Argentum Nitricum 12.0 D • Carbo Vegetabilis 10.0 D • Iodum 8.0 D • Lycopodium clavatum 6.0 D • Mandragora E Radice Siccata 8.0 D • Mercurius Solubilis Hahnemanni 8.0 D • Momordica Balsamina 6.0 D • Podophyllum Peltatum 6.0 D • Veratrum album 4.0 D. Other Ingredients: Sodium Chloride, Water for Injection.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product Momordica Compositum. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of clubmoss.
There is insufficient reliable information available about the effectiveness of European mandrake.
There is insufficient reliable information available about the effectiveness of white hellebore.
Below is general information about the safety of the known ingredients contained in the product Momordica Compositum. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally, short-term (12392,12393,93200,93609,93610,93611,93613). ...when activated charcoal-containing wound dressings are used topically (93603,94731).
POSSIBLY SAFE ...when used orally, long-term. Activated charcoal has been used with apparent safety in doses up to 1.2 grams three times daily for up to 3 years (103193).
PREGNANCY AND LACTATION: POSSIBLY SAFE
when used orally short-term.
Activated charcoal 50 grams three times daily for 8 days has been used with apparent safety in pregnancy (126).
POSSIBLY UNSAFE ...when used orally. Clubmoss contains toxic alkaloids, but no poisonings have been reported (18).
PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when used orally; avoid using.
POSSIBLY UNSAFE ...when used orally. European mandrake contains several anticholinergic alkaloids, which can cause significant side effects when used in therapeutic doses (12). Excessive doses of anticholinergic alkaloids can cause respiratory and cardiac arrest and death (15,17).
CHILDREN: LIKELY UNSAFE
when used orally.
Children can be more susceptible to the adverse effects of anticholinergic alkaloid constituents of European mandrake (15); avoid using.
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally.
European mandrake contains anticholinergic alkaloids that can cross the placenta and adversely effect the fetus (15); avoid using.
LIKELY UNSAFE ...when used orally. All plant parts are considered toxic (6). Between 10-20 mg of alkaloids (1-2 grams of rhizome/root) are lethal (6,18). ...when used topically. Toxic alkaloids can be absorbed through intact skin (6,18).
PREGNANCY: LIKELY UNSAFE
when used orally or topically because it could be teratogenic (6); avoid using.
LACTATION: LIKELY UNSAFE
when used orally or topically (6); avoid using.
Below is general information about the interactions of the known ingredients contained in the product Momordica Compositum. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
The binding action of activated charcoal may be reduced by alcohol.
 Details
Alcohol may lower the adsorptive capacity of activated charcoal (12400).
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Activated charcoal may reduce the clinical effects of oral contraceptives.
Details
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives (103192).
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Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Details
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil (12392,12400,93198,93602,93610,93612,93613,94730,105543). Avoid co-administration, except after drug overdose.
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Syrup of ipecac is inactivated by activated charcoal.
Details
Activated charcoal adsorbs and inactivates syrup of ipecac (12394). Avoid co-administration.
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Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of clubmoss with other acetylcholinesterase (AChE) inhibitors might have additive effects and increase the risk of cholinergic side effects. AChE inhibitors and cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).
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Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of anticholinergic drugs and clubmoss might decrease the effectiveness of club moss or the anticholinergic agent. Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).
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Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of clubmoss with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects. AChE inhibitors and cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).
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Concurrent use may cause additive anticholinergic effects and adverse effects. Anticholinergic drugs include conventional medications containing tropane alkaloids such as atropine, as well as phenothiazines, amantadine, some antiparkinson drugs, glutethimide, meperidine, tricyclic antidepressants, antiarrhythmic agents, and antihistamines (15).
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Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake (15).
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Below is general information about the adverse effects of the known ingredients contained in the product Momordica Compositum. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, activated charcoal is generally well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, black stools, bloating, constipation, and flatulence.
Serious Adverse Effects (Rare):
Orally: Gastrointestinal obstruction and pulmonary aspiration.
Gastrointestinal ...The most common adverse reactions reported with activated charcoal are gastrointestinal in nature. Constipation appears to be the most frequent complaint, but is typically transient. Black stools, abdominal pain, bloating, and flatulence have also been reported (12392,12398,93611,103193). Rarely, activated charcoal may lead to gastrointestinal obstruction (12392).
Pulmonary/Respiratory ...Rarely, pulmonary aspiration has been reported in patients taking activated charcoal orally. This may happen if activated charcoal is regurgitated or if a misplaced nasogastric tube delivers activated charcoal to the lungs rather than the stomach (12392).
General
...Orally, no adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted.
Additionally, clubmoss contains toxic alkaloids, which could cause serious adverse effects (43721). When fir club moss (Lycopodium selago) is mistaken for clubmoss, cholinergic toxicity has been reported. This toxicity is due to huperzine A, which is not present in clubmoss (13193).
Airborne exposure to clubmoss spores might cause symptoms of asthma (43721).
Pulmonary/Respiratory ...Occupational exposure to clubmoss spores, including cases associated with facilities that use the spores to coat condoms, has been reported to cause asthma (43721).
Other ...Clubmoss (Lycopodium clavatum) might be mistaken for fir club moss (Lycopodium selago), which contains huperzine A, a constituent with strong inhibitory activity against acetylcholinesterase. In two case reports, fir club moss was mistaken for clubmoss and ingested as tea. This caused cholinergic toxicity with symptoms of sweating, nausea, dizziness, cramping, and slurred speech (13193).
General
...Orally, European mandrake most commonly causes anticholinergic side effects including confusion, drowsiness, dry mouth, tachycardia, mydriasis, blurred vision, photophobia, decreased urination, decreased sweating and overheating, and flushing (15,17,18).
Although some adverse reactions can occur even with low doses, adverse effects are dose related. Large doses can cause severe adverse reactions including somnolence, central excitation (restlessness, hallucinations, delirium, manic episodes), exhaustion, respiratory and cardiac arrest, and death (17,18). All parts of the European mandrake plant including the root, leaves, and fruit contain anticholinergic alkaloids and can cause these effects (17). Elderly patients and children can be more susceptible to the adverse effects of anticholinergic constituents of European mandrake (15).
There is some evidence that subcutaneous injection may cause anaphylactic shock including swelling of lips and eyelids, nausea, tingling in palms and scalp, abdominal cramping, stool incontinence, and loss of consciousness. This reaction has occurred with a very low dose of 2 mL of a 3 mcg/mL solution of European mandrake extract. Although Immunoglobulin E (IgE) antibodies to European mandrake may not be detected, in vitro evaluation may find strong T lymphocyte proliferation. Skin patch tests with European mandrake root powder in sensitive individuals is likely to produce a delayed-type reaction with erythema resembling acute dermatitis (7022). Skin patch tests should be performed to rule-out hypersensitivity before administration of subcutaneous European mandrake.
General
...Orally and topically, white hellebore is generally regarded as unsafe for any use.
Any benefits of therapy do not outweigh the risk of toxicity.
Most Common Adverse Effects:
Orally: Abdominal pain, blurred vision, bradycardia, confusion, headache, hypotension, nausea, muscle weakness, vomiting.
Topically: Skin irritation.
Serious Adverse Effects (Rare):
Orally: Arrythmias, blindness, gastric erosion, loss of consciousness, paralysis, respiratory depression, seizures, severe bradycardia, severe hypotension, shock
Cardiovascular ...Orally, white hellebore can cause bradycardia and hypotension. Large doses of white hellebore can cause more severe bradycardia and hypotension and even cardiac arrythmias (6,553,95892,95893,101431,109467).
Dermatologic ...Topically, white hellebore can cause skin irritation (18).
Gastrointestinal ...Orally, white hellebore is toxic and usually causes nausea, vomiting, and abdominal pain. Symptoms occur 15-30 minutes after ingestion (553,95893,101431,109467). White hellebore can also cause a burning sensation in the upper abdomen, salivation, and gastric erosion (6,553).
Musculoskeletal ...Orally, white hellebore is toxic and can cause muscle weakness. In large doses it can cause paralysis (101431).
Neurologic/CNS ...Orally, white hellebore is toxic and can cause vertigo, confusion, numbness, headache, paresthesia, seizures, loss of consciousness, and shock (553,101431,95893).
Ocular/Otic ...Orally, white hellebore is toxic and can cause blurred and dim vision, and transitional blindness in case reports (101431,95893).
Pulmonary/Respiratory
...Orally, white hellebore is toxic and can cause respiratory depression in large doses (6,101431).
By inhalation, the powdered root induces violent sneezing and runny nose (6).
