Each capsule contains: BroccoSinolate brand Broccoli plant and sprouts extract (brassica oleracea L., standardized to 4% glucosinolates) 400 mg • Watercress leaf 4:1 extract (nasturtium officinale) 100 mg • Indole 3-Carbinol 50 mg • Rosemary aerial parts and flowers (rosmarinus officinalis, standardized to 7% rosmarinic acid) 50 mg • DIM (di-indolyl-methane) 14 mg. Other ingredients: Kosher Gelatin (capsule), Cellulose, Silicon Dioxide, Magnesium Stearate.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
Below is general information about the effectiveness of the known ingredients contained in the product Cruciferous Vegetables & DIM. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of watercress.
Below is general information about the safety of the known ingredients contained in the product Cruciferous Vegetables & DIM. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in food amounts (14145). There is insufficient reliable information available about the safety of broccoli when used in medicinal amounts.
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in food amounts (14145).
There is insufficient reliable information available about the safety of broccoli when used in medicinal amounts during pregnancy and lactation; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. The typical diet supplies 2-24 mg of diindolylmethane daily (7170,7176,7664).
POSSIBLY SAFE ...when used orally and appropriately in medicinal doses. Diindolylmethane has been used with apparent safety at a dose of 45 mg daily for up to 6 months or at a higher dose of 100-140 mg daily for up to 3 months (47709,47729,93836,103830).
POSSIBLY UNSAFE ...when used orally in doses of 600 mg daily. In one clinical study, two cases of grade 3 asymptomatic hyponatremia were associated with taking diindolylmethane 600 mg daily (47729).
CHILDREN: LIKELY SAFE
when used orally in amounts commonly found in foods.
The typical diet supplies 2-24 mg of diindolylmethane daily (7170,7176,7664).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods.
The typical diet supplies 2-24 mg of diindolylmethane daily (7170,7176,7664). There is insufficient reliable information available about the safety of diindolylmethane when used in amounts greater than those found in foods during pregnancy and lactation; avoid using.
POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts. Doses up to 400 mg daily have been used safely for 3-76 months (7173,93239,93240,93241). There is also some evidence that 400 mg twice daily can be used safely for 4 weeks (93242).
CHILDREN: POSSIBLY SAFE
when used orally and appropriately in medicinal amounts.
There is limited evidence from 9 children with recurrent respiratory papillomatosis that indole-3-carbinol can be safely used in children ages 1.2-16 years for 12-76 months at doses of 6-17 mg/kg of body weight daily (7172,93239).
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of indole-3-carbinol when used during pregnancy and lactation; avoid using.
LIKELY SAFE ...when used orally in amounts typically found in foods. Rosemary has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when the leaf is used orally and appropriately in medicinal amounts (18). Powdered rosemary leaf has been used with apparent safety as a single dose of up to 1.5 grams (18246,91731) or at a dose of 1-4 grams daily for up to 8 weeks (91727,98536,105327,109561). ...when the essential oil is used topically and appropriately for up to 7 months (5177,91729,109560). ...when the essential oil is used by inhalation as aromatherapy, short-term (7107,18323,105324,109559).
LIKELY UNSAFE ...when the essential oil or very large quantities of rosemary leaf are used orally. Ingestion of undiluted rosemary oil or very large quantities of rosemary leaf can cause serious adverse effects (18,515).
PREGNANCY: POSSIBLY UNSAFE
when used orally in medicinal amounts.
Rosemary might have uterine and menstrual flow stimulant effects (4,12,18), and might increase metabolism of estradiol and estrone (18331); avoid using. There is insufficient reliable information available about the safety of rosemary when used topically during pregnancy.
LACTATION:
There is insufficient reliable information available about the safety of using rosemary in medicinal amounts during lactation; avoid using.
LIKELY SAFE ...when consumed in amounts commonly found in foods.
POSSIBLY SAFE ...when used orally in medicinal amounts, short-term. Watercress extract 750 mg/kg daily has been used with apparent safety for up to 5 weeks (103891).
POSSIBLY UNSAFE ...when used orally in excessive amounts or long-term (8,12,19). Watercress can cause gastric mucosal irritation (8,12,85599) or damage (19).
CHILDREN: LIKELY UNSAFE
when used orally in medicinal amounts; avoid using in children younger than 4 years old (12,19).
PREGNANCY: LIKELY UNSAFE
when used in medicinal amounts.
Watercress might stimulate menstruation or have abortifacient effects (19).
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Cruciferous Vegetables & DIM. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
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Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
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Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents (19608).
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Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
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Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
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Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research (47729).
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Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
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Diindolylmethane might have mild estrogenic or antiestrogenic effects (7664). Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.
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Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
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In vitro research shows that indole-3-carbinol inhibits platelet aggregation (98611).
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Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
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Animal research shows that indole-3-carbinol induces CYP1A2 enzymes (7187).
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Indole-3-carbinol might interfere with the effects of estrogen therapy.
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Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
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Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
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Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models (71821,71923). However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults (105327), no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs (105323,105327).
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
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Rosemary is reported to contain salicylates (18330).
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
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Rosemary is reported to contain salicylate (18330).
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Theoretically, rosemary might decrease the levels and clinical effects of CYP1A1 substrates.
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Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
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Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
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Rosemary is reported to contain salicylate (18330).
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Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects. Clinical research in healthy volunteers shows that a single ingestion of watercress 50 grams increases the chlorzoxazone plasma concentration-time curve by about 56% and increases its half-life by about 53% (4018).
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Watercress is thought to have diuretic properties (18). Theoretically, due to these potential diuretic effects, watercress might reduce excretion and increase levels of lithium.
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Watercress contains vitamin K. Consuming large amounts of watercress might antagonize the anticoagulant effects of warfarin (11285).
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Below is general information about the adverse effects of the known ingredients contained in the product Cruciferous Vegetables & DIM. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Broccoli is well tolerated when consumed as food. A thorough evaluation of safety outcomes when broccoli is taken as medicine has not been conducted.
Dermatologic ...Topically, allergic reactions to broccoli have caused contact dermatitis (14158).
Hepatic ...In one case report, a 56-year-old adult developed elevated transaminases, with alanine aminotransferase (ALT) 5. 8 times above normal, aspartate aminotransferase (AST) 2.4 times above normal, and gamma-glutamyl transpeptidase (GGT) 5.1 times above normal. This was thought to be related to the consumption of 800 mL of broccoli juice daily over a 4-week period. Values returned to normal 15 days after cessation of juice consumption (96191).
Immunologic ...Topically, allergic reactions to broccoli have caused contact dermatitis (14158).
General
...Orally, diindolylmethane is generally well tolerated.
Most Common Adverse Effects:
Orally: Diarrhea, gas, headache, nausea, rash, and vomiting.
Serious Adverse Effects (Rare):
Orally: Drug rash with eosinophilia and systemic symptoms (DRESS).
Dermatologic ...Orally, diindolylmethane can cause rash (47615,93836). In one case report, a patient developed drug rash with eosinophilia and systemic symptoms (DRESS) after consuming a product containing diindolylmethane, vitamin E, and broccoli powder. An allergen patch test was positive for diindolylmethane (93840).
Endocrine ...Orally, diindolylmethane was associated with grade 3 asymptomatic hyponatremia in 2 of 4 patients taking 600 mg daily for 28 days in one clinical study. Hyponatremia was not seen in the 8 patients taking diindolylmethane 150-450 mg daily (47729).
Gastrointestinal ...Orally, diindolylmethane can cause nausea, vomiting, diarrhea, and gas (47652,47676,47709,47729,93836).
Genitourinary ...Orally, diindolylmethane can cause the urine to darken (93836).
Hematologic ...In one case report, a 65-year-old male developed a deep vein thromboembolism (DVT) and bilateral pulmonary emboli (PE) within a few weeks of initiating treatment with diindolylmethane. It is unclear if diindolylmethane contributed to this event; the patient was at increased risk for emboli due to his age, weight, tobacco use, and possible history of pulmonary embolism (93835).
Hepatic ...In one case report, a patient developed drug rash with eosinophilia and systemic symptoms (DRESS), involving elevated liver transaminases, after consuming a product containing diindolylmethane, vitamin E, and broccoli powder. An allergen patch test was positive for diindolylmethane (93840).
Immunologic ...In one case report, a patient developed drug rash with eosinophilia and systemic symptoms (DRESS) after consuming a product containing diindolylmethane, vitamin E, and broccoli powder. The patient developed fever, activated lymphocytes, and swollen lymph nodes. An allergen patch test was positive for diindolylmethane (93840).
Musculoskeletal ...Orally, diindolylmethane has been reported to cause arthralgias (47615).
Neurologic/CNS ...Orally, diindolylmethane can cause headache (47652,47676,93836). One case has reported ischemic stroke in a 38-year-old female with a history of a patent foramen ovale (PFO), traumatic subdural hematoma, right partial hemicraniectomy, and use of several supplements, including 200 mg of diindolylmethane daily, vitamin D3, vitamin K2, elderberry, caffeine, and possibly cannabis (112895). It is unclear if diindolylmethane contributed to this event; the patient was at increased risk for stroke due to PFO and other factors.
General
...Orally, indole-3-carbinol seems to be well tolerated.
Most Common Adverse Effects:
Orally: Diarrhea, imbalance, nausea, rash, tremor, unsteadiness.
Dermatologic ...Orally, indole-3-carbinol has been associated with reports of rash (93242). A woman taking indole-3-carbinol 375 mg daily for treatment of systemic lupus erythematosus (SLE) developed a generalized maculopapular rash which resolved when indole-3-carbinol was discontinued and recurred when it was restarted (93240).
Gastrointestinal ...Orally, indole-3-carbinol increases gastrointestinal motility and has been associated with diarrhea (93242,93243).
Neurologic/CNS ...Indole-3-carbinol has been associated with reports of unsteadiness and imbalance, especially at higher doses (7172). An adult male taking 400 mg twice daily for treatment of recurrent respiratory papillomatosis developed imbalance and tremor after 10 days of treatment. This resolved when the dose was halved (93238). Two children who took 3 times the intended weight-based dose of indole-3-carbinol in one day developed unsteadiness and nausea (93238).
General ...Orally, rosemary seems to be well tolerated when used in appropriate medicinal amounts. Undiluted rosemary oil or very large quantities of rosemary leaf should not be consumed. Topically and as aromatherapy, rosemary seems to be well tolerated.
Dermatologic ...Topically, rosemary use can lead to photosensitivity, erythema, dermatitis, and cheilitis in hypersensitive individuals (4,6).
Immunologic
...Topically, allergic reactions can occur.
When used in the mouth, lip and gum edema have occurred (101173). When used on the skin, allergic contact dermatitis has occurred, likely due to the constituent carnosol (71715,71924,71926).
Rosemary might also cause occupational asthma. A case of occupational asthma caused by several aromatic herbs including thyme, rosemary, bay leaf, and garlic has been reported. The diagnosis was confirmed by inhalation challenges. Although all of the herbs caused immediate skin reactivity, a radioallergosorbent test (RAST) showed that garlic was the most potent allergen by weight, with rosemary and the other herbs showing less reactivity (783).
Neurologic/CNS ...Orally, the undiluted oil, as well as the camphor constituent of rosemary, might cause seizures (4,5,6,12868).
General
...Orally, watercress is well-tolerated when consumed in food amounts.
There is limited reliable information available about the adverse effects of watercress when used in medicinal amounts. When excessive doses are used, watercress can cause gastrointestinal irritation (85599). Consuming raw watercress has been associated with the development of fascioliasis, a parasitic fluke disease of the liver (85575,85574,85573,85567,85564,85582,85563,85562,85580,85561,85560)(85554,85558,85596,85579,85571,85569,85583,85586,85584,85588)(85585,85590,85592,85591).
Topically, watercress can cause contact dermatitis (85594,85587).
Dermatologic ...Topically, watercress can cause contact dermatitis, resulting in hives, rash, itching, or swollen skin (85594,85587).
Gastrointestinal ...Orally, large quantities of watercress may cause gastrointestinal irritation (85599).
Hepatic ...Raw, wild watercress can be contaminated with parasitic flukes which, when ingested, cause the liver disease fascioliasis. Symptoms include abdominal pain, fever, vomiting, diarrhea, urticaria, eosinophilia, and hepatomegaly (85575,85574,85573,85567,85564,85582,85563,85562,85580,85561)(85560,85554,85558,85596,85579,85571,85569,85583,85586,85584)(85588,85585,85590,85592,85591). Clinical research shows that taking a standardized extract of watercress orally 750 mg/kg daily for 5 weeks is not associated with increases in liver function enzymes (109666).
Renal ...Orally, excessive or prolonged use of watercress may theoretically cause kidney damage (85598). However, in overweight adults with physical disabilities, taking a watercress extract 750 mg/kg daily for 5 weeks does not cause any change in levels of creatinine or urea (109666).