Each capsule contains: Calcium Pyruvate 750 mg. Other Ingredients: Gelatin, Magnesium Stearate, Stearic Acid.
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Below is general information about the effectiveness of the known ingredients contained in the product Calcium Pyruvate 750 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Calcium Pyruvate 750 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Pyruvate has been used with apparent safety as 6-40 grams daily, typically given in divided doses, for up to 6 weeks (2472,2474,13658,13660,13661,70255,70259,92512). ...when used topically and appropriately. There is some evidence that skin peels containing up to 50% pyruvic acid can be safely applied by a healthcare professional (12020,70285,108892). ...when nebulized and inhaled in recommended doses for up to 6 weeks (70278).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Calcium Pyruvate 750 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Below is general information about the adverse effects of the known ingredients contained in the product Calcium Pyruvate 750 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and topically, pyruvate seems to be well tolerated.
Most Common Adverse Effects:
Orally: Bloating, diarrhea, and flatulence.
Topically: Burning sensation at high concentrations.
Cardiovascular
...Orally, pyruvate may increase triglyceride levels.
In a clinical trial, pyruvate 5 grams twice daily for 30 days before exercise caused a 28% increase in plasma triglycerides when compared with placebo. It is unknown if the increase was temporary or sustained (13660).
Intravenously, pyruvate has been associated with one death following a pyruvate-loading test in a child with restrictive cardiomyopathy (2473).
Dermatologic ...Topically, application of a facial peel containing pyruvic acid 50% can cause an intense burning sensation on the skin and should only be applied over small areas (12020).
Gastrointestinal ...Orally, pyruvate may cause bloating, diarrhea, flatulence, and loose stools. In a clinical trial, pyruvate 22-44 grams daily was associated with gas and bloating in 19% more subjects than placebo and loose stools or diarrhea in 12% and 35% more subjects than placebo, respectively (2474). In another clinical trial, diarrhea, flatulence, and loose stool occurred in 58% of subjects taking pyruvate and 28% of subjects taking placebo (70259).
Pulmonary/Respiratory ...Topically, application of a facial peel containing pyruvic acid 50% can release vapors that are irritating to the respiratory tract. The application should be conducted in a room with adequate ventilation (12020).