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Below is general information about the effectiveness of the known ingredients contained in the product EZbrain. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product EZbrain. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally, intravenously, or intramuscularly and appropriately. Serious adverse effects have not been reported in multiple clinical studies involving more than 22,000 patients and lasting from a few days to 2 years (5189,5201,5202,5219,5231,5232,12231,17490,95075,95076).
PREGNANCY: POSSIBLY SAFE
when used intravenously short-term during the third trimester of pregnancy.
In two small-scale trials, SAMe 800 mg daily was used intravenously for 14-20 days during the third trimester of pregnancy for cholestasis. No adverse effects were observed (5219,5231,5240). However, use of SAMe in pregnancy should only be considered when benefits clearly outweigh the potential risks. There is insufficient reliable information available about the use of SAMe at higher doses, for extended periods of time, or during the earlier trimesters of pregnancy.
LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. A gliadin-protected formulation of superoxide dismutase (Glisodin, Isocell Laboratory) has been used with apparent safety at doses up to 1 gram daily for up to 12 weeks or 500 mg daily for up to 24 weeks (106849). In combination with other ingredients, superoxide dismutase 140 IU and 10 mg have been used with apparent safety for up to 4 months and 12 months, respectively (20488,105502). ...when used parenterally, short term. Intravenous, intramuscular, and local injections of superoxide dismutase have been used with apparent safety, short-term (2230,2231,2232,2233,2241,2243). However, since some preparations are derived from animals, there is concern about contamination with diseased animal parts (1825). So far, there are no reports of disease transmission to humans due to use of contaminated preparations. Lecithinized recombinant superoxide dismutase 20-160 mg as a single intravenous dose has been used with apparent safety (105503). There is insufficient reliable information available about the safety of superoxide dismutase when used topically or in the eye.
CHILDREN: POSSIBLY SAFE
when administered via subcutaneous injection.
Superoxide dismutase 0.25 mg/kg twice daily until ventilator support is no longer required has been used with apparent safety in pre-term infants (2242).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product EZbrain. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
SAMe might reduce the effectiveness of levodopa.
Details
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease (10466).
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Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Details
SAMe has serotonergic effects (3521,5196,5232,5193). Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders (8056). In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization (3521).
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Below is general information about the adverse effects of the known ingredients contained in the product EZbrain. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, SAMe is generally well tolerated when used in typical doses.
Side effects are more common with higher doses.
Most Common Adverse Effects:
Orally: Anorexia, constipation, diarrhea, dizziness, dry mouth, flatulence, headache, insomnia, nausea, nervousness, sweating, vomiting.
Cardiovascular
...There has been some concern that SAMe might increase homocysteine levels.
SAMe is metabolized to s-adenosylhomocysteine, which can be metabolized to homocysteine (5232). Elevated levels of homocysteine have been linked to cardiovascular and kidney disease (1698). However, in a study lasting 4 weeks, administration of SAMe orally in doses titrated up to 1600 mg daily was not associated with a significant increase in homocysteine levels (12231). In another study, there also was no difference in cardiovascular mortality in people with cirrhosis taking SAMe 1200 mg daily for 2 years (1712).
Intravenously, SAMe infusions may cause phlebitis (20204). Also, a case of tachycardia has been reported in a patient treated with intravenous SAMe (72988).
Dermatologic
...Orally, SAMe may cause rash and itching, transient hair loss, sweating, and night sweats (5196,5199,5203,20202,20230,73035).
Intravenously, SAMe may cause rash and sweating (20204,72996,73038).
Gastrointestinal ...When taken orally or given intravenously, SAMe may cause increased salivation, bloating, flatulence, nausea, vomiting, diarrhea, stomach ache, heartburn, constipation, hunger, thirst, anorexia, blood in the stool, and dry mouth (1712,5188,5196,5200,5203,5208,5221,5241,9113,9981,12054,20202,20218,73035,95075,95076).
Genitourinary ...Orally, rare adverse effects associated with SAMe include increased urinary frequency (5196).
Neurologic/CNS
...Orally, SAMe may cause vertigo, headache, insomnia, fatigue, tremors, agitation, dizziness, vivid dreams, and anxiety (5188,5195,5196,5203,5241,9981,12054,17123,20203,20218,20225,20230,20468,20471,72942,73001,95076).
Intramuscularly, SAMe may cause insomnia , anxiety, hostility, dizziness and drowsiness, and headache, although these events are rare (5188,20218,73002).
Intravenously, side effects rarely associated with SAMe include insomnia, anxiety, and psychomotor agitation (20204,72978,72988,73038).
Ocular/Otic ...Orally, rare side effects associated with SAMe include blurred vision, and a hot sensation and itchiness of the ear (5195,5196,9981,20225).
Psychiatric
...Orally, anxiety and tiredness have been reported in patients with depression (5231,14841).
Rare adverse effects associated with SAMe include hypermania (5196). Hypomania has occurred with a combination of intramuscular and oral SAMe (20218). Cases of mania with suicidal ideation have also been reported in otherwise healthy patients (5195,12231). A crawling sensation on the skin has been reported in a clinical trial (5195). In a case report, a patient with depression self-medicated with oral SAMe and attempted suicide four days later (72965).
When used as an injection, rarely SAMe has caused both hypermania and hypomania in people with bipolar disorder or depression (5216,5231,17122,72978). Two suicide attempts occurred in a clinical trial of intramuscular SAMe in patients with major depression (20222).
Pulmonary/Respiratory ...Orally, congestion has occurred rarely in clinical trials of SAMe (5196,20225,72981).
General
...Orally and parenterally, superoxide dismutase seems to be well tolerated.
Most Common Adverse Effects:
Parenterally: Pain and injection site reactions.
Serious Adverse Effects (Rare):
Parenterally: Anaphylaxis, possibly related to impurities in parenteral formulations.
Hematologic ...As an injection, superoxide dismutase may cause elevations in triglyceride and direct bilirubin levels. Cases of transient elevations in triglycerides and direct bilirubin have been reported after a single injection of lecithinized recombinant superoxide dismutase (105503).
Immunologic ...As an injection, superoxide dismutase can cause allergic reactions at the injection site in some patients (2235). It can also cause anaphylactic shock, which may be caused by product impurities (11008).
Musculoskeletal ...As an injection, superoxide dismutase can cause pain at the injection site in some patients (2235).
Neurologic/CNS ...Superoxide dismutase may be prepared from bovine liver. Products made from contaminated or diseased organs might present a human health hazard. There is also concern that spleen extracts produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be contaminated with diseased tissue (1825). Thus far, there have been no reports of BSE transfer to humans from contaminated SOD products.