Bufo Rana 12 X • Buxus sempervirens 6 X • Juglans regia 2 X • Nitricum Acidum 10 X • Oleander 6 X • Oleander 6 X • Stannum Metalllicum 10 X • Sulfur 10 X • Taxus baccata 6 X • Thuga Occidentalis 8 X • Vanadium Metallicum 10 X. Other Ingredients; Ethanol, Purified Water.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product Cheliderm Plex (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Cheliderm Plex (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when the leaf extract is used orally and appropriately. There is some evidence that boxwood leaf extract can be used safely for up to 16 months (5643).
LIKELY UNSAFE ...when the whole leaf is used orally (12,18). The whole boxwood leaf can cause life threatening side effects including seizures, paralysis, and death by asphyxiation (18).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when the whole leaf is used orally (12,18); avoid using.
There is insufficient reliable information available about the safety of boxwood leaf extract when used during pregnancy and lactation; avoid using.
LIKELY SAFE ...when the fruit (nut), leaf, or hull is consumed in amounts normally found in foods (4912,6431,8476,8477).
POSSIBLY SAFE ...when the leaf extract is used orally at doses of up to 200 mg for up to 3 months (97749,97750).
POSSIBLY UNSAFE ...when the bark is used orally or topically, due to its juglone content (12). When applied topically, juglone-containing bark can cause skin irritation. When used orally on a daily basis, juglone-containing bark is associated with increased risk of tongue cancer and lip leukoplakia (2,12). There is insufficient reliable information available about the safety of the fruit, leaf, or hull when used orally in medicinal amounts or when applied topically.
PREGNANCY AND LACTATION: LIKELY SAFE
when the fruit (nut), leaf, or hull is consumed in amounts normally found in foods (4912).
PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when the bark is used orally or topically (12); avoid using.
There is insufficient reliable information available about the safety of the fruit, leaf, or hull when used orally in medicinal amounts during pregnancy and lactation; avoid using.
POSSIBLY UNSAFE ...when applied topically to broken or raw skin. Topical use of a paste containing multiple ingredients including oleander on broken or raw skin has caused bradycardia (94434).
LIKELY UNSAFE ...when used orally. Ingestion of oleander leaf, oleander leaf tea, or oleander seed has led to fatal and non-fatal poisonings (9,3495,65395,65407,65409,65410,65420,65422,65436,65437),(65438,94417,94428,94429,94430,94431,94432,94433,94434,94435),(94436,94437,103238,103239,103240,103241). A safe dose has not been identified, and as few as 2 seeds can cause fatal poisoning (106426).
CHILDREN: LIKELY UNSAFE
when used orally.
Ingestion of oleander leaf, oleander leaf tea, or oleander seed has led to fatal and non-fatal poisonings (65395,65411,65419,65433,65434,65442,65444).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally.
Oleander has been reported to have abortifacient properties (5000). Also, maternal ingestion of oleander seeds during pregnancy has led to fetal toxicity (65425). There is insufficient reliable information available about the safety of topical use of oleander during pregnancy and lactation; avoid using.
POSSIBLY SAFE ...when used topically and appropriately, short-term. Topical products containing sulfur in concentrations up to 10% have been used safely in clinical research for up to 8 weeks (27846,27847,88107,88112,88123,88124,98205,98207,100735). There is insufficient reliable information available about the safety of using sulfur orally.
CHILDREN: POSSIBLY SAFE
when used topically and appropriately, short-term.
Topical products containing sulfur in concentrations up to 6% have been used safely when applied nightly in children and adolescents for up to 6 nights (27846,27847). In infants, topical products containing sulfur in concentrations up to 2% have been safely applied for 3 hours daily for up to 6 days (27847).
PREGNANCY AND LACTATION: POSSIBLY SAFE
when applied topically and appropriately, short-term.
Topical products containing sulfur in concentrations up to 6% have been safely applied nightly for up to 6 nights (27846,27847). There is insufficient reliable information available about the safety of sulfur when used orally; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Cheliderm Plex (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity (37067). Theoretically, concurrent use of anticholinergic drugs and boxwood might decrease the effectiveness of boxwood or the anticholinergic agent.
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Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity (37067). Theoretically, concurrent use of boxwood with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
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Theoretically, using oleander with prolonged corticosteroid therapy can increase the risk of oleander toxicity.
Details
Oleander contains cardiac glycosides. Concomitant use of corticosteroids with oleander can increase the therapeutic and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance (2).
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Theoretically, concomitant use of digoxin and oleander will increase the risk and severity of toxic effects.
Details
Oleander contains cardiac glycosides similar to digoxin, increasing the risk of additive effects with concomitant use (2).
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Theoretically, diuretic drugs may increase the risk of oleander toxicity.
Details
Concomitant use of potassium depleting diuretics and oleander can increase the risk of cardiac glycoside toxicity due to potassium depletion (506).
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Theoretically, macrolide antibiotics may increase the risk of oleander toxicity.
Details
Macrolide antibiotics reduce levels of bacteria in the gut that break down digoxin to inactive metabolites, increasing digoxin bioavailability (17). Theoretically, this same process could increase the bioavailability of cardiac glycosides in oleander, increasing its toxicity.
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Theoretically, quinine may increase the risk of oleander toxicity.
Details
Quinine is known to increase plasma levels of digoxin by inhibiting an efflux pump. This interaction might occur with other cardiac glycosides, including those in oleander (506).
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Theoretically, stimulant laxatives may increase the risk of oleander toxicity.
Details
Overuse or misuse of stimulant laxatives leads to potassium depletion. This might increase the risk of toxicity with cardiac glycosides, including those in oleander (2).
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Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.
Details
Tetracycline antibiotics reduce levels of bacteria in the gut that break down digoxin to inactive metabolites, increasing digoxin bioavailability (17). Theoretically, this same process might increase the bioavailability of cardiac glycosides in oleander, increasing its toxicity.
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Below is general information about the adverse effects of the known ingredients contained in the product Cheliderm Plex (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, boxwood leaf extract seems to be well tolerated (5643).
However, ingestion of whole boxwood leaf can cause serious side effects including vomiting, diarrhea, severe colonic spasms, paralysis, and death secondary to asphyxiation (18).
Topically, the fresh plant and wood can cause allergic contact dermatitis (18,37073).
When inhaled, the wood dust can cause rhinoconjunctivitis and bronchitis (99904).
Gastrointestinal ...Orally, ingestion of whole boxwood leaf can cause serious side effects including vomiting, diarrhea, and severe colonic spasms (18). The extract, however, does not seem to have these effects (5643).
Immunologic ...Occupational exposure to boxwood dust might cause allergic symptoms. In a case report, a 52-year-old male experienced symptoms such as rhinoconjunctivitis and bronchitis following occupational exposure to boxwood wood dust (99904). Cases of allergic contact dermatitis to fresh boxwood leaves and a boxwood recorder have also been reported (18,37073).
Neurologic/CNS ...Orally, ingestion of whole boxwood leaf can cause serious side effects including paralysis and death secondary to asphyxiation (18). The extract, however, does not seem to have these effects (5643).
General
...Orally, the fruit (nut) of English walnut is well tolerated (8476,8477); however, it can cause softening of stools and mild bloating (6431).
Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479). English walnut leaf extract has been reported to cause gastrointestinal adverse events, especially mild diarrhea (97750). Daily use of English walnut bark is associated with increased risk of tongue cancer and lip leukoplakia due to its juglone content (2,12).
Topically, English walnut hull preparations can lead to yellow or brown discoloration of skin and mucous membranes due to its juglone content. It can also cause contact dermatitis (12,12980).
Dermatologic ...Topically, English walnut hull preparations, which contain juglone, can cause a temporary yellow or brown discoloration of skin and mucous membranes. It can also cause contact dermatitis (12,12980).
Gastrointestinal ...Orally, the fruit (nut) of English walnut might cause softening of stools and mild bloating (6431). Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479). Walnut leaf extract has been reported to cause gastrointestinal adverse events, especially mild diarrhea, in 39% of adults in one study (97750). Daily use of walnut bark is associated with increased risk of tongue cancer and lip leukoplakia due to its juglone content (2,12).
Immunologic
...Tree nuts, which include English walnuts, can cause allergic reactions in sensitive individuals.
Due to the prevalence of this allergy in the general population, tree nuts are classified as a major food allergen in the United States (105410).
Oral allergy syndrome may occur in people who are allergic to English walnuts. This is characterized by itching of the oral cavity immediately after consumption. Rarely this syndrome may cause swelling of the lips and tongue (angioedema) (8479).
General
...Oleander can cause significant toxicity by any route of administration.
Most Common Adverse Effects:
Orally: Abdominal pain, bitter taste, diarrhea, headache, mucous membrane irritation, nausea, salivation, stupor, and vomiting.
Topically: Contact dermatitis.
Serious Adverse Effects (Rare):
Orally: Arrhythmias, cardiac arrest, cardiovascular collapse, death, hyperchloremia, hyperkalemia, metabolic acidosis, mydriasis, peripheral neuritis, and vision disturbances.
Cardiovascular
...Orally, oleander can cause malignant dysrhythmias, ventricular ectopy, cardiovascular collapse, cardiac arrest, and death (17,94437,103238,103239).
Oleander can also cause hyperkalemia (2532,3495,65419,65435,94429,94436,94437,103239,103241). Hyperkalemia after oleander ingestion is generally due to inhibition of the sodium-potassium ATPase pump. Digoxin is usually detectable by radioimmunoassay, due to the cross-reactivity between digoxin and the cardiac glycosides contained in oleander (98220).
Topically, applying an oleander paste to penile and perianal ulcers has caused asymptomatic bradycardia. The paste contained oleander bark and leaves, as well as holy basil, tamarind, onion, and neem. There is also one case report of bradycardia requiring atropine treatment and a pacemaker after application of this paste to a penile ulcer. The risk of transcutaneous absorption of oleander is increased if applied to raw or broken skin (94434).
Dermatologic ...Topically, the sap of freshly cut oleander leaves can cause contact dermatitis (5000,65432,65448). In a case report, a 5-year-old child applied oleander leaves to the face and developed skin erythema, followed by blistering, swelling and partial thickness facial burns. The condition resolved with conservative management (106425).
Gastrointestinal ...Orally, oleander leaves, flowers, and seeds have a bitter taste, and can cause a burning sensation in the mouth, nausea, vomiting, and diarrhea (17,18,3495,65395,65411,65419,65422,65423,65431,65437,94417,94430,94432,94435,94436,98220,103239,103241). Oleander can also cause mucous membrane irritation, increased salivation, abdominal pain and cramping, and buccal erythema (3495,5000,65422,94435,94436,98220,103239). In one case report, a male with schizoaffective disorder consumed the leaves of an ornamental oleander plant, resulting in severe diarrhea and diarrhea-induced hypokalemia (94430).
Hematologic ...Oleander use has been associated with thrombocytopenia. A 33-year-old female who ingested an infusion of 20 oleander leaves presented with symptoms of oleander poisoning and, 72 hours after ingestion, developed thrombocytopenia. Another case of thrombocytopenia linked to oleander intake has also been reported (103241).
Hepatic
...Two cases of jaundice, increased bilirubin, and hepatosplenomegaly have been reported after oleander ingestion (65420).
Intramuscularly, there is one case report of a patient with cancer who developed hepatotoxicity after receiving daily injections of a specific oleander extract (Anvirzel, Phoenix Biotech) 1.2 mL/m2 for 2 months. Other causes of hepatotoxicity were ruled out (94428).
Neurologic/CNS ...Orally, oleander can cause weakness, headache, giddiness, dizziness, and malaise or stupor (17,18,3495,65422,65434,65443,65444,94417,94432,94435,94436,98220,103239). It can also cause peripheral neuritis (3495,5000) and numbness of the mouth or tongue (65422,94429). There is one case report of a young child who developed irritability and seizures after ingestion of oleander (65444). In another case, a 12-year-old child developed hypertonia, neck stiffness, and flexor plantar response after ingestion of oleander seeds (65434).
Ocular/Otic ...Orally, oleander can cause visual disturbances and mydriasis (3495,5000). In one case report, a 7-year-old child experienced a change in color vision about 6 hours after ingestion of oleander seeds (65411). There is also a report of dimness of vision and tinnitus after ingesting a water extract from oleander leaves (65424).
Renal ...Orally, oleander can cause acute kidney failure characterized by dark colored, scanty urine (less than 300 mL daily) (65417,65420,106426).
General ...Topically, sulfur is generally well tolerated when used in concentrations of up to 10%. Adverse effects include skin dryness, irritation, and pruritus (27846,88112,88120,88121,88126). Orally, sulfur has been reported to cause diarrhea and metabolic acidosis (27845).
Dermatologic ...Topically, application of sulfur preparations can cause dryness, leading to local irritation and pruritus in up to 28% of patients (27846,88112,88120,88121,88126).
Gastrointestinal ...Orally, sulfur is converted to sulfide in the gastrointestinal tract, causing intestinal irritation which can lead to diarrhea (27845).
Renal ...There is one case report of metabolic acidosis occurring in a 57-year-old woman who had consumed approximately 250 grams of flowers of sulfur, a form of sulfur prepared by sublimation, over a 6-day period (27845). Underlying conditions, including diabetes and renal failure, may have contributed to the acidosis. Sulfur is converted to sulfide by colonic bacteria and then to sulfate in various tissues, generating hydrogen ions which can lead to acidosis when clearance mechanisms are overwhelmed (27845).