Marine Collagen • Hyaluronic Acid • Squalene • Titanium Dioxide • Jonquil Oil .
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Below is general information about the effectiveness of the known ingredients contained in the product Pevonia Anti-Aging Marine Collagen Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Pevonia Anti-Aging Marine Collagen Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally and appropriately. Supplements standardized to contain hyaluronic acid 70%, in an 80 mg daily dose, have been used daily for up to 3 months with no reports of adverse effects (55742,91779). ...when used topically and appropriately. Hyaluronic acid, in a gel or impregnated gauze, has been safely applied to the skin in clinical trials (7889,7892,104389,108627,108640). ...when eye drop preparations containing up to 0.3% hyaluronic acid are used multiple times per day for up to 3 months (97885,97894,97895,110555).
PREGNANCY:
There is insufficient reliable information available about the safety of hyaluronic acid; avoid using.
LACTATION:
There is insufficient reliable information available about the safety of hyaluronic acid.
It is not known if hyaluronic acid is excreted in breast milk (7890); avoid using.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Shark cartilage has been used with apparent safety in clinical trials lasting up to 24 weeks (2015,4893,4938,6709,6716,6717,13086,74741) and for up to 40 months in patients with advanced cancer (10900,17102). ...when used topically and appropriately, short-term. Shark cartilage appears to be safe when applied topically for up to 8 weeks (74729).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Shark liver oil 1.5 grams once daily has been used safely for 8 weeks (94286).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used topically and appropriately. Squalamine eye drops have been safely used twice daily for up to 38 weeks (96044). ...when used intravenously and appropriately. Squalamine has been safely used at a dose of up to 50 mg/m2once weekly for up to 4 weeks, or 300 mg/m2 daily as a 5-day infusion once every 3 weeks for up to 6 cycles (96040,96042,96045). There is insufficient reliable information available about the safety of squalamine when used orally.
CHILDREN: POSSIBLY SAFE
when used topically and appropriately, short-term.
Squalamine 1% lotion has been safely applied to the scalp once daily for up to 3 weeks in children aged 6-15 years (96041).
PREGNANCY AND LACTATION:
Insufficient reliable information is available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Pevonia Anti-Aging Marine Collagen Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, shark cartilage might interfere with immunosuppressive therapy.
Details
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Below is general information about the adverse effects of the known ingredients contained in the product Pevonia Anti-Aging Marine Collagen Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and topically, hyaluronic acid appears to be well tolerated.
Most Common Adverse Effects:
Topically: Eczema, erythema, itching, wound hemorrhage, wound infection (e.g., erysipelas).
Dermatologic
...The use of needle-free devices to inject hyaluronic acid for cosmetic purposes has been reported to cause serious injury, and in some cases permanent harm, to the skin, lips, and eyes (108613).
Topically, hyaluronic acid application has been reported to cause eczema, erythema, itching, wound hemorrhage, and wound infection (e.g., erysipelas) (108628,108640).
Ocular/Otic ...Ocular pain has been reported rarely in patients using eye drops containing up to 0. 3% hyaluronic acid (97885).
General
...Orally, shark cartilage is generally well tolerated.
Most Common Adverse Effects:
Orally: Constipation, dizziness, dyspepsia, erythema, fatigue, hypotension, nausea, taste disturbance, and vomiting.
Serious Adverse Effects (Rare):
Orally: Altered consciousness, decreased motor strength, decreased sensation, generalized weakness, hepatitis, hyperglycemia, hypoglycemia, and peripheral edema.
Cardiovascular ...Orally, shark cartilage can cause hypotension and peripheral edema (2014,2015,6716,10900).
Endocrine ...Orally, shark cartilage can cause hyperglycemia, hypoglycemia, and hypercalcemia (2014,2015,6716,10900,74724).
Gastrointestinal ...Orally, shark cartilage can cause taste disturbances, nausea, vomiting, dyspepsia, constipation, cramping, and bloating (2014,2015,6716,10900,74724,74730,74731).
Hepatic ...Orally, shark cartilage can cause acute hepatitis, with symptoms including low-grade fever, jaundice, yellowing of the eyes, right upper quadrant tenderness, and elevated liver enzymes (2012).
Musculoskeletal ...Orally, shark cartilage can cause decreased motor strength, generalized weakness, and decreased performance (2014,2015,6716,10900).
Neurologic/CNS ...Orally, shark cartilage can cause dizziness, altered consciousness, decreased sensation, and fatigue (2014,2015,6716,10900,74725).
General ...Orally, shark liver oil seems to be well tolerated.
Cardiovascular ...Orally, shark liver oil 15 grams daily for 4 weeks has been shown to increase levels of total cholesterol by about 41. 5 mg/dL to borderline high, and decrease levels of high-density lipoprotein (HDL) cholesterol, in healthy adults. These changes in lipid levels normalized after discontinuation of shark liver oil (94284). Lower doses of shark liver oil, 1.5 grams daily for 8 weeks, do not appear to significantly affect total cholesterol, low-density lipoprotein (LDL) cholesterol, HDL cholesterol or triglyceride levels in healthy patients (94286).
Gastrointestinal ...Orally, shark liver oil has been reported to cause gastrointestinal side effects in one clinical study when taken in doses of 1. 5 grams daily; however, these side effects did not occur more frequently than with placebo (94286).
Hepatic ...Orally, a case of severe acute hepatitis probably related to use of shark liver oil twice daily for 2 weeks has been reported. The patient presented with abdominal discomfort, jaundice, malaise, pruritus, and elevated levels of bilirubin and liver enzymes. Other potential causes were ruled out (94285).
Pulmonary/Respiratory ...Both shark liver oil and the constituent squalene have been associated with cases of aspiration and subsequent lipoid pneumonia (2546,2547,2548).
General
...Topically, squalamine seems to be well tolerated (96041,96044).
No adverse effects have been reported. However, a thorough evaluation of safety outcomes related to topical use has not been conducted.
Intravenously, squalamine also seems to be well tolerated (96040,96042,96045). Possible adverse effects include nausea, vomiting, mild loss of appetite, transient elevation of liver markers, myalgias and muscle cramps, and fatigue (96040).
Gastrointestinal ...Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research (96040).
Hepatic ...Intravenously, squalamine at doses above 192 mg/m2 daily has been associated with reports of elevated hepatic transaminase levels. Levels of aspartate aminotransferase and alanine aminotransferase were about 5 to over 20 times above upper normal levels in some patients. The increased levels were noted 2-5 days after beginning squalamine. Both values returned to baseline within 6-23 days. These patients also had mildly elevated alkaline phosphatase and lactate dehydrogenase and one patient had a moderately elevated bilirubin level (96040).
Musculoskeletal ...Intravenously, squalamine has been associated with reports of mild to moderate myalgias and muscle cramps in clinical research (96040).
Neurologic/CNS ...Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research (96040).