Aurum Mauriaticum natronatum 8 D • Bryonia alba 3 D • Colchicum 3 D • Dulcamara 4 D • Kalium Iodatum 2 D • Mercurius Corrosivus 4 D • Natrii Salicylas 3 D • Rubia tinctorum 2 D • Silica Marina 2 D • Sulphur Sublimatum 4 D • Viscum Album 3 D. Other Ingredients: Alcohol. Caramel. Distilled Water.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product Arth Flex Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of autumn crocus.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of bryonia.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of madder.
Below is general information about the safety of the known ingredients contained in the product Arth Flex Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
UNSAFE ...when consumed orally as a food or medicine. Autumn crocus is associated with significant and potentially fatal adverse effects (33947,99056,99057,99058,99059,99060,99061,111190). Accidental poisoning has occurred when the autumn crocus plant is mistaken for onions, wild garlic, or wild leeks (99057,99060).
PREGNANCY AND LACTATION: UNSAFE
when used orally.
Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects (500,33947,99056,99057,99058,99059,99060,99061); avoid using.
POSSIBLY SAFE ...when the stem is used orally or topically and appropriately (2,18).
LIKELY UNSAFE ...when the leaves or berries are used orally. The plant contains the toxic compounds solanine, solanidine, and dulcamarin (6).
CHILDREN: LIKELY UNSAFE
when used orally; unripe berries have caused poisonings.
A lethal dose is estimated to be 200 berries (18). There is insufficient reliable information available about the safety of bittersweet nightshade when used topically in children; avoid using.
PREGNANCY: LIKELY UNSAFE
when used orally.
The alkaloids of the plant, solasodine, soladulcine, and related compounds have been linked to birth defects in animals (6); avoid using. There is insufficient reliable information available about the safety of bittersweet nightshade when used topically during pregnancy; avoid using.
LACTATION: LIKELY UNSAFE
when orally; avoid using.
There is insufficient reliable information available about the safety of bittersweet nightshade when used topically; avoid using.
LIKELY UNSAFE ...when the root or berries are used orally (2,18). Consuming 40 berries might be fatal (18).
CHILDREN: LIKELY UNSAFE
when the root or berries are used orally (2,18).
Consuming as few as 15 berries can be fatal in children (18).
PREGNANCY: UNSAFE
when the root is used orally.
Bryonia root might have abortifacient effects (2). ...when the berries are used orally (2).
LACTATION: LIKELY UNSAFE
when the root or berries are used orally (2).
POSSIBLY SAFE ...when used orally, subcutaneously, or intravenously and appropriately. There is some evidence that European mistletoe extracts can be used safely (7039,9769,15351,24773,24778,93261,93266,93267,96487,107285). However, they have a narrow therapeutic range; high doses are not safe. Tell patients not to consume more than three mistletoe berries or two leaves (12). Advise patients not to use European mistletoe for self-medication.
LIKELY UNSAFE ...when used orally in high doses. Ingestion of high doses of mistletoe berry or leaf can cause serious adverse reactions. More than three berries or two leaves can cause seizures, bradycardia, hypotension, and death (7039).
PREGNANCY: LIKELY UNSAFE
when used orally or subcutaneously.
European mistletoe might have uterine stimulant and abortifacient activity (19).
LACTATION:
Insufficient reliable information available; avoid using.
LIKELY UNSAFE ...when used orally. It is potentially carcinogenic and mutagenic (2,18,19). There is insufficient reliable information available about the safety of madder when used topically.
PREGNANCY: UNSAFE
when used orally because it may be a potential menstrual stimulant and a genotoxin (2,19).
LACTATION: UNSAFE
when used orally because it is a potential genotoxin (2,19).
It also can cause red-colored breast milk (2).
Below is general information about the interactions of the known ingredients contained in the product Arth Flex Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Avoid concomitant use of autumn crocus with colchicine. Autumn crocus contains colchicine. Concomitant use will increase the adverse effects (2).
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Theoretically, European mistletoe might increase the risk of hypotension when taken with antihypertensive drugs.
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Theoretically, European mistletoe might decrease the effectiveness of immunosuppressants.
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Below is general information about the adverse effects of the known ingredients contained in the product Arth Flex Liquid. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Autumn crocus is generally regarded as unsafe for use.
Any benefits of therapy may not outweigh the risk of toxicity. Autumn crocus contains colchicine and can cause acute poisoning. Accidental poisoning has occurred after oral ingestion when autumn crocus is mistaken for onions, wild garlic, or wild leeks (99057,99060). Long-term use of prescription colchicine is associated with agranulocytosis, aplastic anemia, and peripheral neuritis (6).
Topically, handling fresh slices of autumn crocus corms can cause finger numbness (6).
Cardiovascular ...Predominant cardiovascular symptoms of oral autumn crocus poisoning include tachycardia, hypotension, and reduced cardiac output (99057,99058,99059,99060,111190). Arrhythmias can also occur, and cardiovascular collapse, refractory cardiogenic shock, or sudden asystole have been reported as causes of death within 30-72 hours after poisoning (33947,99057,99058,99059). Acute myocardial injury is associated with an elevated troponin 1 level, which can be used as a marker of severe toxicity (111190).
Dermatologic ...Alopecia has been reported during the recovery phase from acute oral autumn crocus poisoning, about 7-21 days after oral ingestion (33947,99057,99060).
Endocrine ...Predominant endocrine symptoms of autumn crocus poisoning include metabolic acidosis, hyponatremia, hypocalcemia, and hypoglycemia (99057,99058).
Gastrointestinal ...Gastrointestinal symptoms are often the first signs of autumn crocus poisoning and include burning of the mouth, vomiting, diarrhea, abdominal pain, and ileus. These symptoms typically occur within 2-12 hours after oral ingestion, with early onset indicating a poorer prognosis (33947,99056,99057,99058,99059,99060,111190). Pancreatitis has also been reported with severe autumn crocus poisoning (33947,99057). In fatal cases of poisoning, the gastrointestinal mucosa is inflamed and the intestinal villi are found to be shortened and blunted (99057,99059).
Hematologic ...Predominant hematologic symptoms of autumn crocus poisoning include pancytopenia, thrombocytopenia, leukopenia or leukocytosis, and coagulopathy (33947,99056,99058,99059,99060). Long-term use of colchicine, a constituent of autumn crocus, is associated with aplastic anemia (6).
Hepatic ...Predominant hepatic symptoms of autumn crocus poisoning include elevated liver function tests (LFTs) and liver failure with necrosis (33947,99056,99057,99058,99059).
Musculoskeletal ...Autumn crocus poisoning can cause rhabdomyolysis, with serum myoglobin and creatine kinase elevated to twice the upper limit of normal (111190).
Neurologic/CNS
...Predominant neurologic symptoms of autumn crocus poisoning include hemiparesis, encephalopathy, brain edema, coma, and death (99056,99057,99059).
Peripheral neuropathy has occurred as a long-term consequence of autumn crocus poisoning (33947,111190).
Topically, handling fresh slices of autumn crocus corms can cause finger numbness (6).
Pulmonary/Respiratory ...Predominant pulmonary symptoms of autumn crocus poisoning include tachypnea, respiratory distress or failure, and pleural effusions (99057,99058,99059,33947). Some patients require mechanical ventilation or extracorporeal membrane oxygenation (ECMO) for life support (99060).
Renal ...Predominant renal symptoms of autumn crocus poisoning include acute renal failure and anuria, with elevated serum creatinine (33947,99056,99058,111190).
General
...When used orally, the leaves and berries of bittersweet nightshade may be unsafe.
There is limited information available about the adverse effects of the stem of bittersweet nightshade when used in medicinal amounts.
Serious Adverse Effects (Rare):
Orally: The leaves and berries can cause toxicity, including circulatory and respiratory depression, convulsions, cyanosis, diarrhea, dilated pupils, gastrointestinal bleeding, headache, scratchy throat, speech difficulties, subnormal temperature, vertigo, vomiting, and even death.
Cardiovascular ...Orally, bittersweet nightshade leaf and berry can cause circulatory depression (6).
Gastrointestinal ...Orally, bittersweet nightshade leaf and berry can cause diarrhea, gastrointestinal bleeding, scratchy throat, vomiting and (6).
Neurologic/CNS ...Orally, bittersweet nightshade leaf and berry can cause convulsions, headache, speech difficulties, subnormal temperature, and vertigo (6).
Ocular/Otic ...Orally, bittersweet nightshade leaf and berry can cause dilated pupils (6).
Pulmonary/Respiratory ...Orally, bittersweet nightshade leaf and berry can cause cyanosis and respiratory depression (6).
General
...Orally, bryonia root can cause dizziness, vomiting, convulsions, colic, bloody diarrhea, abortion, nervous excitement, and kidney damage.
Large doses of bryonia can cause anuria, collapse, paralysis, and death (2). Bryonia berries can be fatal when taken orally; 40 berries can be fatal in adults, and 15 berries can be fatal in children (18).
Topically, skin contact with fresh bryonia may cause irritation (19).
Dermatologic ...Topically, skin contact with fresh bryonia may cause irritation (19).
Gastrointestinal ...Orally, bryonia root can cause vomiting, colic, and bloody diarrhea (2).
Genitourinary ...Orally, bryonia root can cause abortion (2). Large doses of bryonia can cause anuria and death (2).
Musculoskeletal ...Orally, large doses of bryonia can cause paralysis and death (2).
Neurologic/CNS ...Orally, bryonia root can cause dizziness, convulsions, and nervous excitement (2). Large doses of bryonia can cause paralysis and death (2).
Renal ...Orally, bryonia root can cause kidney damage (2). Large doses of bryonia can cause anuria and death (2).
Other ...Orally, bryonia berries can be fatal. Consuming 40 berries can be fatal in adults and as few as 15 berries can be fatal in children (18).
General
...Orally, European mistletoe seems to be well tolerated when used in small amounts.
However, a thorough evaluation of safety outcomes has not been conducted. Parenterally, European mistletoe may be safe when administered by a healthcare provider. High oral or parenteral doses may be unsafe.
Most Common Adverse Effects:
Orally: Diarrhea, intestinal cramps, and vomiting at high doses.
Parenterally: Chills, diarrhea, eosinophilia, fever, flatulence, headache, malaise, nausea, pruritus, vomiting, and pain and inflammation at the injection site.
Serious Adverse Effects (Rare):
Orally: Hepatitis, seizures, coma, and death at high doses.
Parenterally: Necrosis at injection site. Allergic reactions, including anaphylaxis, in sensitive individuals.
Cardiovascular ...Subcutaneously, European mistletoe may cause angina and orthostatic circulatory disturbances (7044,7045,9769).
Dermatologic ...Subcutaneously and intravenously, European mistletoe may cause pruritus, skin rash, and angioedema (93261,93265,93266,96476,107285,107286). When administered subcutaneously, the use of an extended dose-escalation regimen may limit the development of localized reactions in comparison to rapid dose escalation (96476).
Endocrine ...Intravenously, aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, may cause hypokalemia (16385).
Gastrointestinal ...Orally, European mistletoe may cause vomiting, diarrhea, and intestinal cramps (18). Intraperitoneal and intratumoral injection may cause nausea, vomiting, and abdominal pain (7106,93264,96495). Subcutaneously, European mistletoe may cause flatulence, loose stools, diarrhea, nausea, and vomiting (93261,93265). Intravenously, aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, may cause nausea and vomiting (16385,93261).
Genitourinary ...Intravenously, aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, may change urinary frequency (16385,93261).
Hematologic ...Subcutaneously, intraperitoneally, or intratumorally, European mistletoe may cause eosinophilia (7044,7045,7106,9769).
Hepatic
...Orally, European mistletoe has been associated with two cases of hepatotoxicity when used in combination with other herbal ingredients.
In one case, in which a patient took a combination herbal product, it was deemed unlikely that European mistletoe was the causative agent. It was determined to be most likely due to another ingredient or product contamination (3932). In another case, a previously healthy male presented to the hospital with mild fever, brownish urine, and elevated liver function enzymes after frequent use of European mistletoe extract for 1 month and kudzu root extract for 10 days. Upon discontinuation of the two extracts, liver function slowly returned to normal with no other symptoms (88777). It is unclear if European mistletoe, kudzu, or the combination was responsible for this adverse effect.
Intravenously, aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, may cause elevated liver enzymes (16385,93261).
Immunologic
...Subcutaneously, European mistletoe may cause allergic reactions (7044,7045,9769) or flu-like symptoms or mild infections (93261).
Early research shows that European mistletoe is not associated with an increase in side effects when it is administered in conjunction with targeted cancer treatments such as monoclonal antibodies and immunotherapy regimens, including PD-1/PD-L1 or CTLA-4 inhibitors (96490,96489). There are two case reports of apparent immunologic response to the application of European mistletoe for pleurodesis, resulting in acute respiratory distress and pneumonitis (96488,96494).
There are at least 5 reports of anaphylactic reactions associated with subcutaneous European mistletoe extract (15352,107286). In one case, anaphylaxis did not occur until after 2 years of treatment with European mistletoe (15352). Aviscumine has also been associated with anaphylactic reactions in people who have previously used European mistletoe products (16385).
Musculoskeletal ...Subcutaneous, intratumoral, intraperitoneal, and intravenous administration of European mistletoe can cause pain at the injection site (7044,7045,9769,93264,93266,7106,93261,96495). There is one report of a benign abdominal wall mass developing at the European mistletoe injection site, which was likely the result of a local inflammatory response (15350). Necrosis can also occur at the site of injection (8).
Neurologic/CNS ...Orally, European mistletoe may cause seizures, coma, and death (18). Subcutaneously, European mistletoe can cause headaches (7044,7045,9769,93261,93265) or fatigue or malaise (93261,93265). When injected into the tumor, European mistletoe can cause headaches (93264,96495). Intravenous infusion of aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, can cause fatigue (16385,93261).
Ocular/Otic ...Orally, European mistletoe may cause contraction of the pupil and uncontrollable eye movement (18). Subcutaneously, European mistletoe may cause dry eyes (93261).
Pulmonary/Respiratory ...There are multiple reports of acute respiratory effects after application of European mistletoe for pleurodesis. In one case, a 52-year-old male presenting with pneumothorax received European mistletoe extract 40 mg (ABNOBAviscum F, ABNOBA Helmittel GmbH) with 50 mL of normal saline into the pleural space. After 3 days, the patient experienced worsening dyspnea with right pleural effusion and bilateral lung infiltration requiring intubation and mechanical ventilation (96488). In another case, a 58-year-old male presenting with postoperative pleural effusion received pleurodesis with European mistletoe extract 500 mg (ABNOBAviscum F) on days 6, 8, 12, and 16 after surgery. Imaging revealed apparent acute respiratory distress and pneumonitis, but without corresponding clinical symptoms, which improved after 5 days of supportive care (96494). In a small retrospective study, 28% of elderly patients with secondary spontaneous pneumothorax who underwent chemical pleurodesis with European mistletoe extract 60 mg (Abnova Viscum-F) in 50 mL of normal saline experienced dyspnea with associated desaturation. These adverse effects were attributed to pain caused by the induced pleural inflammation, and may have also been related to the patients' underlying impaired pulmonary function. Treatment with oxygen via nasal cannula resulted in improvement of symptoms in most patients within 24 hours (105838).
Other ...Subcutaneously, intravenously, and intratumorally, European mistletoe can cause malaise, chills, and high fever (7044,7045,9769,93261,93264,93265,93266,93268,96495,99499). Intravenous infusion of aviscumine, a pure form of mistletoe lectin I produced by recombinant DNA techniques, can cause fever (16385,93261).
General
...There is currently a limited amount of information available about the adverse effects of madder.
Orally, madder can cause red colored urine, saliva, and perspiration (2). There is some concern that madder can stain contact lenses. Advise patients to be cautious (6002).
Topically, contact dermatitis has been reported while handling madder (20044).
Dermatologic ...Orally, madder can cause red-colored perspiration (2).
Gastrointestinal ...Orally, madder can cause red-colored saliva (2).
Genitourinary ...Orally, madder can cause red-colored urine (2).
Immunologic ...A case of contact dermatitis has been reported in a woman who handled madder while working in the garden (20044).
Ocular/Otic ...There is some concern that madder can stain contact lenses (6002).