Ingredients | Each Serving Contains: |
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(Juglans regia )
(bud)
((1:20) (4.7 mg dried equivalent))
(English Walnut (Juglans regia) bud extract PlantPart: bud Genus: Juglans Species: regia Note: (1:20) (4.7 mg dried equivalent) )
|
0.09 mL |
(Rosmarinus officinalis )
(young shoot)
((1:20) (4.7 mg dried equivalent))
(Rosemary (Rosmarinus officinalis) young shoot extract PlantPart: young shoot Genus: Rosmarinus Species: officinalis Note: (1:20) (4.7 mg dried equivalent) )
|
0.09 mL |
(Vaccinium vitis-idaea )
(young shoot)
((1:20) (4.7 mg dried equivalent))
(Lingonberry (Vaccinium vitis-idaea) young shoot extract PlantPart: young shoot Genus: Vaccinium Species: vitis-idaea Note: (1:20) (4.7 mg dried equivalent) )
|
0.09 mL |
purified Water, Ethanol (Form: Grain), Glycerin
Below is general information about the effectiveness of the known ingredients contained in the product Intest-gen. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Intest-gen. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when the fruit (nut), leaf, or hull is consumed in amounts normally found in foods (4912,6431,8476,8477).
POSSIBLY SAFE ...when the leaf extract is used orally at doses of up to 200 mg for up to 3 months (97749,97750).
POSSIBLY UNSAFE ...when the bark is used orally or topically, due to its juglone content (12). When applied topically, juglone-containing bark can cause skin irritation. When used orally on a daily basis, juglone-containing bark is associated with increased risk of tongue cancer and lip leukoplakia (2,12). There is insufficient reliable information available about the safety of the fruit, leaf, or hull when used orally in medicinal amounts or when applied topically.
PREGNANCY AND LACTATION: LIKELY SAFE
when the fruit (nut), leaf, or hull is consumed in amounts normally found in foods (4912).
PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when the bark is used orally or topically (12); avoid using.
There is insufficient reliable information available about the safety of the fruit, leaf, or hull when used orally in medicinal amounts during pregnancy and lactation; avoid using.
LIKELY SAFE ...when consumed in the amounts commonly found in foods.
POSSIBLY SAFE ...when lingonberry concentrate is used orally and appropriately. A beverage containing cranberry concentrate 7.5 grams and lingonberry concentrate 1.7 grams in 50 mL water has been used with apparent safety for up to 6 months (8253).
POSSIBLY UNSAFE ...when lingonberry leaf extracts are used orally, long-term. Lingonberry leaf contains a constituent that might be hepatotoxic (18). However, a high quality safety assessment of lingonberry leaf in humans has not been conducted. There is insufficient reliable information available about the safety of lingonberry leaf extracts when used orally, short-term.
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally because some constituents have mutagenic effects, potentially harming the developing fetus (18); avoid using.
CHILDREN: POSSIBLY SAFE
when lingonberry concentrate is used orally and appropriately.
A beverage containing cranberry concentrate 7.5 grams and lingonberry concentrate 1.7 grams in 50 mL water has been used with apparent safety for up to 6 months (46452).
CHILDREN: POSSIBLY UNSAFE
when lingonberry leaf extracts are used orally, long-term.
Lingonberry leaf contains constituents that might be hepatotoxic (18).
LIKELY SAFE ...when used orally in amounts typically found in foods. Rosemary has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when the leaf is used orally and appropriately in medicinal amounts (18). Powdered rosemary leaf has been used with apparent safety as a single dose of up to 1.5 grams (18246,91731) or at a dose of 1-4 grams daily for up to 8 weeks (91727,98536,105327,109561). ...when the essential oil is used topically and appropriately for up to 7 months (5177,91729,109560). ...when the essential oil is used by inhalation as aromatherapy, short-term (7107,18323,105324,109559).
LIKELY UNSAFE ...when the essential oil or very large quantities of rosemary leaf are used orally. Ingestion of undiluted rosemary oil or very large quantities of rosemary leaf can cause serious adverse effects (18,515).
PREGNANCY: POSSIBLY UNSAFE
when used orally in medicinal amounts.
Rosemary might have uterine and menstrual flow stimulant effects (4,12,18), and might increase metabolism of estradiol and estrone (18331); avoid using. There is insufficient reliable information available about the safety of rosemary when used topically during pregnancy.
LACTATION:
There is insufficient reliable information available about the safety of using rosemary in medicinal amounts during lactation; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Intest-gen. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
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Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Details
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models (71821,71923). However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults (105327), no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs (105323,105327).
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Details
Rosemary is reported to contain salicylates (18330).
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Details
Rosemary is reported to contain salicylate (18330).
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Theoretically, rosemary might decrease the levels and clinical effects of CYP1A1 substrates.
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Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Details
Rosemary is reported to contain salicylate (18330).
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Below is general information about the adverse effects of the known ingredients contained in the product Intest-gen. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, the fruit (nut) of English walnut is well tolerated (8476,8477); however, it can cause softening of stools and mild bloating (6431).
Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479). English walnut leaf extract has been reported to cause gastrointestinal adverse events, especially mild diarrhea (97750). Daily use of English walnut bark is associated with increased risk of tongue cancer and lip leukoplakia due to its juglone content (2,12).
Topically, English walnut hull preparations can lead to yellow or brown discoloration of skin and mucous membranes due to its juglone content. It can also cause contact dermatitis (12,12980).
Dermatologic ...Topically, English walnut hull preparations, which contain juglone, can cause a temporary yellow or brown discoloration of skin and mucous membranes. It can also cause contact dermatitis (12,12980).
Gastrointestinal ...Orally, the fruit (nut) of English walnut might cause softening of stools and mild bloating (6431). Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479). Walnut leaf extract has been reported to cause gastrointestinal adverse events, especially mild diarrhea, in 39% of adults in one study (97750). Daily use of walnut bark is associated with increased risk of tongue cancer and lip leukoplakia due to its juglone content (2,12).
Immunologic
...Tree nuts, which include English walnuts, can cause allergic reactions in sensitive individuals.
Due to the prevalence of this allergy in the general population, tree nuts are classified as a major food allergen in the United States (105410).
Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479).
General ...Orally, rosemary seems to be well tolerated when used in appropriate medicinal amounts. Undiluted rosemary oil or very large quantities of rosemary leaf should not be consumed. Topically and as aromatherapy, rosemary seems to be well tolerated.
Dermatologic ...Topically, rosemary use can lead to photosensitivity, erythema, dermatitis, and cheilitis in hypersensitive individuals (4,6).
Immunologic
...Topically, allergic reactions can occur.
When used in the mouth, lip and gum edema have occurred (101173). When used on the skin, allergic contact dermatitis has occurred, likely due to the constituent carnosol (71715,71924,71926).
Rosemary might also cause occupational asthma. A case of occupational asthma caused by several aromatic herbs including thyme, rosemary, bay leaf, and garlic has been reported. The diagnosis was confirmed by inhalation challenges. Although all of the herbs caused immediate skin reactivity, a radioallergosorbent test (RAST) showed that garlic was the most potent allergen by weight, with rosemary and the other herbs showing less reactivity (783).
Neurologic/CNS ...Orally, the undiluted oil, as well as the camphor constituent of rosemary, might cause seizures (4,5,6,12868).