Each 1 scoop serving contains: Trehalose 5 g • Ribose 3 g • Leucine 1 g • Valine • Isoleucine 500 mg • Multi-Sate Carbohydrate Blend: Maltodextrin, Trehalose , Ribose , Fructose, Glucose, Sucraose • Protein Blend: Whey Protein Isolate , Leucine , Isoleucine , Valine . Other Ingredients: Citric Acid, Disodium Phosphate Anhydrous, Natural and Artificial Flavors, Sodium Chloride, Dipotassium Phosphate, Sodium Ascorbate, dl-Alpha Tocopherol Acetate, Magnesium Phosphate, Acesulfame Potassium, Plydimethylsiloxane, Tricalcium Phosphate, Yellow #6, Sucralose.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
Below is general information about the effectiveness of the known ingredients contained in the product Endurathon. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Endurathon. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally and appropriately. BCAAs 12 grams daily have not been associated with significant adverse effects in studies lasting for up to 2 years (68,72,73,74,10117,10146,10147,37120,92643,97531,103351,103352). ...when used intravenously and appropriately. BCAAs are an FDA-approved injectable product (13309).
CHILDREN: LIKELY SAFE
when used orally in dietary amounts of 71-134 mg/kg daily (11120,13308).
CHILDREN: POSSIBLY SAFE
when larger, supplemental doses are used orally and appropriately for up to 6 months (13307,13308,37127).
PREGNANCY:
Insufficient reliable information available; avoid using amounts greater than those found in food.
Although adverse effects have not been reported in humans, some animal research suggests that consumption of supplemental isoleucine, a BCAA, during the first half of pregnancy may have variable effects on birth weight, possibly due to abnormal placental development (103350).
LACTATION:
Insufficient reliable information available; avoid using amounts greater than those found in food.
Although the safety of increased BCAA consumption during lactation is unclear, some clinical research suggests that a higher concentration of isoleucine and leucine in breastmilk during the first 6 months postpartum is not associated with infant growth or body composition at 2 weeks, 2 months, or 6 months (108466).
LIKELY SAFE ...when used in amounts commonly found in food. Consuming ribose up to 36 mg/kg daily from food sources is considered safe by the European Food Safety Authority (103292). ...when used orally and appropriately, short-term (15218,15723,15724,15725,15726,15727,15728,15729,15730). Ribose has been used safely at doses up to 15 grams daily for up to 12 weeks (15218,15725,15727,15730,71601,100680,103291,108959). ...when used intravenously and appropriately, short-term (5662,5663,5676,5680,71603). There is insufficient reliable information available about the safety of ribose when used long-term.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally and appropriately. Whey protein up to 30 grams has been safely used in clinical trials for up to 6 months (4930,16728,16729,105587).
CHILDREN: LIKELY SAFE
when used orally and appropriately as a dietary protein in food or infant formula.
Hydrolyzed whey protein-based formula has been safely used in infants for up to 6 months in clinical trials (4927,105585,105594).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Endurathon. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, BCAAs might alter the effects of antidiabetes medications.
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BCAAs in large doses can reduce the effects of levodopa.
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BCAAs may compete with levodopa for transport systems in the intestine and brain and decrease the effectiveness of levodopa (66,2719). Small clinical studies how that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease (3291,3292,3293,3294).
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Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
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Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
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Theoretically, whey protein might reduce the absorption of bisphosphonates.
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Theoretically, whey protein might decrease levodopa absorption.
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Theoretically, whey protein might decrease quinolone absorption.
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Theoretically, whey protein might decrease tetracycline absorption.
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Below is general information about the adverse effects of the known ingredients contained in the product Endurathon. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally or intravenously, BCAAs are generally well tolerated.
Most Common Adverse Effects:
Orally: Abdominal distension, diarrhea, nausea, vomiting.
All routes of administration: High doses can lead to fatigue and loss of motor coordination.
Cardiovascular ...Orally, a single case of hypertension following the use of BCAAs has been reported (37143).
Dermatologic ...Orally, a single case of skin blanching following the use of BCAAs has been reported (681). It is not known if this effect was due to use of BCAAs or other factors.
Gastrointestinal ...Orally, BCAAs can cause nausea, vomiting, diarrhea, and abdominal distension. Nausea and diarrhea has been reported to occur in about 10% of people taking BCAAs (10117,37143,92643,97531).
Neurologic/CNS ...Orally and intravenously, BCAAs can cause fatigue and loss of motor coordination due to increased plasma ammonia levels (693,694,10117). Short-term use of 60 grams of BCAAs containing leucine, isoleucine, and valine for 7 days in patients with normal metabolic function seems to increase levels of ammonia, but not to toxic plasma levels (10117). However, liver function should be monitored with high doses or long-term use (10117). Due to the potential of increased plasma levels of ammonia and subsequent fatigue and loss of motor coordination, BCAAs should be used cautiously before or during activities where performance depends on motor coordination (75). Orally, BCAAs may also cause headache, but this has only been reported in one clinical trial (681).
General
...Orally and intravenously, ribose is generally well-tolerated for up to 1 month.
Most Common Adverse Effects:
Orally: Diarrhea, gastrointestinal discomfort, headache, hypoglycemia, nausea.
Intravenously: Hypoglycemia.
Endocrine
...Orally, ribose can decrease blood glucose levels (5667,92891).
In one pharmacokinetic study, fasting plasma glucose declined after single ribose doses of 2.5-10 grams. At all doses, serum glucose returned to near normal 2 hours post-administration but remained slightly below pre-dose levels for up to 5 hours. One case of symptomatic hypoglycemia 70 minutes post-dose was reported in a 53 kg female who took ribose 10 grams. The reaction was considered mild; however, specific blood glucose levels were not reported (92891).
Intravenously, ribose has been reported to cause hypoglycemia, increased serum insulin levels, and decreased serum phosphate (5650,5662,5663,5676).
Gastrointestinal ...Orally, ribose can cause diarrhea, gastrointestinal discomfort, and nausea (5664,5676,15218,92891). In one study, lowering the dose of ribose resolved the nausea (15218).
Neurologic/CNS ...Orally, ribose can cause headache (5664,92891). It has also been reported to cause a hyperanxious feeling, lightheadedness, increased appetite, and mild anxiety (15218). In one study, lowering the dose of ribose resolved the feeling of anxiety (15218).
General
...Orally, whey protein is generally well tolerated.
Most Common Adverse Effects:
Orally: Acne, bloating, cramps, diarrhea, fatigue, headache, nausea, reflux, reduced appetite, and thirst. Most adverse effects are dose-related.
Cardiovascular ...In one case report, use of an unclear quantity of whey protein over one month was thought to be probably responsible for the development of coronary embolism in three coronary arteries in a 33-year-old male with no history of atherosclerosis risk factors. The patient required treatment with intravenous glycoprotein IIb/IIIa inhibitor and heparin (96023).
Dermatologic ...Orally, whey protein has been reported to trigger the onset or worsening of acne. Multiple case reports in teenagers and young adults have associated intake of whey protein with the development of acne or the worsening of existing acneiform lesions. In these reports, the discontinuation of whey protein was typically associated with the clearance of acne lesions. In some cases, patients who were unresponsive to acne treatments while using whey protein became responsive after whey protein discontinuation (103965,103970,103971). Cow's milk, which is comprised of 20% whey protein, is also thought to exacerbate acne. It is theorized that this effect may be due to the growth factor and alpha-lactalbumin content of whey protein (103971,103982).
Gastrointestinal ...Orally, whey protein, especially in higher doses of 2. 3-6.5 grams/kg daily, may cause increased bowel movements, nausea, thirst, bloating, esophageal reflux, cramps, and reduced appetite (2640,85961,85702,86043,86074,86075,86084,86089,86095).
Hepatic ...In two case reports, acute cholestatic liver injury occurred after consumption of the combination of whey protein and creatine supplements (46701,90319).
Musculoskeletal ...In one case report, a 26-year-old male experienced fasciitis, or swelling of the forearms, hands, and legs, after consuming the supplement Pure Whey (85895).
Neurologic/CNS ...Orally, high doses of whey protein may cause tiredness or fatigue and headache (2640). Mild drowsiness has also been reported (86089,86092,86124).