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Several medications have the potential to affect nutrient levels within the body. In some cases, medications deplete nutrients to an extent that a nutrient supplement might be necessary. However, in many other cases, the nutrient depletion is temporary or insignificant. The following ratings provide a snapshot of the clinical significance of a nutrient depletion issue along with guidance about whether a nutrient supplement might be necessary.
Major Depletion = A supplement is needed for most patients.
Evidence consistently shows that many patients taking this medication will require a supplement to prevent nutrient depletion and symptoms of nutrient depletion.
Moderate Depletion = Monitor for depletion; a supplement is needed in some patients.
Evidence shows that some people might develop nutrient depletion and related symptoms. Nutrient depletion might not occur in most patients, but it occurs in enough patients that monitoring for depletion is needed. A nutrient supplement should be used for patients who develop low nutrient levels.
Insignificant Depletion = A supplement is not needed for most patients.
Evidence shows that there is some evidence of changes in nutrient levels, but these changes are either transient or clinically insignificant. Most patients will not develop nutrient depletion and a nutrient supplement is usually not needed.
Insufficient Evidence to Rate = Clinical significance is not known.
Some evidence suggests that there are affects on nutrient levels; however, evidence is too preliminary or inconsistent to know if potential nutrient depletion is significant.
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