)

One capsule daily. May increase to two capsules daily as needed

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Bacterial vaginosis
  • Group B streptococcal colonization
  • Rheumatoid arthritis (RA)
  • Urinary tract infections (UTIs)

Visbiome

(ExeGi Pharma)

(Requires refrigeration but can be kept at room temperature for up to a week with no potency loss.)

[Some research on this formulation was conducted under the name VSL #3]

Lactobacillus acidophilus DSM24735, Lactiplantibacillus plantarum DSM24730, Lacticaseibacillus paracasei DSM24733, Lactobacillus delbrueckii subsp. bulgaricus DSM24734, Bifidobacterium longum DSM24736, B. breve DSM24732, B. infantis DSM24737, Streptococcus thermophilus DSM24731

450 billion live bacteria per packet

225 billion live bacteria per two capsules

A medical food intended for the dietary management of dysbiosis associated with irritable bowel syndrome, ulcerative colitis, pouchitis, and hepatic encephalopathy Two to eight capsules daily as directed by a physician

POSSIBLY EFFECTIVE for...

  • Diabetes
  • Pouchitis
  • Ulcerative colitis

 

Yakult

(Yakult U.S.A. Inc.)

(Keep refrigerated)

Lactobacillus casei Shirota

8 billion active bacteria per 80 mL bottle

Balance digestive system and maintain health

One to two bottles daily

POSSIBLY EFFECTIVE for...

  • Upper respiratory tract infections

POSSIBLY INEFFECTIVE for...

  • Exercise-induced respiratory tract infections

INSUFFICIENT RELIABLE EVIDENCE to RATE for…

  • Antituberculosis treatment-associated adverse effects
  • Constipation
  • Fractures
  • Small intestinal bacterial overgrowth (SIBO)