Anaphylaxis Linked to Popular Supplements

Anaphylaxis due to dietary supplements may be a "hidden risk" – since people often view supplements as safer than prescription and OTC drugs. Here are a few ingredients worth discussing.

Andrographis, an herb used in Ayurvedic medicine, is commonly found in herbal supplements promoted for immune health – some clinical evidence shows it might improve common cold symptoms. While it’s likely safe for most people when used short-term, there are many reported cases of severe allergic reactions, including anaphylactic shock. Keep this ingredient on your radar, and advise caution in patients with known allergies – they might be more prone to a severe reaction.

Echinacea is also a notable culprit. It’s widely used in immune support supplements promoted for both adults and kids. But there are serious concerns about allergic reactions such as anaphylaxis in children. So much so, the Medicines and Healthcare Products Regulatory Agency in the United Kingdom recommends against the use of oral echinacea products in children under 12. Tell parents to be cautious. Also note that patients with allergies to other members of the Asteraceae family, including ragweed, chrysanthemums, marigolds, and daisies, might be at greater risk for allergic reactions to echinacea.

Finally, watch out for soy. Allergic reactions can occur with all routes of administration – the Food Allergen Labeling and Consumer Protection Act (FALCPA) of 2004 recognizes soy as a major food allergen in the US. Itching and skin rash are among the most reported minor reactions, but it’s also been linked to anaphylaxis. Be especially cautious in children with severe allergy to cow’s milk as they are also frequently sensitive to soy protein.

Take advantage of the adverse effects section of our monographs to learn more. We highlight both common and serious adverse effects, and breakdown details by category.