Demineralized Water • Butea superba extract • Methyl Paraben • Propyl Paraben • Perfume • PEG 40 Hydrogenated Carbomer • Castor Oil • Allantoin • FD&C Brown #1 • Vitamin B5 • Cucumber extract • Diazolidyl Urea • Triethanolamine .
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
Below is general information about the effectiveness of the known ingredients contained in the product Plus for Him Gel. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Plus for Him Gel. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when Butea superba tuber is used orally and appropriately in medicinal amounts, short-term. The dried, powdered tuber has been used with apparent safety in doses up to 1 gram daily in clinical studies lasting up to 3 months (14920,99718).
PREGNANCY AND LACTATION:
Insufficient reliable information is available; avoid using.
LIKELY SAFE ...when castor oil is used orally and appropriately, short-term (16). In clinical research, a single oral dose of up to 60 mL of castor oil has been used prior to imaging procedures of the colon (40090,40163,40166,40185,40187,40188,40192).
POSSIBLY SAFE ...when the hulled castor seed is used orally and appropriately, short-term. There is some evidence that a single dose of castor seed with the outer coat removed (hulled) can be used safely (7127,7128). ...when castor oil is used topically and appropriately. Castor oil eye drops appear to be safe when used for up to 30 days (40169,40178).
POSSIBLY UNSAFE ...when castor oil is used orally in high doses or for extended periods. Taking castor oil for greater than one week or exceeding the typical dose of 15-60 mL per day can increase the risk of fluid and electrolyte disturbances (272).
UNSAFE ...when the whole seed is used orally. Safety depends on whether or not the seed is chewed or if the outer coat is ruptured. Chewing as few as 1-6 whole seeds can be lethal in an adult. If the seed is swallowed intact, poisoning is less likely; however, prompt medical attention should be sought after ingestion of any whole castor seed (5611).
CHILDREN: POSSIBLY SAFE
when castor oil is used orally and appropriately, short-term (16).
CHILDREN: POSSIBLY UNSAFE
when castor oil is used orally in high doses or for extended periods.
Taking castor oil for greater than one week or exceeding the typical children's dose of 1-15 mL per day, depending on age, can increase the risk of fluid and electrolyte disturbances (272).
CHILDREN: UNSAFE
when the whole seed is used orally.
The chewed or uncoated seeds can cause severe toxic effects (5611,5612) and death (5611). There is insufficient reliable information available about the safety of the hulled seed or topical use of castor in children.
PREGNANCY: POSSIBLY SAFE
when castor oil is used orally in pregnant women at term.
Although there have been reports of fetal meconium passage being more common with castor oil use in pregnant women (40184), clinical research shows that the incidence of fetal meconium passage does not significantly differ from no castor oil use (7191,40177). Midwives routinely use castor oil for labor induction in pregnant women at term. This practice does not appear to adversely affect the mother or fetus (1122,7191,40177). However, castor oil should not be used without the supervision of a clinician.
PREGNANCY: LIKELY UNSAFE
when castor oil is used orally in pregnant women who are not at term.
Castor oil might induce premature labor and induce miscarriage (12); avoid using.
PREGNANCY: UNSAFE
when the whole seed is used orally.
The chewed or uncoated seeds can cause severe toxic effects, including death (5611); avoid using. There is insufficient reliable information available about the safety of using the hulled seed or topical use of castor during pregnancy.
LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used in food amounts. Cucumbers are a common food source (103382,103385). ...when the extract, fruit, fruit extract, fruit water, juice, seed extract, and seed oil are used topically and appropriately. These ingredients have been shown to be safely used in cosmetic products in levels of 0.4% to 3% (103382,103395).
POSSIBLY SAFE ...when cucumber extract or cucumber seed extract is used orally and appropriately. A specific cucumber extract (Q-Actin) has been used with apparent safety in doses of up to 10 mg twice daily for 6 months (103385). Cucumber seed extract has been used with apparent safety in doses of up to 500 mg daily for 6 weeks (103386). There isn't enough reliable information to know if other cucumber products are safe to use in amounts greater than those found in food.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of cucumber in amounts greater than those found in foods; avoid using.
LIKELY SAFE ...when used orally and appropriately. The pantothenic acid derivative calcium pantothenate has a generally recognized as safe (GRAS) status for use in food products (111258). While a tolerable upper intake level (UL) has not been established, pantothenic has been used in doses of 10-20 grams daily with apparent safety (15,6243,111258) ...when applied topically and appropriately, short-term. The Cosmetic Ingredient Review Expert Panel has concluded that pantothenic acid and its derivatives are safe for use in cosmetic products in concentrations up to 5.3% (111258). Gels or ointments containing a derivative of pantothenic acid, dexpanthenol, at concentrations of up to 5%, have been used safely for up to 30 days (67802,67806,67817).
POSSIBLY SAFE ...when applied intranasally and appropriately, short-term. A dexpanthenol nasal spray has been used with apparent safety up to four times daily for 4 weeks (67826). ...when applied in the eyes appropriately, short-term. Dexpanthenol 5% eyedrops have been used with apparent safety for up to 28 days (67783). ...when injected intramuscularly and appropriately, short-term. Intramuscular injections of dexpanthenol 500 mg daily for up to 5 days or 250 mg weekly for up to 6 weeks have been used with apparent safety (67822,111366).
CHILDREN: LIKELY SAFE
when used orally and appropriately (15,6243).
Calcium pantothenate is generally recognized as safe (GRAS) when used as a food additive and in infant formula (111258). However, a tolerable upper intake level (UL) has not been established (15,6243). ...when applied topically and appropriately (67795,105190,111262). Infant products containing pantothenic acid and its derivatives have been used safely in concentrations of up to 5% for infant shampoos and 2.5% for infant lotions and oils. The Cosmetic Ingredient Review Expert Panel has concluded that pantothenic acid and derivatives are safe for use in topical infant products. (111258).
PREGNANCY: LIKELY SAFE
when used orally and appropriately.
The daily adequate intake (AI) during pregnancy is 6 mg (3094).
LACTATION: LIKELY SAFE
when used orally and appropriately.
The daily adequate intake (AI) during lactation is 7 mg (3094).
Below is general information about the interactions of the known ingredients contained in the product Plus for Him Gel. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Butea superba is thought to inhibit phosphodiesterase and cause vasodilation (14920). Theoretically, concurrent use of phosphodiesterase-5 inhibitors and Butea superba might result in additive vasodilation and hypotension. Phosphodiesterase-5 inhibitors include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
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Theoretically, castor oil might increase the risk of hypokalemia when taken with diuretic drugs.
 Details
There is some concern that overuse of castor oil might compound diuretic-induced potassium loss (15).
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Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Details
Animal research shows that cucumber seed extract can decrease blood glucose levels (103391). Monitor blood glucose levels closely.
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Below is general information about the adverse effects of the known ingredients contained in the product Plus for Him Gel. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and topically, castor oil is generally well tolerated.
Hulled castor seeds with the outer coat removed also seem to be well tolerated when used orally. High doses or long-term use of castor oil may be unsafe, and whole castor seeds are generally regarded as unsafe in any amount.
Most Common Adverse Effects:
Orally: Abdominal discomfort, cramping, dizziness, and nausea (castor oil).
Serious Adverse Effects (Rare):
Orally: Severe abdominal pain, diarrhea, fluid and electrolyte disturbances, gastrointestinal bleeding, hemolysis, nausea, vomiting, and death (whole castor bean seeds).
Cardiovascular
...Orally, hulled castor seeds can result in elevated blood pressure (7128).
In one case report, a woman at full-term pregnancy experienced amniotic fluid embolism and cardiopulmonary arrest within one hour of ingestion of 30 mL of castor oil (1219).
Orally, chewing whole castor bean seeds can cause peripheral vascular collapse (5611,5612,92998,93000,93505,93507).
Dermatologic ...Topically, the castor plant, crushed castor seeds, or castor seed dust can cause dermatitis in some patients (5611). Castor oil does not appear to cause these effects. In one case report, a child developed cheilitis over the course of 3 weeks, which was determined to be an allergic reaction to castor oil contained in lip balm (103864).
Gastrointestinal
...Orally, castor oil, like all stimulant laxatives, can cause abdominal discomfort, cramping, nausea, and faintness (15,272,40183,40186,40187,40192,40177,40185,40188,40163).
Nausea can also occur because of the unpleasant taste of castor oil (7191). Using flavored products might reduce this effect. Castor oil can also cause fluid and electrolyte loss, particularly potassium, which can result in hypokalemia. It can also cause malabsorption from intestinal hypermotility (15,272). Chronic ingestion over long periods of time can lead to cathartic colon (15).
Chewing whole castor bean seeds causes severe toxicity. Gastrointestinal symptoms of castor seed toxicity typically occur with 4-6 hours of ingestion and include nausea, vomiting, diarrhea, and abdominal pain which usually resolves after supportive care (7128,13715,92998,93000,93505).
Genitourinary ...Orally, hulled castor seeds have been associated with cases of dysmenorrhea (7128). Although there have been reports of fetal meconium passage being more common with castor oil use in pregnant women (40184), clinical research shows that the incidence of fetal meconium passage does not significantly differ from no castor oil use (7191,40177). In one case report, a woman at full-term pregnancy experienced amniotic fluid embolism and cardiopulmonary arrest within one hour of ingestion of 30 mL of castor oil (1219). However, midwives routinely use castor oil for labor induction in pregnant women at term. This practice does not appear to adversely affect the mother or fetus (1122,7191,40177).
Hematologic ...Orally, chewing whole castor bean seeds can cause dehydration, hemolysis, and severe fluid and electrolyte disturbances (5611,5612,92998,93000,93505,93507).
Hepatic ...Orally, chewing whole castor bean seeds can cause damage to liver 2-5 days after ingestion (5611,5612,92998,93000,93505,93507).
Immunologic ...Exposure to castor beans, plants, or seed dust can cause contact dermatitis and anaphylaxis in sensitive individuals (5611). Castor oil does not appear to cause these effects. In one case report, a child developed cheilitis over the course of 3 weeks, which was determined to be an allergic reaction to castor oil contained in lip balm (103864). Orally, castor oil did not cause rash in clinical research (40185).
Musculoskeletal ...After inhalation, ricin, the toxic constituent of the castor seed hull, typically causes severe illness within 8 hours, but symptoms may be delayed. Symptoms include arthralgias and fever (13715).
Neurologic/CNS ...Orally, castor oil has been associated with syncope or dizziness in 2-20% of patients in clinical research (40188,40163,40187,40192). In a study of women taking castor seeds as a contraceptive, there were some reports of headache (7128).
Ocular/Otic ...Ophthalmically, castor oil emulsion eye drops resulted in blurred vision in 2 of 27 patients in one study (40178). In another study 2% castor oil eye drops caused slight eye irritation after storage at 60°C for four weeks, and no irritation when stored at 4°C (40169).
Psychiatric ...Taken orally for bowel cleansing, castor oil has been associated with insomnia (40185).
Pulmonary/Respiratory ...After inhalation, ricin, the toxic constituent of the castor seed hull, typically causes respiratory illness within 8 hours, but symptoms may be delayed. Symptoms include cough, dyspnea, and fever. Progression to respiratory distress and death can occur (13715).
Renal ...Orally, chewing whole castor bean seeds can cause renal failure secondary to hypovolemia. Cellular damage to kidneys typically occurs 2-5 days after ingestion (5611,5612,92998,93000,93505,93507).
Other
...Intravenously, castor bean extract can cause multi-organ failure and death.
In one case report, a 26-year-old male presented to the emergency room with severe abdominal cramps, nausea, and headache after intravenously injecting castor bean extract as a suicide attempt. The patient rapidly deteriorated and died from multi-organ failure 10 hours after injection despite supportive care (100835).
Orally, chewing whole castor bean seeds can cause significant toxicity and death (5611,5612,92998,93000,93505,93507).
General
...Orally, cucumber is well tolerated in food amounts.
Cucumber extract and seed extract also seem to be well tolerated. Topically, the extract, fruit, fruit extract, fruit water, juice, seed extract, and seed oil of cucumber are well tolerated.
Most Common Adverse Effects:
Topically: Allergic eczema, erythema, irritation.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis.
Dermatologic ...Topically, mild redness and irritation have occurred rarely (103382).
Immunologic
...Orally, anaphylaxis with dizziness, vomiting, trouble breathing, and itching, occurring 5 minutes after eating a partially peeled cucumber, has been reported in a 76-year-old woman (103382,103384).
Topically, allergic eczema related to exposure to cucumber leaves and stems has been reported in a greenhouse worker (103382,103393).
General
...Orally, pantothenic acid is generally well tolerated.
Topically and intramuscularly, dexpanthenol, a synthetic form of pantothenic acid, seems to be well tolerated.
Most Common Adverse Effects:
Topically: Burning, contact dermatitis, eczema, irritation, and itching related to dexpanthenol.
Cardiovascular ...There is one case of eosinophilic pleuropericardial effusion in a patient taking pantothenic acid 300 mg per day in combination with biotin 10 mg per day for 2 months (3914).
Dermatologic ...Topically, dexpanthenol has been associated with itching, burning, skin irritation, contact dermatitis, and eczema (67779,67781,67788,111258,111262). Three cases of allergic contact dermatitis have been reported (111260,111261).
Gastrointestinal ...Orally, pantothenic acid has been associated with diarrhea (67822,111258).
