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Below is general information about the effectiveness of the known ingredients contained in the product Blood Pressure Balance. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Blood Pressure Balance. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately. Kudzu appears to be safe for up to 4 months (10386,11386,92257). ...when used intravaginally and appropriately. Kudzu 5% to 6% gel has been used with apparent safety for up to 12 weeks (96740,105521,110702).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE. ..when used orally in food amounts. The flowers, seeds, leaves, and rhizomes of lotus are all edible (95261). There is insufficient reliable information available about the safety of medicinal lotus.
PREGNANCY AND LACTATION:
Insufficient reliable information available on the medicinal use of lotus; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Blood Pressure Balance. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
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Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
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Theoretically, taking kudzu with caffeine might increase levels of caffeine.
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In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited (23583). This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.
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Theoretically, kudzu might alter the effects of estrogen therapy.
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Theoretically, concomitant use might have additive hepatotoxic effects.
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Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
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Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs) (13296).
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Theoretically, kudzu might interfere with tamoxifen activity.
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Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.
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Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
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Animal research shows that the ethanolic extract of lotus reduces blood glucose levels and potentiates the effects of injected insulin (60053). Monitor blood glucose levels closely. Dose adjustments might be necessary.
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Theoretically, taking lotus concomitantly with pentobarbital might increase sedation.
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Animal research shows that lotus extract increases pentobarbitone-induced sleeping time (60051). It is not known if this occurs in humans or if this effect occurs with other barbiturates or sedatives.
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Below is general information about the adverse effects of the known ingredients contained in the product Blood Pressure Balance. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and intravaginally, kudzu seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Elevated liver transaminases.
Cardiovascular ...Orally, side effects of kudzu reported in clinical trials have included palpitations and chest discomfort; however, these effects did not occur more frequently than with placebo (57924,57927).
Dermatologic ...Orally, a side effect of kudzu reported in one clinical trial has included urticaria; however, this effect did not occur more frequently than with placebo (57924). There is one case report of allergic reaction following use of a combination herbal product (Kakkonto) containing kudzu involving a maculopapular eruption starting on the thighs and spreading over the entire body (13111,57886).
Gastrointestinal ...Orally, some side effects of kudzu reported in clinical trials have included nausea, dyspepsia, and bloating; however, these effects did not occur more frequently than with placebo (57927,57942).
Genitourinary ...Intravaginally, irritation of the vulva has been reported with kudzu gel. These cases were generally mild and transient (110702).
Hematologic ...Intravenously, the kudzu derivative, puerarin, has caused intravascular hemolysis (13298,15025,57947).
Hepatic ...Orally, there are several cases reports of liver injury following use of kudzu involving elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (88777,92260).
Neurologic/CNS ...Orally, a side effect of kudzu reported in one clinical trial has included dizziness; however, this effect did not occur more frequently than with placebo (57924).
Other ...Orally, a side effect of kudzu reported in one clinical trial has included mastodynia; however, this effect did not occur more frequently than with placebo (57942).
General ...Orally, adverse effects to lotus seem to be rare when taken in medicinal amounts; however, a thorough safety evaluation has not been conducted.
Immunologic ...Orally and topically, lotus root can cause allergic reactions such as urticaria and contact dermatitis. In a case report, a 6-year-old female developed urticaria after ingesting lotus root. She had also developed contact dermatitis on body areas that had been in contact with the lotus root (99738).