Prunella • Hawthorn fruit • Solomon Seal • Jujube • Jasmine flower.
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Below is general information about the effectiveness of the known ingredients contained in the product Digest Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of Solomon's seal.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Digest Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Hawthorn preparations in doses of up to 1800 mg daily seem to be safe when used for up to 16 weeks. Although hawthorn might be safe for long-term use, current studies have not evaluated safety past 16 weeks (8279,8280,8281,10144,17203,104689). There is insufficient reliable information available about the safety of hawthorn when used topically.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in the amounts commonly found in foods. Jasmine has Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of jasmine in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using in amounts greater than those found in food.
There is insufficient reliable information available about the safety of self-heal.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
There is insufficient reliable information available about the safety of Solomon's seal when used orally or topically.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when zizyphus fruit is consumed in the amounts typically found in foods.
POSSIBLY SAFE ...when zizyphus fruit or seed is used orally and appropriately, short-term. Zizyphus fruit powder has been used with apparent safety at doses up to 30 grams daily for up to 12 weeks (93317,104507). Zizyphus fruit extract has been used with apparent safety at a dose of 20-40 drops daily for up to 12 weeks (93316). Zizyphus seed extract has been used with apparent safety at a dose of 2 grams daily for 4 weeks (107921). There is insufficient reliable information available about the safety of zizyphus when used topically.
PREGNANCY AND LACTATION: LIKELY SAFE
when zizyphus fruit is consumed in the amounts typically found in foods.
There is insufficient reliable information available about the safety of zizyphus fruit in amounts greater than those found in foods; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Digest Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
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In vitro and animal research shows that hawthorn can inhibit platelet aggregation (95528,95529,95530,95531). However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract (95527). However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans (54664).
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Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
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Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
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Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
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Theoretically, concomitant use might cause additive coronary vasodilatory effects.
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Theoretically, concomitant use might result in additive vasodilation and hypotension.
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Hawthorn might inhibit PDE-5 and cause vasodilation (12595).
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Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control (19). Monitor blood glucose.
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Concomitant use may cause additive hypoglycemic effects (19).
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Insulin dosage adjustments may be necessary, due to the possible hypoglycemic effects of Solomon's seal (19).
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Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
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Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
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Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
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Animal research shows that zizyphus induces CYP1A2 enzymes (93311). However, this effect has not been reported in humans.
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Below is general information about the adverse effects of the known ingredients contained in the product Digest Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, hawthorn seems to be well tolerated when used appropriately.
Topically, no adverse effects have been reported, although a thorough evaluation of safety outcomes has not been conducted.
Serious Adverse Effects (Rare):
Orally: Multiorgan hypersensitivity reactions resulting in acute renal failure have been reported rarely.
Cardiovascular ...Orally, tachycardia (with facial pains) of uncertain relationship to hawthorn was reported in a multicenter clinical trial (54640). Palpitations (19244) were reported in three patients in a large surveillance trial of 3,664 patients with cardiac failure (54692) and in 11 patients with congestive heart failure (CHF) in a literature review of 5,577 patients (19247). Circulation failure has been reported in two patients with CHF in a literature review of 5,577 patients (19247). Incidences of hospitalization, hospitalization due to CHF, worsening of CHF, angina, and atrial fibrillation have also been reported with the use of hawthorn extract WS 1442 (Crataegutt forte), although it is unclear if these events are related to hawthorn supplementation or existing CHF (19222). In clinical trials, chest pain (8281), short-term increases in blood pressure (19240), and other non-specific heart problems (17203) have also been reported following the use of various hawthorn preparations (e.g. WS 1442, Korodin).
Dermatologic ...Orally, erythematous rash has been reported in patients with CHF in a literature review of 5,577 patients (19247). Non-specific rashes and itching (19222,19243) as well as toxiderma from the fruits of hawthorn (54670) have also been reported.
Gastrointestinal ...Orally, rare abdominal discomfort of uncertain relationship to hawthorn has been reported in a large clinical trial, surveillance study, and a literature review (19247,54640,54692). Digestive intolerance (19241), diarrhea (19243), flatulence (8281), gastroenteritis (8281), increased bowel movements (19243), obstipation (8281), mild and rare nausea (10144,19247,19244), nutritional and metabolic problems (17203), and other non-specific gastrointestinal effects (19222), have also been reported. Furthermore, gastrointestinal hemorrhage has been reported in two patients with CHF in a literature review of 5,577 patients (19247).
Musculoskeletal ...In clinical trials, arthritis (8281), back pain (8281), weakness (19243), and other non-specific musculoskeletal effects (19222) have been reported following the use of various hawthorn preparations g. WS 1442, CKBM-A01).
Neurologic/CNS ...Orally, headache and dizziness/vertigo were reported in two patients in a large surveillance trial of 3,664 patients with cardiac failure (54692), in 15 patients with CHF as reported in a literature review of 5,577 patients (19247), and in a varying number of clinical trial participants (8281,19222,19244). Incidences of fainting (19222), fever (17203), and infrequent, mild and transient sleepiness have also been reported (19221,54692).
Psychiatric ...Orally, agitation was reported in a large surveillance trial of 3,664 patients with cardiac failure (54692).
Pulmonary/Respiratory ...Orally, bronchitis has been reported following the use of hawthorn extract WS 1442 (8281).
Renal ...A case of multiorgan hypersensitivity reaction and acute renal failure following the consumption of C. orientalis has been reported (54654).
Other ...Flu-like syndrome (8281) and other non-specific infections have been reported following the use of the hawthorn extract WS 1442 (17203,19222). Hawthorn has also been reported to cause nosebleeds (8281,10144).
General ...Topically, jasmine may cause allergic contact dermatitis, delayed-type hypersensitivity, and type 1 hypersensitivity (56955,57027,57032,98684).
Immunologic ...Topically, jasmine essential oil and jasmine flower can cause allergic contact dermatitis (56955,57027,57032). Among patients who are sensitive to fragrance materials, jasmine may cause delayed-type hypersensitivity. The reported prevalence of this type of reaction ranges from 0.4% to 1.6% (89684). One case of type 1 hypersensitivity to jasmine has also been reported. The patient experienced chest tightness, wheezing, itchy skin, and macular erythematous eruption within minutes of exposure to jasmine. The eruption subsided within 20 minutes of moving away from the plant. An immunoblotting assay revealed IgE reactivity (98684).
General ...Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea. Orally and topically, self-heal has been reported to cause allergic reactions in sensitive individuals (12).
Gastrointestinal ...Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea (12). A combination product containing self-heal, Clematis mandshurica, and Chinese cucumber has been reported to cause epigastric pain, abdominal discomfort, nausea, reduced appetite, and dyspepsia. It is not clear if these effects are due to self-heal, the other ingredients, or the combination (101041).
Immunologic ...Orally and topically, self-heal has been reported to cause allergic reactions, including rashes and swelling of the throat, lips, and tongue, in sensitive individuals (12).
General ...A thorough evaluation of safety outcomes has not been conducted. Orally, long-term use of Solomon's seal has been reported to cause gastrointestinal irritation. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).
Gastrointestinal ...Orally, Solomon's seal may cause gastrointestinal irritation when used long-term. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).
General ...Orally, zizyphus fruit extract and powder seem to be well tolerated.
Gastrointestinal ...Orally, zizyphus fruit extract was associated with three cases of mild diarrhea in newborn infants (93306). Zizyphus seed extract was associated with one case of dry mouth and one case of increased bowel movements in a small clinical study (107921).
Neurologic/CNS ...Orally, zizyphus seed extract was associated with two cases of headache in a small clinical study (107921).